ライフサイエンスコーパス: hyperdynamic

1 t major architectural chromatin proteins are hyperdynamic and bind loosely to chromatin in ES cells.

2 uction did not prevent the occurrence of the hyperdynamic and hypercardiovascular response during the

3 ous, unrestrained rats prevented LPS-induced hyperdynamic and hypodynamic circulatory shock, hyperlac

4 Hyperdynamic binding is a property of pluripotent cells,

5 We suggest that hyperdynamic binding of structural chromatin proteins is

6 ures enriched for active chromatin marks and hyperdynamic binding of structural chromatin proteins.

7 Our hypotheses were that 1) hyperdynamic blood flow is absent in septic shock; 2) no

8 ction may exist to coordinately maintain the hyperdynamic cardiac contractile performance of the PLN-

9 ngendorff perfusion indicated that the basal hyperdynamic cardiac function of the knockout mouse was

10 Intriguingly, this hyperdynamic cardiac function was maintained throughout

11 egardless of the resting EF, all players had hyperdynamic cardiac responses with exercise.

12 All sheep developed a hyperdynamic cardiovascular response by 40 hrs that was

13 The sheep developed a hyperdynamic cardiovascular response characterized by a

14 The hyperdynamic cardiovascular state (high cardiac index an

15 According to this report, hyperdynamic chromatin is both specific and functionally

16 Lipoic acid prevented the development of the hyperdynamic circulation (cardiac index [CI]: 15.7 +/- 2

17 All but one of the patients had a hyperdynamic circulation (cardiac index, 4.2 to 7.3 lite

18 al hypertension develops differently, with a hyperdynamic circulation and angiogenic biomarker profil

19 l hypertensive (PHT) gastric mucosa leads to hyperdynamic circulation and increased susceptibility to

20 aused haemodynamic changes consistent with a hyperdynamic circulation and induced increases in muscle

21 ent hypermetabolic response characterized by hyperdynamic circulation and severe muscle catabolism an

22 Patients with subclinical PHT have less hyperdynamic circulation and significantly lower portal

23 dilatation (splanchnic and systemic) and the hyperdynamic circulation are hemodynamic abnormalities t

24 Additionally, vasodilatation and the hyperdynamic circulation are hemodynamic abnormalities t

25 Vasodilatation (splanchnic and systemic) and hyperdynamic circulation are hemodynamic abnormalities t

26 dilatation (splanchnic and systemic) and the hyperdynamic circulation are hemodynamic abnormalities t

27 olely from portal hypertension, although the hyperdynamic circulation contributes to variceal growth

28 olely from portal hypertension, although the hyperdynamic circulation contributes to variceal growth

29 Peripheral vasodilation initiates the hyperdynamic circulation in cirrhosis.

30 s been implicated in the pathogenesis of the hyperdynamic circulation in portal hypertension.

31 We have previously demonstrated that the hyperdynamic circulation in the partial portal vein-liga

32 lipoic acid prevents the development of the hyperdynamic circulation in the rat model of biliary cir

33 The hyperdynamic circulation was dose dependently reversed b

34 Although hyperdynamic circulation was still maintained by day 7,

35 NO production, blunts the development of the hyperdynamic circulation, and decreases portal pressure

36 ment of liver cirrhosis, is characterized by hyperdynamic circulation, angiogenesis, and portosystemi

37 L-NMMA reversed the hyperdynamic circulation, causing an increase in arteria

38 Caffeine decreased PP, ameliorated hyperdynamic circulation, PSS, mesenteric angiogenesis,

39 first 24 hrs of sepsis (n = 21) developed a hyperdynamic circulation.

40 e control group showed a continuation of the hyperdynamic circulation.

41 iliary cirrhosis, portal hypertension, and a hyperdynamic circulation.

42 The injury induced a hypotensive-hyperdynamic circulation; increases in pulmonary capilla

43 rtal vein ligation or sham operation until a hyperdynamic circulatory state developed.

44 A hyperdynamic circulatory state frequently is observed in

45 day 4, portal vein-ligated rats developed a hyperdynamic circulatory state with a normal central blo

46 receiving the bacterial infusion developed a hyperdynamic circulatory state with hypotension, decreas

47 fter 24 hrs of sepsis, all sheep developed a hyperdynamic circulatory state with increased cardiac in

48 is and ascites showed a typical pattern of a hyperdynamic circulatory state, when compared with their

49 Pseudomonas infusion, all sheep developed a hyperdynamic circulatory state, with increased cardiac i

50 ues, and the work overload associated with a hyperdynamic circulatory state.

51 hunts, pulmonary arteriovenous shunts, and a hyperdynamic circulatory state.

52 ylene conjugate in septic sheep reverses the hyperdynamic circulatory state.

53 The hyperdynamic circulatory syndrome observed in chronic li

54 econd, experimental models used to study the hyperdynamic circulatory syndrome; and third, the vasodi

55 vity was correlated with a prevention of the hyperdynamic contractile response and enhanced myocardia

56 bserved in most infants (29/40; 72%); 17 had hyperdynamic contractility, and 24 had altered LV geomet

57 heart, but the earliest signs of disease are hyperdynamic contraction and impaired relaxation.

58 These data indicate that hyperdynamic contraction is essential for HCM pathobiolo

59 the hearts of older mutant mice also showed hyperdynamic contraction, with increased end-systolic ch

60 ncreased wall thickness, small chamber size, hyperdynamic ejection fraction, and left ventricular con

61 This typically induces hyperdynamic ejection, impaired relaxation, delayed earl

62 s characterized by diastolic dysfunction and hyperdynamic features.

63 ncy in mice did not alter cardiac structure, hyperdynamic function, or antifibrotic effects induced b

64 pport the increased metabolic demands of the hyperdynamic hearts.

65 months after thermal injury, ameliorates the hyperdynamic, hypermetabolic, hypercatabolic, and osteop

66 and prolonged QT interval) and functionally (hyperdynamic left ventricular [LV] contractility along w

67 lar dimensions, left atrial enlargement, and hyperdynamic left ventricular systolic function.

68 data are consistent with the hypothesis that hyperdynamic microtubules impair axonal transport and ac

69 Hyperdynamic microvascular blood flow was not found.

70 describes a new trait of pluripotent cells: hyperdynamic or "breathing" chromatin.

71 icrobial sepsis is characterized by an early hyperdynamic phase (2-10 hrs after cecal ligation and pu

72 Sepsis is characterized by an early, hyperdynamic phase and a late, hypodynamic phase.

73 crobial sepsis is characterized by an early, hyperdynamic phase followed by a late, hypodynamic phase

74 crobial sepsis is characterized by an early, hyperdynamic phase followed by a late, hypodynamic phase

75 gulated CYP4A3 is associated with the early, hyperdynamic phase of sepsis and the down-regulated CYP2

76 ays or even prevents the transition from the hyperdynamic phase to the hypodynamic phase of sepsis, a

77 ays or even prevents the transition from the hyperdynamic phase to the hypodynamic phase of sepsis, a

78 o be responsible for the transition from the hyperdynamic phase to the hypodynamic phase of sepsis.

79 sequently observed that produced a transient hyperdynamic phase; however, progressive RV distension d

80 to meet the increased ATP utilization in the hyperdynamic phospholamban-deficient hearts.

81 tate to meet the increased ATP demand in the hyperdynamic phospholamban-deficient hearts.

82 We show that in SCA mice, anemia-induced hyperdynamic physiology was gradually superimposed with

83 Upon differentiation, the hyperdynamic proteins become immobilized on chromatin.

84 A Cushing reflex, followed by a hyperdynamic response and diabetes insipidus, occurred i

85 A systemic hyperdynamic response characterized by an increase in bo

86 GI2 synthesis prevents the occurrence of the hyperdynamic response during early sepsis.

87 dergoing exercise testing had an appropriate hyperdynamic response in cardiac function.

88 Although the hyperdynamic response observed in septic patients underg

89 rotects against I/R injury by preventing the hyperdynamic response of isolated perfused hearts during

90 appear to play a major role in producing the hyperdynamic response under such conditions.

91 The Cushing phenomenon, hyperdynamic response, and diabetes insipidus were obser

92 eptide, plays a major role in initiating the hyperdynamic response.

93 lop a standardized and reproducible model of hyperdynamic sepsis after smoke inhalation in sheep.

94 ensin II and norepinephrine and induction of hyperdynamic sepsis by administration of live Escherichi

95 During infusion of E. coli, hyperdynamic sepsis developed with hypotension, tachycar

96 This animal model closely resembles hyperdynamic sepsis in humans and may be of great value

97 nthase inhibitors in a large animal model of hyperdynamic sepsis in which acute kidney injury occurs

98 ures and maintains mean arterial pressure in hyperdynamic sepsis without reversal of sepsis-induced v

99 In sheep with nonhypotensive hyperdynamic sepsis, creatinine clearance halved (32 to

100 In hyperdynamic sepsis, intrarenal infusion of a highly sel

101 In experimental hyperdynamic sepsis, renal denervation was associated wi

102 In this ovine model of experimental hyperdynamic sepsis, renal excretory function decreases

103 In a large animal model of hyperdynamic sepsis, renal hyperemia was associated with

104 lyoxyethylene conjugate in an ovine model of hyperdynamic sepsis.

105 All patients had hyperdynamic septic shock and impaired renal function.

106 tion of TNF-alpha attenuated the severity of hyperdynamic shock induced by a subsequent infusion of e

107 5 hrs or 10 hrs after CLP (i.e., the early, hyperdynamic stage of sepsis), the thoracic aorta was is

108 taining endothelial cell function during the hyperdynamic stage of sepsis.

109 nitric oxide) is depressed during the early, hyperdynamic stage of sepsis.

110 itric oxide significantly contributes to the hyperdynamic state associated with sepsis.

111 re only normalized at T3 associated with the hyperdynamic state at this point.

112 All three doses of hemoglobin reversed this hyperdynamic state by increasing mean arterial pressure

113 ) plays a significant role in modulating the hyperdynamic state during early sepsis.

114 ponse syndrome of fever, leukocytosis, and a hyperdynamic state is common in trauma patients, especia

115 l replicates the mortality, hypotension, and hyperdynamic state seen in clinical sepsis.

116 The E. coli infusions were associated with a hyperdynamic state, pulmonary hypertension, systemic hyp

117 ndotoxemia induced an immediate hypotensive, hyperdynamic, tachycardic state with progressive lactic

118 1 (AMBP-1) prevented the transition from the hyperdynamic to the hypodynamic stage in the progression