ライフサイエンスコーパス: hyperexcitable

1 V1.7 make dorsal root ganglion (DRG) neurons hyperexcitable.

2 e dorsal raphe nucleus (DRN), rendering them hyperexcitable.

3 rotonin neurons at postnatal day 4 (P4) were hyperexcitable.

4 nels within DRG neurons rendered these cells hyperexcitable.

5 changes in HCN channel expression and became hyperexcitable.

6 ts render dorsal root ganglion (DRG) neurons hyperexcitable.

7 ations rendered dorsal root ganglion neurons hyperexcitable.

8 t R185H renders dorsal root ganglion neurons hyperexcitable.

9 orsal root ganglion (DRG) nociceptors become hyperexcitable.

10 ts of BD patients are electrophysiologically hyperexcitable.

11 renders DRG and trigeminal ganglion neurons hyperexcitable.

12 nglion (DRG) and trigeminal ganglion neurons hyperexcitable.

13 ons render dorsal root ganglia (DRG) neurons hyperexcitable.

14 uggested that A863P could render DRG neurons hyperexcitable.

15 striatal neurons in mHTT glial chimeras are hyperexcitable.

16 nervous system because immature circuits are hyperexcitable.

17 ave shown that spinal sensory neurons become hyperexcitable after axonal injury, and electrophysiolog

18 Spinal motoneurons become hyperexcitable after SCI, but the plastic responses of l

19 ons of heterozygous and homozygous mice were hyperexcitable and generated long-lasting depolarizing p

20 cal slices from drug-resistant patients made hyperexcitable and hypersynchronous by Mg(2+)-free media

21 Hilar ectopic granule cells (HEGCs) are hyperexcitable and may therefore increase circuit excita

22 ns, and renders dorsal root ganglion neurons hyperexcitable and superior cervical ganglion neurons hy

23 LM may render epileptic hippocampal networks hyperexcitable and susceptible to glutamate-mediated exc

24 types of neurons, it renders sensory neurons hyperexcitable and sympathetic neurons hypoexcitable.

25 ngly, the visual cortex of NARP(-/-) mice is hyperexcitable and unable to express ocular dominance pl

26 7, which render dorsal root ganglion neurons hyperexcitable, are present in a substantial proportion

27 me progressively less excitable, rather than hyperexcitable, as mossy fiber sprouting progressed and

28 pyramidal neurons in mPFC layers II/III were hyperexcitable at baseline but hypoexcitable following D

29 The hyperexcitable blink reflex may be a maladaptive consequ

30 quence relationship may offset a potentially hyperexcitable blink reflex, thereby reducing the likeli

31 ant epileptic patients made hypersynchronous/hyperexcitable by elevated potassium or inhibition of GA

32 epileptogenic foci acting upon a temporarily hyperexcitable central autonomic network.

33 t the mechanisms that render the hippocampus hyperexcitable chronically (in epilepsy) or acutely (in

34 firing shows that Scn1b null DRG neurons are hyperexcitable compared with WT.

35 hus, uIPSPs can increase neuronal gain under hyperexcitable conditions, and this effect is probably d

36 We show that, under hyperexcitable conditions, slices from the epileptic den

37 CA3 pyramidal cell activity under basal and hyperexcitable conditions.

38 in cultured hippocampal neurons cultured in hyperexcitable conditions.

39 of delayed responses can identify regions of hyperexcitable cortex in the human brain.

40 Together these changes resulted in hyperexcitable dendrites with enhanced dendritic AP back

41 in these interneuron classes showed markedly hyperexcitable dentate gyrus field-potential responses t

42 only in neuropathic pain but also in other "hyperexcitable" diseases of the nervous system such as s

43 letal muscle from transgenic R6/2 HD mice is hyperexcitable due to decreased chloride and potassium c

44 Our model suggests the TSNC may become hyperexcitable due to loss of tonic inhibition by functi

45 Motor neurons become hyperexcitable during progression of amyotrophic lateral

46 pike probability, suggesting an unstable and hyperexcitable early cortical network.

47 rge that the dendrites of motoneurons become hyperexcitable, enhancing ionotropic inputs by fivefold

48 normalize with a CaV 2.1 gating modifier in hyperexcitable FHM1 mice.

49 ers of neocortically derived neurons exhibit hyperexcitable firing activity and may be a source of he

50 transient (I(A))-type potassium current and hyperexcitable firing.

51 s are likely to influence the development of hyperexcitable foci in posttraumatic limbic circuits.

52 that noise-exposed bushy cells would remain hyperexcitable for a period after returning to normal qu

53 When the LNVs are made hyperexcitable, free-running behavioral rhythms decompos

54 ate that dentate granule cells are maximally hyperexcitable immediately after SE, prior to mossy fibe

55 e conclude that cortical networks in FXS are hyperexcitable in a brain state-dependent manner during

56 te cells of the entorhinal cortex, which are hyperexcitable in animal models of temporal lobe epileps

57 so than somata, of hippocampal neurons were hyperexcitable in mice overexpressing Abeta.

58 mutually excitatory CA3 pyramidal cells are hyperexcitable in these rats.

59 polarizing direction, and render DRG neurons hyperexcitable, in I-SFN patients with no mutations of S

60 ed motor function, motor unit pathology, and hyperexcitable MNs.

61 ncreased excitability further in the already hyperexcitable -/- MNTB neurons, suggesting that -/- IKL

62 underlying APPL-dependent synapse formation, hyperexcitable mutants, which also alter synaptic growth

63 alpha(-/-) mice result in the formation of a hyperexcitable network but act in part neuroprotectively

64 citatory synaptic transmission, leading to a hyperexcitable network state that is characterized by th

65 static plasticity, both of which result in a hyperexcitable network state.

66 lepsy is based on the reflex activation of a hyperexcitable network that subserves the function of sp

67 ise mechanisms underlying the development of hyperexcitable networks are largely unknown.

68 study was to analyze the conditions in which hyperexcitable networks can generate either IESs or FRs

69 sy, a neurological disorder characterized by hyperexcitable networks.

70 taneous activity is generated in developing, hyperexcitable networks.

71 Hyperexcitable neuronal networks are mechanistically lin

72 o the pathways that lead from mutant gene to hyperexcitable neurones.

73 on, may offer a way of inhibiting only those hyperexcitable neurons responsible for clinical problems

74 ory-induced seizure activity in mutants with hyperexcitable neurons.

75 visually triggered in widespread regions of hyperexcitable occipital cortex.

76 g in utero electroporation also results in a hyperexcitable phenotype similar to the conditional knoc

77 modulin 5' and 3' UTRs also induces the same hyperexcitable phenotype.

78 on 14 SCI subjects with velocity-dependent, hyperexcitable plantarflexors.

79 been proposed as crucial to development of a hyperexcitable, potentially seizure-prone circuit.

80 y increases network activity, resulting in a hyperexcitable, potentially seizure-prone circuit.

81 ed (small vs large), spatial distribution of hyperexcitable pyramidal cells (clustered vs uniform), a

82 on of the extra K+ channel gene results in a hyperexcitable rather than a hypoexcitable phenotype.

83 a(v)1.7 renders dorsal root ganglion neurons hyperexcitable, reducing the current threshold for gener

84 Hyperexcitable reflex blinks are a cardinal sign of Park

85 elid with reduced motility evoked bilateral, hyperexcitable reflex blinks, whereas contralateral SO s

86 be partly responsible for the appearance of hyperexcitable reflexes following spinal cord injury (SC

87 a result, these Kcnq2-deficient neurons are hyperexcitable, responding to current injections with an

88 iving mossy cells play a crucial role in the hyperexcitable responses of the post-traumatic dentate g

89 ncement of EPSCs in computer simulations and hyperexcitable responsiveness to innocuous and noxious p

90 entry of primary nociceptors into a chronic hyperexcitable-SA state that may provide a useful therap

91 Hyperexcitable SGCs could augment dentate throughput to

92 that MeCP2 null LC neurons are electrically hyperexcitable, smaller in size, and express less of the

93 suggest that this change makes these neurons hyperexcitable so that they act as pain amplifiers and g

94 nced Hoffman reflex (H-reflex), indicating a hyperexcitable spinal cord.

95 Hyperexcitable spinal neurons show reduced thresholds, g

96 sensory neurons, triggering in nociceptors a hyperexcitable state and spontaneous activity (SA) that

97 ation were not attributable to a generalized hyperexcitable state in noise-exposed animals.

98 ted Kv3.4 channel has been implicated in the hyperexcitable state of dorsal root ganglion (DRG) neuro

99 ippocampal circuitries may contribute to the hyperexcitable state of the DA system that is present in

100 eceptor so that abrupt withdrawal produces a hyperexcitable state that leads to seizures, delerium tr

101 channels) play a key role in the sensitized (hyperexcitable) state of nociceptive sensory neurons (no

102 ion, and the homeostatic control of abnormal hyperexcitable states.

103 results in clonal transformants that exhibit hyperexcitable swimming behaviors reminiscent of certain

104 death, elevated extracellular glutamate, and hyperexcitable synaptic activity.

105 c granule cells from epileptic rats are more hyperexcitable than granule cells in the GCL.

106 Granule cells were maximally hyperexcitable to afferent stimulation immediately after

107 igra pars compacta neurons created rats with hyperexcitable trigeminal reflex blinks but normally exc

108 he trigeminal reflex blinks of subjects with hyperexcitable trigeminal reflex blinks caused by Parkin

109 ock neurons was tested by rendering the LNVs hyperexcitable via transgenic expression of a low activa

110 nt neurons, urethral afferent neurons may be hyperexcitable well into DM progression.

111 ny newborn DGCs integrate aberrantly and are hyperexcitable, whereas others may integrate normally an

112 vs. CONTROLS: Scn8a(N1768D/+) myocytes were hyperexcitable, with a lowered threshold for AP firing,

113 ly effective in modulating the activities of hyperexcitable young neurons, which may have important i