ライフサイエンスコーパス: hypermutable

1 utagenesis and that this subpopulation(s) is hypermutable.

2 nditions that predispose to PNH PIG-A may be hypermutable.

3 Somatic WS cells are hypermutable and have elongated S phases, suggesting pos

4 ample set, suggesting that these markers are hypermutable and should prove valuable for the discrimin

5 ion mutants are sensitive to UV irradiation, hypermutable, and hyper-rec.

6 We suggest that FAA is hypermutable, and that slipped-strand mispairing, a muta

7 pressor TP53 (coding for the protein p53) is hypermutable at some stage of carcinogenesis, the freque

8 The published data indicate that TP53 is hypermutable at some stage of tumor development.

9 is suggested that at immunoglobulin loci in hypermutable B cells, mismatched base pairs are "correct

10 The correlation of hypermutable base frequencies with -DeltaG values is poo

11 DNA folding analysis indicates that the most hypermutable bases in exons 5, 7, and 8 of the p53 tumor

12 pression of the FMR1 gene, which carries the hypermutable CGG repeat in the 5' untranslated portion o

13 Hypermutable colorectal and endometrial tumors with func

14 s insufficient to differentiate cells into a hypermutable condition.

15 s per kilobase (kb), and only 3.7% of the 30 hypermutable CpG dinucleotide pairs in the consensus rem

16 2.4% from the consensus, retained 54% of its hypermutable CpG pairs, and which has a full-length tran

17 e assay to identifying genetic variations in hypermutable CpG regions across human chromosome 21.

18 the strength of gBGC does not differ between hypermutable CpG sites and non-CpG sites, suggesting tha

19 nitely associated with presumably methylated hypermutable CpG sites, and in a typical GC-asymmetric g

20 pected, the younger orthologs contained more hypermutable CpGs than the older ones because of their c

21 rom 17 patients, we used somatic variants in hypermutable DNA regions to reconstruct high-confidence

22 ature of Ig hypermutation is the presence of hypermutable DNA sequences that are preferentially found

23 The repair defect of the three hypermutable, drug-resistant cell lines is only evident

24 results suggest that the genus Oenococcus is hypermutable due to the loss of mutS and mutL, which occ

25 Therefore, IESs are volatile, hypermutable elements that are inserted, removed, shifte

26 cancer predisposition in which cells become hypermutable, exhibit high frequency of sister chromatid

27 Both rad28 and rad26 null mutants are hypermutable following exposure to UV light.

28 a with elevated mutability that often remain hypermutable for the duration of selection.

29 g defective cells there exists a transiently hypermutable fraction that would be inviable if cells we

30 was significantly decreased targeting of the hypermutable G in RGYW motifs.

31 GTPase family that was first identified as a hypermutable gene in human B lineage lymphomas.

32 Intriguingly, the four hypermutable genes are susceptible to chromosomal transl

33 iking contrast, all mutations arising in the hypermutable GFP+/- strains were small (1- to 2-base) ch

34 families with BHD and therefore represents a hypermutable "hotspot" for mutation in BHD.

35 as been suggested that the PIG-A gene may be hypermutable in PNH.

36 Here we have mapped mutations in hypermutable intergenic and intronic polyguanine tracts

37 enomes possess minisatellite-like sequences, hypermutable loci have not been identified that suggest

38 RS is hypermutable over the total 625 nucleotides of the varia

39 Microsatellite instability (MSI) is a hypermutable phenotype caused by the loss of DNA mismatc

40 However, in many cases, despite that a hypermutable phenotype is detected in a patient, no muta

41 LE, MLH1, and MSH6 and the tumor cells had a hypermutable phenotype.

42 results in microsatellite instability and a hypermutable phenotype.

43 sed assay interrogating somatic variation in hypermutable polyguanine (poly-G) repeats can provide a

44 hypothesize that these deletions occur in a hypermutable region because of surrounding repetitive se

45 s were identified in the previously reported hypermutable region of BCL6 in all three tumors.

46 coded protein, this mutation creates a small hypermutable region of the gene, indirectly causing canc

47 satellites in the hMSH3 and hMSH6 genes, and hypermutable regions of p53 were unaffected.

48 Recently, we have shown a hypermutable response to the food-associated heterocycli

49 combination rate and an increased density of hypermutable sequence contexts.

50 gs invoke the notion of "unmasking" specific hypermutable sequences in particular genes adding furthe

51 Phase variation of hypermutable simple sequence repeats (SSRs) is a widespr

52 tune gene networks in Escherichia coli using hypermutable simple sequence repeats embedded in the spa

53 E. coli deficient in mismatch repair unmasks hypermutable sites in certain genes or intergenic region

54 On average, only 20% of the 73 surmised CpG hypermutable sites in the consensus remain.

55 c regulatory alteration that makes the cells hypermutable so that when the cell population inheriting

56 sis in a subpopulation of starved cells (the hypermutable state model).

57 the mutation rate in response to stress (the hypermutable state model, HSM).

58 0(5) cells (the number proposed to enter the hypermutable state).

59 ion and real-time visualization of transient hypermutable states in situ.

60 The hypermutable status of the genus Oenococcus explains the

61 Of nine independently derived hypermutable strains, seven contained a defective mutS a

62 The existence of such a hypermutable subpopulation(s) raises important considera

63 phenotype would render MMR-deficient animals hypermutable to IR, we compared IR mutagenesis of Pms2-d