ライフサイエンスコーパス: hyperactivated

1 id cells in disease states where p21(ras) is hyperactivated.

2 lls in which the beta-catenin/Tcf pathway is hyperactivated.

3 ast some CSF-1R-associated proteins also are hyperactivated.

4 arental Kras(G12D) mice, where STAT3 was not hyperactivated.

5 duced while ER O-glycosylation initiation is hyperactivated.

6 ome various barriers, their motility must be hyperactivated, a motion that is characterized by vigoro

7 nhibition of the Rheb-mTOR pathway, which is hyperactivated after loss of TSC2, decreased MCP-1 produ

8 However, if mTORC1 was hyperactivated after myelination onset, radial hypermyel

9 Because LNCaP cells have hyperactivated Akt function due to PTEN inactivation, we

10 ncer agent for patients whose tumors express hyperactivated Akt.

11 Strains harboring a hyperactivated allele of CDC28 that is CAK1 independent

12 Lyn-deficient DCs were hyperactivated and hyperresponsive to Toll-like receptor

13 d progenitor cells (HSPCs), whereas they are hyperactivated and lost in the circulation when wild-typ

14 Lat2(-/-) T cells were hyperactivated and produced more cytokines than Lat2(+/+

15 urther that CD4+ T cells of 4.1R-/- mice are hyperactivated and that they displayed hyperproliferatio

16 hock sensitivity of a strain in which RAS is hyperactivated and the heat shock sensitivity of a wscDe

17 /RSK MAPK signaling module is constitutively hyperactivated, and Bad is maintained in its inactive st

18 Lymphocytes from these transgenic mice were hyperactivated, and T cells produced large amounts of ty

19 Aurora kinases A, B, and C, were found to be hyperactivated, and the altered expression of CDK1 was f

20 Thus, neither costimulatory tumor cells nor hyperactivated antitumor lymphocytes were sufficient to

21 Nevertheless, doubly deficient B cells were hyperactivated, as evidenced by extremely elevated serum

22 Hyperactivated beta-catenin is a commonly found molecula

23 ession and binding to p300 may contribute to hyperactivated beta-catenin transcriptional activity in

24 Mechanisms to mute hyperactivated brain regions and delink dysregulated neu

25 increased parasympathetic signaling leads to hyperactivated bronchoconstriction and abnormal respirat

26 e, extramedullary splenic erythropoiesis was hyperactivated, but this did not lead to accelerated rec

27 nnel critical for mechanosensation that when hyperactivated by a mec-4(d) mutation induces necrosis o

28 s, most genes from the male X chromosome are hyperactivated by a special dosage compensation system.

29 d T257I are inhibited, the other mutants are hyperactivated by AdoMet.

30 way was particularly emphasized when ECS was hyperactivated by AEA and in ob/ob tissue.

31 Mus81-Mms4 is hyperactivated by Cdc5-mediated phosphorylation in meios

32 bnormal automaticity when these channels are hyperactivated by elevated Ca(2+) .

33 Consequently, HSCs are hyperactivated by interleukin-1beta and possibly other p

34 genes), in which the reporter construct was hyperactivated by low temperature, but not by abscisic a

35 ns between MPFC and DLPFC, a region that was hyperactivated by patients and relatives during WM perfo

36 Caenorhabditis elegans DEG/ENaC MEC-4 is hyperactivated by the (d) mutation and induces death of

37 al RNA methylation, was identified as a gene hyperactivated by the BL-associated Myc mutants.

38 In each case, the target is hyperactivated by the drug.

39 Here, we found that hyperactivated c-Met led to increased NF-kappaB signalin

40 vation of c-Raf containing mutated W342 in a hyperactivated c-Raf, but not in a wild type c-Raf and (

41 nases (TALERs): engineered fusions between a hyperactivated catalytic domain from the DNA invertase G

42 oly(ADP-ribose) polymerase-1 (PARP-1) can be hyperactivated, causing (ADP-ribosyl)ation of nuclear pr

43 cumulation of proinflammatory CD57(+)CD28(-) hyperactivated CD8(+) T cells that may promote atheroscl

44 ojection extension is stimulated by Bem1 and hyperactivated Cdc42.

45 partial inhibition of the spliceosome in MYC-hyperactivated cells leads to global intron retention, w

46 tor 2 (TRAF2), are upstream of JNK in PARP-1 hyperactivated cells, because PARP-1-induced JNK activat

47 protein (MAP) kinase (MAPK) is significantly hyperactivated compared with ERalpha+ breast cancer.

48 es in sarcomas where PI3K and mTOR are often hyperactivated could improve the suitable recruitment of

49 h increasing prevalence, is characterized by hyperactivated cytokines of helper T cell subset 2 and i

50 1) and Hop(T42) both hyperphosphorylated and hyperactivated D-Stat when overexpressed in Drosophila c

51 Furthermore, A20-silenced, hyperactivated DCs exhibited an enhanced homing capacity

52 Because hyperactivated DDC signalling can lead to a persistent a

53 Hyperactivated DEG/ENaCs induce neuronal death through e

54 al that an important mTOR substrate is found hyperactivated downstream of Myc oncogenic activity to p

55 TMEM16F-deficient T cells are hyperactivated during the early phase of infection, exhi

56 cell death, all phenotypes characteristic of hyperactivated EGFR signaling.

57 pressed in body wall muscle precursor cells, hyperactivated EGL-15 can also interfere with the proper

58 size in roots, premature cell expansion and hyperactivated endocycle in leaves.

59 ulin-binding region from ACVIII results in a hyperactivated enzyme state and a loss of Ca2+ sensitivi

60 In cystic fibrosis airway epithelia, a hyperactivated epithelial Na(+) conductance operates in

61 gh incidence of activating RAS mutations and hyperactivated ERK1/2 signaling observed in many human t

62 Hyperactivated extracellular signal-regulated kinase (ER

63 ld-type ezrin, closed ezrin, open ezrin, and hyperactivated ezrin.

64 broken allele also suppresses the effects of hyperactivated FGF but not EGF receptors.

65 FGF and can be phosphorylated in response to hyperactivated FGF signaling in Xenopus embryos.

66 t process of capacitation, the transition to hyperactivated flagellar motility, develops with a simil

67 We identified hyperactivated focal adhesion kinase (FAK) activity in n

68 lysis has proposed that there may be a third hyperactivated form of ezrin.

69 hey may be related to the stabilization of a hyperactivated form of the enzyme, like in the case of l

70 s not the sole activator of Race, although a hyperactivated form of zen (a zen-VP16 fusion protein) c

71 essed endosperm and seed coat regulators and hyperactivated genes encoding ribosomal, photosynthetic,

72 fic sequences were found in the promoters of hyperactivated genes.

73 tism and inflammatory liver cancer caused by hyperactivated GH signaling (GH(tg) ) to mice with hepat

74 ormation of aggressive HCC in the setting of hyperactivated GH signaling.

75 in a pure C57BL/6 background does not induce hyperactivated granulocyte macrophage colony-stimulating

76 ese findings correlated with the presence of hyperactivated helper T cells, which proliferated more v

77 SDH(var+) cells showed stabilized and hyperactivated hypoxia inducible factor (HIF)1alpha sign

78 not of the virus infection per se but of the hyperactivated immune response.

79 s identify a pathway, present in WT mice and hyperactivated in 53BP1-deficient mice, by which microbi

80 unaltered ERK activation but in AKT that was hyperactivated in a BRAF-dependent manner.

81 PARP1 is highly expressed and constitutively hyperactivated in a majority of human CDDP-resistant can

82 It is overexpressed and/or hyperactivated in a variety of cancer cells, thus its in

83 ption 5 (STAT5) is activated by G-CSF and is hyperactivated in acute myeloid leukemia.

84 ase 5 (Cdk5), a critical neuronal kinase, is hyperactivated in AD brains and is, in part, responsible

85 ortantly, similar to lyn(-/-) cells, Fyn was hyperactivated in ASK cells.

86 ion of normal T cells and are constitutively hyperactivated in both HTLV-1-transformed human T cell l

87 ain development and function and is commonly hyperactivated in brain cancer.

88 We found that Src was hyperactivated in brain-seeking breast cancer cells deri

89 udies show that Rac1 GTPase is overexpressed/hyperactivated in breast cancer cells and is associated

90 inositol-3-kinase (PI3K) pathway is commonly hyperactivated in cancer.

91 he phosphoinositide 3-kinase/Akt pathway was hyperactivated in cells expressing physiologic levels of

92 ecretions and that this signaling pathway is hyperactivated in CF human, pig, ferret, and mouse SMGs.

93 Akt, mTOR, and their substrates were hyperactivated in colon epithelium of Apcmin/+/Sigirr-/-

94 Pak1 is frequently overexpressed and/or hyperactivated in different human cancers, including hum

95 Akt is a key component of this pathway and hyperactivated in different tumors including neuroblasto

96 n summary, these data suggest that mTORC2 is hyperactivated in gliomas and functions in promoting tum

97 We show that p42/44 MAPK (ERK1/2) is hyperactivated in hearts derived from Cav-3 knock-out mi

98 ATM/ATR are hyperactivated in hMMS21-RNAi cells upon DNA damage.

99 Upon ionizing radiation, ATM is hyperactivated in HOXB9-expressing cells during the earl

100 EK and JAK/STAT signaling, which is commonly hyperactivated in human and mouse CMML, potently inhibit

101 tors, and lipid signaling, is upregulated or hyperactivated in human breast cancer.

102 The Akt pathway is frequently hyperactivated in human cancer and functions as a cardin

103 Akt is frequently hyperactivated in human cancers and is targeted for canc

104 -activated protein kinases (MAPKs) are often hyperactivated in human cancers, where they affect multi

105 ll survival and proliferation, is frequently hyperactivated in human cancers.

106 K)4 and CDK6 are frequently overexpressed or hyperactivated in human cancers.

107 androgen receptor (AR) is overexpressed and hyperactivated in human castration-resistant prostate ca

108 K1; official name RPS6KA1) was significantly hyperactivated in human melanoma lines and metastatic ti

109 aled that the inflammatory cytokine IL-6 was hyperactivated in IkappaBepsilon(-/-) B cells.

110 Here, we show that NF-kappaB was hyperactivated in in vitro models of OXA-acquired resist

111 Clinically, this PML degradation pathway is hyperactivated in lung cancer and correlates with poor p

112 The PI3K-AKT pathway is hyperactivated in many human cancers, and several drugs

113 abolic pathways and protein synthesis and is hyperactivated in many human cancers.

114 the mammalian target of rapamycin (mTOR) is hyperactivated in many human tumors, including hamartoma

115 ylated by AKT/PKB, a survival kinase that is hyperactivated in many late stage tumors.

116 radation of subcellular constituents that is hyperactivated in many neurodegenerative conditions.

117 he mechanistic target of rapamycin (mTOR) is hyperactivated in many types of cancer, rendering it a c

118 ctor receptor (EGFR) and Torso pathways, are hyperactivated in maternal Rho1 mutants, consistent with

119 mune-modulating kinase, is overexpressed and hyperactivated in MDSs.

120 the target of cucurbitacin-I inhibition, was hyperactivated in NF1-deficient primary astrocytes and n

121 ng phosphatase 2 (SHP-2) that is mutated and hyperactivated in Noonan syndrome and a significant port

122 lins and cyclin-dependent kinases (CDKs) are hyperactivated in numerous human tumors.

123 ested the hypothesis that AMPK would also be hyperactivated in O vs YA fast-twitch extensor digitorum

124 Because the AKT-mTOR pathway is frequently hyperactivated in ovarian cancer, we hypothesized that t

125 In this report we have shown that mTOR is hyperactivated in Pkd1-null mouse cells due to failure o

126 The PI3K/AKT pathway is hyperactivated in prostate cancer but its effective ther

127 , phosphoinositide 3-kinase/Akt signaling is hyperactivated in Pten conditional knock-out (cKO) retin

128 Here, we surprisingly show that PARP1 is hyperactivated in replicating BRCA2-defective cells.

129 f rapamycin complex 1 (mTORC1) signaling was hyperactivated in several tissues from Pip4k2c(-/-) mice

130 STAT3 signaling is hyperactivated in SSc in a TGFbeta-dependent manner.

131 Canonical Wnt signaling was hyperactivated in SSc skin biopsy specimens.

132 ssion, and that when the PI3K-Akt pathway is hyperactivated in Teff cells, these cells are resistant

133 ond to astrocyte-derived matrices and become hyperactivated in the Lamc3(-/-) retina or when tested i

134 AT3, AKT, and Wnt/beta-catenin pathways were hyperactivated in the skin and the lungs of diseased mic

135 t of rapamycin complex 1 (mTORC1) pathway is hyperactivated in tissues and tumors derived from LKB1-d

136 ing factor 1alpha (HIF1alpha) is known to be hyperactivated in TNBCs.

137 des promote normal growth and are frequently hyperactivated in tumour cells.

138 g A20-deficient NKT1 and NKT2 thymocytes are hyperactivated in vivo and secrete elevated levels of Th

139 he percentage of reactivated sperm that were hyperactivated increased to 80% when free Ca2+ was incre

140 e inactivated and enhancing it when they are hyperactivated, indicative of cells that normally play a

141 These data demonstrate that although hyperactivated IRE1 specifically cleaves BLOC1S1, this c

142 pressed in XBP1-deficient mice livers due to hyperactivated IRE1alpha.

143 a direct consequence, both Akt and Rac1 are hyperactivated, leading to cytoskeletal rearrangements a

144 des from abnormally low levels to normal pre-hyperactivated levels and, in 20-40% of sperm, induced h

145 growth in the adult CNS at both moderate and hyperactivated levels of ERK1/2 when upregulation commen

146 locus in a snf5Delta mutant and resulted in hyperactivated levels of SUC2 mRNA under inducing condit

147 ic components within the oxPAPC mixture that hyperactivated macrophages, allowing these cells to rele

148 Conversely, loss of Spry2 function hyperactivated MAPK-ERK signaling and caused increased B

149 In C. elegans, a hyperactivated MEC-4(d) ion channel induces necrotic-lik

150 3T3-L1 transfectants containing hyperactivated MEK1 or overexpressed MAPK displayed impa

151 in hematopoiesis, it remains unclear whether hyperactivated mitophagy affects the maintenance and dif

152 of the gene encoding the AAA+-ATPase Atad3a hyperactivated mitophagy in mouse hematopoietic cells.

153 Production of hyperactivated motility also required an alkaline enviro

154 el of sperm (CatSper) is essential for sperm hyperactivated motility and fertility.

155 CatSper4 also abrogated ICatSper, sperm cell hyperactivated motility and male fertility but did not a

156 and CatSper2 proteins are critical to sperm-hyperactivated motility and male fertility.

157 ple piece of the sperm tail is essential for hyperactivated motility and male fertility.

158 Sperm cells acquire hyperactivated motility as they ascend the female reprod

159 Ca(2+) entry pathways that support not only hyperactivated motility but possibly also normal pre-hyp

160 motility in the sperm population increasing hyperactivated motility by more than 10-fold as assessed

161 mportant for the sperm to be able to achieve hyperactivated motility in order to reach and fertilize

162 nnel that controls Ca2+ entry to mediate the hyperactivated motility needed late in the preparation o

163 ibited normal motility but could not achieve hyperactivated motility needed to traverse the female ge

164 ed Ca(2+)-selective channel required for the hyperactivated motility of spermatozoa and male fertilit

165 amplitude flagellar bends characteristic of hyperactivated motility than to produce activated motili

166 ll sperm indicates that a critical lesion in hyperactivated motility underlies the infertility phenot

167 Hyperactivated motility, a swimming pattern of mammalian

168 permatozoa have normal progressive motility, hyperactivated motility, and acrosome reactions.

169 , they acquire progressive motility, develop hyperactivated motility, and are readied for the acrosom

170 Thus, CatSper2 is responsible for driving hyperactivated motility, and, even with typical sperm fo

171 equired for successful fertilization such as hyperactivated motility, chemotaxis, and the acrosome re

172 ases in protein tyrosine phosphorylation and hyperactivated motility, which occur late in capacitatio

173 the null sperm cells is a failure to acquire hyperactivated motility, which seems to render spermatoz

174 Ca(2+) ([Ca(2+)](i)), and the appearance of hyperactivated motility.

175 lators of sperm tail calcium entry and sperm hyperactivated motility.

176 eir spermatozoa lack both Ca(2+) current and hyperactivated motility.

177 re the transition from activated motility to hyperactivated motility.

178 ge role in the initiation and maintenance of hyperactivated motility.

179 -selective current (I(CatSper)) required for hyperactivated motility.

180 ivated motility but possibly also normal pre-hyperactivated motility.

181 onal motion during CatSper channel-dependent hyperactivated motility.

182 e model flagellum compare well with data for hyperactivated mouse sperm.

183 for depolarization-evoked Ca2+ entry and for hyperactivated movement, a key flagellar function.

184 These spine deficits correlate with hyperactivated mTOR and impaired autophagy.

185 This crosstalk reveals how hyperactivated mTOR may suppress metastasis locally, whi

186 Recent studies show that hyperactivated mTOR, the 'target of rapamycin' that sens

187 social behavior deficits in ASD models with hyperactivated mTOR.

188 Hyperactivated mTORC1 signaling, an important feature of

189 nhibit ligand binding, and gain-of-function, hyperactivated mutant alphaPS2 proteins cause blistering

190 cence response triggered by Tax is caused by hyperactivated NF-kappaB and mediated by cyclin-dependen

191 s remodeling, including normalization of the hyperactivated p38, in the setting of pre-existing heart

192 e cells to PARP inhibitors is related to the hyperactivated PARP1 in these cells.

193 Interference with the hyperactivated pathways with various pharmacological and

194 nificantly enlarged T cell compartment and a hyperactivated peripheral T cell population.

195 Thus, we suggest that the NK hyperactivated phenotype observed in the Noe mice might

196 isingly, Sphk2(-/-) CD4(+) T cells exhibit a hyperactivated phenotype with significantly enhanced pro

197 Hyperactivated PI3K/Akt signaling led to upregulation of

198 and DSB repair, perhaps as a consequence of hyperactivated PI3K/Akt-1 signaling.

199 tion reverses trastuzumab resistance via the hyperactivated PIK/AKT/mTOR pathway due to PTEN loss, by

200 AP) kinase signaling pathway were abnormally hyperactivated prior to the onset of significant cardiac

201 Additionally, the Noe-NK cells were hyperactivated, probably due to increased Helios express

202 n the absence of IL-27R myeloid cells become hyperactivated, produce pro-inflammatory cytokines and a

203 JMML leukemogenesis is linked to a hyperactivated RAS pathway, with driver mutations in the

204 How to best contravene hyperactivated RAS signaling has remained elusive in hum

205 ed the amount of GTP-bound, active K-Ras and hyperactivated Ras-ERK1/ERK2 signaling.

206 -jun gene deletion reduced c-Src expression, hyperactivated ROCK II signaling, and reduced cellular p

207 To understand how a hyperactivated RTK functions differently from wild-type

208 In cancer cells, hyperactivated signaling pathways influence translation,

209 ay from a tethering point and consequently a hyperactivated sperm cell bound to an epithelial surface

210 affect the established waveform asymmetry of hyperactivated sperm.

211 The forceful asymmetric motion of hyperactivated spermatozoa requires Ca2+ entry into the

212 ACK2 is enhanced in cells overexpressing the hyperactivated Src(Y527F) mutant.

213 3 dimerization inhibitor capable of blocking hyperactivated STAT3 and suppressing malignant transform

214 Aberrantly hyperactivated STAT3 has been found in human liver cance

215 tination and degradation of LEF-1 protein by hyperactivated STAT5.

216 Like hyperactivated Stat92E, Chinmo misexpression in CySCs is

217 , wg is autonomously repressed in cells with hyperactivated Stat92E.

218 plored whether CD151 would mark T cells in a hyperactivated state.

219 Lymphoid and myeloid cells were in a hyperactivated state.

220 mulated with anti-CD28 mAb consistent with a hyperactivated state.

221 ent cations and shift dramatically upward to hyperactivated states with cell signaling in leukocytes.

222 ent cations and shift dramatically upward to hyperactivated states with cell signaling.

223 One form of sepsis, or endotoxic shock, is a hyperactivated systemic response caused by excessive exp

224 The hyperactivated T cells in these mice show defective TCR-

225 is is an inflammatory skin disease caused by hyperactivated T cells regulated by positive and negativ

226 The hyperactivated T cells that develop in these mice have d

227 or the majority of these adverse events is a hyperactivated T-cell response with reactivity directed

228 of development, the innate immune system was hyperactivated to a contraproductive level that impaired

229 ned when its downstream effector kinases are hyperactivated to trigger the negative feedback inhibiti

230 ncreased aliphatic glucosinolate content and hyperactivated transcript accumulation of the jasmonic a

231 lar resonance frequency, at which cells show hyperactivated transcriptional stress responses.

232 edback inhibition of Akt may occur in mTORC1 hyperactivated Tsc-associated tumours.

233 ell subsets: they inhibited T(reg) cells and hyperactivated tumor-infiltrating cytotoxic T lymphocyte

234 ERK is hyperactivated upon c-kit signaling in adherent and disp

235 phorylation in ubp8Delta ubp10Delta cells is hyperactivated upon stress, which may compensate for the

236 Hyperactivated variants of the resolvase/invertase famil

237 downstream effector of PTEN is Akt, which is hyperactivated via PTEN inactivation.

238 A mechanical advantage of this hyperactivated waveform has been hypothesized to be the

239 spleens, of diseased 5B6 transgenic mice are hyperactivated when compared with age-matched healthy mi

240 3(25,26,53,54) mutant protein stabilized and hyperactivated wild-type p53, which then inappropriately

241 ther immune and inflammatory pathways become hyperactivated with age and promote degeneration or whet

242 Phagocytic cells hyperactivated with lipopolysaccharide (LPS), which indu

243 extant macrophages and dendritic cells were hyperactivated, with CD11b and GR1 (Ly6G/C) highly expre

244 We have established a Drosophila model with hyperactivated Wnt signaling caused by partial loss of a

245 Many types of human cancers having hyperactivated Wnt signaling display no causative altera

246 Hyperactivated Wnt signaling increased expression of the

247 isingly, the Overinduced phenotype caused by hyperactivated Wnt signaling is not dependent on signali

248 cient embryos (embryonic day 8.0-8.5) showed hyperactivated Wnt signaling, as well as aberrant differ

249 tion of TAK1 is linked to its suppression of hyperactivated Wnt signaling, evident in both endogenous

250 ing mutation occurs in Apc, which results in hyperactivated Wnt signalling.

251 The hyperactivated Wnt/beta-catenin signaling acts as a swit