ライフサイエンスコーパス: hypermorphic

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1 c mutations in its Brd and GY boxes exhibits hypermorphic activity that results in characteristic def

2 1(Pro) alleles is not consistent with simple hypermorphic activity.

3 In contrast, a hypermorphic allele of T-bet can reverse silencing of th

4 ssion of TEC1, by expression of the dominant hypermorphic allele STE11-4 or by deletion of HOG1, Ty1

5 Screens for suppressors of lin-12 hypermorphic alleles in C. elegans have identified core

6 e identified three of four such mutations as hypermorphic alleles of Gnaq and Gna11, which encode wid

7 ors of the egg-laying defect associated with hypermorphic alleles of lin-12.

8 tains its potency against yeast carrying the hypermorphic alleles PDR1-11 or PDR1-3.

9 ) to chronic mucocutaneous candidiasis (CMC; hypermorphic alleles).

10 Constitutively active mutants are hypermorphic as they trigger proliferation and death mor

11 vo, resulting in phenotypic suppression of a hypermorphic bin2 mutation and enhanced resistance to a

12 liogenesis and report that mutant Htt causes hypermorphic ciliogenesis and ciliary dysfunction.

13 atient we identified two rare, recessive and hypermorphic coding variants in GPATCH3, a gene of unide

14 n mutations enhance hypomorphic and suppress hypermorphic D-ERK mutant phenotypes.

15 l and histologic analyses established if the hypermorphic Egfr(Dsk5) allele can rescue the woe embryo

16 We propose that the Rad50(S) allele is hypermorphic for DNA damage signaling, and that the resu

17 ified as a dominant suppressor of EgfrElp, a hypermorphic form of the Drosophila Epidermal growth fac

18 s were likely caused by either neomorphic or hypermorphic gain-of-function mutations in the BIN2 gene

19 lele can be spatiotemporally switched to the hypermorphic H allele by Cre-loxP recombination.

20 rmant studies confirmed that the mutation is hypermorphic in vivo, but the DER function was elevated

21 with previous results, PLCG2(R665W) confers hypermorphic induction of downstream signaling events.

22 Here we analyze Pten hypermorphic mice (Pten(hy/+)), expressing 80% normal le

23 Here we show that a previously characterized hypermorphic mutant FtsA (FtsA*) partially disassembled

24 In contrast, a hypermorphic mutant of FtsA (FtsA*) forms mainly arcs in

25 ome (BAC)-based transgenic system in which a hypermorphic mutation has been introduced into the murin

26 The hypermorphic mutations are also associated with arterial

27 morphic mutations in STAT3 and patients with hypermorphic mutations in STAT1 share several clinical a

28 Hypermorphic mutations in the Wnt co-receptor LRP5 sugge

29 5F be referred to as allomorphic rather than hypermorphic mutations of PLCG2 Rerouting of the transme

30 m of fixation in the presence of amorphic or hypermorphic mutations, we consider a diallelic model at

31 ral vector to drive expression of wild-type, hypermorphic, or hypomorphic MYC in bone marrow that exp

32 The p53 hypermorphic (p53+/m) mice display phenotypes of prematu

33 ,C186S) not targeted to membranes produced a hypermorphic phenotype and stimulated mitogen-activated

34 These hypermorphic phenotypes could be relieved by deleting mo

35 the highly conserved Lys-774 residue induced hypermorphic phenotypes that mimicked the loss of phosph

36 ons of this cleavage site produced the first hypermorphic point mutation within the Apaf1/Ced-4 gene

37 The hypermorphic Rad50(S) allele encodes a variant of Rad50,

38 Hematopoietic cells expressing the hypermorphic Rad50(s) allele show hematopoietic failure,

39 We report the positional cloning of a hypermorphic, regulatory mutation in Fpn1 from radiation

40 A previously characterized hypermorphic sir3 mutation, D205N, greatly improves sile

41 Here, we analyze mice with a hypermorphic Zap70 mutation, W131A, which destabilizes t

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