ライフサイエンスコーパス: hyperhomocysteinemia

1 uced the prevalence of folate deficiency and hyperhomocysteinemia.

2 ue to vegetarianism is increasing and causes hyperhomocysteinemia.

3 hepatic necroinflammation and apoptosis, and hyperhomocysteinemia.

4 uced activity, increased thermolability, and hyperhomocysteinemia.

5 hionine intake with B vitamin deficiency and hyperhomocysteinemia.

6 th elevated levels of homocysteine, known as hyperhomocysteinemia.

7 s of excess dietary methionine from those of hyperhomocysteinemia.

8 al macrophages was higher in the presence of hyperhomocysteinemia.

9 tion of placebo and after methionine-induced hyperhomocysteinemia.

10 associated with poor cognition, anemia, and hyperhomocysteinemia.

11 n peritoneal macrophages were not changed by hyperhomocysteinemia.

12 ncreased incidence of stroke associated with hyperhomocysteinemia.

13 on may contribute to vascular dysfunction in hyperhomocysteinemia.

14 ontribute to endothelial dysfunction in mild hyperhomocysteinemia.

15 o inactivating nitric oxide in chronic, mild hyperhomocysteinemia.

16 ively low blood folate levels and consequent hyperhomocysteinemia.

17 iciency in the elderly and its role in their hyperhomocysteinemia.

18 thogenesis of both homocystinuria and modest hyperhomocysteinemia.

19 ence of this mutation is not associated with hyperhomocysteinemia.

20 H2S in the thrombotic events associated with hyperhomocysteinemia.

21 mmation, and activation of fibrogenesis) and hyperhomocysteinemia.

22 -beta-synthase (cbs) were used as a model of hyperhomocysteinemia.

23 ized by a plethora of vascular disorders and hyperhomocysteinemia.

24 steatosis or UPR activation despite inducing hyperhomocysteinemia.

25 macrovascular occlusion in individuals with hyperhomocysteinemia.

26 functional changes in cerebral arterioles in hyperhomocysteinemia.

27 regulation and has possible implications for hyperhomocysteinemia.

28 e the most common cause of severe hereditary hyperhomocysteinemia.

29 LF) diet for 6 to 8 months to produce graded hyperhomocysteinemia.

30 eta-synthase (Cbs)-heterozygous mice develop hyperhomocysteinemia.

31 ugmentation was significantly blunted during hyperhomocysteinemia (1.06 +/- 1.00 ml/min/g vs. 0.58 +/

32 hial artery vasodilation was impaired during hyperhomocysteinemia (4.4 +/- 2.6% vs. 2.6 +/- 2.3%, pla

33 been observed in renal disease patients with hyperhomocysteinemia, a cardiovascular disease risk fact

34 Hyperhomocysteinemia, a condition that recent epidemiolo

35 Mild hyperhomocysteinemia, a putative risk factor for arterio

36 Mild hyperhomocysteinemia, a putative risk factor for atherot

37 instead, these inadequacies could result in hyperhomocysteinemia, a recently identified risk factor

38 Hyperhomocysteinemia, a risk factor for CAD, may cause a

39 lymorphism is a genetic determinant for mild hyperhomocysteinemia, a risk factor for cardiovascular d

40 m is the most frequent genetic cause of mild hyperhomocysteinemia, a risk factor for cardiovascular d

41 We tested the hypothesis that hyperhomocysteinemia accelerates arterial thrombosis in

42 tomography (PET) to test the hypothesis that hyperhomocysteinemia adversely effects coronary microvas

43 o diet-induced hyperhomocysteinemia and that hyperhomocysteinemia alters tissue methylation capacity

44 Mice fed the MCD diet developed severe hyperhomocysteinemia and activation of the hepatic UPR.

45 ts and a relation was recently shown between hyperhomocysteinemia and Alzheimer disease.

46 regard to the 2 independent risk factors of hyperhomocysteinemia and arterial hypertension.

47 al failure, a condition associated with both hyperhomocysteinemia and atherosclerosis, treatment with

48 Other markers such as hyperhomocysteinemia and deficiencies of antithrombin, p

49 Tg-I278T Cbs(-/-) mice exhibited severe hyperhomocysteinemia and endothelial dysfunction in cere

50 e Mthfr gene sensitizes mice to diet-induced hyperhomocysteinemia and endothelial dysfunction.

51 on to the fatty liver and no contribution to hyperhomocysteinemia and ER stress in intragastric alcoh

52 s containing ethanol or homocysteine induced hyperhomocysteinemia and glucose intolerance in control,

53 Using an atherogenic diet that produces both hyperhomocysteinemia and hypercholesterolemia, we tested

54 Investigations have revealed severe hyperhomocysteinemia and hypomethioninemia, reduced fibr

55 Alcohol feeding induced modest hyperhomocysteinemia and increased homocysteine levels i

56 that expression of Tg-CBS rescued the severe hyperhomocysteinemia and neonatal lethality of Cbs delet

57 ociated with the degree of liver injury were hyperhomocysteinemia and strain-dependent differences in

58 literature regarding the association between hyperhomocysteinemia and TCAD.

59 /-) genotype sensitizes mice to diet-induced hyperhomocysteinemia and that hyperhomocysteinemia alter

60 hydrofolate reductase (MTHFR) predisposes to hyperhomocysteinemia and vascular disease.

61 An association between moderate hyperhomocysteinemia and vascular dysfunction was confir

62 objective was to determine the prevalence of hyperhomocysteinemia and vitamin B-12 deficiency in elde

63 generative diseases that are associated with hyperhomocysteinemia and, more recently, have implicated

64 Hypothyroidism may be a treatable cause of hyperhomocysteinemia, and elevated plasma homocysteine l

65 In vivo studies using CBS+/-, a model for hyperhomocysteinemia, and sibling CBS+/+ control mice re

66 steatosis, endoplasmic reticulum stress, and hyperhomocysteinemia, and this correlates with induction

67 )S increases progressively with the grade of hyperhomocysteinemia, and under conditions of severely e

68 hionine intake with B vitamin deficiency and hyperhomocysteinemia; and (iii) normal methionine intake

69 Hyperhomocysteinemia appears to be an independent risk f

70 Low cobalamin concentrations and mild hyperhomocysteinemia are common in the elderly but ethni

71 e cellular hypomethylation in the setting of hyperhomocysteinemia because of cystathionine beta-synth

72 hat supplementation with B vitamins prevents hyperhomocysteinemia but is not sufficient to prevent th

73 Mice exhibited a remarkable hyperhomocysteinemia but no increase was seen in rats.

74 alcoholic mouse liver and that correction of hyperhomocysteinemia by betaine or other approaches may

75 to tPA can be inhibited by homocysteine and hyperhomocysteinemia can be induced by L-methionine supp

76 Although moderate hyperhomocysteinemia can be treated effectively by admin

77 In many patients, hyperhomocysteinemia can be treated or prevented by diet

78 Because hyperhomocysteinemia can occur in cholesterol gallstone

79 abolism, combined methylmalonic acidemia and hyperhomocysteinemia, cblC type, is caused by mutations

80 Hyperhomocysteinemia confers a high risk for thrombotic

81 Hyperhomocysteinemia contributes to vascular dysfunction

82 form of combined methylmalonic acidemia and hyperhomocysteinemia, designated cblX.

83 Mice with moderate/severe hyperhomocysteinemia due to deficiency or absence of the

84 In humans, severe hyperhomocysteinemia due to genetic alterations in cysta

85 Hence, mild hyperhomocysteinemia due to reduced CBS expression impai

86 Hyperhomocysteinemia during pregnancy, which is a conseq

87 of mouse to up-regulate BHMT which prevents hyperhomocysteinemia, endoplasmic reticulum stress, and

88 We conclude that hyperhomocysteinemia enhances susceptibility to arterial

89 ), as was the prevalence of mild-to-moderate hyperhomocysteinemia (>12 microM; NHD, 57%; SHD, 94%; P

90 13.0 vs. 11.0+/-3.0 micromol/L, P<0.01), and hyperhomocysteinemia (>90th percentile for controls, 14.

91 Hyperhomocysteinemia has been associated with endoplasmi

92 Hyperhomocysteinemia has been commonly found among heart

93 Hyperhomocysteinemia has been correlated with hepatic st

94 Hyperhomocysteinemia has been proposed to inhibit the pr

95 Hyperhomocysteinemia has been recognized as an important

96 Hyperhomocysteinemia has been recognized as an independe

97 Although hyperhomocysteinemia has been recognized recently as a p

98 Alcohol-induced hyperhomocysteinemia has been reported in rats and human

99 ysfunction, and ERG defects; those with mild hyperhomocysteinemia have delayed retinal morphological/

100 that precipitate low blood folate levels and hyperhomocysteinemia have not been investigated previous

101 Animals with genetic hyperhomocysteinemia have so far not displayed atheromat

102 Many elderly subjects with hyperhomocysteinemia have undiagnosed vitamin B-12 defic

103 However, the joint effect of hyperhomocysteinemia (HHcy) and hyperglycemia (HG) on en

104 Hyperhomocysteinemia (HHcy) has been considered a vascul

105 Hyperhomocysteinemia (HHcy) impairs re-endothelializatio

106 Hyperhomocysteinemia (HHcy) increases permeability of th

107 Hyperhomocysteinemia (HHcy) is a reliable indicator of c

108 Although hyperhomocysteinemia (HHcy) is a well-known risk factor

109 Hyperhomocysteinemia (HHcy) is an independent risk facto

110 Hyperhomocysteinemia (HHcy) is associated with endotheli

111 Hyperhomocysteinemia (HHcy) is associated with several h

112 Hyperhomocysteinemia (HHcy) is prevalent in patients wit

113 Hyperhomocysteinemia (HHcy) is prevalent in patients wit

114 Using a Tg-I278T Cbs(-/-) mouse model of hyperhomocysteinemia (HHcy) which replicates the connect

115 We previously reported that hyperhomocysteinemia (HHcy), an independent risk factor

116 Vitamin B deficiencies, which can lead to hyperhomocysteinemia (Hhcy), are commonly reported in pa

117 either a control diet or a diet that induces hyperhomocysteinemia (HHcy).

118 Hyperhomocysteinemia (hHcys) enhances ceramide productio

119 Hyperhomocysteinemia (hHcys) is considered an independen

120 ing in podocyte and glomerular injury during hyperhomocysteinemia (hHcys).

121 Hyperhomocysteinemia (hyperHcy) is an important risk fac

122 rs, including smoking, hypercholesterolemia, hyperhomocysteinemia, hypertension, and diabetes mellitu

123 therefore, support the hypothesis that acute hyperhomocysteinemia impairs microvascular dilation in t

124 We therefore conclude that hyperhomocysteinemia impairs postnatal angiogenesis by d

125 nce of folate and cobalamin deficiencies and hyperhomocysteinemia in Bangladesh.

126 rocess, has been shown to be associated with hyperhomocysteinemia in experimental and human studies.

127 his article is to evaluate the prevalence of hyperhomocysteinemia in heart transplant recipients but

128 Despite a very high prevalence of hyperhomocysteinemia in MHD patients, lower values of tH

129 Thus, hyperhomocysteinemia in mice was associated with hypertr

130 generation of APC by thrombin is impaired in hyperhomocysteinemia in monkeys and that hyperhomocystei

131 ose folic acid lowers but fails to normalize hyperhomocysteinemia in patients with predialysis chroni

132 Studies of the prevalence and mechanism of hyperhomocysteinemia in RA are warranted.

133 serum alanine aminotransferase increase, and hyperhomocysteinemia in rats than in mice.

134 The underlying cause of hyperhomocysteinemia in renal disease is not entirely un

135 entation may be necessary to prevent fasting hyperhomocysteinemia in such persons.

136 om low plasma PLP in most subgroups and from hyperhomocysteinemia in the elderly.

137 ients have a persistent excess prevalence of hyperhomocysteinemia in the era of fortification but rem

138 Despite a reduction in hyperhomocysteinemia in the folic acid group compared wi

139 d fortification program on the prevalence of hyperhomocysteinemia in the older population with coexis

140 in metabolism seem to be the major causes of hyperhomocysteinemia in this particular population.

141 FVa by APC are not impaired during moderate hyperhomocysteinemia in vivo.

142 l to study ANXII function and the effects of hyperhomocysteinemia in vivo.

143 rol and low-density lipoprotein cholesterol, hyperhomocysteinemia, increased lesional oxidative stres

144 ysfunction, we investigated whether moderate hyperhomocysteinemia induced by an oral methionine load

145 he first time, that the relationship between hyperhomocysteinemia induced by folate deficiency and pr

146 Remarkably, hyperhomocysteinemia induced in wild-type and cystathion

147 Overexpression of DDAH1 protects from hyperhomocysteinemia-induced alterations in cerebral art

148 Hyperhomocysteinemia is a major and independent risk fac

149 Hyperhomocysteinemia is a potential risk factor for card

150 Hyperhomocysteinemia is a putative risk factor for cardi

151 Hcy damages cerebrovascular endothelium, and hyperhomocysteinemia is a risk factor for stroke.

152 Hyperhomocysteinemia is a risk factor for thrombosis, bu

153 Mild hyperhomocysteinemia is accepted as a risk factor for pr

154 ospective and case-control studies show that hyperhomocysteinemia is an independent risk factor for a

155 Hyperhomocysteinemia is an independent risk factor for c

156 Although hyperhomocysteinemia is an independent risk factor for c

157 Because hyperhomocysteinemia is an independent risk factor for c

158 Hyperhomocysteinemia is an independent risk factor for c

159 Hyperhomocysteinemia is an independent risk factor for c

160 These prospective observations confirm that hyperhomocysteinemia is an independent risk factor for c

161 Hyperhomocysteinemia is an independent risk factor for c

162 Considerable evidence suggests that hyperhomocysteinemia is an independent vascular risk fac

163 Hyperhomocysteinemia is associated with abnormal endothe

164 Hyperhomocysteinemia is associated with increased risk f

165 Hyperhomocysteinemia is associated with increased risk o

166 Hyperhomocysteinemia is associated with inflammation and

167 These results suggest that isolated hyperhomocysteinemia is atherogenic and alters hepatic a

168 Hyperhomocysteinemia is caused by genetic and lifestyle

169 It has been suggested that hyperhomocysteinemia is caused by MTX and is responsible

170 Mild hyperhomocysteinemia is common among maintenance hemodia

171 Severe hyperhomocysteinemia is due to rare genetic defects resu

172 zed H2S-generating reactions to the grade of hyperhomocysteinemia is in stark contrast to the respons

173 Hyperhomocysteinemia is now recognized as a common risk

174 These studies indicate that although hyperhomocysteinemia is often associated with hepatic st

175 Hyperhomocysteinemia is often associated with liver and

176 from vascular complications whereas dietary hyperhomocysteinemia is often used to induce atheroscler

177 Mild to moderate hyperhomocysteinemia is prevalent in humans and is impli

178 Hyperhomocysteinemia is related to poor recall and this

179 , mildly elevated plasma total homocysteine (hyperhomocysteinemia) is associated with increased risk

180 Elevated plasma homocysteine (hyperhomocysteinemia) is associated with occlusive vascu

181 bout it, and what the clinical impact of the hyperhomocysteinemia itself is.

182 Thus, we conclude that hyperhomocysteinemia leads to significant increases in t

183 e acknowledged left ventricular hypertrophy, hyperhomocysteinemia, lipoprotein(a) excess, hypertrigly

184 Post-methionine-load hyperhomocysteinemia may be due to heterozygous cystathi

185 These findings suggest that inflammation and hyperhomocysteinemia may be important mechanisms by whic

186 tor V and that the prothrombotic tendency in hyperhomocysteinemia may be related to impaired inactiva

187 y be increased in Alzheimer disease (AD) and hyperhomocysteinemia may contribute to disease pathophys

188 Excessive H(2)S production in hyperhomocysteinemia may contribute to the associated ca

189 in vivo and suggest that methionine-induced hyperhomocysteinemia may reverse hyperfibrinolysis in AP

190 The prevalence of hyperhomocysteinemia (men: >11.4 micromol/L; women: >10.

191 Despite hyperhomocysteinemia, no patients exhibited lens disloca

192 Relative to their RTR counterparts, the hyperhomocysteinemia of HD patients seems to be consider

193 th comparable baseline tHcy levels, the mild hyperhomocysteinemia of maintenance HD patients is much

194 The effect of hyperhomocysteinemia on H19 DMD methylation was tissue-s

195 We examined effects of hyperhomocysteinemia on structure and mechanics of cereb

196 rly in populations with folate deficiency or hyperhomocysteinemia or both, may lower blood arsenic co

197 uctase C677T genotype was not a predictor of hyperhomocysteinemia or CAC status.

198 Elevated blood levels of homocysteine (Hcy), hyperhomocysteinemia or homocystinuria, have been associ

199 16 microM) or in human volunteers with acute hyperhomocysteinemia (plasma tHcy, 45 +/- 6 microM).

200 In aorta, hyperhomocysteinemia produced an increase in H19 DMD met

201 The present study determined whether hyperhomocysteinemia produces decreased tissue methylati

202 in hyperhomocysteinemia in monkeys and that hyperhomocysteinemia produces resistance to APC in monke

203 We conclude that hyperhomocysteinemia produces tissue-specific changes in

204 Whereas diet-induced hyperhomocysteinemia promotes atherosclerosis in animal

205 These findings suggest that hyperhomocysteinemia promotes cerebral vascular hypertro

206 dies with human beings and animals with mild hyperhomocysteinemia provided encouraging results in the

207 emodialysis patients (ie, >90%) exhibit mild hyperhomocysteinemia refractory to treatment with either

208 The hyperhomocysteinemia regularly found in hemodialysis pat

209 Hyperhomocysteinemia resulted in a reduction in the MBF

210 In mouse models, dietary or genetic hyperhomocysteinemia results in liver or brain pathologi

211 In humans, severe genetic hyperhomocysteinemia results in premature death from vas

212 In mice, hyperhomocysteinemia secondary to a high-methionine diet

213 d 59-fold and 72-fold in human patients with hyperhomocysteinemia secondary to mutations in methylene

214 Mild hyperhomocysteinemia seen in fasting conditions is due t

215 -vitamin-deficient diet for 10 weeks induced hyperhomocysteinemia, significantly impaired spatial lea

216 ine beta-synthase knockout mice, a model for hyperhomocysteinemia, suggesting that one-carbon metabol

217 e United Kingdom have a higher prevalence of hyperhomocysteinemia than do their European counterparts

218 1.8 micro mol/L, and 94% of the patients had hyperhomocysteinemia (tHcy >13.5 micro mol/L).

219 Although folic acid reduces hyperhomocysteinemia, the effect on adverse vascular eve

220 Hyperhomocysteinemia, the MTHFR C677T mutation, and fola

221 as an inhibitory mechanism in patients with hyperhomocysteinemia, the sensitivity of DDAH-1 to inhib

222 The odds ratio relating hyperhomocysteinemia to recall of > or =1 of 3 previousl

223 A MEDLINE search using the key words hyperhomocysteinemia, transplant coronary artery disease

224 tamin B(12), and vitamin B(6)) would prevent hyperhomocysteinemia, vascular dysfunction, and atherosc

225 hen methionine-rich diets are used to induce hyperhomocysteinemia, vascular pathology is often observ

226 Hyperhomocysteinemia was accompanied by higher levels of

227 In brain, hyperhomocysteinemia was accompanied by increased H19 DM

228 Hyperhomocysteinemia was defined as total serum homocyst

229 Hyperhomocysteinemia was defined as total serum homocyst

230 Hyperhomocysteinemia was found in 91.35% of HCV-infected

231 Hyperhomocysteinemia was induced by feeding mice alcohol

232 METHODS AND Hyperhomocysteinemia was induced in DDAH1 transgenic (DD

233 Hyperhomocysteinemia was more frequent in patients with

234 rposes of this study were to explore whether hyperhomocysteinemia was related to MTX administration a

235 nd the difference between extreme and severe hyperhomocysteinemia, we have examined two mouse models

236 e, hypertension, diabetes, dyslipidemia, and hyperhomocysteinemia were established as aggravating fac

237 e, hypertension, diabetes, dyslipidemia, and hyperhomocysteinemia were found significantly different

238 Low blood folate levels result in hyperhomocysteinemia, which has been associated with inc

239 Hyperhomocysteinemia, which is an independent risk facto

240 morphisms may play a role in the etiology of hyperhomocysteinemia, which is correlated with cardiovas

241 Bangladeshi men have a high prevalence of hyperhomocysteinemia, which is more closely associated w

242 Hyperhomocysteinemia, which is most strongly associated

243 volunteers or patients newly diagnosed with hyperhomocysteinemia with a C677T polymorphism of the MT

244 s enzyme are the leading cause of hereditary hyperhomocysteinemia with attendant cardiovascular and o

245 cular changes may mediate the association of hyperhomocysteinemia with human age-related cognitive de

246 d B vitamin-deficient diets developed severe hyperhomocysteinemia without any increase in vascular pa