ライフサイエンスコーパス: hydroxytryptophan

1 d by biogenic amine precursors (L-DOPA and 5-hydroxytryptophan).

2 up and metabolize the serotonin precursor 5-hydroxytryptophan.

3 h further improvement with the addition of 5-hydroxytryptophan.

4 n-dependent hydroxylation of tryptophan to 5-hydroxytryptophan.

5 precursor levodopa and serotonin precursor 5-hydroxytryptophan.

6 it IV), almost certainly due to formation of hydroxytryptophan.

7 f molecular oxygen into tryptophan to form 5-hydroxytryptophan.

8 produce 5-HT from its immediate precursor, 5-hydroxytryptophan.

9 on emission tomography (PET) marker [(11)C]5-hydroxytryptophan ([(11)C]5-HTP) for this purpose.

10 adjunct treatment with the 5-HT precursor 5-hydroxytryptophan (5-HTP) elevates 5-HTExt beyond the SS

11 ) determination ex vivo of accumulation of 5-hydroxytryptophan (5-HTP) in tissue from the dorsal and

12 Accumulation of 5-hydroxytryptophan (5-HTP) in vivo, in the presence of th

13 ed, treatment with the serotonin precursor 5-hydroxytryptophan (5-HTP) increased the intensity of ser

14 bution of the immediate precursor of 5-HT, 5-hydroxytryptophan (5-HTP), in two model opisthobranch mo

15 ed during lactation and after injection of 5-hydroxytryptophan (5-HTP).

16 Following oxidation of 5-hydroxytryptophan (5-HTPP) at a pyrolytic graphite elect

17 Central serotonin (5-hydroxytryptophan, 5-HT) modulates somatosensory transdu

18 e by itself, was then combined either with 5-hydroxytryptophan (5HTP), a serotonin precursor, or with

19 The concentrations of 5HT and 5-hydroxytryptophan (5HTP, an index of 5HT synthesis) were

20 urther show that 7-azatryptophan (7AW) and 5-hydroxytryptophan (5HW) can also serve as a FRET accepto

21 yptophan analogues, 7-azatryptophan (7AW), 5-hydroxytryptophan (5HW), and 4-, 5-, and 6-fluorotryptop

22 The set of tryptophan analogues includes 5-hydroxytryptophan, 7-azatryptophan, 4-fluorotryptophan,

23 The tryptophan analogues, 5-hydroxytryptophan, 7-azatryptophan, 4-fluorotryptophan,

24 After intravenous injection of (11)C-hydroxytryptophan, a 60-min dynamic PET scan was acquire

25 (11)C-hydroxytryptophan accumulated rapidly in both endocrine

26 ll line (CM) were applied for in vitro (11)C-hydroxytryptophan accumulation/efflux experiments and bl

27 Tyrosine and the serotonin-precursor 5-hydroxytryptophan also activate AHR signaling in combina

28 ) antagonist, N-acetyl-5-hydroxytryptophyl-5-hydroxytryptophan amide, and by 1.0 microM tropisetron,

29 5-Hydroxytryptophan and 7-azatryptophan have red-shifted a

30 s of 5-HT, its precursors L-tryptophan and 5-hydroxytryptophan and the metabolite 5-hydroxyindole ace

31 xyindoles serotonin (5-hydroxytryptamine), 5-hydroxytryptophan, and 5-hydroxyindole acetic acid are r

32 ed for the synthesis of physostigmine from 5-hydroxytryptophan, as shown by in vitro total reconstitu

33 ctively monitors the fluorescence yield of 5-hydroxytryptophan by exciting the reaction mix at 300 nm

34 hesis and similarly serves as a cofactor for hydroxytryptophan decarboxylase, the enzyme that is part

35 , such as l-(11)C-methionine and l-1-(11)C-5-hydroxytryptophan, demonstrated promising results, inclu

36 tracer for beta-cell mass, based on an (11)C-hydroxytryptophan derivative with increased resistance t

37 The unfolding data show that 5-hydroxytryptophan does not perturb the stability of wild

38 -Raman spectroscopy proves the presence of 5-hydroxytryptophan, epidermal TPH activity is completely

39 Chemical-quench analyses show that 5-hydroxytryptophan forms with a rate constant of 1.3 s(-1

40 ically encoded the noncanonical amino acid 5-hydroxytryptophan in both E. coli and eukaryotes, enabli

41 sm and the retention of the PET tracer (11)C-hydroxytryptophan in endocrine and exocrine pancreas in

42 ET images showed clear accumulation of (11)C-hydroxytryptophan in the pancreas in both animal groups,

43 demonstrate that both the formation of the 6-hydroxytryptophan intermediate (+16 Da) and subsequent o

44 spectral characteristics of tryptophan and 5-hydroxytryptophan is presented.

45 (11)C-hydroxytryptophan is trapped in beta-cells but not in ex

46 an initial increase in the 5-HT precursor 5-hydroxytryptophan it too decreased with increasing ammon

47 f the purified fusion enzyme is 80 nmol of 5-hydroxytryptophan/min/mg.

48 rescence lifetimes of "free" Trp derivatives hydroxytryptophan (OH-Trp), N-formylkynurenine (NFK), ky

49 urenine (Kyn), N-formylkynurenine (NFK), and hydroxytryptophan (OH-Trp).

50 of the N-(1,1-dimethyl-2,3-epoxypropyl)-beta-hydroxytryptophan residue of cyclomarin A was further il

51 The 5-hydroxytryptophan residue was shown to allow rapid, chem

52 anine and tryptophan, forming tyrosine and 5-hydroxytryptophan, respectively.

53 recursor of dopamine), and tryptophan into 5-hydroxytryptophan (the precursor of serotonin), respecti

54 agments were isolated and characterized as 6-hydroxytryptophan using matrix-assisted laser desorption

55 lated tryptophan (W(1)) and C(2)-hexosylated hydroxytryptophan (W(2)), the latter of which is redox a

56 ndole acetic acid, but not L-tryptophan or 5-hydroxytryptophan, were reduced in the medulla by 45 and

57 rbance spectrum of W(2) is consistent with 7-hydroxytryptophan, which represents an intriguing new th