ライフサイエンスコーパス: hyperacetylated

1 H3 and H4 revealed that H4, but not H3, was hyperacetylated.

2 persensitive site forms, and the enhancer is hyperacetylated.

3 reporter is activated, its promoter becomes hyperacetylated.

4 strain in which surface-associated EsxA was hyperacetylated.

5 sB isolated from the ackA or cobB mutant was hyperacetylated.

6 in beta (C/EBPbeta) and c-Myc, which is also hyperacetylated.

7 tor BRM is replaced by BRG1 and histones are hyperacetylated.

8 or to nucleosomes in which these domains are hyperacetylated.

9 the absence of HDAC3, the RORC promoter was hyperacetylated.

10 mic, but inactive, to a stabilised, possibly hyperacetylated, active state.

11 Additional proximal domains were hyperacetylated after stimulation of transcription.

12 seven lysine residues in hsp90alpha that are hyperacetylated after treatment of eukaryotic cells with

13 indicate Vbeta and DbetaJbeta segments to be hyperacetylated and accessible in DN thymocytes.

14 enome is organized into histone H3 (K9, K14) hyperacetylated and hypoacetylated regions corresponding

15 t (LBH589), the extracellular hsp90alpha was hyperacetylated and it bound to MMP-2, which was associa

16 henomenon and found that Geminin maintains a hyperacetylated and open chromatin conformation at neura

17 ycle, an increase of comparable magnitude of hyperacetylated and phosphorylated histone H3 at Zp and

18 udies revealed that the polyQ-expanded AR is hyperacetylated and that pharmacologic reduction of acet

19 When chromatin templates were first hyperacetylated and then incubated with NURF, significan

20 In diabetic mice, CYP7A1 chromatin is hyperacetylated, and fasting to refeeding response is im

21 ed with chromatin, histone H4 became locally hyperacetylated, and gene expression was induced.

22 Hyperacetylated arrays show no change in the preference

23 ns were not induced, although histone H3 was hyperacetylated as measured by immunoblotting or by ChIP

24 However, the locus is not uniformly hyperacetylated, as there are regions of hypoacetylation

25 In Nonabokra, the upstream region was hyperacetylated at H3K9 and H3K27, and this acetylation

26 ated that during latency the LAT promoter is hyperacetylated at histone H3 (K9, K14) relative to lyti

27 reveal that the proximal insulin promoter is hyperacetylated at histone H3 only in beta cells.

28 Actively transcribed genes are typically hyperacetylated at Lys residues of histones H3 and H4 an

29 HDA1 deletion, many Tup1-repressed genes are hyperacetylated at lysine 18 of histone H3, yet are not

30 hain acyl coenzyme A dehydrogenase (LCAD) is hyperacetylated at lysine 42 in the absence of SIRT3.

31 ith regions of chromatin containing histones hyperacetylated at lysine residues, a characteristic of

32 anscript (LAT) region of the viral genome is hyperacetylated at lysines 9 and 14 of histone 3 [H3(K9,

33 hypoacetylated on histone H3, whereas it is hyperacetylated at the plasma cell stage.

34 Germline V(H) genes were not hyperacetylated at this stage, which accounts for D(H) t

35 sines on histone 3 at the Cad6b promoter are hyperacetylated before neural crest emigration, correlat

36 colocalize in discrete nuclear foci that are hyperacetylated but transcriptionally inactive.

37 Histones H3 and H4 simultaneously become hyperacetylated, but it remains unclear whether this is

38 ects of dSir2 with native histones that were hyperacetylated by treatment with acetic anhydride.

39 d Brd3 associate preferentially in vivo with hyperacetylated chromatin along the entire lengths of tr

40 scriptionally active macronucleus containing hyperacetylated chromatin and a transcriptionally silent

41 se activity, providing a direct link between hyperacetylated chromatin and transcriptional activation

42 se (HAT) Esa1p or Gcn5p creates a segment of hyperacetylated chromatin that is at least 2.6 kb in siz

43 tylated chromatin, and in distributions from hyperacetylated chromatin, particularly for long repeat

44 the upstream locus control region reside in hyperacetylated chromatin.

45 disrupted ATRX binding to the centromeres of hyperacetylated chromosomes resulting in abnormal chromo

46 find that histones at the active origins are hyperacetylated, coincident with binding of the origin r

47 active promoters, with H3 being dramatically hyperacetylated compared with that from inactive promote

48 ers, however, resulted in the formation of a hyperacetylated domain over these genes in definitive er

49 The hyperacetylated domain was not seen in male cells or in

50 e erythroblasts reside within a single large hyperacetylated domain.

51 pothesize that formation of extended histone hyperacetylated domains across the Ifng gene region repr

52 ow the range of possible mechanisms by which hyperacetylated domains form.

53 These hyperacetylated domains occur exclusively at loci contai

54 on and active transcription, similar histone hyperacetylated domains were found in NK cells.

55 Previously, we characterized such hyperacetylated domains within mammalian beta-globin gen

56 term such patterns of histone modifications "hyperacetylated domains." Little is known of either the

57 tone H3 and H4 Lys residues are not globally hyperacetylated during phas expression.

58 ds and was absent from moderately condensed, hyperacetylated euchromatic bands and highly condensed,

59 and Hst4p, in which H3 K56 is constitutively hyperacetylated, exhibit hallmarks of spontaneous DNA da

60 relate with approximately 100 unprecedented, hyperacetylated expanses of chromatin that reach up to 2

61 g euchromatic genes, with active genes being hyperacetylated for H3 and H4 and hypermethylated at Lys

62 reases in H2A.Z levels in yeast mutants with hyperacetylated H3K56.

63 geting p300 on the presence of RNAPII, p300, hyperacetylated H4 and H3 and unmodified H4 and H3 in tr

64 While hyperacetylated H4 and H3 were found in the coding regio

65 Antibodies to hyperacetylated H4 were used to immunoprecipitate dinucl

66 Mle colocalizes with hyperacetylated H4Ac16 on the X-chromosome and some auto

67 s subsaturating levels with nonacetylated or hyperacetylated HeLa histones.

68 us subsaturated levels with nonacetylated or hyperacetylated HeLa histones.

69 These elements were also associated with hyperacetylated histone 3 in a lineage-specific manner a

70 ng was a COPD-specific eightfold increase of hyperacetylated histone H3.3.

71 Hyperacetylated histone H4 appeared within 2 h of the ad

72 aining peptides are comparable to those of a hyperacetylated histone H4-mimicking cognate peptide, an

73 s) that does not correlate directly with the hyperacetylated histone status.

74 ors such as trapoxin A (TPX), which leads to hyperacetylated histone, alters local chromatin architec

75 With this hyperacetylated histone-DNA complex, we observed potent

76 Domains of hyperacetylated histones and hypomethylated DNA extended

77 ponding reduction in the amounts of p300 and hyperacetylated histones associated with the transcribin

78 e H3 at lysine-4 (H3-meK4), colocalizes with hyperacetylated histones H3 and H4 in mammalian chromati

79 ) protocols to determine the distribution of hyperacetylated histones H3 and H4 in the Saccharomyces

80 ated at lysine 4 (H3-meK4) co-localizes with hyperacetylated histones H3 and H4 in transcriptionally

81 complex 2 protein (ORC2) and was enriched in hyperacetylated histones H3 and H4 relative to other reg

82 ted histones H3 and H4 more efficiently than hyperacetylated histones H3 and H4.

83 However, nucleosome assembly by hyperacetylated histones on interrupted CGG tracts was i

84 Assembly of the hyperacetylated histones onto DNA yields a soluble histo

85 of Gcn5p-regulated genes are associated with hyperacetylated histones upon activation by low-copy Gcn

86 Interestingly, hypomethylated DNA and hyperacetylated histones were also located at the cyclin

87 We show that hyperacetylated histones were recruited to this site in

88 n in repressed conditions in the presence of hyperacetylated histones.

89 e DNA-bending protein HMG-1 or by the use of hyperacetylated histones.

90 yrate and trichostatin A were used to create hyperacetylated histones.

91 g around the nuclei of spermatids containing hyperacetylated histones.

92 histones are used, compared to assembly with hyperacetylated histones.

93 ed DNA and, importantly, was associated with hyperacetylated histones.

94 promoter is unmethylated and associated with hyperacetylated histones.

95 and repressively marked histones but not to hyperacetylated histones.

96 atients with ALD, there was disulfide-bonded hyperacetylated HMGB1, disulfide-bonded non-acetylated H

97 nction of hsp90, and targeting extracellular hyperacetylated hsp90alpha may undermine tumor invasion

98 SIRT3 is hyperacetylated in aged and obese mice, in which SIRT1 a

99 Core histones are hyperacetylated in cells overproducing functional Gcn5p,

100 t dominate the adult TCRdelta repertoire are hyperacetylated in DN thymocytes, independent of their p

101 he cyclin D1 promoter was hypomethylated and hyperacetylated in expressing cell lines and patient sam

102 at OPA1, a mitochondrial fusion protein, was hyperacetylated in hearts under pathological stress and

103 Hypersensitive site two of the LCR was also hyperacetylated in murine embryonic stem cells, whereas

104 shown that heart mitochondrial proteins are hyperacetylated in OVE26 mice, a transgenic model of typ

105 iate domain and the 3' V(H) genes, which are hyperacetylated in response to DJ(H) recombination.

106 )-dependent reversible acetyl-lysine that is hyperacetylated in Sirt3/ livers at 3 months of age.

107 t that histone H3 and H4 were constitutively hyperacetylated in the donor Smu region before and after

108 Furthermore, CerS1, -2, and -6 are hyperacetylated in the mitochondria of SIRT3-null mice,

109 and both active and inactive promoters were hyperacetylated in yolk sac.

110 Moreover, c-Myc is hyperacetylated, levels of p27 are reduced, and cyclin-d

111 ealed the formation of ZNF532-NUT-associated hyperacetylated megadomains, distinctly localized but ot

112 sulted in increased DNase I accessibility on hyperacetylated mononucleosomes and substantial reductio

113 Hyperacetylated nucleosomal arrays show only subtle diff

114 We find hyperacetylated nucleosomes less susceptible to CoREST/L

115 t it is thermodynamically more difficult for hyperacetylated nucleosomes to assemble onto the 172-12

116 o a more natural system involving intact but hyperacetylated nucleosomes.

117 ed identical cleavage patterns in normal and hyperacetylated nucleosomes.

118 Nav1.5 is hyperacetylated on K1479 in the hearts of patients with

119 erform assays with arrays reconstituted with hyperacetylated or trypsinized histones and isolated his

120 matin immunoprecipitation with antibodies to hyperacetylated or unacetylated H4 or H3.

121 al arrays reconstituted with hypoacetylated, hyperacetylated, or partially trypsinized histones.

122 Pull-down assays revealed that hyperacetylated p300 HAT is more efficiently retained by

123 300 HAT acetylation of a histone H4 peptide, hyperacetylated p300 HAT is much more potently inhibited

124 utoacetylation was retained about as well as hyperacetylated p300 HAT, suggesting that the loop and A

125 the cytosol, autophagy is abrogated, ATG7 is hyperacetylated, p53 acetylation is abolished, and p300

126 athways but encoding normal small T showed a hyperacetylated pattern similar to that of wild-type vir

127 Of note, the top 38 case hyperacetylated promoters (P < 0.05) included >15 genes

128 terochromatic domains in vivo, histone H3 is hyperacetylated, providing evidence that the chromatin a

129 anied by enhanced chromatin accessibility at hyperacetylated regions in the gene body.

130 (HDACs) revealed hundreds of genes linked to hyperacetylated regions targeted by CBP.

131 region containing the 5' exon of KOS/29 was hyperacetylated relative to lytic gene regions in the ab

132 on of SIRT1 in macrophages renders NF-kappaB hyperacetylated, resulting in increased transcriptional

133 Smarce1 as well as in the reorganization of hyperacetylated round spermatid chromatin.

134 erved an increased frequency of mutations in hyperacetylated Sgamma DNA segments immunoprecipitated w

135 The hyperacetylated species concentrates at the 5' end of ac

136 plays a detrimental role when cells are in a hyperacetylated state and experience treatment with radi

137 We find that acetate induces a hyperacetylated state of histone H3 in hypoxic cells.

138 overexpressed a point mutant that mimics the hyperacetylated state of Hsp90 at lysine K294.

139 We found that inducing a histone hyperacetylated state via HDAC inhibition transforms a l

140 nitially, a 120 kb domain of germline DNA is hyperacetylated, that extends from D(FL16.1), the 5'-mos

141 criptionally inactive state but not with the hyperacetylated transcriptionally active form.

142 promoter-associated histones are transiently hyperacetylated, while those in the coding region are no

143 r normal locations, and that histones became hyperacetylated within these regulatory elements.

144 s complemented with XPA-K6367Q, which mimics hyperacetylated XPA, display significantly higher UV sen