ライフサイエンスコーパス: hyperreactive

1 ately 25-50 are reduced, with 6-8 considered hyperreactive.

2 ased from endothelium is ultralarge (UL) and hyperreactive.

3 not conclude whether or not asthmatic ASM is hyperreactive.

4 hat natural ovarian steroids directly reduce hyperreactive 5-HT and thromboxane A2-stimulated Ca2+ an

5 y exposed workers and control subjects to be hyperreactive (95% confidence interval, 1.8-25.2; p = 0.

6 against syngeneic MHC-II(+) skin grafts, (2) hyperreactive against third-party MHC-II(+) skin grafts,

7 ant therapeutic targets for the treatment of hyperreactive airway disease.

8 tself is not required for the asthmatic-like hyperreactive airway response.

9 class had diminished lung function and more hyperreactive airways compared with all other classes.

10 ty and creating a NO deficiency that induces hyperreactive airways.

11 rs the TCR threshold and renders lymphocytes hyperreactive and capable of unwanted immune responses.

12 Platelets from patients with diabetes are hyperreactive and demonstrate increased adhesiveness, ag

13 , CD44(high), but not CD44(low) T cells, are hyperreactive and hyperproliferative in vivo.

14 ollapse, 23% of highly exposed subjects were hyperreactive as compared with only 11% of moderately ex

15 nd hyperreactivity persisted in 55% of those hyperreactive at 1 and/or 3 months.

16 ically silencing these neurons abolished the hyperreactive broncho-constrictions, even in the presenc

17 rlapping with those identified previously as hyperreactive by administration of exogenous reagents (t

18 e c oxidase-negative/succinate dehydrogenase-hyperreactive (COX-/SDH++) fibers from normal aging huma

19 work is the first to directly identify seven hyperreactive cysteines: 1040, 1303, 2436, 2565, 2606, 2

20 primarily mediated through highly reactive (hyperreactive) cysteines.

21 ibody-drug conjugates, and identification of hyperreactive methionine residues in whole proteomes.

22 ll transfer from long-term exposed mice into hyperreactive mice also restored normal airway responsiv

23 how that normal responsiveness in previously hyperreactive mice, achieved after long-term allergen ch

24 represents an important mechanism behind the hyperreactive nature of basophils that has long been obs

25 the rs956115 marker of the IRS-1 gene have a hyperreactive platelet phenotype and increased risk of M

26 marker were more commonly associated with a hyperreactive platelet phenotype.

27 et messenger RNA (mRNA) from subjects with a hyperreactive platelet phenotype.

28 anges in platelet gene expression creating a hyperreactive platelet, despite antiplatelet therapy.

29 tion in humans, but can cumulatively lead to hyperreactive platelets and increase risk for negative o

30 Both children had hyperreactive platelets, as determined by whole blood pl

31 Hyperreactive responses to the combination of 5-HT and U

32 t alterations in the allergen-induced airway hyperreactive responses.

33 et therapies, and it has been suggested that hyperreactive reticulated platelets underlie this altere

34 ted for reducing the rate of CPM labeling of hyperreactive SR thiols (IC50 = 0.3 and 1.8 microM, resp

35 oup is essential for modulating the state of hyperreactive SR thiols.

36 Hyperreactive sulfhydryl groups associated with the Ca(2

37 nd dose-dependently interact with a class of hyperreactive sulfhydryl groups localized on ryanodine-s

38 lcoumarin (CPM) to measure the reactivity of hyperreactive sulfhydryl moieties on sarcoplasmic reticu

39 itions previously shown to selectively label hyperreactive sulfhydryls and eliminate redox sensing.

40 ely and reversibly alters the redox state of hyperreactive sulfhydryls localized in the RyR/Ca2+ chan

41 Alkylation of hyperreactive sulfhydryls on RYR1 with N-ethylmaleimide

42 Hyperreactive sulfhydryls previously shown to reside wit

43 The hyperreactive systemic inflammatory response seen in age

44 The hyperreactive T residue in the six sites detected as wel

45 lated to their ability to selectively modify hyperreactive thiols regulating normal functioning of mi

46 In summary, TRAF3 renders B cells hyperreactive to antigens and TLR agonists, promoting au

47 ound that pre-GT WASp-deficient B cells were hyperreactive to B cell receptor stimulation (BCR stimul

48 onsequence, TIPE2 knockout myeloid cells are hyperreactive to Poly (I:C) stimulation, and TIPE2 knock

49 Antigen-challenged animals were hyperreactive to vagal stimulation, and demonstrated los

50 ent antigen-presenting cells (APCs) but were hyperreactive to wild-type APCs.

51 ence of E3Q EcFpg, the Sp nucleotide (nt) is hyperreactive toward cleavage by MPE-Fe(II)-generated hy

52 together with a pathological accumulation of hyperreactive ultra-large VWF (UL-VWF) multimers.

53 age (IL-6), resulting in the accumulation of hyperreactive ULVWF in plasma and on the surface of endo

54 ease with thrombospondin motif) converts the hyperreactive unusually large (UL) forms of von Willebra

55 To test this hypothesis, we treated hyperreactive VMC from ovariectomized (ovx) monkeys in v

56 ADAMTS13 cleaves ultralarge and hyperreactive von Willebrand factor (ULVWF) freshly rele

57 These findings suggest an important role for hyperreactive VWF in SCD pathology and connect SCD to ot