ライフサイエンスコーパス: hypermethylated

1 ands surrounding the PGC7-binding motifs are hypermethylated.

2 dinucleotides in the Cosmc core promoter are hypermethylated.

3 re hypomethylated, while EMX2 and HOXB1 were hypermethylated.

4 centromeres can be either hypomethylated or hypermethylated.

5 quence carried by the transgene was markedly hypermethylated.

6 CpG site within the calbindin1 promoter was hypermethylated.

7 CpG islands of the down-regulated genes are hypermethylated.

8 D1) locus reverts from CpG hypomethylated to hypermethylated.

9 rich promoter regions in both DUOX genes are hypermethylated.

10 nces tumor suppressor genes when they become hypermethylated.

11 being hypomethylated and male hybrids being hypermethylated.

12 sites at the upstream region of miR-184 were hypermethylated.

13 G islands are intragenic and gene bodies are hypermethylated.

14 redistribution of Pol V to sites that become hypermethylated.

15 nscript, mature kinetoplastid mRNA acquire a hypermethylated 5'-cap structure, but its function has b

16 Loci that are hypermethylated across cancer types are enriched for sit

17 the atherosclerotic portion of the aorta was hypermethylated across many genomic loci in comparison w

18 buted DMRs are largely intergenic and become hypermethylated after the blastocyst stage.

19 tion level, with 684 CpG sites significantly hypermethylated and 1,640 hypomethylated in tumor, compa

20 ons (DMRs) identified in ACF, 537 (66%) were hypermethylated and 274 (34%) were hypomethylated.

21 e discovered that 440 DMRs of 648 genes were hypermethylated and 274 DMRs of 336 genes were hypomethy

22 ndividuals aged 2 to 92 yr identified 18,735 hypermethylated and 45,407 hypomethylated CpG sites asso

23 pleters relative to comparison subjects (273 hypermethylated and 93 hypomethylated).

24 , surround the hMLH1 promoter when it is DNA hypermethylated and aberrantly silenced, but are absent

25 es, identifying only LGALS4 as significantly hypermethylated and down-regulated in smokers.

26 , we identify ISL1 as a direct DNMT1 target, hypermethylated and downregulated in mammary tumours and

27 ith upstream CpG sites becoming consistently hypermethylated and downstream CpG sites becoming consis

28 yte survival, such as BCL2L2 and NDRG1, were hypermethylated and expressed at lower levels in multipl

29 w that, although the E-cadherin gene becomes hypermethylated and heterochromatic, kinase inhibitors c

30 Such agglomerates of hypermethylated and hypomethylated DMRs spanned up to se

31 many differentially-methylated regions, both hypermethylated and hypomethylated, across the entire ge

32 of miR-342 within an intron of the EVL gene, hypermethylated and involved in tumorigenesis, suggested

33 t to placental trophoblast, however, ELF5 is hypermethylated and largely repressed in human ES cells

34 EPHA7 was hypermethylated and repressed in both mouse and human GC

35 Gene loci that are hypermethylated and repressed in embryonic (ESCs) but hy

36 In normal GECs, P1 was hypermethylated and repressed, whereas in immune lineage

37 ometrial stroma) is one of the most commonly hypermethylated and silenced genes in endometrial cancer

38 sed genes and not within promoter regions of hypermethylated and silenced genes is consistent with th

39 scription during EZH2 knockdown, densely DNA hypermethylated and silenced genes retain their methylat

40 is a putative tumor suppressor gene that is hypermethylated and silenced in T or NK LGL leukemia.

41 its corresponding endogenous RD29A gene are hypermethylated and silenced in the Arabidopsis DNA deme

42 COL2A is hypermethylated and silenced, while COL2D is repressed i

43 issues that have recovered from infection is hypermethylated and that host recovery requires AGO4, a

44 Certain tumor suppressor gene promoters are hypermethylated and transcriptionally inactivated, where

45 genes, including tumor suppressor genes, are hypermethylated and transcriptionally repressed, a pheno

46 n B cell lymphoma (B-NHL), in which TET1 was hypermethylated and transcriptionally silenced.

47 e WNT pathway antagonist FRZB was aberrantly hypermethylated and underexpressed in MDS stroma.

48 YA4 is frequently and concomitantly deleted, hypermethylated and underexpressed in multiple independe

49 he methyltransferase, DNMT3A, was aberrantly hypermethylated and underexpressed, but not mutated in m

50 athways, including 1-carbon metabolism, were hypermethylated and underexpressed.

51 ing, because the pericentromeric regions are hypermethylated and were expected to be the regions most

52 ic expression of the noncoding RNA MHM (male hypermethylated) and acetylation of histone 4 lysine 16

53 , isolated from murine dorsal root ganglion (hypermethylated) and striated cells (hypomethylated), wa

54 The CpG islands surrounding miR-433 were hypermethylated, and the DNA methylation agent 5'-aza-2'

55 region of intron 2 of Rad9 in DU145 cells is hypermethylated at CpG islands, and treatment with 5'-az

56 ted state of NG59, NG59 minichromosomes were hypermethylated at specific lysines in H3 and also showe

57 RNA (snoRNA), and telomerase RNA, is further hypermethylated at the exocyclic N2 of the guanosine to

58 igenetic gene regulation, which binds to the hypermethylated BAI1 gene promoter.

59 colocalization of hypomethylated R-DMRs with hypermethylated C-DMRs and bivalent chromatin marks, and

60 Many DNA-hypermethylated cancer genes are occupied by the Polycom

61 Hypermethylated cancer populations are hard to treat due

62 Kinetoplastid mRNAs possess a unique hypermethylated cap 4 structure derived from the standar

63 The 5' end of kinetoplastid mRNA possesses a hypermethylated cap 4 structure, which is derived from s

64 r (SL) to polycistronic precursors conveys a hypermethylated cap 4, including a cap 0 m7G and seven a

65 level, while the expression is suppressed in hypermethylated carcinoma cell lines (R=-0.73).

66 Significant enrichment of hypermethylated cDMRs in CGI shores (P < 10(-60)), non-C

67 in chromosomal regions encompassing compact, hypermethylated centromeric and pericentromeric DNA.

68 Hypermethylated CGI events in the model were predicted b

69 i-2/NuRD is important for the maintenance of hypermethylated chromatin in B cells.

70 s lacking the CCR5-Delta32 mutation but with hypermethylated cis-regions have CCR5 levels similar to

71 , CD49d expression was recovered in CD49d(-) hypermethylated CLL cells upon in vitro treatment with t

72 hylation-related genes that could rescue the hypermethylated Cnr mutant.

73 Lastly, genomic DNA from most CRPC was hypermethylated compared with benign prostate tissue.

74 duplicate gene pairs, one partner is always hypermethylated compared with the other.

75 beta1 could promote expression of COX-2 in a hypermethylated COX-2 vector, and observed TGF-beta1-ind

76 ed epigenetic modification recapitulated the hypermethylated CpG island methylator phenotype (CIMP) o

77 Several of these hypermethylated CpG islands are associated with genes in

78 Most genes with hypermethylated CpG islands at promoters are suppressed

79 Genes with hypermethylated CpG islands in malignant meningiomas (su

80 elopmental expression patterns of genes with hypermethylated CpG islands in primary human lung carcin

81 evels of genomic DNA methylation and contain hypermethylated CpG islands, but the full extent and seq

82 Each tumor contained several hundred hypermethylated CpG islands.

83 The hypermethylated CpG loci included promoter, 5'-UTRs, ups

84 s prior to chemo/radiotherapy identified one hypermethylated CpG site (CpG6882469) in the VAV1 gene b

85 % showed marked enrichment and selection for hypermethylated CpG sites within the proximal region of

86 FP locus stably integrated and silenced by a hypermethylated cytomegalovirus (CMV) promoter.

87 YB5 contains a hypermethylated cytomegalovirus promoter driving green f

88 Hypermethylated DMCs were enriched at transcription star

89 example of a newly discovered agglomerate of hypermethylated DMRs associated with gene silencing in b

90 Hypermethylated DMRs were more likely to overlap with Cp

91 strated that 37%-63% of cases had detectable hypermethylated DNA (>/= 5% methylation) for these five

92 RPS, a repetitive hypermethylated DNA fragment from Petunia hybrida, attra

93 y, the sequence characteristics of hypo- and hypermethylated domains in cerebellum were distinct.

94 y, increased forces were required to convert hypermethylated dsDNA into an extended S-form configurat

95 igidity and intrinsic stiffness decreased in hypermethylated dsDNA, pointing at structural compaction

96 Here we show that the TNFalpha promoter is hypermethylated during endotoxin tolerance and that H3K9

97 The transition from primed hypermethylated embryonic stem cells (ESCs) to naive hyp

98 Upregulation of hypermethylated endogenous retrovirus (ERV) genes accomp

99 Hypermethylated enhancer regions overlapped with binding

100 ttern of methylation, although at some loci, hypermethylated epialleles persist.

101 , and (3) sporadic transitions from hypo- to hypermethylated equilibria as a result of methylation no

102 A signature based on the number of hypermethylated events distinguished patients with high-

103 ated maternal sequences are digested leaving hypermethylated fetal sequences detectable.

104 e determined that the IRF8 gene promoter was hypermethylated frequently in human STS.

105 lanilide hydroxamic acid in induction of the hypermethylated genes and anti-MCL cytotoxicity.

106 We discover pancancer hypo- and hypermethylated genes and identify novel methylation-dri

107 We additionally find that when DNA-hypermethylated genes are demethylated and reexpressed,

108 e-wide analysis, we demonstrate that ~75% of hypermethylated genes are marked by PcG in the context o

109 hypermethylated in reprogramming cells, and hypermethylated genes associated with pluripotency fail

110 ng; however, expression of only 245 of these hypermethylated genes becomes downregulated in A2780/cp7

111 tatistical criteria, we further identified 4 hypermethylated genes CDKN2B, MLF-1, PCDH8, and HOXD8 an

112 Hypermethylated genes exhibited enrichment of repressive

113 e increasing interest in reexpression of DNA-hypermethylated genes for the treatment of cancer.

114 ularly H3K4me2 levels, crisply separates DNA-hypermethylated genes from those where histone deacetyla

115 the biological function of the collective of hypermethylated genes has not been conducted so far.

116 loit this vast dataset to identify hypo- and hypermethylated genes in cancer.

117 tor, decitabine, restored expression of some hypermethylated genes in EBV-infected and EBV-negative t

118 One of the hypermethylated genes in GBM, ULK2, an upstream autophag

119 Elevated DNMT3A is also demonstrated at hypermethylated genes in Wilms' tumour cells, including

120 y expressed genes, in which 20.7% distinctly hypermethylated genes showed down-regulated expression i

121 and mRNA expression data, we identified 164 hypermethylated genes showing concurrent down-regulation

122 s in the tumors is unusual in that other DNA hypermethylated genes tested in such cultures preserve t

123 SCLC cell lines had a greater number of hypermethylated genes than primary tumors.

124 ls exist that can formally identify hypo and hypermethylated genes that are predictive of transcripti

125 A subset of 7 differentially hypermethylated genes was assayed by quantitative revers

126 Hypomethylated and hypermethylated genes were associated with increased and

127 a pharmacologic unmasking approach to detect hypermethylated genes whose inactivation contributes to

128 These data provide the first set of hypermethylated genes with the potential to complement T

129 array techniques, we identified 59 candidate hypermethylated genes, including LOXL1, a lysyl oxidase-

130 identified many lymphoma-specific candidate hypermethylated genes, including Stk39.

131 gulated RAS/MAPK signaling with silencing of hypermethylated genes, which normally inhibit these path

132 ls of hydroxymethylation and distinct set of hypermethylated genes.

133 embryonic stem cells were enriched among the hypermethylated genes.

134 hance identification of truly silent and DNA-hypermethylated genes.

135 eplication, transcription, and reparation of hypermethylated genetic regions.

136 s, thus the dual stability of both hypo- and hypermethylated genomic regions, and (3) sporadic transi

137 itumor effects by reactivation of aberrantly hypermethylated growth regulatory genes and cytoxicity r

138 with the interpretation that recognition of hypermethylated histone H3 K4 promotes efficient V(D)J r

139 PCDHGC3 was hypermethylated in 17/28 carcinomas (60.7%) according to

140 However, the CpG island of TNFRSF9 was hypermethylated in 19% of astrocytic tumours and 87% of

141 TFAP2E was hypermethylated in 38 of 74 patients (51%) in the initia

142 the GADD45A promoter region was shown to be hypermethylated in 82% of wild-type TP53 sarcomas that d

143 At least one of these genes was hypermethylated in 87% of the cases, suggesting that mea

144 IRF6 promoter was hypermethylated in 9 (45%) of 20 VLS specimens, 1 (20%)

145 etic stem cells expanded with cytokines were hypermethylated in a DNMT3A-dependent manner, suggesting

146 ar, it was not investigated whether INK4b is hypermethylated in all cytogenetic subtypes of AML.

147 embryonic stem cells were preferentially DNA hypermethylated in APL cells.

148 We also found that 12% of the loci were hypermethylated in apparently normal urothelium from bla

149 2/3 NHD13 mice and 2/3 RUNX1 mice) were also hypermethylated in at least two of 19 human MDS samples.

150 iption, we showed that the GAD1 promoter was hypermethylated in both colon and liver cancer cells, le

151 some promoters were either hypomethylated or hypermethylated in both females and males.

152 n, containing multiple CpG dinucleotides, is hypermethylated in both naive Tet1KO mice and after exti

153 sites in various genomic contexts that were hypermethylated in both non-CIMP and CIMP colon cancers

154 The SOX7 promoter is hypermethylated in breast cancer cell lines compared wit

155 is region has previously been reported to be hypermethylated in breast cancer.

156 This chromosomal region contains HYPERMETHYLATED IN CANCER 1 (HIC1), a transcriptional re

157 activation of another tumor suppressor gene, Hypermethylated in Cancer 1 (HIC1), often occurs in huma

158 The tumor suppressor gene hypermethylated in cancer 1 (HIC1), which encodes a tran

159 The tumor suppressor gene hypermethylated in cancer 1 (HIC1), which encodes a tran

160 HIC1 (hypermethylated in cancer 1) is a tumor suppressor gene

161 HIC1 (hypermethylated in cancer 1) is a tumor suppressor gene

162 The transcriptional repressor HIC1 (Hypermethylated in Cancer 1) is a tumor suppressor gene

163 latively few have thus far been validated as hypermethylated in cancer among over 14,000 candidates w

164 influence the propensity of a gene to become hypermethylated in cancer and that DNMT3B plays an impor

165 articularly, CpG rich regions are frequently hypermethylated in cancer tissues, but not methylated in

166 omoter that contains binding sites for HIC1 (hypermethylated in cancer) protein.

167 and the effect of cancer stage on SIRT1 and hypermethylated in cancer-1 (HIC-1).

168 Hypermethylated in cancer-1 (HIC1) is a tumor suppressor

169 of PRC2 targets that were more likely to be hypermethylated in cancer.

170 ation of PcG target genes that are typically hypermethylated in cancer.

171 with key developmental genes, is frequently hypermethylated in cancers and in vitro cell culture, po

172 nes encoding for hsa-miR-9 are significantly hypermethylated in ccRCC tumors compared with adjacent n

173 This region contained a CpG island that was hypermethylated in CD133-ve glioma stem cells (GSC) and

174 The gamma promoters are initially hypermethylated in CD34(+) cells.

175 e, CpG dinucleotides adjacent to the DHS are hypermethylated in CD8(+) T cells.

176 s, we identified loci at 4092 genes becoming hypermethylated in chemoresistant A2780/cp70 compared wi

177 An additional 2026 sites were found to be hypermethylated in CIMP tumors only; and importantly, 80

178 lation of sites that are already prone to be hypermethylated in colon cancer.

179 gulation) was hypomethylated in placenta and hypermethylated in cord blood.

180 genes that have previously been shown to be hypermethylated in cutaneous T-cell lymphomas (CTCLs), u

181 copy number gains such as STC2 and CCND1 and hypermethylated in deletions such as CLCNKB, VHL, and CD

182 GC B cells, but many of them are aberrantly hypermethylated in DLBCL, suggesting disruption of norma

183 re both significantly altered, 16 genes were hypermethylated in DNA associated with decreased mRNA ex

184 n 16 genes (including HTR2B cg27531267) were hypermethylated in EA cases (5.6 x 10(-9) </= P </= 9.5

185 and pyrosequencing showed that survivin was hypermethylated in endometrial tumors and correlated wit

186 In addition, the CpG sites that are hypermethylated in ependymomas are proximal to CpG islan

187 at 0.5% (120 loci) of human CpG islands were hypermethylated in epithelial cells derived from estroge

188 A total of 13/41 genes were consistently hypermethylated in further independent cisplatin-resista

189 sses, whereas low-CpG genes, predicted to be hypermethylated in germlines, are enriched with function

190 CpG sites that were hypermethylated in group H were more frequently located

191 d a CpG-rich region in the first intron were hypermethylated in HCC cells.

192 ith a genome-wide approach, additional genes hypermethylated in HCC that could be used for more accur

193 The 5'-promoter of DCLK1-gene is reportedly hypermethylated in hCRCs, resulting in loss of expressio

194 methylated at lysine 4, while H3 lysine 9 is hypermethylated in latently infected mice.

195 We found that GPC5 was significantly hypermethylated in lung cancer tissues and lung cancer c

196 he first intron of the human BCL6 locus were hypermethylated in lymphoma cells that expressed high am

197 te pyrosequencing shows that CYP24A1 gene is hypermethylated in malignant lesions compared with match

198 After showing the ID4 promoter is hypermethylated in MCF7 cells but hypomethylated in MCF/

199 romoter region of LXN was almost universally hypermethylated in melanoma cell lines and tumors, and t

200 ver, numerous promoters and gene bodies were hypermethylated in mutant iPGCs, which is consistent wit

201 d1, Arg1, Cdk18, and Fes, were significantly hypermethylated in Mvarphis isolated from hyperlipidemia

202 showed an average of 512/3445 (14.9%) genes hypermethylated in NHD13 MDS, and 331 (9.6%) genes hyper

203 at 25% were adjacent to sites that were also hypermethylated in non-CIMP tumors.

204 strate bipolar DNA methylation pattern, i.e. hypermethylated in one cell subset but hypomethylated in

205 lele are hypomethylated in seedlings, become hypermethylated in organs formed in the adult phase, and

206 ses the distal enhancer element of P1-rr, is hypermethylated in P1-pr compared to P1-rr.

207 KLF8, MOB3B, SLC18A2, and GSTP1) known to be hypermethylated in PC.

208 ent and function, and lipid metabolism) were hypermethylated in placenta and cord blood from SGA newb

209 ller and distinct from PMDs, with some being hypermethylated in placenta compared with other tissues.

210 ied the promoter region of the DOC2B gene as hypermethylated in pre-malignant, malignant cervical tis

211 Thus, NMDAR2A is commonly hypermethylated in primary human CRC and possesses tumor

212 After HR, the repaired DNA is hypermethylated in recombinant clones showing low GFP ex

213 The genome of Aid-null cells remains hypermethylated in reprogramming cells, and hypermethyla

214 fite sequencing confirmed that 14 genes were hypermethylated in resistant cell lines but not in the s

215 roblasts identified multiple genes that were hypermethylated in response to PGE(2).

216 ethylated in NHD13 MDS, and 331 (9.6%) genes hypermethylated in RUNX1 MDS.

217 rmined that the PTPRT promoter is frequently hypermethylated in several cancers, including HNSCC (60.

218 GI, is hypomethylated in male germ cells but hypermethylated in somatic tissues, regardless of genomi

219 g, we determined that these CpG islands were hypermethylated in TDEC but not in MDEC.

220 CpGs (tet2-DMCs) in NCGIs, 86% of which were hypermethylated in TET2-MT cases, suggesting a strikingl

221 To determine whether the same CpG island is hypermethylated in the cerebella of cases in whom aberra

222 e maternal allele of many A. lyrata PEGs was hypermethylated in the CHG context.

223 DNA was not hypermethylated in the Cyp3a locus at any age.

224 ted B cells produce iPSCs that are uniformly hypermethylated in the imprinted Dlk1-Dio3 gene cluster

225 fferentially methylated region 2 of Igf2 was hypermethylated in the liver of E17 choline-deficient fe

226 of the 9 CpG loci in SST were significantly hypermethylated in the older individuals.

227 t identify all individual CpG sites that are hypermethylated in the presence of a mutation.

228 Of these, 537 CpG sites were hypermethylated in the tumor DNA, whereas 1,689 sites sh

229 However, when DNA-hypermethylated in tumors, we find that these genes are

230 s more than 20) consecutive CpG islands were hypermethylated in tumors.

231 region was confirmed as being substantially hypermethylated in two other cortical regions (superior

232 ethylated CpG sites (76% hypomethylated, 24% hypermethylated) in patients with advanced vs mild NAFLD

233 hat also binds the transcriptional repressor Hypermethylated-In-Cancer-1 (HIC1).

234 nuclear chromatin architecture for genes in hypermethylated inactive versus nonmethylated active sta

235 er CpG islands of ABCC3 and SLCO2A1 were not hypermethylated, indicating that these genes were not ep

236 Two other clusters of hypermethylated islands were at sequences of recent gene

237 However, the hypermethylated loci in ER-negative tumors were clustere

238 evels of nuclear methylation, we detected 23 hypermethylated loci in gene-poor, repeat-rich regions.

239 rone receptor-positive tumors displayed more hypermethylated loci than estrogen receptor (ER)-negativ

240 vity and specificity of the method to detect hypermethylated loci were 88% and 96%, respectively, acc

241 as in Monos, 155 hypomethylated loci and 247 hypermethylated loci were found (fold change >/=1.3; P <

242 ildren, while regions in RAD50 and IL13 were hypermethylated (lowest P-value (STAT6) = 0.001).

243 other tumors and normal tissues possessed a hypermethylated LTR preventing proviral expression.

244 lications to delay the progression of RASSF1-hypermethylated lung tumors.

245 consisting of novel and known breast cancer hypermethylated markers identified by mining our previou

246 as characterized by numerous novel, aberrant hypermethylated marks that were located mainly outside o

247 ation also has been observed across the male hypermethylated (MHM) region, which has been suggested t

248 analysis found a significant correlation of hypermethylated miR-129-2 with microsatellite instabilit

249 L-6, HMGA2, and Sox2 protein expressions and hypermethylated miR142-3p promoter also demonstrate poor

250 In cell lines with a hypermethylated MITF-pathway, overexpression of MITF did

251 ite sequencing of KLF4 promoter identified a hypermethylated myocyte enhancer factor-2 binding site.

252 ptive behavior are separable as males with a hypermethylated OA neuronal genome exhibited a decrease

253 hose from patients with Lynch syndrome, MLH1-hypermethylated, or microsatellite-stable tumors.

254 or suppressor gene (TSG) was more frequently hypermethylated (P = .003).

255 sited on hypomethylated maternal alleles and hypermethylated paternal alleles, respectively.

256 ours harbour increased H3K27me3 signal and a hypermethylated phenotype, mainly occupying the polycomb

257 Additionally, the hypermethylated Pomc gene was detected in sperm of fetal

258 ed segment and amplifies the HR-L expressor (hypermethylated) population.

259 ZNF238 to be most significantly enriched in hypermethylated promoter regions.

260 Three downregulated genes with hypermethylated promoters and restored expression in res

261 alent chromatin marks, and colocalization of hypermethylated R-DMRs with hypomethylated C-DMRs and th

262 We further confirmed that hypermethylated RAB25 is inversely correlated with its m

263 Eleven samples (12%) had no detectable hypermethylated RASSF1A and 10 of these (91%) had gestat

264 Use of this assay for the detection of hypermethylated RASSF1A as a universal fetal marker has

265 The hypermethylated RASSF1A promoter has been reported as a

266 Hypermethylated RASSF1A was amplified for 79 samples (88

267 n the cortical and striatal demethylation of hypermethylated reelin and GAD67 promoters.

268 is novel CE detection assay by analyzing the hypermethylated region of the fragile-X FMR1 locus.

269 We identified 2,465 differentially hypermethylated regions and 4,692 hypomethylated regions

270 in both models with a shared core set of DNA hypermethylated regions and suppression of stem cell-rel

271 Furthermore, hypermethylated regions in MM were methylated in stem ce

272 DNA pyrosequencing identified hypermethylated regions of the alpha-SMA gene in PARP-1-

273 Hypomethylated and hypermethylated regions were associated with increased a

274 ly expressed memory markers; rather, several hypermethylated regions were identified in known transcr

275 actor binding sites and human differentially hypermethylated regions.

276 mi-1, and/or Nanog and their CpG islands are hypermethylated relative to nontumorigenic cells.

277 13, PGR, CDH1, and IGSF4) were significantly hypermethylated relative to the degree of malignancy (af

278 mDnmt2 silencing and the identification of a hypermethylated, repetitive intron within a predicted fo

279 Among hypermethylated sequences identified, several fragments

280 As in differentiated cells, hypermethylated sequences were enriched in chromatin rep

281 demonstrated that four TFBS were enriched in hypermethylated sequences.

282 The hypermethylated set was enriched for genes known to be i

283 By analysing sequence motifs surrounding hypermethylated sites across the four cancer types, and

284 ter-associated CpG islands (CGIs) in cancer, hypermethylated sites in MM, as opposed to normal plasma

285 s and primary lung tumor tissues harboring a hypermethylated SOX30.

286 We identify predominately hypermethylated T2D-related differentially methylated re

287 Approximately half of the hypermethylated targets are developmental regulators, an

288 c acid receptor activation pathway among the hypermethylated targets.

289 at normal temperature, root hairs were more hypermethylated than were stripped roots.

290 ers, with ratios of significantly (P < .001) hypermethylated to hypomethylated CpGs of 1.7 and 2.9, r

291 , the sites outside CpG islands were heavily hypermethylated to the same degree in both genders.

292 C1) occupy the promoters of several of these hypermethylated TSGs and physically and functionally int

293 evealed that genes whose promoter region was hypermethylated upon myoblast differentiation were highl

294 ecipitation (ChIP) in HCT116 cells and their hypermethylated variant showed that BORIS binds to methy

295 erentiation and signaling are preferentially hypermethylated, whereas those of housekeeping genes rem

296 er region of the peptide ligand gene EPF2 is hypermethylated, which greatly reduces EPF2 expression a

297 130) showed that promoters H3R8 and H4R3 are hypermethylated, which in turn triggers pocket protein t

298 r cells frequently have regions of their DNA hypermethylated, which results in transcriptional silenc

299 were enriched at genomic regions that become hypermethylated with increasing cell culture passage.

300 uated, only one c9FTD sample was found to be hypermethylated within the C9orf72 promoter region.

301 It is hypermethylated within transposable elements (TEs), acco