ライフサイエンスコーパス: hyperphosphorylated

1 ogical state of tau is often referred to as "hyperphosphorylated".

2 g, which alleviates Fpk1 inhibition, Akl1 is hyperphosphorylated.

3 loss of NCC function, whereas NKCC2 becomes hyperphosphorylated.

4 otubule-associated protein Tau is abnormally hyperphosphorylated.

5 DNA replication stress, RPA2 is extensively hyperphosphorylated.

6 Hyperphosphorylated 4E-BP dissociates from eIF4E, allowi

7 nterestingly, overexpressed and subsequently hyperphosphorylated 4EBP1.

8 Lesions containing hyperphosphorylated aggregated TDP-43 characterize amyot

9 acterized by the progressive accumulation of hyperphosphorylated, aggregated forms of tau.

10 The scFvs significantly reduced levels of hyperphosphorylated, aggregated tau in brain tissue of P

11 y the presence of neurofibrillary tangles of hyperphosphorylated, aggregated tau protein and extracel

12 The antibodies markedly reduced hyperphosphorylated, aggregated, and insoluble tau.

13 ha-Syn) is a key protein that accumulates as hyperphosphorylated aggregates in pathologic hallmark fe

14 expression with concomitant accumulation of hyperphosphorylated and abnormally folded proteinase K r

15 kinase Kns1 is differentially expressed and hyperphosphorylated and accumulates in the nucleus after

16 These mice show amyloid pathology, hyperphosphorylated and aggregated normal mouse tau, sig

17 Neuronal inclusions of hyperphosphorylated and aggregated tau protein are a pat

18 The pathological accumulation of abnormally hyperphosphorylated and aggregated tau, a neuronal micro

19 eatures of AD, including amyloid deposition, hyperphosphorylated and aggregated tau, behavioral chang

20 NS5A is a phosphoprotein that exists in hyperphosphorylated and basally phosphorylated forms.

21 peptide (Abeta) within the brain along with hyperphosphorylated and cleaved forms of the microtubule

22 Here we show that FANCM is hyperphosphorylated and degraded during mitosis.

23 laforin function, insoluble glucans that are hyperphosphorylated and exhibit sparse branching accumul

24 Because hyperphosphorylated and insoluble Tau are hallmarks in n

25 In AD, tau becomes hyperphosphorylated and misfolded at both presynaptic an

26 protein that stabilizes microtubules and is hyperphosphorylated and mislocalized in Alzheimer's dise

27 tubule-associated protein tau, which becomes hyperphosphorylated and pathologically aggregates in a n

28 togen-activated protein kinases (MAPKs) were hyperphosphorylated and the kinase Akt and its downstrea

29 tic initiation factor 2alpha (eIF2alpha) was hyperphosphorylated and total protein translation was de

30 C-terminal fragment led to the formation of hyperphosphorylated and ubiquitinated inclusions in moto

31 Cytoplasmic inclusions containing hyperphosphorylated and ubiquitinated TDP-43 are a patho

32 Synaptic tau seems to be hyperphosphorylated and ubiquitinated, and forms stable

33 f cTnI (cardiac troponin I) is significantly hyperphosphorylated, and in vitro studies suggest that i

34 ological TDP-43 is abnormally ubiquitinated, hyperphosphorylated, and N-terminally cleaved to generat

35 protein and their conversion into insoluble, hyperphosphorylated, and ubiquitinated pathological spec

36 fically associates with a fraction of RNAPII hyperphosphorylated at Ser5 and Ser7, which is a hallmar

37 In contrast, PPARgamma in PP5-KO cells was hyperphosphorylated at serine 112 but had reduced rosigl

38 showed that the C-terminal domain of RNAP is hyperphosphorylated at serine 5 (S5(P)) on VZV genes 9,

39 This site becomes hyperphosphorylated at the MBT, thus allowing the dockin

40 At the onset of diabetes, tau was hyperphosphorylated at the tau-1, AT8, CP13, pS262, and

41 ed kinase 1A (DYRK1A) was one of the kinases hyperphosphorylated at Tyr-321 in all HNSCC cell lines.

42 In the absence of ANXA2, VEC is hyperphosphorylated at tyrosine 731 in response to vascu

43 Herein, we show that halpha-Syn forms hyperphosphorylated (at S129) and ubiquitin-positive LB-

44 gation only when large (>10 mer) aggregated, hyperphosphorylated (AT8- and AT100-positive) and nitrat

45 es of BAF's antiviral activity revealed that hyperphosphorylated BAF is unable to suppress viral DNA

46 state in the SE-Brg1 mutant, suggesting that hyperphosphorylated Brg1 cannot remodel chromatin.

47 s, ARF promoted the chromatin association of hyperphosphorylated, but not basal phosphorylated, topo

48 When stress is terminated, Grb7 is hyperphosphorylated by focal adhesion kinase (FAK), lose

49 Upon exposure to stress, Atf1 is hyperphosphorylated by the mitogen-activated protein kin

50 rs through its N-terminal WW domains and the hyperphosphorylated C-terminal domain (CTD) of RNA polym

51 e in hypophosphorylated cdc24 mutants, while hyperphosphorylated cdc24 mutants that were resistant to

52 Hyperphosphorylated coat subunits accumulate in the sit4

53 It is hypothesized that the hyperphosphorylated, conformationally altered, and multi

54 the tandem FF repeat that interacts with the hyperphosphorylated CTD (PCTD).

55 al S83 site, resulting in a mitosis-specific hyperphosphorylated delta isoform.

56 pho-specific antibody, we show that PELP1 is hyperphosphorylated during cell cycle progression.

57 ssembly of these copolymers when vimentin is hyperphosphorylated during mitosis.

58 We found that Mih1 is hyperphosphorylated early in the cell cycle and is depho

59 Tau is well known to aggregate to form hyperphosphorylated filamentous deposits in several neur

60 with PKC activity upregulates the level of a hyperphosphorylated form of CREB (hyper-PO4 CREB) and tr

61 This site is a component of the hyperphosphorylated form of NS5A, which is in good agree

62 hough methylation at R1810 is present on the hyperphosphorylated form of RNAPII in vivo, Ser2 or Ser5

63 report that Yra1 directly binds in vitro the hyperphosphorylated form of the CTD characteristic of el

64 bed around the pSer202/pThr205 region of the hyperphosphorylated form of the neuronal protein tau.

65 The microtubule-associated protein tau, in a hyperphosphorylated form, aggregates into insoluble pair

66 conversion of CasL into its serine/threonine hyperphosphorylated form, which is important for lymphoc

67 biquitination of IRS1 N-terminal fragment in hyperphosphorylated form, which was isolated from infect

68 CRL7) mediates the ubiquitination of IRS1 in hyperphosphorylated form.

69 In the disease Tau aggregates and becomes hyperphosphorylated forming paired helical and straight

70 and virion assembly, and exists in hypo- and hyperphosphorylated forms.

71 usion bodies formed by polyubiquitinated and hyperphosphorylated full-length and truncated TDP-43.

72 ar phenotype; an excess amount of insoluble, hyperphosphorylated glucans accumulates in cells.

73 accumulation of insoluble, poorly branched, hyperphosphorylated glycogen in brain, muscle, heart, an

74 g the glycogen phosphatase laforin result in hyperphosphorylated glycogen that forms water-insoluble

75 d by the intracellular buildup of insoluble, hyperphosphorylated glycogen-like particles, called Lafo

76 d mice with either gene disrupted accumulate hyperphosphorylated glycogen.

77 lled ribosomes and activated to synthesize a hyperphosphorylated guanosine analogue, (p)ppGpp, which

78 Small modified nucleotides such as the hyperphosphorylated guanosine molecules ppGpp and pppGpp

79 in vitro data confirmed that PINCH binds to hyperphosphorylated (hp) Tau and to E3 ubiquitin ligase,

80 provide the direct evidence that NF-M/H are hyperphosphorylated in AD compared with control brain an

81 d tau at several sites, and these sites were hyperphosphorylated in adult DS brains.

82 Nup62, Nup153, and Nup214 each became hyperphosphorylated in an L-dependent manner.

83 We found that S6K was hyperphosphorylated in ANDV-infected, hypoxia-treated ME

84 HDAC2 was also hyperphosphorylated in cells infected with PRV lacking U

85 omain-containing inositol 5 phosphatase were hyperphosphorylated in GC cells and remained colocalized

86 e similar between groups; however, titin was hyperphosphorylated in HFpEF and correlated with betaLA.

87 n is supported by our finding that SAMHD1 is hyperphosphorylated in monocytoid THP-1 cells under nonr

88 In this study, we discovered that BRD4 is hyperphosphorylated in NUT midline carcinoma and identif

89 We found that STAT1 was hyperphosphorylated in response to cytokine stimulation

90 this modification stimulates RPA2 to become hyperphosphorylated in response to mitotic DNA damage ca

91 translocase FANCM, which we have shown to be hyperphosphorylated in response to various genotoxic age

92 ospholamban, and Ser23/24 in troponin-I were hyperphosphorylated in SA mice, whereas phosphorylation

93 Cdc2 expression is increased and Ubc9 is hyperphosphorylated in several cancers, and this represe

94 P70S6K was hyperphosphorylated in Tg1 somatosensory cortex, suggest

95 We also found that SK2 is hyperphosphorylated in the brain samples from a model of

96 Our data indicate that cTnI is hyperphosphorylated in the failing SHR myocardium compar

97 low copper and becomes more phosphorylated ("hyperphosphorylated") in elevated copper.

98 sion, resultant TTP protein builds up in the hyperphosphorylated inactive form.

99 most of the E4BP1 in the infected cell in a hyperphosphorylated, inactive state.

100 m target, acetyl-CoA carboxylase (ACC), were hyperphosphorylated, indicative of AMPK activation and A

101 athway leading from soluble and monomeric to hyperphosphorylated, insoluble and filamentous tau prote

102 ultimately leads to the rapid degradation of hyperphosphorylated isoforms via a mechanism involving t

103 aiA can bind stably to complexes of KaiB and hyperphosphorylated KaiC.

104 Ten hyperphosphorylated KSP sites have been identified on th

105 diomyocytes, Ca(v)1.2 and phospholamban were hyperphosphorylated, leading to increased Ca(2+) spark o

106 Hyperphosphorylated lipin-1 remains sequestered in the c

107 lex with a Cdk regulatory subunit (Cks) to a hyperphosphorylated loop of Apc3.

108 a mutant version of hLigI, which mimics the hyperphosphorylated M-phase form of hLigI, does not inte

109 tent evidence of accelerated accumulation of hyperphosphorylated microtubule associated protein tau i

110 Aggregates of the hyperphosphorylated microtubule-associated protein tau (

111 typified by the intracellular aggregation of hyperphosphorylated microtubule-associated protein tau (

112 The hyperphosphorylated microtubule-associated protein tau i

113 ted with neurofibrillary tangles composed of hyperphosphorylated microtubule-associated protein, tau.

114 id beta peptide and intraneuronal tangles of hyperphosphorylated microtubule-associated tau protein (

115 eration, G(2)/M arrest, and on the levels of hyperphosphorylated mitotic Cdc25C and Cyclin B1 protein

116 with interphase chromatin, are released from hyperphosphorylated mitotic chromosomes, but reassociate

117 or ubiquitin, amyloid precursor protein, and hyperphosphorylated neurofilament proteins.

118 ed microtubules, while vNSP2 associates with hyperphosphorylated NSP5.

119 In Fmr1 KO neurons, Mdm2 is hyperphosphorylated, nuclear localized basally, and unaf

120 Analysis of the hyperphosphorylated Nup species revealed only phosphoser

121 Cdk1 activity is high in metaphase, Mde4 is hyperphosphorylated on Cdk1 phosphorylation sites and lo

122 in of the paused polymerase large subunit is hyperphosphorylated on serine 5, and phosphorylation of

123 Moreover, htau became progressively hyperphosphorylated over 2 months in vitro beginning wit

124 beginning with nonsymptomatic neurons, while hyperphosphorylated P301S-htau-positive neurons from 5-m

125 may result from proteasome overload because hyperphosphorylated Pin4C aggregation is associated with

126 ry to the central nucleoplasm and to foci of hyperphosphorylated Pol II "transcription factories" (TF

127 ivation in T-ALL and other cancers driven by hyperphosphorylated PP2A substrates has therapeutic pote

128 Cortactin was originally identified as a hyperphosphorylated protein in v-Src-transformed cells,

129 EGFR-driven resistance are characterized by hyperphosphorylated protein kinase AKT, a biomarker we v

130 tep in promoting cell cycle progression, and hyperphosphorylated Rb is commonly found in tumors.

131 regulated cell cycle proteins, cyclin D1 and hyperphosphorylated Rb.

132 RyR2s are oxidized, nitrosylated, and PKA hyperphosphorylated, resulting in "leaky" channels in fa

133 lly, BaP treatment increased accumulation of hyperphosphorylated retinoblastoma protein (pRb) which c

134 RDGC, which dephosphorylates Rh1, results in hyperphosphorylated Rh1.

135 Enrichment of hyperphosphorylated RNA polymerase II (Pol II) and histo

136 hromosomes is virtually identical to that of hyperphosphorylated RNA polymerase II (RNAPII), but is d

137 , Nanos1-depleted PGCs prematurely exhibit a hyperphosphorylated RNA polymerase II C-terminal domain

138 ulation of S-phase cells with high levels of hyperphosphorylated RPA-loaded single-stranded DNA.

139 Hyperphosphorylated Rpb1 is not primarily targeted for p

140 n was also detected on chromatin-associated, hyperphosphorylated Rpb1, consistent with a role in tran

141 Enhanced SR Ca(2+) leak through CaMKII-hyperphosphorylated RyR2, in combination with larger I(N

142 Hyperactive, hyperphosphorylated RyRs because of reduced local phosph

143 nodine receptor (RyR1), is progressively PKA-hyperphosphorylated, S-nitrosylated, and depleted of the

144 We identified 13 hyperphosphorylated sites of NF-M; 9 Lys-Ser-Pro (KSP) s

145 The two mAbs significantly reduced hyperphosphorylated soluble Tau in long term brain slice

146 ; (iii) strong and selective accumulation of hyperphosphorylated soluble tau multimers into the synap

147 related oligomeric amyloid-beta assemblies, hyperphosphorylated soluble tau species localized in syn

148 hat S222 phosphorylation predominates in the hyperphosphorylated species.

149 d, referred to as basally phosphorylated and hyperphosphorylated species.

150 Here, we show that ATR is transformed into a hyperphosphorylated state after DNA damage, and that a s

151 y, we found that PALB2 is transformed into a hyperphosphorylated state in response to ionizing radiat

152 hus, strategies that maintain eIF2alpha in a hyperphosphorylated state may be a novel therapeutic app

153 mmediately after blood feeding, 4E-BP became hyperphosphorylated, suggesting rapid inhibition of its

154 ant intraneuronal pathological inclusions of hyperphosphorylated T40PL-GFP.

155 Detergent-resistant, ubiquitinated and hyperphosphorylated Tar DNA binding protein 43 (TDP-43,

156 3xTg mice, PMX205 also significantly reduced hyperphosphorylated tau (69%).

157 Aggregated filamentous forms of hyperphosphorylated tau (a microtubule-associated protei

158 crease in intraneuronal oligomeric Abeta and hyperphosphorylated tau (AT8) immunoreactivity in the hi

159 ase, the grafted tissue was characterized by hyperphosphorylated tau (AT8; immunofluorescent staining

160 Amyloid-beta (Abeta) and hyperphosphorylated tau (p-tau) aggregates form the two

161 eport that lysozyme induced the formation of hyperphosphorylated tau (P-tau) in cultured neurons, we

162 gyrus using antibodies to synaptic vesicles, hyperphosphorylated tau (pTau), neurofibrillary tangle c

163 e, the grafted tissue showed the presence of hyperphosphorylated tau [both AT8 (phospho-tau Ser202 an

164 is an ordered and predictable progression of hyperphosphorylated tau abnormalities through the nervou

165 human diseases such as HIV transmission and hyperphosphorylated tau accumulation in Alzheimer's dise

166 tau pathology by looking for the presence of hyperphosphorylated tau aggregates, co-localization of t

167 changes in the 3R:4R isoform ratio and AT100-hyperphosphorylated tau aggregates, while P301L neurons

168 l as with cerebrospinal fluid levels of tau, hyperphosphorylated tau and abeta 42 proteins.

169 , neuroinflammation, increased production of hyperphosphorylated tau and amyloidogenic Abeta-peptides

170 The present quantitative study of hyperphosphorylated tau and beta amyloid in drug user br

171 yloid precursor protein and toxic effects of hyperphosphorylated tau and beta-amyloid probably contri

172 se in brain amyloid beta protein aggregates, hyperphosphorylated tau and microglia load as observed b

173 hyperactivity and perikaryal aggregations of hyperphosphorylated Tau and neurofilaments, pathogenic h

174 -mediated neuropathological changes, such as hyperphosphorylated tau and neuronal death.

175 nied by a significant reduction in levels of hyperphosphorylated tau and oligomeric Abeta, the precur

176 sts SRPK2 may contribute to the formation of hyperphosphorylated tau and the pathogenesis of AD.

177 Filamentous inclusions made of hyperphosphorylated tau are characteristic of numerous h

178 NFTs contain aberrantly hyperphosphorylated Tau as paired helical filaments (PHF

179 mice, brain A beta was reduced by 65-85% and hyperphosphorylated tau by 50-60%.

180 g that mice overexpressing CRF had increased hyperphosphorylated tau compared with wild-type litterma

181 We also found that hyperphosphorylated tau contained 4-fold less O-GlcNAc t

182 ynaptotoxic role in Alzheimer's disease, and hyperphosphorylated tau facilitates Abeta toxicity.

183 Neurofibrillary tangles, composed of hyperphosphorylated tau fibrils, are a pathological hall

184 ta, reduces cognitive deficits, and prevents hyperphosphorylated tau immunoreactivity.

185 maze (RAWM) test and decreased the level of hyperphosphorylated tau immunostained with AT8 and PHF-1

186 n mitochondrial dysfunction and assesses how hyperphosphorylated tau impairs axonal transport of orga

187 inked to neurofibrillary tangles composed of hyperphosphorylated tau in AD.

188 where they interact and are associated with hyperphosphorylated Tau in Alzheimer disease brain.

189 e the cause of the increased cytotoxicity of hyperphosphorylated tau in Alzheimer's disease and also

190 Hyperphosphorylated tau in Alzheimer's disease appearing

191 erized by abundant filamentous inclusions of hyperphosphorylated tau in both neurons and glia.

192 Histological analysis demonstrated hyperphosphorylated tau in brainstem nuclei, directly or

193 We have shown previously that deposits of hyperphosphorylated tau in drug user brains exceed those

194 The levels of hyperphosphorylated tau in drug users fell far short of

195 the apoE4-driven accumulation of Abeta42 and hyperphosphorylated tau in hippocampal neurons, as well

196 no correlation between high beta amyloid and hyperphosphorylated tau in individual cases.

197 The accumulation of hyperphosphorylated tau in neurofibrillary tangles (NFTs

198 s and contribute to aberrant accumulation of hyperphosphorylated tau in neuronal cells affected by ta

199 c studies revealed a significant increase of hyperphosphorylated tau in synaptosomes of demented dogs

200 Accumulation of hyperphosphorylated tau in the entorhinal cortex (EC) is

201 sis and markedly reduced levels of total and hyperphosphorylated TAU in the spinal cord, brain stem,

202 y associated with the presence or absence of hyperphosphorylated tau in these cells.

203 By localizing and quantifying hyperphosphorylated tau in vivo, results of tau PET imag

204 urodegenerative tauopathies characterized by hyperphosphorylated tau include frontotemporal dementia

205 Neurofibrillary pathology of abnormally hyperphosphorylated Tau is a key lesion of Alzheimer dis

206 Aggregation of hyperphosphorylated tau is a major hallmark of many neur

207 to SH3 domains; no binding was detected with hyperphosphorylated tau isolated from Alzheimer brain, b

208 Hyperphosphorylated tau levels correlated significantly

209 owed neuronal loss and extensive deposits of hyperphosphorylated tau mainly involving the tegmentum o

210 However, the addition of a hyperphosphorylated tau mimic 352PHPtau significantly in

211 protein (T40PL-GFP Tg mouse line) exhibited hyperphosphorylated tau mislocalized to the somatodentri

212 The accumulation of hyperphosphorylated tau oligomers at human AD synapses i

213 Our findings suggest that synaptic hyperphosphorylated tau oligomers may be an important me

214 tauopathy by means of reducing the levels of hyperphosphorylated tau oligomers.

215 r topographical distribution and severity of hyperphosphorylated tau pathologic findings measured by

216 Thirty-one of 33 cases (94%) showed hyperphosphorylated tau pathology in the form of neuropi

217 We hypothesized that hyperphosphorylated tau pathology is associated with cog

218 ic traumatic encephalopathy, the spectrum of hyperphosphorylated tau pathology ranged in severity fro

219 The mTau mice show a progressive increase in hyperphosphorylated tau pathology with age up to 15 to 1

220 Hyperphosphorylated tau positive (AT8, AT100) neuropil t

221 Hyperphosphorylated tau positive neuropil threads increa

222 the RCAN1-1L protein exhibit accumulation of hyperphosphorylated tau protein (AT8 antibody), an early

223 function due to the regional accumulation of hyperphosphorylated tau protein (p-tau).

224 gp120-transgenic mice, we found evidence for hyperphosphorylated tau protein (paired helical filament

225 characterized by intraneuronal inclusions of hyperphosphorylated tau protein and abnormal expression

226 o effectively blocks accumulation of soluble hyperphosphorylated TAU protein and slows down the disea

227 rs suggests that repetitive brain trauma and hyperphosphorylated tau protein deposition promote the a

228 lical filaments (PHF), which are composed of hyperphosphorylated Tau protein dissociating from microt

229 f PET radiotracers for imaging aggregates of hyperphosphorylated tau protein in neurofibrillary tangl

230 hFTAA also stained intracellular lesions of hyperphosphorylated Tau protein in P301S Tau transgenic

231 ation of misfolded amyloid-beta peptides and hyperphosphorylated tau protein in the brain.

232 Deposition of aggregates of hyperphosphorylated tau protein is a hallmark of tauopat

233 Accumulation of neurotoxic hyperphosphorylated TAU protein is a major pathological

234 We identified hyperphosphorylated tau protein using AT8 immunohistoche

235 ile plaques, neurofibrillary tangles made of hyperphosphorylated tau protein with neuronal loss.

236 , are characterized by insoluble deposits of hyperphosphorylated tau protein within brain neurons.

237 elated tauopathies are composed of insoluble hyperphosphorylated Tau protein, but the mechanisms unde

238 n pathologic feature of aggregates formed of hyperphosphorylated tau protein, which are associated wi

239 tauopathies, are comprised of aggregates of hyperphosphorylated tau protein.

240 urofibrillary tangles composed of abnormally hyperphosphorylated tau protein.

241 contain neurofibrillary tangles comprised of hyperphosphorylated tau protein.

242 protein and intracellular tangles containing hyperphosphorylated Tau protein.

243 strated that neurofibrillary tangles made of hyperphosphorylated tau proteins are closely associated

244 eins (Abeta) and neurofibrillary deposits of hyperphosphorylated tau proteins are the diagnostic lesi

245 ptides in senile plaques and accumulation of hyperphosphorylated tau proteins in neurofibrillary tang

246 des, and neurofibrillary tangles composed of hyperphosphorylated tau proteins.

247 intracellular aggregation of abnormally and hyperphosphorylated tau proteins.

248 Tangles are composed of misfolded hyperphosphorylated tau proteins; however, the link betw

249 In contrast, pyramidal cells containing hyperphosphorylated tau retain monoacylglycerol lipase e

250 : neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau selectively affect pyramidal neu

251 In TgF344-AD rats, hyperphosphorylated tau was detected in the locus coerul

252 Hyperphosphorylated tau was labeled in the corresponding

253 abnormalities caused by the accumulation of hyperphosphorylated tau within intact dendritic spines,

254 and neurofibrillary tangles (NFTs) formed by hyperphosphorylated tau, a microtubule-associated protei

255 ry tangles (NFTs), composed of truncated and hyperphosphorylated tau, are a common feature of numerou

256 ced intracellular levels of amyloid-beta and hyperphosphorylated tau, as well as microglial activatio

257 les (NFTs), which are composed of abnormally hyperphosphorylated tau, but the mechanism of tau hyperp

258 tau contained 4-fold less O-GlcNAc than non-hyperphosphorylated tau, demonstrating for the first tim

259 rticular, p25/Cdk5 has been shown to produce hyperphosphorylated tau, neurofibrillary tangles as well

260 d activator p25, results in the formation of hyperphosphorylated tau, neuroinflammation, amyloid depo

261 Lewy body pathology and the accumulation of hyperphosphorylated tau, supporting a link between PLA2G

262 ciated kinases that promote the formation of hyperphosphorylated tau, the major component of neurofib

263 Twenty-six percent of the neurons contained hyperphosphorylated tau, while the level of NFT-related

264 aracterized by intracellular accumulation of hyperphosphorylated tau.

265 a contributing factor to the accumulation of hyperphosphorylated Tau.

266 ed of paired helical filaments of abnormally hyperphosphorylated tau.

267 and its role in the formation of abnormally hyperphosphorylated tau.

268 e levels correlated with PHF-1 immunostained hyperphosphorylated tau.

269 in (APP) and neurofibrillary tangles made of hyperphosphorylated Tau.

270 seases marked by intracellular aggregates of hyperphosphorylated Tau.

271 ls of Abeta, and a decrease in the levels of hyperphosphorylated tau.

272 ith a decline in the levels of total tau and hyperphosphorylated tau.

273 ques and neurofibrillary tangles composed of hyperphosphorylated tau.

274 se in brain A beta and a 35-45% reduction in hyperphosphorylated tau.

275 believed to be involved in the generation of hyperphosphorylated tau.

276 aggregates of conformationally abnormal and hyperphosphorylated tau.

277 ed mitochondria, and accumulation of soluble hyperphosphorylated tau.

278 ar 'ghost' tangles due to the recognition of hyperphosphorylated tau.

279 y tangles and dystrophic neurites containing hyperphosphorylated tau.

280 mpal neurons expressing TERT did not contain hyperphosphorylated tau.

281 nomers, induce accumulation of pathological, hyperphosphorylated tau.

282 major pathologies: amyloid-beta (Abeta) and hyperphosphorylated tau.

283 of amyloid-beta (Abeta) and accumulation of hyperphosphorylated tau.

284 urite outgrowth and cause an accumulation of hyperphosphorylated Tau.

285 urofibrillary tangles composed of aggregated hyperphosphorylated tau.

286 ibrillary tangles, composed predominantly of hyperphosphorylated tau; and cerebral amyloid angiopathy

287 hsp110(-)(/)(-) mice exhibit accumulation of hyperphosphorylated-tau (p-tau) and neurodegeneration.

288 thology in a distribution pattern similar to hyperphosphorylated-tau.

289 smic accumulation of toxic ubiquitinated and hyperphosphorylated TDP-43 fragments and the loss of nor

290 lts in a dramatic reduction of insoluble and hyperphosphorylated TDP-43 that enhances cell survival,

291 ing increased the DNA relaxation activity of hyperphosphorylated topo I by enhancing its association

292 Hyperphosphorylated transactive response DNA-binding pro

293 These aggregates were hyperphosphorylated, Triton insoluble, and thioflavin-S

294 hies is thought to involve the generation of hyperphosphorylated, truncated, and oligomeric tau speci

295 t pathological TDP-43 species, which include hyperphosphorylated, ubiquitinated, and N-terminally cle

296 we found the Arg-389 variant of ADRB1 to be hyperphosphorylated upon continuous stimulation with nor

297 sthesia-induced hypothermia, MT-free tau was hyperphosphorylated, which impaired its ability to bind

298 In Alzheimer's disease, tau is hyperphosphorylated, which is thought to detach it from

299 trogliotic tissues, however, the protein was hyperphosphorylated, with evidence implicating the p38/m

300 sclerosis (ALS), NF proteins are aberrantly hyperphosphorylated within the cell bodies.