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1 wing treatment protocols, all rats underwent hyperinsulinemic (0.2 units kg(-1) min(-1)), severe hypo
2 On the fourth day, rats were subjected to a hyperinsulinemic (0.2 units x kg(-1) x min(-1)) severe h
3 pups were glucose intolerant (P = 0.04) and hyperinsulinemic (1.3-fold increase, P = 0.02) by 1 mont
4 ded hypoglycemic (100, 70, 50, and 30 mg/dl) hyperinsulinemic (20 mU/kg/min) clamps and nonhypoglycem
5 360-600 min, the remaining dogs underwent a hyperinsulinemic (4x basal) hyperglycemic clamp (arteria
7 50 pmol/L)-euglycemic (5 +/- 0.1 mmol/L) or hyperinsulinemic (812 +/- 50 pmol/L)-hypoglycemic (2.9 +
8 Day 1 consisted of morning and afternoon 2-h hyperinsulinemic- (9 pmol x kg(-1) x min(-1)) euglycemic
9 al diet had reduced perigonadal fat but were hyperinsulinemic and by age 12 months, were insulin defi
10 insulin receptor substrate-1 (IRS1-het) are hyperinsulinemic and insulin resistant during pregnancy,
11 ably, obese patients with MC4R mutations are hyperinsulinemic and resistant to obesity-induced hypert
12 sed CB(1) specifically in hepatocytes became hyperinsulinemic as a result of reduced insulin clearanc
13 ctose but in the presence of a hyperglycemic-hyperinsulinemic challenge including portal vein glucose
16 before and 1 month after RYGB by euglycemic hyperinsulinemic clamp (EHC), by intravenous glucose tol
17 dilution, insulin sensitivity by euglycemic-hyperinsulinemic clamp (steady-state glucose utilization
18 Here we show that initiation of a euglycemic-hyperinsulinemic clamp 4 h after single-legged exercise
20 Insulin sensitivity (S(I)) was assessed by hyperinsulinemic clamp and lean body mass (LBM) and tota
22 , or glucose disposal rates under euglycemic hyperinsulinemic clamp conditions (SMD: 0.00; 95% CI: 20
23 se homeostasis was assessed using euglycemic-hyperinsulinemic clamp coupled with tracer radioactively
26 ds to assess resistance are available (e.g., hyperinsulinemic clamp or minimal model), but surrogate
27 od before the initiation of the hypoglycemic-hyperinsulinemic clamp protocol and during the last 30 m
36 conducted a meal challenge and a euglycemic-hyperinsulinemic clamp to evaluate insulin sensitivity a
37 her saline infusion (sham) or an isoglycemic-hyperinsulinemic clamp using B28-Asp-insulin (which can
39 igitorum longus muscle during the euglycemic-hyperinsulinemic clamp was increased in lean gamma3(R225
40 y and muscle insulin sensitivity (euglycemic-hyperinsulinemic clamp with 2-deoxyglucose) and fat util
42 tabolism (insulin tolerance test, euglycemic-hyperinsulinemic clamp, and hepatic expression of genes
43 sulin sensitivity was analyzed by euglycemic-hyperinsulinemic clamp, and molecular tools were used to
45 atients at risk for CIM underwent euglycemic-hyperinsulinemic clamp, muscle microdialysis studies, an
48 ssociation of genetic scores with euglycemic-hyperinsulinemic clamp- and oral glucose tolerance test-
56 obtained before and after 8-h hyperglycemic-hyperinsulinemic clamping in 13 normal subjects and in 6
59 pre- and 3 months post-RYGB, and euglycemic-hyperinsulinemic clamps were used to assess insulin sens
60 ree different occasions during hyperglycemic-hyperinsulinemic clamps with concomitant infusions of GI
61 sensitivity, as measured by using euglycemic-hyperinsulinemic clamps with infusion of [6,6-(2)H(2)]gl
62 rs with DM and 19 control subjects underwent hyperinsulinemic clamps with maintained sequential hyper
63 ed glucose uptake measured during euglycemic-hyperinsulinemic clamps, suggesting a role of beige cell
64 c (5.0 mmol/L) and hypoglycemic (2.8 mmol/L) hyperinsulinemic clamps, we compared brain activation re
66 eripheral insulin resistance, they were less hyperinsulinemic during a glucose tolerance test because
67 insulinemic hypoglycemia (bolus insulin), 2) hyperinsulinemic euglycemia (bolus insulin and glucose i
68 nsulinemic clamps with maintained sequential hyperinsulinemic euglycemia (plasma glucose, 90 mg/dL [5
69 eline, the subsequent changes in MBFR during hyperinsulinemic euglycemia and hyperinsulinemic hypogly
70 e dipyridamole stress at baseline and during hyperinsulinemic euglycemia and hyperinsulinemic hypogly
71 In control subjects, MBFR increased during hyperinsulinemic euglycemia by 0.57 U (22%) above baseli
72 onsisted of either morning and afternoon 2-h hyperinsulinemic euglycemia or 2-h hyperinsulinemic hypo
75 ight fast, all subjects underwent a two-step hyperinsulinemic euglycemic (5.0 mmol/L)-hypoglycemic (2
77 ealthy non-diabetic participants underwent a hyperinsulinemic euglycemic (92+/-3 mg/dL) - hypoglycemi
80 were assessed with a 40-mU x m(-2) x min(-1) hyperinsulinemic euglycemic clamp combined with a [6,6-(
81 ,3,3-(2)H(5)]glycerol, in combination with a hyperinsulinemic euglycemic clamp during the last 3 hrs.
82 taken from both legs before and after a 3-h hyperinsulinemic euglycemic clamp performed 3 h after a
85 ion and glucose clearance were quantified by hyperinsulinemic euglycemic clamp studies and pyruvate t
91 raphy), insulin sensitivity (measured with a hyperinsulinemic euglycemic clamp with [6,6-(2)H(2)]-glu
92 aging (MRI), and insulin sensitivity using a hyperinsulinemic euglycemic clamp with a glucose isotope
93 o metabolic (oral glucose tolerance test and hyperinsulinemic euglycemic clamp) and imaging studies (
94 of glucose turnover and insulin sensitivity (hyperinsulinemic euglycemic clamp) were performed before
95 R or RES training on insulin sensitivity (by hyperinsulinemic euglycemic clamp), body composition (by
97 This finding was confirmed with the use of hyperinsulinemic euglycemic clamping, showing a glucose
99 unctional MRI (fMRI) combined with a stepped hyperinsulinemic euglycemic-hypoglycemic clamp and behav
101 insulin sensitivity were assessed using the hyperinsulinemic- euglycemic clamp combined with the glu
102 cells (PBMCs) and monocytes obtained during hyperinsulinemic-euglycemic (5.0 mmol/L)-hypoglycemic (2
103 -(13)C]glucose over 22-54 h after undergoing hyperinsulinemic-euglycemic (glucose concentration 92.4
106 nsulin-sensitive (IS; n = 10), determined by hyperinsulinemic-euglycemic clamp (>30% greater in IS co
107 Insulin action was measured by a three-stage hyperinsulinemic-euglycemic clamp (4, 8, and 40 mU/m(2)/
108 centration 57.2 +/- 9.7 mg/dl) than during a hyperinsulinemic-euglycemic clamp (95.3 +/- 3.3 mg/dl),
109 Twenty-three patients underwent a two-step hyperinsulinemic-euglycemic clamp (HEC) with glucose tra
110 full-heritage Pima Indians (P = 0.027) or a hyperinsulinemic-euglycemic clamp among 536 nondiabetic
114 ndrial function in type 1 diabetes using the hyperinsulinemic-euglycemic clamp and (31)P-MRS before,
115 tivity and secretion were evaluated by a 3-h hyperinsulinemic-euglycemic clamp and a 2-h hyperglycemi
117 beginning and end of each dietary period, a hyperinsulinemic-euglycemic clamp and an intravenous glu
119 e, and secretion and glucose tolerance using hyperinsulinemic-euglycemic clamp and intravenous and or
120 cose tolerance and insulin sensitivity using hyperinsulinemic-euglycemic clamp and muscle insulin rec
121 cTg mice were highly insulin sensitive under hyperinsulinemic-euglycemic clamp conditions, eliminatin
125 ion (r = 0.31, P < 0.05) and negatively with hyperinsulinemic-euglycemic clamp glucose infusion rate
127 In addition, infusion of insulin during a hyperinsulinemic-euglycemic clamp induced conspicuous ER
130 rations, under basal conditions and during a hyperinsulinemic-euglycemic clamp procedure (HECP), with
131 d after treatment was evaluated by using the hyperinsulinemic-euglycemic clamp procedure in conjuncti
133 473), and p-AKT(Thr308) in 22 women during a hyperinsulinemic-euglycemic clamp procedure with and wit
139 e, insulin, and pyruvate tolerance tests and hyperinsulinemic-euglycemic clamp studies established in
144 glucose homeostasis on a high-fat diet, and hyperinsulinemic-euglycemic clamp studies revealed that
148 ize, glucose and insulin tolerance tests and hyperinsulinemic-euglycemic clamp studies were performed
149 iled 364 biopsies harvested before and after hyperinsulinemic-euglycemic clamp studies, at baseline a
150 increased hepatic insulin sensitivity during hyperinsulinemic-euglycemic clamp studies, which was ass
158 us of amino acids was administered and a 3-h hyperinsulinemic-euglycemic clamp was commenced ("fed" p
160 n sensitivity in Wistar rats assessed by the hyperinsulinemic-euglycemic clamp was minimally affected
162 ecific insulin sensitivity was assessed by a hyperinsulinemic-euglycemic clamp with [6,6-(2)H2]-gluco
163 e SAs and 12 matched Cs underwent a two-step hyperinsulinemic-euglycemic clamp with skeletal muscle b
164 epatic insulin sensitivity (assessed using a hyperinsulinemic-euglycemic clamp with stable isotope tr
165 tests (OGTTs), graded glucose infusion, and hyperinsulinemic-euglycemic clamp with stable-isotope-la
166 ssion: with and without insulin stimulation (hyperinsulinemic-euglycemic clamp) using [18F]fluorodeox
167 a], [(2)H5]glycerol at baseline and during a hyperinsulinemic-euglycemic clamp), lipid oxidation (ind
168 ences in insulin sensitivity, as measured by hyperinsulinemic-euglycemic clamp, and skeletal muscle m
171 -fold more insulin sensitive, as measured by hyperinsulinemic-euglycemic clamp, than C57BL/6 wild-typ
172 and BMI-matched controls (n = 6) underwent a hyperinsulinemic-euglycemic clamp, VO2max test, dual-ene
173 ere hepatic insulin resistance assessed by a hyperinsulinemic-euglycemic clamp, which could mostly be
174 whole-body and leg glucose disposal during a hyperinsulinemic-euglycemic clamp, while decreasing hepa
191 r intralipid/heparin-infusion (high FFA) and hyperinsulinemic-euglycemic clamping (low FFA) in a rand
193 ects underwent studies comparing fasting and hyperinsulinemic-euglycemic clamping with tracer infusio
198 nd women underwent research tests, including hyperinsulinemic-euglycemic clamps and vastus lateralis
199 er day) or vehicle treatment, mice underwent hyperinsulinemic-euglycemic clamps combined with radiola
201 and insulin sensitivity was determined using hyperinsulinemic-euglycemic clamps in conscious mice.
203 ity using glucose tolerance tests (GTTs) and hyperinsulinemic-euglycemic clamps in mouse models of ty
204 integrin interaction in IR was studied using hyperinsulinemic-euglycemic clamps on integrin alpha(2)b
205 involved one of the following: 1) two 90-min hyperinsulinemic-euglycemic clamps plus naloxone infusio
207 a, investigation of insulin resistance using hyperinsulinemic-euglycemic clamps revealed no significa
209 ance spectroscopy to assess IMCL content and hyperinsulinemic-euglycemic clamps using [6,6-(2)H(2)] g
211 s and oral-glucose-tolerance test (OGTT) and hyperinsulinemic-euglycemic clamps were performed to ass
213 uced by dietary methionine restriction (MR), hyperinsulinemic-euglycemic clamps were used to examine
214 ivity using acute insulin administration and hyperinsulinemic-euglycemic clamps with [(3)H]glucose in
217 s naloxone infusion (control); 2) two 90-min hyperinsulinemic-euglycemic clamps with exercise at 60%
218 ped hyperinsulinemic-hypoglycemic and paired hyperinsulinemic-euglycemic clamps with infusion of 6,6-
219 tic resonance spectroscopy before and during hyperinsulinemic-euglycemic clamps with isotope dilution
220 ay absorptiometry), insulin sensitivity (via hyperinsulinemic-euglycemic clamps), and insulin secreti
223 ased on glucose and insulin tolerance tests, hyperinsulinemic-euglycemic clamps, and insulin signalin
224 glucose production in isolated hepatocytes, hyperinsulinemic-euglycemic clamps, liver triglyceride c
233 Day 1 consisted of morning and afternoon 2-h hyperinsulinemic-euglycemic or hypoglycemic clamps with
235 rmined systemic glucose uptake by euglycemic-hyperinsulinemic glucose clamp in 15 normal-weight and 1
237 -glucose positron emission tomography during hyperinsulinemic glucose clamps at nominal plasma glucos
238 asting plasma insulin <11.2 mU/L, n = 18) or hyperinsulinemic (HI) (fasting plasma insulin >11.2 mU/L
239 line (low insulin/sham clamp) or isoglycemic-hyperinsulinemic (high insulin) clamps using B28-Asp ins
240 ulinemic-euglycemic clamp) and postprandial (hyperinsulinemic hyperaminoacidemic-euglycemic clamp) co
242 ct and store more glucose in the presence of hyperinsulinemic hyperglycemia later in the same day, in
244 -fat and -fructose diet [P-HFF]) underwent a hyperinsulinemic-hyperglycemic clamp with intraportal gl
245 rnoon 2-h hyperinsulinemic euglycemia or 2-h hyperinsulinemic hypoglycemia (2.9 mmol/l) with either 1
246 examined on three randomized study days: 1) hyperinsulinemic hypoglycemia (bolus insulin), 2) hyperi
249 glucose, 90 mg/dL [5.0 mmol/L]) followed by hyperinsulinemic hypoglycemia (plasma glucose, 50 mg/dL
250 0.38 to 0.75; P<0.0001) and decreased during hyperinsulinemic hypoglycemia by 0.36 U (14%) below base
251 -controlled cross-over trial using a stepped hyperinsulinemic hypoglycemia clamp was performed in 12
252 MBFR during hyperinsulinemic euglycemia and hyperinsulinemic hypoglycemia in DM patients were simila
258 oop variant and GCK variants associated with hyperinsulinemic hypoglycemia reveal two distinct mechan
259 -1 in postprandial glycemia in patients with hyperinsulinemic hypoglycemia syndrome after gastric byp
260 ibitor sirolimus in four infants with severe hyperinsulinemic hypoglycemia that had been unresponsive
262 thase activity was completely ablated during hyperinsulinemic hypoglycemia, and catecholamine signali
270 geted microinjection of ephrinA5-Fc before a hyperinsulinemic hypoglycemic clamp study caused a reduc
271 participants (n = 10 per group) underwent a hyperinsulinemic-hypoglycemic (2.6 mmol/L) clamp, either
272 lucose concentration 92.4 +/- 2.3 mg/dl) and hyperinsulinemic-hypoglycemic (52.9 +/- 4.8 mg/dl) clamp
273 ahepatic islet transplantation using stepped hyperinsulinemic-hypoglycemic and paired hyperinsulinemi
274 means +/- SD, P < 0.02, n = 5) during a 2-h hyperinsulinemic-hypoglycemic clamp (glucose concentrati
275 3 weeks (range 19-25) after GBP surgery with hyperinsulinemic-hypoglycemic clamp (stepwise to plasma
279 diaphragmatic vagotomy (TSV) were exposed to hyperinsulinemic-hypoglycemic clamps where glycemia was
280 On day 2, all were studied with stepped hyperinsulinemic-hypoglycemic clamps, using hormone conc
281 sing a catecholamine-specific neurotoxin and hyperinsulinemic-hypoglycemic clamps, we found that symp
282 entrations in the VMH were assessed during a hyperinsulinemic-hypoglycemic glucose clamp study in chr
285 imental approaches: 1) glucose gavage and 2) hyperinsulinemic intravenous infusion, for studies in ei
287 thotopic mammary tumors in control FVB/n and hyperinsulinemic MKR mice, and treated them with the ins
291 y, Tregs from the visceral adipose tissue of hyperinsulinemic, obese mice showed a similar specific d
292 f weight reduction on vascular function with hyperinsulinemic patients deriving the greatest benefit.
294 tigate how severe hypoglycemia can be fatal, hyperinsulinemic, severe hypoglycemic (10-15 mg/dL) clam
295 l tangles, presently observed aberrations in hyperinsulinemic states may participate in linking insul
296 Conserved activation of hepatic aPKC in hyperinsulinemic states of T2DM, obesity and MetSyn is p
298 or underlying this is dyslipidemia, which in hyperinsulinemic subjects with early type 2 diabetes is
299 se mice: mice with normal glucose tolerance, hyperinsulinemic yet glucose-tolerant mice, and prediabe
300 ry and biotelemetry in male Wistar and obese hyperinsulinemic Zucker diabetic fatty (ZDF) rats 45 min
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