ライフサイエンスコーパス: hyperactivation

1 oxc2, alone or in combination, exhibited ERK hyperactivation.

2 tween B7-2 and CD28, inducing thereby T-cell hyperactivation.

3 ent recognition by pVHL, thus leading to Akt hyperactivation.

4 f Keap1 hypomorphic mice, which possess Nrf2 hyperactivation.

5 CRC cells, in correlation with beta-catenin hyperactivation.

6 in dendritic spine morphology following mTOR hyperactivation.

7 differentiation, effects mediated by Notch1 hyperactivation.

8 f C2 and WW on Hect and thereby causing WWP1 hyperactivation.

9 ccumulates upon HACE1 loss resulting in Rac1 hyperactivation.

10 anine 444, but only under conditions of IRE1 hyperactivation.

11 RC1 lysosomal recruitment and prevent mTORC1 hyperactivation.

12 ly, represent a plausible mechanism of STAT3 hyperactivation.

13 suggesting a major contribution from mTORC1 hyperactivation.

14 bly in other conditions associated with mTOR hyperactivation.

15 lpha kinase activity results in inflammasome hyperactivation.

16 cytosolic cytokines under conditions of cell hyperactivation.

17 he cell to promote inflammasome-dependent DC hyperactivation.

18 to PP2ACalpha-knockout-induced IKKalpha/beta hyperactivation.

19 that is deficient in p25 generation and Cdk5 hyperactivation.

20 a valuable model of epilepsy caused by mTOR hyperactivation.

21 n drug withdrawal as a consequence of ERK1/2 hyperactivation.

22 ulates sperm orientation by modulating sperm hyperactivation, a vigorous motility required for penetr

23 minimum (for example, non-functional BCR) or hyperactivation above maximum (for example, self-reactiv

24 We tested the hypothesis that targeted hyperactivation--above a maximum threshold--will engage

25 Wnt-signaling hyperactivation, albeit in GSK-3beta independent manner,

26 ERK/MAPK hyperactivation also led to reduced corticospinal axon e

27 showed significantly greater convergence of hyperactivation among BD-youths than BD-adults in the in

28 ignificantly greater convergence of amygdala hyperactivation among BD-youths than BD-adults.

29 eumoniae and Escherichia coli; vi) MAIT cell hyperactivation and anergy co-utilize a signaling pathwa

30 USP5 deletion causes BRAF(V600E)-induced ERK hyperactivation and cellular senescence.

31 cted hu-mice but did not rescue their immune hyperactivation and dysfunction.

32 tment with cetuximab was associated with AXL hyperactivation and EGFR association.

33 e principal sperm Ca(2+) channel involved in hyperactivation and essential for fertility.

34 Hs6st1(-/-) embryos that could underpin Erk hyperactivation and excessive glial movement to the indu

35 Accordingly, we demonstrated TCR hyperactivation and generation of potent CD8(+) T cell r

36 ychological stress in rMDD, as manifested by hyperactivation and hyperconnectivity with the amygdala

37 e whether IFN-alpha is a cause of the T cell hyperactivation and IL-7 signaling pathway defects that

38 /18-depleted cells showed PI3K/Akt/NF-kappaB hyperactivation and increased MMP2 and MMP9 expression.

39 ated fine-tuning mechanism to regulate sperm hyperactivation and orientation for successful penetrati

40 al spleen tyrosine kinase (SYK) reversed ERK hyperactivation and proliferation of CLL cells from mult

41 d by changes associated with mammalian sperm hyperactivation and quantitative aspects, such as the ac

42 blockade fully reversed HIV-1-induced immune hyperactivation and rescued anti-HIV-1 immune responses

43 ic mice are worsened by astroglial NF-kappaB hyperactivation and resulting C3 elevation, whereas trea

44 d that loss of SNF5 phenocopies beta-catenin hyperactivation and that SNF5 is essential for regulatin

45 ion and consequent unfolded protein response hyperactivation and tissue injury of the exocrine pancre

46 epidermal syncytium formation following JNK hyperactivation and wounding appeared to be direct disas

47 Nf2 leads to similar phenotypes as does YAP hyperactivation, and deleting Yap suppresses these pheno

48 the IRF4-to-IRF8 ratio, abrogated BCR-NOTCH hyperactivation, and reduced NOTCH2 expression in cGVHD

49 actor (GM-CSF) hypersensitivity, Akt and Erk hyperactivation, and skewed hematopoietic progenitor dis

50 Dopaminergic medication downregulates this hyperactivation, and the degree of downregulation predic

51 th mechanistic target of rapamycin complex 1 hyperactivation, and treatment of emphysema mouse models

52 compensatory processes accompanying frontal hyperactivation appear to be responsible for these alter

53 , we demonstrate that platelet apoptosis and hyperactivation are 2 distinct states that depend on the

54 Neoangiogenesis and STAT3 hyperactivation are known to be fundamentally important

55 orter inhibitors (DAT-Is) supports transient hyperactivation as a unifying hypothesis of abused drugs

56 rom HIV-infected patients revealed basal PMN hyperactivation associated with deregulation of the apop

57 CDK4/Cyclin D kinase hyperactivation, associated with mutation of CDK4, ampli

58 s the male MTBI group showed a regression of hyperactivation at visual comparison of activation maps.

59 ively less attention despite its age-related hyperactivation being postulated to interfere with spati

60 ively less attention despite its age-related hyperactivation being postulated to interfere with spati

61 Previous fMRI studies have reported such hyperactivation, but it is unclear whether increases rep

62 s study demonstrates that inhibition of Drp1 hyperactivation by a Drp1 peptide inhibitor P110 is neur

63 The HSC hyperactivation by CB-1, however, did not affect T-cell

64 re we show selective inhibition of Cdk5/p25 -hyperactivation by TFP5/TP5 peptide, which identifies th

65 Consistent with inflammasome and caspase-I hyperactivation, cardiomyocyte death and IL-18 secretion

66 Protein kinase A (PKA) hyperactivation causes hereditary endocrine neoplasias;

67 t trigger poly(ADP-ribose) polymerase (Parp) hyperactivation, cellular bioenergetics failure, and nec

68 ic myeloid leukemia (aCML), preceded by ROCK hyperactivation, centrosome amplification, and cytogenet

69 with the schizophrenia risk phenotype DLPFC hyperactivation commonly considered a measure of brain i

70 Akt hyperactivation contributes to many pathophysiological c

71 stent with the observation that BMP receptor hyperactivation correlates with bone abnormalities and p

72 Neuronal inactivation and hyperactivation during behavior reveal that only two cla

73 ypoactivation during reward anticipation and hyperactivation during reward outcome in the striatum of

74 l repair response, whereas persistent PARP-1 hyperactivation during severe genotoxic stress is associ

75 cting results, with both hypoactivations and hyperactivations during anticipation and outcome notific

76 s of RAS, PTEN, and TSC1, which cause mTORC1 hyperactivation, enhance immunoproteasome formation in c

77 minished Foxp3 expression, depleted numbers, hyperactivation, enhanced proliferation, and profound lo

78 generates the massive dentate gyrus circuit hyperactivation evident in animals during and following

79 anced pharmacodynamic endpoints (e.g., PARP1 hyperactivation, gammaH2AX, and ATP depletion).

80 king memory load of three numbers, for which hyperactivation had been shown in schizophrenia patients

81 h is a binary cell-fate determinant, and its hyperactivation has been implicated as oncogenic in seve

82 regulation of the JAK/STAT pathway, that is, hyperactivation, has pathological implications in autoim

83 c redox imbalance and circulating neutrophil hyperactivation have been observed in BD patients and ar

84 Siblings exhibited hyperactivation in a bilateral frontoparietal network.

85 d excessive habits that were associated with hyperactivation in a key region implicated in the pathop

86 Immune cell hyperactivation in BALB/c mice was accompanied by a cyto

87 ween aberrant cell cycle progression and Akt hyperactivation in cancer.

88 in Aim2 and NLRC4 inflammasome and caspase-I hyperactivation in cardiomyocytes and cardiac macrophage

89 meostatic (hypothalamus) food motivation and hyperactivation in cognitive control (anterior cingulate

90 amic-limbic activation, but they also showed hyperactivation in cognitive control mediating dorsolate

91 tance to cisplatin and reverse the apoptotic hyperactivation in HOIP-depleted cells.

92 n subjects, OCD patients showed task-related hyperactivation in left dorsal frontal areas and left pr

93 Hyperactivation in mammalian sperm is characterized by a

94 Moreover, we observed that LCK hyperactivation in PPR patients upregulates the calcineu

95 Thus, multiple phagocytes are capable of hyperactivation in response to oxPAPC, with CD14 acting

96 wing task-general and task-specific effects: hyperactivation in subgenual anterior cingulate cortex (

97 n caudate (P < .01) across aggregated tasks; hyperactivation in thalamus (P < .03) and parahippocampa

98 hreat induced a pattern of right-lateralized hyperactivation in the amygdala and fusiform gyrus that

99 Untreated patients demonstrated abnormal hyperactivation in the amygdala, fusiform gyrus, insula,

100 n in OCD patients, which was associated with hyperactivation in the caudate, was observed.

101 The OCD group, as a whole, showed hyperactivation in the medial orbitofrontal cortex durin

102 ally important endogenous suppressor of ASK1 hyperactivation in the pathogenesis of NASH and identify

103 rg(C/-) CD4(+) T cells contributed to B-cell hyperactivation in the spleen.

104 vation, which is important for limiting PI3K hyperactivation in Treg cells despite PTEN haploinsuffic

105 at TFP5/TP5 selective inhibition of Cdk5/p25 hyperactivation in vivo and in vitro rescues nigrostriat

106 site binding likely contributes to PPARgamma hyperactivation in vivo, perhaps explaining why PPARgamm

107 t mice of Lgr4 (Lgr4 CKO) exhibit osteoclast hyperactivation (including elevation of osteoclast numbe

108 We identified 3 distinct mechanisms of hyperactivation, including reduced binding to DEP domain

109 n mouse platelet membranes leads to platelet hyperactivation, increased microparticle formation, and

110 Further, Yorkie or Scalloped hyperactivation induced ectopic crystal cells in a non-c

111 immune kamikazing." Therefore, Ag-dependent, hyperactivation-induced cell death can be regarded as a

112 terbalance the deleterious effects of origin hyperactivation-induced DNA damage.

113 Notably, MYC hyperactivation induces an increase in total precursor m

114 g, genetic loss of FA proteins, or local JNK hyperactivation, involved misregulation of mitosis or ap

115 etailed memories suggests that Abeta-related hyperactivation is compensatory.

116 Specifically, dACC hyperactivation is consistent with abnormal promotion of

117 that amygdala, prefrontal, and visual system hyperactivation is important in the emotional dysfunctio

118 unt for full Akt activation, and whether Akt hyperactivation is linked to misregulated cell cycle pro

119 MYC (also known as c-MYC) overexpression or hyperactivation is one of the most common drivers of hum

120 mTORC1 hyperactivation leads to podocyte hypertrophy, but the d

121 erization of mechanisms underlying leukocyte hyperactivation may contribute to the fundamental unders

122 in the diagnosis of PLAID and that leukocyte hyperactivation may underlie cutaneous lesions in patien

123 These findings suggest that amygdala hyperactivation may underlie paranoia in schizophrenia.

124 llagen expression, supporting that FAK(Y397) hyperactivation may underlie the aberrant mechanobiology

125 e-dependent suppression of PI3Kdelta pathway hyperactivation (measured as phosphorylation of AKT/S6)

126 rs, cell death mechanism switches from PARP1 hyperactivation-mediated programmed necrosis with beta-l

127 Although platelet hyperactivation, mitochondrial dysfunction, aldose reduc

128 pies transcriptional enhancers and restrains hyperactivation of a subset of these enhancers.

129 on of long-term HSCs ex vivo in part through hyperactivation of adenosine 5'-monophosphate-activated

130 R phosphorylation and PR activity due to the hyperactivation of AF-1.

131 Hyperactivation of Akt is associated with oncogenic chan

132 orders involving insulin resistance, whereas hyperactivation of AKT is linked to cancer pathogenesis.

133 potential target, IGF-1 receptor, along with hyperactivation of Akt signaling, in miR-133a-deficient

134 propose that targeted inhibition of PTEN and hyperactivation of AKT triggers a checkpoint for the eli

135 GWL is a human oncoprotein that promotes the hyperactivation of AKT via the degradation of its phosph

136 of PTEN in human pre-B ALL cells resulted in hyperactivation of AKT, activation of the p53 tumor supp

137 Cbl/Cbl-b DKO in mammary organoids leads to hyperactivation of AKT-mTOR signaling with depletion of

138 in which loss of DNA-PKcs function leads to hyperactivation of ATM and amplification of the p53 resp

139 sion of PELI1 resulted in ligand-independent hyperactivation of B cells and facilitated the developme

140 ared to controls, PD_OFF showed compensatory hyperactivation of bilateral putamen and posterior insul

141 Immunohistochemical analysis indicates that hyperactivation of BMP signaling is common in human brea

142 , increased protein kinase C expression, and hyperactivation of calcineurin/nuclear factor of activat

143 istimerin and lupeol considerably diminished hyperactivation of capacitated spermatozoa.

144 f its half-life, and increased cell death by hyperactivation of caspase-9.

145 of SIV infection, and this defect is due to hyperactivation of cofilin and inefficient actin polymer

146 CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, a

147 se requires condensin and coincides with the hyperactivation of condensin DNA supercoiling activity.

148 d LCMV-specific T-cell responses by limiting hyperactivation of CTL.

149 ipids, a hallmark of dying cells, triggering hyperactivation of dendritic cells and macrophages.

150 ation of FoxP3(+) regulatory T (Treg) cells, hyperactivation of effector T cells, and lymphocytic inf

151 Here, we provide evidence for PRL-3-induced hyperactivation of EGFR and its downstream signaling cas

152 Hyperactivation of ENaC, which creates an osmotic gradie

153 The increased PLD activity is engaged by hyperactivation of epidermal growth factor receptor (EGF

154 in FMR1 abolish FMRP expression, leading to hyperactivation of ERK and mTOR signaling upstream of mR

155 Molecularly, we found a surprising hyperactivation of Erk signaling in Hs2st(-/-) (2-fold)

156 overexpression of oncogenic Nras, leading to hyperactivation of ERK1/2 signaling.

157 s JMML/MP-CMML-initiating cells, show strong hyperactivation of ERK1/2, promoting hyperproliferation

158 inhibition of mTORC2 consequently results in hyperactivation of ERK1/2.

159 Somatic mutations, overexpression and hyperactivation of EZH2 have been implicated in the path

160 on, and bone growth and mutations that cause hyperactivation of FGFR3 are responsible for a collectio

161 The decrease of CAV1 contributed to the hyperactivation of fibrogenesis-associated RUNX2, a tran

162 conferred by these GEFs in CTCs implies that hyperactivation of G-protein signaling by these GEFs is

163 This germline defect is suppressed by hyperactivation of glp-1 or disruption of genes downstre

164 through mTORC1 activation, which results in hyperactivation of glycogen synthase kinase 3beta (GSK3b

165 n, with its excessive activity promoting the hyperactivation of hair follicle stem/progenitor cells a

166 ssue damage under hypoxic stress, as well as hyperactivation of inflammasomes and increased mortality

167 fector T cells and the associated downstream hyperactivation of inflammatory phagocytes, which are ca

168 olerance occurs to protect the organism from hyperactivation of innate immune responses, primarily me

169 ve protein homeostasis (proteostasis) due to hyperactivation of insulin-sensitive pathways such as pr

170 Artificial hyperactivation of IPS neurons caused a large increase i

171 d hepatocellular carcinoma primarily through hyperactivation of its downstream effector, YAP.

172 on of the Hippo tumor suppressor pathway and hyperactivation of its downstream effectors Yes-associat

173 synthase kinase (GSK)3beta overactivity and hyperactivation of its downstream mitogen-activated prot

174 abrogated by other oncogenic events, such as hyperactivation of its endogenous repressors MDM2 or MDM

175 mutations in the pseudokinase domain lead to hyperactivation of JAK2 and clinical disease have been u

176 mutants devoid of ATP binding ameliorate the hyperactivation of JAK2 V617F.

177 imerization with C-Raf causing a paradoxical hyperactivation of MAPK pathway.

178 nase (PI3K)/Akt and Lkb1/Ampk signaling with hyperactivation of mTOR signaling.

179 ding the TSC1/TSC2 complex, resulting in the hyperactivation of mTOR- and Raf/MEK/MAPK-dependent sign

180 Hyperactivation of mTORC1 in SZT2-deficient cells could

181 provide insights into the mechanism by which hyperactivation of mTORC1 promotes breast cancer progres

182 Hyperactivation of mTORC1 via TSC1 gene deletion in chon

183 O sensitize leukemic cells to R-2HG, whereas hyperactivation of MYC signaling confers resistance that

184 genetic ablation, constitutive silencing, or hyperactivation of neuronal activity and also include co

185 se of Nckx4 knock-out mice is accompanied by hyperactivation of neurons in the PVN, evidenced by high

186 and reactive oxygen species, thus preventing hyperactivation of NLRP3 inflammasome.

187 To investigate how hyperactivation of Notch in larval neuroblasts leads to

188 Unexpectedly, hyperactivation of Notch signaling also suppressed cardi

189 ubsequent loss of acinar differentiation and hyperactivation of oncogenic KRAS.

190 Hdac8-deficient LT-HSCs displayed hyperactivation of p53 and increased apoptosis under gen

191 KO dorsal motor nucleus of vagus resulted in hyperactivation of parasympathetic signaling-induced bro

192 on, display developmental defects resembling hyperactivation of Pc.

193 However, hyperactivation of pDC can cause life-threatening autoim

194 ession in murine prostate tumors resulted in hyperactivation of PI3K/AKT and MAPK signaling, promotin

195 In primary melanocytes, hyperactivation of PI3K/AKT signaling leads to premature

196 xide formation, which damages DNA and causes hyperactivation of poly(ADP-ribose) polymerase, resultin

197 he XRCC1 partner protein PNKP and implicates hyperactivation of poly(ADP-ribose) polymerase/s as a ca

198 ath, induced by cytotoxic alkylating agents, hyperactivation of poly-ADP-ribose polymerase (PARP) lea

199 nduced NR4A1 as an important determinant for hyperactivation of pro-oncogenic TGF-beta signalling in

200 ergic receptor protein levels leading to the hyperactivation of protein kinase A (PKA) signaling.

201 ed increases in appetite are associated with hyperactivation of putative mesocorticolimbic reward cir

202 Similarly, hyperactivation of RagA did not affect HSC function.

203 Hyperactivation of Rap1 results in severe growth delays

204 This research provides further evidence that hyperactivation of reward circuitry in adolescence may b

205 regressing tumour microenvironment revealed hyperactivation of several signalling pathways, most pro

206 SAN pacemaker activity produces intermittent hyperactivation of SK channels, leading to arrhythmic pa

207 1-2 mutants, leading to its accumulation and hyperactivation of SnRK1 signaling.

208 In addition, hyperactivation of specificity protein 1 transcription f

209 se model of spontaneous osteopenia caused by hyperactivation of STAT1/3 signaling downstream of gp130

210 Moreover, ETP-ALL showed hyperactivation of STAT5 in response to interleukin-7, a

211 In contrast, RalB depletion triggers hyperactivation of STK38, resulting in STK38-dependent a

212 tes SnRK1 signaling and prevents detrimental hyperactivation of stress responses.

213 f caudate-prefrontal circuits accompanied by hyperactivation of subthalamic nucleus/putaminal regions

214 SHIP1), we demonstrated that pharmacological hyperactivation of SYK and engagement of negative B-cell

215 Hyperactivation of T cells, particularly of CD8(+) T cel

216 We found that prolonged and hyperactivation of TAK1 induced phosphorylation and acti

217 vels in autoimmune diseases with established hyperactivation of the BAFF-APRIL system.

218 Hyperactivation of the bone morphogenetic protein (BMP)-

219 InFlo was the only algorithm to identify hyperactivation of the cAMP-CREB1 axis as a key mechanis

220 he NAD(+)-SIRT1-PGC-1alpha axis triggered by hyperactivation of the DNA damage sensor PARP-1.

221 alled forks results in fork restart defects, hyperactivation of the DNA damage signal, accumulation o

222 PTSD youth showed hyperactivation of the dorsal anterior cingulate cortex

223 e conductance regulator (CFTR) combined with hyperactivation of the epithelial sodium channel (ENaC).

224 N-Ras in mutant K-Ras cancer cells leads to hyperactivation of the Erk/p90RSK and PI3K/Akt pathways

225 ery symptoms were associated with widespread hyperactivation of the executive network.

226 ymptoms and those with no mood symptoms) was hyperactivation of the hippocampus/amygdala, when contro

227 induced depressive behaviors, and results in hyperactivation of the hypothalamic-pituitary-adrenal ax

228 JAK1 in MM cell lines, which contributes to hyperactivation of the IL-6-JAK-STAT3 signaling importan

229 y PB T cells in MS is indicative of aberrant hyperactivation of the immune system.

230 c disease, consistent with parasite-mediated hyperactivation of the inflammatory response driving chr

231 uncontrolled growth and causes the systemic hyperactivation of the inflammatory response.

232 We conclude that defects associated with hyperactivation of the insulin signaling pathway are unl

233 Here we show that hyperactivation of the interleukin 1 pathway, through ei

234 ole of the miR-34a-SIRT1-p65 axis in causing hyperactivation of the intestinal B cell system.

235 owth arrest and premature senescence through hyperactivation of the IRE1alpha RNase.

236 s by E2A-PBX1 in pre-B-ALL, which results in hyperactivation of the key oncogenic effector enzyme PLC

237 Hyperactivation of the mechanistic target of rapamycin (

238 reased phosphorylation of the kinase Akt and hyperactivation of the metabolic checkpoint kinase mTOR,

239 hosphorylation of cell division proteins via hyperactivation of the Mn-dependent protein phosphatase

240 Hyperactivation of the mTOR pathway impairs hematopoieti

241 its inactive or full-length version leads to hyperactivation of the nodule organogenic program in Med

242 The latter has been coupled to hyperactivation of the nonselective cation channel, tran

243 ncrease their antioxidant production through hyperactivation of the NRF2 pathway, which promotes tumo

244 panel of stemness-associated genes and drove hyperactivation of the nuclear factor kappa B p65 pathwa

245 n or pharmacologic inhibition of CypB caused hyperactivation of the oncogenic RAS-mitogen-activated p

246 ed in aLivGHRkd mice was not associated with hyperactivation of the pathway by which insulin is class

247 ed, by either rare disruptive events causing hyperactivation of the pathway, or through the collectiv

248 Hyperactivation of the PI3K-mTOR signaling network, via

249 l cognitive performance through compensatory hyperactivation of the putamen.

250 Although hyperactivation of the Ras-Erk signaling pathway is know

251 Hyperactivation of the receptor tyrosine kinase c-Met an

252 d megakaryocytes was due to upregulation and hyperactivation of the small GTPase, RhoA, rather than N

253 el to examine the pathogenic contribution of hyperactivation of the STAT3 arm of IL6 signaling on KRA

254 s treat the disease, fostering the view that hyperactivation of the thiazide-sensitive sodium-chlorid

255 Experimental hyperactivation of this circuit in young flies results i

256 Hyperactivation of this region during elevated state anx

257 ly released by the thyroid, but in states of hyperactivation of thyroid-stimulating hormone receptors

258 Hyperactivation of transforming growth factor-beta (TGF-

259 nd NUCB2 have revealed that GPCR-independent hyperactivation of trimeric G proteins can fuel metastat

260 he differentiation inhibition coincides with hyperactivation of Wg signaling caused by the accumulati

261 provides a molecular basis for FLNA-mediated hyperactivation of WHIM receptor signaling.

262 hemistry showed significant upregulation and hyperactivation of YAP in castration-resistant prostate

263 Aberrant hyperactivation of YAP/TAZ causes tissue overgrowth and

264 tions and mutations in the DSB system caused hyperactivation of YfiN and subsequent CsgD-independent

265 ate, we show that suppression of eye fate by hyperactivation of yki does not change the cell fate (fr

266 Loss of compensatory hyperactivation on dopaminergic medication correlated wi

267 talloenzymes are particularly susceptible to hyperactivation or mismetallation, suggesting the need f

268 igin for cSCC, and that RAS/RAF/MAPK pathway hyperactivation or Tp53 mutation, coupled with loss of T

269 ines the multiple mechanisms leading to Rac1 hyperactivation, particularly focusing on emerging parad

270 els of sepsis, conditions that promoted cell hyperactivation resulted in inflammation but not lethali

271 s, and RhoA inhibition mimics the osteoclast hyperactivation resulting from Gna13-deficiency.

272 h MS, N-back accuracy improved while frontal hyperactivation (seen at baseline relative to HCs) disap

273 as a mechanism contributing to granule cell hyperactivation specifically during early epilepsy devel

274 FF/CD19(+) B-cell ratio, supporting a B-cell hyperactivation state in vivo.

275 horylation by PKA and PKC, leading to enzyme hyperactivation that abnormally lowers cAMP levels.

276 sulted in a heart failure phenotype with AKT hyperactivation that was rescued by treatment with rapam

277 In contrast to CDK hyperactivation, the acceleration of S-phase progression

278 in the JAK1 tyrosine kinase that results in hyperactivation, thereby leading to skin serine protease

279 MAPK pathway hyperactivation (through Braf(V600E) or Kras(G12D) knock

280 as contraceptive compounds by averting sperm hyperactivation, thus preventing fertilization.

281 interaction, PTSD youth showed dorsal (d)ACC hyperactivation to happy faces relative to healthy youth

282 (+) T cells, preventing virus-induced immune hyperactivation to limit disease progression and blockin

283 However, the mechanisms of mTORC1 hyperactivation to promote the growth and metastasis of

284 The potential contribution of Rac hyperactivation to resistance to anticancer agents, incl

285 activation in executive circuitry and limbic hyperactivation to threat could reflect partly independe

286 ients can be pharmacologically directed from hyperactivation toward maturity.

287 cer and activator of transcription 5 (STAT5) hyperactivation, transformed Ba/F3 cells resulting in cy

288 Moreover, Akt hyperactivation was accompanied by hyperphosphorylation

289 Akt hyperactivation was confirmed in individual neurons of a

290 cer cells in a paracrine fashion, whereas no hyperactivation was detectable in cell lines harboring m

291 orking memory functional MR imaging studies, hyperactivation was found in the male MTBI group and hyp

292 Interestingly, this hyperactivation was greater in HIV(I) than HIV(NI) patie

293 In younger patients, initial hyperactivation was seen in the right precuneus and righ

294 ral or knock-in PIK3CA mutations and/or PI3K hyperactivation, we show that PIK3CA-E545K mutations (fo

295 ll lymphoma and are associated with H3K27me3 hyperactivation, which contributes to lymphoma pathogene

296 Furthermore, HIV-1-induced immune hyperactivation, which is a prognosticator of disease pr

297 nized that phagocytes can achieve a state of hyperactivation, which is defined by their ability to se

298 NKKY101 cells on rapamycin and observed TOR1 hyperactivation, which leads to Hsp90-dependent calcineu

299 n vertebrate animal models indicates pathway hyperactivation with a concomitant increase in cell and

300 plastic dedifferentiation, as well as mTORC1 hyperactivation with reduced Akt phosphorylation.