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1 od is associated with an upregulation of the hyperpolarization-activated and cyclic nucleotide-gated
2 ed levels of the type 3a bipolar cell marker hyperpolarization-activated and cyclic nucleotide-gated
3 t by KCNQ5 channels, together with Na(+) and hyperpolarization-activated and cyclic nucleotide-gated
5 cAMP, reminiscent of the dual modulation in hyperpolarization-activated and cyclic nucleotide-gated
7 zipper in the S5 segment of HCNs, regulating hyperpolarization-activated and instantaneous current co
8 o and in situ to measure currents carried by hyperpolarization-activated and nucleotide-gated cation
9 with cysteine residues (S-nitrosylation) on hyperpolarization-activated and nucleotide-gated cation
10 tion, dibutyryl cAMP was found to increase a hyperpolarization-activated Ba(2+) conductance (I(Ba)).
11 d stimulates the activity of plasma membrane hyperpolarization-activated Ca2+ channels, the predomina
12 ture epidermal protoplasts a plasma membrane hyperpolarization-activated Ca2+-permeable channel was a
13 protoplasts resulted in the appearance of a hyperpolarization-activated Ca2+-permeable conductance.
15 ine monophosphate (cAMP)-dependent gating in hyperpolarization-activated cAMP-regulated (HCN) channel
17 ing and video microscopy, we discovered that hyperpolarization-activated cation (HCN) channel block w
21 ing transcripts for connexin, Na(+), Ca(2+), hyperpolarization-activated cation and K(+) channels, an
22 and upper urinary tract involves coexpressed hyperpolarization-activated cation and T-type Ca(2+) cha
26 nnels, calcium-dependent cation channels, or hyperpolarization-activated cation channels but was halv
27 , axin, beta- and delta-catenin, neuroligin, hyperpolarization-activated cation channels, beta1-adren
28 interspike interval regularity and that the hyperpolarization-activated cation current (I(h)) contri
30 ort evidence that dopaminergic inhibition of hyperpolarization-activated cation current (I(h)) is inv
31 Pacemaking was not inhibited by blocking hyperpolarization-activated cation current (I(h)) or blo
32 tified the relative contributions of I(NaP), hyperpolarization-activated cation current (I(h)), and c
37 ubpopulations of BF GABAergic neurons [large hyperpolarization-activated cation current (Ih) and smal
39 N1 channel subunits, which contribute to the hyperpolarization-activated cation current (Ih), are sel
40 current, P-type and T-type calcium current, hyperpolarization-activated cation current (Ih), voltage
43 rhinal cortex (mEC) are endowed with a large hyperpolarization-activated cation current [h current (I
44 ss the low-threshold calcium current and the hyperpolarization-activated cation current are not criti
45 o the preBotC of adult rats, we identify the hyperpolarization-activated cation current as a critical
46 e differences, we analyzed properties of the hyperpolarization-activated cation current I(h) in volta
49 owed that these effects were produced by the hyperpolarization-activated cation current, I(H), which
50 ments as a result of the deactivation of the hyperpolarization-activated cation current, Ih, but incr
52 f midbrain DA neurons characterized by small hyperpolarization-activated cation currents (Ih) is spar
54 aptic input, whereas the remainder exhibited hyperpolarization-activated cation currents and low thre
55 ese changes were indicative of a decrease in hyperpolarization-activated cation nonselective current
56 use a gradient of inductance in the form of hyperpolarization-activated cation-nonselective (HCN) ch
59 that VIP and PACAP38 reversibly activated a hyperpolarization-activated cationic current (I(H)) in t
60 ype mice, HCN1 channels underlie a dendritic hyperpolarization-activated cationic current (I(h)) that
63 negative current injections and mediated by hyperpolarization-activated cationic currents were not a
64 use hypokalaemic periodic paralysis induce a hyperpolarization-activated cationic leak through the vo
69 depolarized potentials and distal dendritic hyperpolarization-activated channels that mediated site
70 acidic S3-S4 linker residue conserved in all hyperpolarization-activated channels, by Ala substitutio
72 veral tissues, the molecular identity of the hyperpolarization-activated Cl(-) current in other organ
73 y the occasional observation of oocytes with hyperpolarization-activated Cl(-) current when these ooc
76 (244 +/- 42 pA pF(-1) at 0 mV; n=19), and a hyperpolarization-activated current (HCN), but no inward
77 s to lower heart rate, including sarcolemmal hyperpolarization-activated current (I f) and ryanodine
78 or sodium orthovanadate shifted ventricular hyperpolarization-activated current (I(f), generated by
79 current by tetraethylammonium (5 mM) or the hyperpolarization-activated current (I(h)) by ZD7288 (10
83 ances that govern neuronal excitability, the hyperpolarization-activated current (I(h)) plays complex
84 gerbils during the first week of hearing, a hyperpolarization-activated current (I(h)) progressively
85 neurons in the medial VTA exhibit a smaller hyperpolarization-activated current (I(h)) than more lat
86 n the maximal conductance (G(max)) of the LP hyperpolarization-activated current (I(h)), but only in
90 e, a specific blocker of inwardly rectifying hyperpolarization-activated current (Ih) channels, hyper
92 properties indicative of A-current (IA) and hyperpolarization-activated current (Ih) tended to be mu
93 on average, lower input resistance, greater hyperpolarization-activated current (Ih), depolarized re
95 ar cAMP levels, increased the density of the hyperpolarization-activated current and intracellular ca
96 used on the HCN1 channels that conduct Ih, a hyperpolarization-activated current crucial for shaping
97 nucleotide-gated (HCN) channels mediate the hyperpolarization-activated current I(h) and thus play i
101 blockade, rather than a specific role of the hyperpolarization-activated current in generating persis
104 r most established role is in generating the hyperpolarization-activated current, I(h), in photorecep
107 component of the underlying mechanism is the hyperpolarization-activated current, Ih, as pharmacologi
108 annels are the major contributors to Ih, the hyperpolarization-activated current, which regulates the
110 in the central nervous system, and underlie hyperpolarization-activated currents (I(h)) that contrib
111 HCN1 gene encodes ion channels that mediate hyperpolarization-activated currents (I(h)) that control
113 nstants of up to 225 ms, and small-amplitude hyperpolarization-activated currents (IH), characteristi
114 ences in the kinetics and ion selectivity of hyperpolarization-activated currents in bipolar cells (K
115 e effects on pyramidal neurons by increasing hyperpolarization-activated currents in juvenile rat pre
116 re required for rapid and full activation of hyperpolarization-activated currents in stellate neurons
117 on using an independent approach, we studied hyperpolarization-activated currents uncoupled from inac
118 -methylaminopyrimidinium chloride)-sensitive hyperpolarization-activated currents were also observed
119 K currents were inhibited by Na(+)(o), while hyperpolarization-activated currents were augmented by N
120 erforated patch experiments we also observed hyperpolarization-activated currents which were inhibite
121 s, which, combined with weaker expression of hyperpolarization-activated currents, lengthened hyperpo
124 This directional summation was dependent on hyperpolarization activated cyclic nucleotide-gated (HCN
125 l expression and function of the ion channel hyperpolarization-activated cyclic adenosine monophospha
126 4.2 down-regulation and post-transcriptional hyperpolarization-activated cyclic AMP-gated channel (HC
127 to and functions as an auxiliary subunit of hyperpolarization-activated cyclic nucleotide (HCN)-gate
128 ng gene variants with cosegregation, a novel hyperpolarization-activated cyclic nucleotide channel 4
130 s can be accounted for by differences in the hyperpolarization-activated cyclic nucleotide gated cati
131 ulation of the pacemaking ion channel, HCN4 (hyperpolarization-activated cyclic nucleotide gated chan
132 afferent by altering ion permeation through hyperpolarization-activated cyclic nucleotide-gated (HCN
136 s a recently discovered accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN
142 tion-activated current, I(h), is mediated by hyperpolarization-activated cyclic nucleotide-gated (HCN
144 TRIP8b) is an auxiliary subunit for neuronal hyperpolarization-activated cyclic nucleotide-gated (HCN
147 shift in the voltage-dependent activation of hyperpolarization-activated cyclic nucleotide-gated (HCN
151 no-atrial and atrio-ventricular nodal cells, hyperpolarization-activated cyclic nucleotide-gated (HCN
154 ylation activity by Src in the modulation of hyperpolarization-activated cyclic nucleotide-gated (HCN
155 e supports roles for the current mediated by hyperpolarization-activated cyclic nucleotide-gated (HCN
156 ted by h channels comprised primarily of the hyperpolarization-activated cyclic nucleotide-gated (HCN
158 underlie regulation of structurally related hyperpolarization-activated cyclic nucleotide-gated (HCN
159 thens WM through inhibition of cAMP, closing Hyperpolarization-activated Cyclic Nucleotide-gated (HCN
163 ose of this study was to examine whether the hyperpolarization-activated cyclic nucleotide-gated (HCN
164 demonstrated a differential distribution of hyperpolarization-activated cyclic nucleotide-gated (HCN
165 ic plasticity and spatial memory through the hyperpolarization-activated cyclic nucleotide-gated (HCN
166 ons resulting from effects on either TASK or hyperpolarization-activated cyclic nucleotide-gated (HCN
170 ic neuron by altering ion permeation through hyperpolarization-activated cyclic nucleotide-gated (HCN
171 ntify an interneuron-specific attenuation of hyperpolarization-activated cyclic nucleotide-gated (HCN
172 A and is expressed via a mechanism involving hyperpolarization-activated cyclic nucleotide-gated (HCN
173 rking memory by increasing the open state of hyperpolarization-activated cyclic nucleotide-gated (HCN
174 ,5'-cyclic adenosine monophosphate (cAMP) to hyperpolarization-activated cyclic nucleotide-gated (HCN
177 (+) flux through presynaptic plasma membrane hyperpolarization-activated cyclic nucleotide-gated (HCN
181 taneous tonic firing of 2-10 Hz generated by hyperpolarization-activated cyclic nucleotide-gated (HCN
182 his study sought to test the hypothesis that hyperpolarization-activated cyclic nucleotide-gated (HCN
183 th their resonance properties and with their hyperpolarization-activated cyclic nucleotide-gated (HCN
185 Here, we investigated the effects of NFA on hyperpolarization-activated cyclic nucleotide-gated cati
188 oked Ca2+ responses, suggesting that neither hyperpolarization-activated cyclic nucleotide-gated cati
189 soform-specific changes in the expression of hyperpolarization-activated cyclic nucleotide-gated cati
191 lus-based pattern of expression of the HCN2 (hyperpolarization-activated cyclic nucleotide-gated chan
193 a a D(1)-type receptor mechanism to modulate hyperpolarization-activated cyclic nucleotide-gated chan
196 region includes Hcn2, the gene encoding the hyperpolarization-activated cyclic nucleotide-gated chan
200 axon initial segment and markedly depends on hyperpolarization-activated cyclic nucleotide-gated chan
201 atory effect results from an augmentation of hyperpolarization-activated cyclic nucleotide-gated chan
202 near the plexus showed immunoreactivity for hyperpolarization-activated cyclic nucleotide-gated chan
203 vioral results support an important role for hyperpolarization-activated cyclic nucleotide-gated chan
204 , Gnai1, protein kinase C gamma (Prkcc), and hyperpolarization-activated cyclic nucleotide-gated chan
207 the binding of PIP(2) to SpIH, a sea urchin hyperpolarization-activated cyclic nucleotide-gated ion
209 olarization, apparently by directly engaging hyperpolarization-activated cyclic nucleotide-gated ion
211 the subcellular distribution and function of hyperpolarization-activated cyclic nucleotide-gated nons
212 clic nucleotide-gated (CNG) channels and the hyperpolarization-activated cyclic nucleotide-modulated
213 cture of the carboxyl-terminal region of the hyperpolarization-activated cyclic nucleotide-modulated
214 uronal and cardiac pacing, is encoded by the hyperpolarization-activated cyclic nucleotide-modulated
221 s of the related ether-a-go-go-like K(+) and hyperpolarization-activated cyclic nucleotide-modulated
222 er region may be highly dynamic in the KCNH, hyperpolarization-activated cyclic nucleotide-modulated,
225 ural changes of the gating ring of the mouse hyperpolarization-activated cyclic nucleotide-regulated
227 tory elements that control expression of the hyperpolarization-activated cyclic-nucleotide gated ion
229 we demonstrate that dendritically expressed hyperpolarization-activated cyclic-nucleotide-gated (HCN
233 n membrane conductance were abolished by the hyperpolarization-activated cyclic-nucleotide-gated chan
234 aneuronal map of spectral tuning mediated by hyperpolarization-activated cyclic-nucleotide-gated nons
235 nding domain (CNBD) structure of the related hyperpolarization-activated cyclic-nucleotide-modulated
237 er cells, identified by immunoreactivity for hyperpolarization activated, cyclic nucleotide-gated cha
239 ated with loss of expression and function of hyperpolarization-activated, cyclic nucleotide-gated (HC
240 techniques to investigate the properties of hyperpolarization-activated, cyclic nucleotide-gated (HC
241 protein (MiRP1 or KCNE2) interacts with the hyperpolarization-activated, cyclic nucleotide-gated (HC
243 hesized that localized overexpression of the hyperpolarization-activated, cyclic nucleotide-gated (HC
245 at N-methyl-D-aspartate receptor (NMDAR) and hyperpolarization-activated, cyclic nucleotide-gated (HC
247 ated sodium (NaV), T-type calcium (CaV), and hyperpolarization-activated, cyclic nucleotide-gated (HC
248 s to investigate an alternative channel, the hyperpolarization-activated, cyclic nucleotide-gated cat
251 rdly rectifying K(+) conductance (G(IRK)) or hyperpolarization-activated, cyclic nucleotide-gated cha
253 -dimensional model, based on animal HCN (for Hyperpolarization-activated, cyclic nucleotide-gated K(+
255 gation model in the rat, we demonstrate that hyperpolarization-activated, cyclic nucleotide-modulated
257 s, a distinct type of ion channel called the hyperpolarization-activated, cyclic nucleotide-regulated
258 of some isoforms of their pore forming HCN (hyperpolarization-activated, cyclic nucleotide-regulated
259 pening of wild-type and cAMP/H+(I)-uncoupled hyperpolarization-activated, cyclic nucleotide-regulated
260 set of the resonance is shown to depend on a hyperpolarization-activated depolarizing current, I(h).
261 roscopy, potassium channel subunits and HCN (hyperpolarization-activated) family members were localiz
262 proposed: (i) the "voltage-clock," where the hyperpolarization-activated funny current If causes dias
264 hetic etidocaine favored the conclusion that hyperpolarization-activated gating results from opening
265 multiple amino acids for L226 indicated that hyperpolarization-activated gating was correlated with a
269 action of cAMP to enhance the opening of the hyperpolarization-activated HCN2 channels, whose cytopla
270 .T)) type Ca2+, delayed rectifier K+ (I(K)), hyperpolarization-activated (I(f)) currents, and action
271 ce calcium-activated potassium currents, and hyperpolarization-activated (I(H)) current to bursting w
274 on investigating the functional role of the hyperpolarization-activated inward current (I(h)) on the
275 l neurons support rebound spikes mediated by hyperpolarization-activated inward current (I(h)), and n
276 Hyperpolarization was counteracted by a hyperpolarization-activated inward current (I(h)), and t
277 cooperatively regulate spontaneous bursting: hyperpolarization-activated inward current (I(h)), persi
280 ich we find encodes a major component of the hyperpolarization-activated inward current (Ih) and is a
281 l) caused by the down-regulation of both the hyperpolarization-activated inward current and I(T).
282 lic nucleotide-gated channels conducting the hyperpolarization-activated inward current and the activ
283 how that both calcium currents I(Ca) and the hyperpolarization-activated inward current I(h) are impo
286 Delta229-231/Delta235-237 all yielded robust hyperpolarization-activated inward currents, indicating
287 ility, but copy numbers for IH (encoding the hyperpolarization-activated, inward-current channel) and
288 l criteria for VTA DA neurons, including the hyperpolarization-activated inwardly rectifying non-spec
290 ane potential, an effect mediated by a fast, hyperpolarization-activated, inwardly rectifying potassi
292 eversal potential for GABA(A) receptors, the hyperpolarization-activated mixed cation current (I(h))
294 d potassium-selective channel, Kv1.4, into a hyperpolarization-activated nonselective channel by site
295 sal potential (E(Cl)), combined with a large hyperpolarization-activated nonspecific cationic current
296 kers is the pacemaker current encoded by the hyperpolarization-activated nucleotide-gated channel (HC
300 d almost exclusively in the medial rNTS, and hyperpolarization-activated potassium/sodium channels (I
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