ライフサイエンスコーパス: hyperpolarize

1 pre-decision membrane potentials were stably hyperpolarized.

2 Hyperpolarized 1-hexene was polymerized in situ with a C

3 neous polarization transfer from dynamically hyperpolarized (1)H to (13)C during magic-angle spinning

4 e advantages could also arise from observing hyperpolarized (1)H, short relaxation times limit the ut

5 H non-invasively, we applied the redox probe hyperpolarized [1-(13)C] dehydroascorbic acid (HP DHA),

6 y however, in our cells the observed drop in hyperpolarized [1-(13)C] glutamate was likely mediated n

7 Hyperpolarized [1-(13)C]-pyruvate has shown tremendous p

8 Previous studies have shown that the rate of hyperpolarized [1-(13)C]dehydroascorbic acid (DHA) reduc

9 Hyperpolarized [1-(13)C]DHA can be used, therefore, to a

10 We show here that the rate of hyperpolarized [1-(13)C]DHA reduction is increased in tu

11 We used hyperpolarized [1-(13)C]pyruvate magnetic resonance spec

12 All animals underwent in vivo hyperpolarized [1-(13)C]pyruvate magnetic resonance spec

13 C-bicarbonate signal after administration of hyperpolarized [1-(13)C]pyruvate was readily detected in

14 Following injection of hyperpolarized [1-(13)C]pyruvate, the resulting (13)C-bi

15 nous administration of a 0.1 mmol/kg dose of hyperpolarized [1-(13)C]pyruvate.

16 specific proteins in complex media by using hyperpolarized (129) Xe NMR is reported.

17 Hyperpolarized (129)Xe and (3)He are gases used as contr

18 nal sensitivity sufficient to directly image hyperpolarized (129)Xe dissolved in the human brain.

19 Hyperpolarized (129)Xe gas has found use in the study of

20 rpolarized (129)Xe MR ventilation images and hyperpolarized (129)Xe MR diffusion-weighted images afte

21 tructive Lung Disease stage II-IV) underwent hyperpolarized (129)Xe MR imaging at 1.5 T, quantitative

22 bar ventilation and ADC values obtained from hyperpolarized (129)Xe MR imaging demonstrated correlati

23 Conclusion Hyperpolarized (129)Xe MR imaging is an injection-free m

24 using automated segmentation of multisection hyperpolarized (129)Xe MR ventilation images and hyperpo

25 signals smaller than 20 nT, and transport of hyperpolarized (129)Xe over millimeter lengths.

26 n minute-long kinetic measurements where the hyperpolarized (13)C enhanced, via (13)C --> (1)H cross-

27 enzyme, by measuring the rate of exchange of hyperpolarized (13)C label between bicarbonate (H(13)CO3

28 ed pH due to incomplete equilibration of the hyperpolarized (13)C label between the H(13)CO3(-) and (

29 plied a three-dimensional dynamic dual-agent hyperpolarized (13)C magnetic resonance spectroscopic im

30 Here we show that hyperpolarized (13)C magnetic resonance spectroscopic im

31 Hyperpolarized (13)C magnetic resonance spectroscopy (MR

32 design and provide an overview of the latest hyperpolarized (13)C MR spectroscopic imaging probes dev

33 his review will highlight recent advances in hyperpolarized (13)C MR spectroscopic imaging, which can

34 novel probe for evaluating glycolysis using hyperpolarized (13)C MRS.

35 n vivo with sub-second time resolution using hyperpolarized (13)C MRS.

36 Hyperpolarized (13)C NMR spectra were used to characteri

37 Here, we developed a new hyperpolarized (13)C probe, [6-(13)C]-arginine, to image

38 Hyperpolarized (13)C-labeled dl-methionine enantiomers w

39 PDH activity was monitored in these cells by hyperpolarized (13)C-magnetic resonance spectroscopy ((1

40 slice (13)C MRI after tail vein injection of hyperpolarized (13)C-phospholactate in mice.

41 In particular, the conversion of hyperpolarized (13)C-phospholactate to (13)C-lactate in

42 and indirectly image the Warburg effect with hyperpolarized (13)C-pyruvate and (18)F-FDG PET imaging,

43 Conclusion The findings suggest that hyperpolarized (13)C-pyruvate MR spectroscopy may serve

44 al workflow for performing (18)F-FDG PET and hyperpolarized (13)C-pyruvate MRS imaging simultaneously

45 sample temperature below its melting point, hyperpolarized (13)C-substrates can be extracted from th

46 d into an injectable solution containing the hyperpolarized (13)C-substrates can therefore be perform

47 duction of a dose ( approximately 2-3 mL) of hyperpolarized (13)C-succinate with %P13C approximately

48 hogenic protozoan, Trypanosoma brucei, using hyperpolarized (13)C1 pyruvate as a substrate and compar

49 This work establishes hyperpolarized [(13)C]-Glyc as a novel agent for clinica

50 In vivo spectroscopic studies with hyperpolarized [(13)C]-Glyc in rat liver furnished metab

51 6-(13)C]-arginine can be hyperpolarized, and hyperpolarized [(13)C]-urea production from [6-(13)C]-ar

52 tect a statistically significant increase in hyperpolarized [(13)C]-urea production in MDSCs when com

53 Here, we report an investigation of hyperpolarized (15)N-pyridine derivatives as ultrasensit

54 which revealed a reduction in metabolism of hyperpolarized 2-(13)C-pyruvate to 5-(13)C-glutamate, re

55 Lung ventilation defects identified by using hyperpolarized 3-helium gas ((3)He) lung magnetic resona

56 We aimed to use hyperpolarized (3)He diffusion magnetic resonance at mul

57 ith the tracer gas sulfur hexafluoride), and hyperpolarized (3)He diffusion magnetic resonance.

58 lung fractional ventilation as measured with hyperpolarized (3)He in all subjects (mean, 0.24 +/- 0.0

59 Conclusion Multibreath wash-in hyperpolarized (3)He MR imaging of fractional ventilatio

60 a direct measurement of lung ventilation at hyperpolarized (3)He MR imaging.

61 to decrease STOC frequency in cells held at hyperpolarized (-40 mV) but not depolarized (-20 mV) vol

62 ichloroacetate (DCA) increased production of hyperpolarized 5-(13)C-glutamate in IDH1 mutant cells.

63 Hyperpolarized [6-(13)C]-arginine could therefore serve

64 In brain slices, mu opioid agonists hyperpolarized a distinct population (61%) of KF neurons

65 ivation of mu opioid receptors on KF neurons hyperpolarized a distinct population (61%) of neurons.

66 nt vehicle for potential in vivo delivery of hyperpolarized acetate to probe metabolism in living org

67 ide cotransporter KCC2 (which determines the hyperpolarizing action of GABA) and GABAA receptors.

68 gs showed EQQ and EQQQQ to have increasingly hyperpolarized activation, reduced conductance, and shor

69 ngs revealed that the Nav1.7-A1632G mutation hyperpolarizes activation and depolarizes fast-inactivat

70 ns on the nanodiamond surface can be used to hyperpolarize adsorbed liquid compounds at low fields an

71 hypokalaemia, human cardiomyocytes show both hyperpolarized and depolarized resting membrane potentia

72 (129)Xe is hyperpolarized and detected in locations more than 1 cm

73 Notably, we found that OVLT neurons are hyperpolarized and electrically silenced.

74 ll patch-clamp recordings, we show that 5-HT hyperpolarizes and abolishes phasic discharge in rat neu

75 ed on differences in the voltage-response to hyperpolarizing and depolarizing current injection.

76 We show that [6-(13)C]-arginine can be hyperpolarized, and hyperpolarized [(13)C]-urea producti

77 3-5 Hz Vm oscillations where the Vm baseline hyperpolarized as the Vm underwent high amplitude rhythm

78 witched their direction from depolarizing to hyperpolarizing as a result of neuronal depolarization a

79 of population bursts, it transiently becomes hyperpolarizing at the peak of the population bursts.

80 oximately EC50), [Ca(2+)]i increased as V(m) hyperpolarized below -40 mV and decreased as V(m) depola

81 d with the non-injured hemisphere, while the hyperpolarized bicarbonate-to-lactate ratio was 33 +/- 8

82 l exchange from a single aliquot of a ligand hyperpolarized by dissolution dynamic nuclear polarizati

83 is in sharp contrast to most mature neurons hyperpolarized by GABA.

84 Thus, the population of KF neurons that are hyperpolarized by mu opioid agonists are likely mediator

85 ese results suggest that KF neurons that are hyperpolarized by opioids could contribute to opioid-ind

86 icantly diversify the substrates that can be hyperpolarized by PHIP for biomedical utilization.

87 peaks in solution-phase experiments could be hyperpolarized by spontaneous magnetization transfers fr

88 recently reported, (15) N2 -diazirine can be hyperpolarized by the SABRE-SHEATH method, sustaining bo

89 (FDG) positron emission tomography (PET) and hyperpolarized carbon 13 ((13)C)-pyruvate magnetic reson

90 Using hyperpolarized carbon-13 ((13)C)-magnetic resonance spec

91 MKII attenuated persistent current, evoked a hyperpolarized channel inactivation, and suppressed neur

92 ergic interneurons (ChIs) of the dSt whereas hyperpolarizing ChIs from the vSt by acting on different

93 age dependence of gNa inactivation was 13 mV hyperpolarized compared with SCs.

94 Following the introduction of an externally hyperpolarized compound, real-time NMR enables the measu

95 he excessive activation of calcium-activated hyperpolarizing conductances.

96 eter for efficient production of payloads of hyperpolarized contrast agent and in situ quality assura

97 n open-source hyperpolarizer producing (13)C hyperpolarized contrast agents using parahydrogen induce

98 cent protons may enable production of (13) C hyperpolarized contrast agents with %P13C of 20-50 % in

99 of a direct effect on spikelet activity from hyperpolarizing current injection suggest they do not ar

100 Hyperpolarizing current injection, but not AMPA receptor

101 by either stimulation of GABAergic inputs or hyperpolarizing current injections, are enhanced by a su

102 activity of CI1 by injecting depolarizing or hyperpolarizing current or killing the cell using laser

103 tophyte alga Guillardia theta generate large hyperpolarizing currents at membrane potentials above th

104 currents increased choice hysteresis, while hyperpolarizing currents suppressed it.

105 decrease in firing frequency in response to hyperpolarizing currents.

106 arboxyl zinc-finger of Gata6 induces loss of hyperpolarizing cyclic nucleotide-gated channel, subtype

107 atrioventricular node with some retention of hyperpolarizing cyclic nucleotide-gated channel, subtype

108 We found that 5-HT predominantly hyperpolarizes dBNST neurons, reducing their activity in

109 y induced when postsynaptic interneurons are hyperpolarized, depends on Ca(2+) entry through Ca(2+)-p

110 -dependence of channel activation toward the hyperpolarizing direction by approximately 145 mV (gamma

111 ransitions between depolarized Up states and hyperpolarized Down states.

112 simultaneous (18)F-FDG PET, anatomic MR, and hyperpolarized dynamic nuclear polarization with (13)C-p

113 sed densely-expressed depolarizing (ChR2) or hyperpolarizing (eArch3.0, eNpHR3.0) tools to create a s

114 muscle cells (HASMCs) demonstrated membrane hyperpolarizing effects, well related to the intracellul

115 ich is a precursor for preparation of (13) C hyperpolarized ethyl acetate-1-(13) C, which provides a

116 to produce nitric oxide, endothelium-derived hyperpolarizing factor, or prostaglandins to cause vasod

117 late following intravenous administration of hyperpolarized fumarate with a progressive increase in t

118 Rs shifts the type I/II boundary toward more hyperpolarized GABAR reversal potentials.

119 administered a series of identical normoxic hyperpolarized gas breaths to the subject; after each in

120 The Hyperpolarized gas Chemical Exchange Saturation Transfer

121 using treatment response mapping (TRM) with hyperpolarized gas magnetic resonance (MR) imaging.

122 The short-term test-retest repeatability of hyperpolarized gas MR imaging of regional Pao2 was good.

123 y new class of samples to be investigated by hyperpolarized-gas NMR spectroscopy.

124 in fast synaptic inhibition by maintaining a hyperpolarizing gradient for chloride ions.

125 on dioxide ((13)CO2), following injection of hyperpolarized H(13)CO3(-), using (13)C-magnetic resonan

126 Hyperpolarizing HCs stimulated inward feedback currents

127 mize the accuracy of the multibreath wash-in hyperpolarized helium 3 ((3)He) approach to ventilation

128 6-minute walk distance (6MWD), and underwent hyperpolarized helium 3 ((3)He) magnetic resonance (MR)

129 ed in 20 adult patients with asthma by using hyperpolarized helium 3 ((3)He) ventilation MR imaging.

130 roducing catalyst-free agents via SABRE with hyperpolarized heteronuclear spins, and thus is promisin

131 omises to be a simple, cost-effective way to hyperpolarize heteronuclei.

132 Light, which hyperpolarizes horizontal cells, causes synaptic alkalin

133 amase (bla) as a single-protein reporter for hyperpolarized (HP) (129) Xe NMR, with significant satur

134 dogenous reduction-oxidation (redox) sensor, hyperpolarized (HP) (13)C dehydroascorbate (DHA), in con

135 Hyperpolarized (HP) (13)C magnetic resonance spectroscop

136 Hyperpolarized (HP) (13)C magnetic resonance spectroscop

137 Hyperpolarized (hp) (83)Kr is a promising MRI contrast a

138 We investigated whether (13)C MRSI of hyperpolarized (HP) [1-(13)C] pyruvate, a non-invasive m

139 s, such as ciliary photoreceptors [3,4] that hyperpolarize in response to illumination [5].

140 O solutions, on substrates that could not be hyperpolarized in traditional (1)H-SABRE experiments, an

141 ressive, metastatic subline PC3M assessed by hyperpolarized in vivo pyruvate studies, nuclear magneti

142 establishing the Cl(-) gradient required for hyperpolarizing inhibition in the central nervous system

143 Hyperpolarizing inhibition mediated by type A GABA (GABA

144 al neurons display differential responses to hyperpolarizing inhibitory stimuli that favors a higher

145 a multiplexed NMR experiment, where a single hyperpolarized ligand sample is rapidly mixed with prote

146 The creation of such hyperpolarized long-lived polarization reflects an impor

147 be herein a model reaction for read-out of a hyperpolarized long-lived state in dimethyl maleate usin

148 gically oriented dDNP studies have relied on hyperpolarizing long-lived nuclear spin species such as

149 Hyperpolarized magnetic resonance spectroscopy (HP MRS)

150 , and help to refine the design of impending hyperpolarized magnetic resonance studies in humans.

151 AMGO ([D-Ala2,N-Me-Phe4,Gly5-ol]-Enkephalin) hyperpolarizes medially located ITCs (mITCs) in acute br

152 We observed reduced input resistance, hyperpolarized membrane potential, and increased current

153 or channel opening and then recovers during hyperpolarized membrane potentials or channel closure.

154 channel C-type inactivation occurred during hyperpolarized membrane potentials or with decreased int

155 ase in surface KATP channels results in more hyperpolarized membrane potentials than control cells at

156 Pten knock-out neurons fired at more hyperpolarized membrane potentials, displayed greater pe

157 ectifier channels conduct greater current at hyperpolarized membrane potentials.

158 seen in depolarized regimes and bursting at hyperpolarized membrane potentials.

159 Hyperpolarized metabolic magnetic resonance (MR) imaging

160 Hyperpolarized metabolic MR imaging can be used to succe

161 s demonstration paves the way for the use of hyperpolarized metabolic MR imaging in the assessment of

162 le injection permits the introduction of the hyperpolarized metabolite within 3 s after the electrica

163 aves the aqueous phase and becomes a gaseous hyperpolarized molecule.

164 ding (15)N site (using J(2)H-(15)N), we also hyperpolarized more distant (15)N sites in metronidazole

165 Our results illustrate the use of hyperpolarized MRI as a sensitive technique to monitor d

166 Hyperpolarized MRI localized the increase in cardiac lac

167 uction in lactate production as monitored by hyperpolarized MRI, also followed by tumor size changes.

168 vity decay through simulated depolarizing or hyperpolarizing network stimulation.

169 ysiological techniques, we show that ghrelin hyperpolarizes neurons and inhibits currents evoked by l

170 isolated rat vagal neurons show that ghrelin hyperpolarizes neurons by activating K(+) conductance.

171 Furthermore, AgRP is a biased agonist that hyperpolarizes neurons by binding to MC4R and opening Ki

172 er-soluble polarization transfer catalyst to hyperpolarize nitrogen-15 in a variety of molecules with

173 In particular, hyperpolarized nitroimidazole and its derivatives have p

174 of several seconds underlines the utility of hyperpolarized NMR for quantifying early events in polym

175 onance imaging (conventional (1)H as well as hyperpolarized noble gases such as (129)Xe, (3)He, and i

176 on the level of maturation (depolarizing vs. hyperpolarizing) of postsynaptic GABAA receptor actions.

177 he membrane potential using depolarizing and hyperpolarizing opsins; the ability to induce prolonged

178 olarized VIP BCs whereas PV BCs depolarized, hyperpolarized or produced biphasic responses.

179 ivation, they more frequently responded with hyperpolarizing or biphasic responses.

180 GluRs at the same time as the interneuron is hyperpolarized, or by postsynaptic trains of action pote

181 d measurement of the enzymatic conversion of hyperpolarized oxaloacetate to malate, the two signal co

182 ctrical threshold and increased responses to hyperpolarizing (P < 0.00007) and depolarizing currents

183 induced by hypoxia and hypercapnia; however, hyperpolarizing pFL neurons attenuated active expiration

184 Hyperpolarizing pFL neurons had no effect on breathing a

185 In contrast, hyperpolarizing pFV neurons affected breathing at rest b

186 onstrate that shv3svl1, like fer, exhibits a hyperpolarized plasma membrane H(+) gradient that likely

187 Strikingly, hyperpolarizing posterior or ventral cells induces the p

188 ting its half-maximum inactivation to a more hyperpolarized potential.

189 The magnitude of the after-hyperpolarizing potential (AHP) following a train of spi

190 We found that both the after-hyperpolarizing potential magnitude and the underlying a

191 activation of both K525C and K525C/L529I to hyperpolarized potentials (-131 +/- 4 mV for K525C and -

192 D-serine also inhibits some NMDARs active at hyperpolarized potentials (HA-NMDARs), and we previously

193 dorsal spinal neurons, is activated at more hyperpolarized potentials and inactivated more slowly th

194 ivation of presynaptic Ca(2+) influx to more hyperpolarized potentials and increased the spontaneous

195 the voltage dependence of channel opening to hyperpolarized potentials thereby conferring gain-of-fun

196 channel inactivation and activation at more hyperpolarized potentials, producing increased intracell

197 voltage dependence of S4 movement to extreme hyperpolarized potentials, such that in the physiologica

198 bute to the preferential induction of LTP at hyperpolarized potentials.

199 of activation and inactivation towards more hyperpolarized potentials.

200 PSs just ahead of SLE were associated with hyperpolarizing potentials coupled with a complete block

201 and muscarinic ACh receptor (mAChR)-mediated hyperpolarizing potentials in AC L5B corticocallosal neu

202 However, in contrast to the mAChR-mediated hyperpolarizing potentials in corticocallosal neurons, A

203 1.3-R990H channels conduct omega-currents at hyperpolarizing potentials, but not upon membrane depola

204 U591 exhibits voltage-dependent knock-off at hyperpolarizing potentials, suggesting that the binding

205 Hyperpolarizing preBotC neurons decreased inspiratory ac

206 when inspiratory activity was suppressed by hyperpolarizing preBotC neurons.

207 cilitated when postsynaptic interneurons are hyperpolarized, presumably because Ca(2+) entry through

208 vide feedforward inhibition that transiently hyperpolarizes principal neurons.

209 Next, we will shift our focus to hyperpolarized probe design and provide an overview of t

210 ation of propyne over ceria nanocubes yields hyperpolarized propene with a similar pairwise selectivi

211 With mildly depolarizing or hyperpolarizing pulses just above threshold potentials,

212 ould also be elicited by single depolarizing/hyperpolarizing pulses of very high field strength.

213 stepwise and gradually with depolarizing and hyperpolarizing pulses, respectively.

214 ords show notable decays during large 100 ms hyperpolarizing pulses.

215 information that is uniquely available from hyperpolarized pyruvate and its metabolites, thus improv

216 this study, we show that metabolic MRI with hyperpolarized pyruvate is biased by tumor perfusion and

217 These findings demonstrate the ability of hyperpolarized pyruvate magnetic resonance spectroscopy

218 Hyperpolarized pyruvate was injected at five stages: at

219 ghted MR imaging, dynamic MR spectroscopy of hyperpolarized pyruvate, and (18)F-FDG PET/computed tomo

220 analysis, including metabolic imaging using hyperpolarized pyruvate, points to reduced oxidative flu

221 13C magnetic resonance spectroscopy (MRS) of hyperpolarized pyruvate, we confirmed that FX11 administ

222 SCN cells from Fbxl3(Afh/Afh) mice were more hyperpolarized, receiving more GABAergic input than thei

223 Such an epigenetic modification in GALR3, a hyperpolarizing receptor, might contribute to the dysreg

224 inhibit current spread in M/T dendrites via hyperpolarizing reciprocal dendrodendritic synapses.

225 PS neurons had a more hyperpolarized resting membrane potential from infancy t

226 rons which are characterized by a relatively hyperpolarized resting membrane potential, higher sponta

227 sociated with increased input resistance and hyperpolarized resting membrane potential, respectively.

228 activity; shRNA-mediated depletion of Nalcn hyperpolarized RTN neurons, and reduced leak Na(+) curre

229 The multiplexed detection of two or more hyperpolarized samples increases throughput of D-DNP by

230 n the pore module of Nav1.7 produces a large hyperpolarizing shift (-18 mV) in the voltage dependence

231 The hyperpolarizing shift in gating was attributed to decrea

232 Acrolein exposure induced a hyperpolarizing shift in INa, and acrolein-induced cell

233 The mutant channel also had a marked hyperpolarizing shift in its voltage dependence of inact

234 mutations (A1236E and L1831X) resulted in a hyperpolarizing shift in steady-state fast inactivation.

235 in incomplete fast inactivation and a small hyperpolarizing shift in steady-state slow inactivation,

236 ecrease in T-type current amplitude due to a hyperpolarizing shift in the steady-state inactivation.

237 binds to the pore-forming domain, causing a hyperpolarizing shift in the voltage dependence of chann

238 in transient Na(+) current amplitude, and a hyperpolarizing shift in the voltage dependence of Nav c

239 that the loss of iFGF14 results in a marked hyperpolarizing shift in the voltage dependence of stead

240 us cells, the L1302F mutation caused a large hyperpolarizing shift in the voltage-dependence of activ

241 ular application of bromo-cAMP abolished the hyperpolarizing shift in the voltage-dependent activatio

242 ons of the contralateral mPFC, we observed a hyperpolarizing shift in the voltage-dependent activatio

243 panied by a relatively small but significant hyperpolarizing shift in the voltage-gated activation ki

244 s to prevent the runaway gating phenotype, a hyperpolarizing shift in voltage sensitivities and faste

245 ests as a potentiation of current amplitude, hyperpolarizing shift in voltage sensitivity, and slowin

246 with a loss of HCN1 surface expression and a hyperpolarizing shift in voltage-dependence of activatio

247 g shift of voltage-dependent activation or a hyperpolarizing shift of channel availability (steady-st

248 either decreased amplitudes or an additional hyperpolarizing shift of the inactivation curve.

249 unction (gain-and loss-of-function) due to a hyperpolarizing shift of voltage-dependent activation co

250 t patients or only gain-of-function effects (hyperpolarizing shift of voltage-dependent activation, i

251 e in postsynaptic excitability was traced to hyperpolarizing shifts in both the half-inactivation and

252 of these positions, we observed significant hyperpolarizing shifts in the voltage dependence.

253 In this study, we demonstrate that sampling hyperpolarized signals using a permanent magnet at 1 Tes

254 However, OVLT neurons in CLP rats were hyperpolarized significantly compared with shams.

255 Under global control of de- and hyperpolarizing slow oscillations (SOs), sleep spindles

256 Alkalization hyperpolarizes sperm and produces Ca(2+) entry.

257 ytic combustion without measurable losses in hyperpolarized spin state of either (83)Kr or (129)Xe.

258 ted by the relatively fast decay time of the hyperpolarized spin state together with the constraint o

259 The signal of the hyperpolarized spins was detected in situ with a standar

260 ing that the Afh mutation prolongs nighttime hyperpolarized states of vSCN cells through increased GA

261 Ambystoma tigrinum cones and rods evoked by hyperpolarizing steps applied to synaptically coupled HC

262 the single-scan approach enables one to use hyperpolarized substances to boost the sensitivity by se

263 Imaging hyperpolarized substrates by magnetic resonance is unlik

264 and present a new pharmacokinetic model for hyperpolarized substrates that accounts for these effect

265 tivity is an essential prerequisite for fast hyperpolarizing synaptic inhibition mediated by type A g

266 Using recently developed neuronal hyperpolarizing technologies, we functionally dissect th

267 thalamic downstates; (2) thalamic downstates hyperpolarize thalamic cells, thus triggering spindles;

268 In hyperpolarized thalamocortical neurons, T-type Ca(2+)cha

269 simulate a Hodgkin-Huxley network model of a hyperpolarized thalamus and corticothalamic inputs.

270 eous transient outward currents (STOCs) that hyperpolarize the cell and reduce voltage-dependent Ca(2

271 eous transient outward currents (STOCs) that hyperpolarize the cell membrane and reduce voltage-depen

272 um-dependent potassium channels to shunt and hyperpolarize the hair cell.

273 of cardiac GIRK channels, which is likely to hyperpolarize the myocellular membrane potential and thu

274 by reversible exchange (SABRE) technique to hyperpolarize the target (1) H nuclei and store this pol

275 Zinc chloride indeed hyperpolarized the chloride equilibrium potential in MNs

276 ly excluding protons and larger cations, and hyperpolarized the membrane of cultured animal cells wit

277 ation with NS1619 inhibited oscillations and hyperpolarized the resting potential.

278 droxytryptamine 1A (5-HT1A) receptors, which hyperpolarizes the activation range of HCN channels.

279 Opening of BLINK1 channels hyperpolarizes the cell to the K(+) equilibrium potentia

280 campal neurons increases KCC2 expression and hyperpolarizes the reversal potential for Cl(-).

281 During sperm capacitation SLO3 hyperpolarizes the sperm, whereas CATSPER allows Ca(2+)

282 reduces intracellular Cl(-) levels in RGCs, hyperpolarizing the resting membrane potential.

283 Hyperpolarizing the supplementary motor complex using tr

284 ty with increased membrane input resistance, hyperpolarized threshold, and larger action potential am

285 ms for their removal from the cleft when HCs hyperpolarize to light remain unknown.

286 occurs while the membrane is depolarized or hyperpolarized to voltages beyond so-called threshold po

287 that provide unprecedented fast and powerful hyperpolarizing tools for optogenetics.

288 ory protein p27(Kip1) (p27) was nuclear spin hyperpolarized using dissolution dynamic nuclear polariz

289 ommonly from experiments, where analytes are hyperpolarized using dissolution dynamic nuclear polariz

290 n in which the sperm plasma membrane becomes hyperpolarized via activation of potassium (K(+)) channe

291 The channels are activated by hyperpolarizing voltage but are also receptors for the i

292 oderate compared to channels preactivated by hyperpolarizing voltage.

293 Measurements of the PD neuron MPR at more hyperpolarized voltages resulted in a reduction of fres

294 s exon show intense CDI and activate at more hyperpolarized voltages than Cav1.4FL The robust CDI of

295 of channel activation and shifts it to less hyperpolarized voltages.

296 usion coefficient (ADC) values obtained with hyperpolarized xenon 129 ((129)Xe) magnetic resonance (M

297 magnetic resonance (MR) imaging with inhaled hyperpolarized xenon 129 ((129)Xe).

298 They can also be imaged with hyperpolarized xenon MRI using chemical exchange saturat

299 Studies of hyperpolarized xenon-129 (hp-(129)Xe) in media such as l

300 e potential to increase the sensitivity of a hyperpolarized xenon-129 MRI contrast agent.