ライフサイエンスコーパス: hypersecretion

1 ter B cells and plasma cells as well as IgG1 hypersecretion.

2 ides an enlarged pituitary contribute to the hypersecretion.

3 esponsiveness (AHR), inflammation, and mucus hypersecretion.

4 ng in increased airway eosinophils and mucus hypersecretion.

5 ciated with goblet cell metaplasia and mucus hypersecretion.

6 functional K(ATP) channels leads to insulin hypersecretion.

7 striction, parenchymal destruction and mucus hypersecretion.

8 lications for the management of airway mucus hypersecretion.

9 s were airway hyperresponsiveness and mucous hypersecretion.

10 matory airway diseases associated with mucus hypersecretion.

11 ons, which are associated with further mucus hypersecretion.

12 nic factors predominated in sinusitis mucous hypersecretion.

13 pharmacological intervention to treat mucus hypersecretion.

14 local invasion, hypopituitarism, or hormone hypersecretion.

15 uid and airway tissue eosinophilia and mucus hypersecretion.

16 targeted specifically for therapy of airway hypersecretion.

17 sequence of rapid glucose appearance and GIP hypersecretion.

18 l infiltration, VCAM-1 expression, and mucus hypersecretion.

19 rising from pituitary intermediate lobe ACTH hypersecretion.

20 B(4) may play a major role in allergic nasal hypersecretion.

21 ain fatty acids replicates the basal insulin hypersecretion.

22 tty acids (FAs) replicates the basal insulin hypersecretion.

23 ttenuated, thereby causing the basal insulin hypersecretion.

24 nt of diseases that rely on SNAP-23-mediated hypersecretion.

25 and increases viral titres, leading to mucus hypersecretion.

26 volves airway hyper-responsiveness and mucus hypersecretion.

27 competent CTLs/NK cells and caused cytokine hypersecretion.

28 D of p53 as a determinant for chronic mucous hypersecretion.

29 or after prolonged exposure induces insulin hypersecretion.

30 he severity of airway inflammation and mucus hypersecretion.

31 ultures with induced mucous metaplasia/mucin hypersecretion.

32 oblet cell hyperplasia/metaplasia, and mucus hypersecretion.

33 etermined by gland size (10%) versus hormone hypersecretion (3%) was statistically different (P < 0.0

34 ficiencies (B12 and magnesium), rebound acid hypersecretion, acute interstitial nephritis, gastric ca

35 or NU7441 reduced airway eosinophilia, mucus hypersecretion, airway hyperresponsiveness, and OVA-spec

36 ld-type mice had chronic inflammation, mucus hypersecretion, airway remodeling, emphysema, and reduce

37 notype in Muc5ac-Tg mice suggests that mucin hypersecretion alone is not sufficient to trigger lumina

38 FD in C57BL/6NTac mice entails early insulin hypersecretion and a robust growth phase along with hype

39 Effective control of GH and IGF1 hypersecretion and ablation or stabilization of the pitu

40 disease characterized by inflammation, mucus hypersecretion and abnormal airway smooth muscle (ASM) c

41 s result in dysregulated growth hormone (GH) hypersecretion and acromegaly; however, regulatory mecha

42 ic airway inflammation, which leads to mucus hypersecretion and airway hyperresponsiveness.

43 Local allergen challenge causes nasal hypersecretion and also causes local leukotriene (LT) re

44 ituted the goblet cell hyperplasia, cytokine hypersecretion and decreased ciliary function of asthmat

45 Remodeling processes, such as mucus hypersecretion and extracellular matrix protein producti

46 to enhanced beta-cell excitability, insulin hypersecretion and hypoglycaemia, and in humans lead to

47 models of depression, namely stress hormone hypersecretion and increased passive coping behavior, su

48 tress responses and allow for glucocorticoid hypersecretion and its attendant pathophysiology.

49 that Lyn overexpression decreased the mucus hypersecretion and levels of the muc5ac transcript in mi

50 of the airways that is associated with mucus hypersecretion and obstruction of small airways.

51 Mucus hypersecretion and persistent airway inflammation are co

52 Ac-1-phosphotransferase results in hydrolase hypersecretion and profound lysosomal storage.

53 ficient animals specifically inhibited mucus hypersecretion and reduced IL-13.

54 All had controlled acid hypersecretion and were assessed yearly, with a mean fol

55 ltration, goblet cell hyperplasia with mucus hypersecretion, and accumulation and activation of intra

56 ity, eosinophilic airway inflammation, mucus hypersecretion, and Ag-specific Ig production.

57 ic inflammation, Th2 cytokine release, mucus hypersecretion, and AHR.

58 ion in airway eosinophil infiltration, mucus hypersecretion, and airway hyperreactivity in response t

59 atures of asthma: airway eosinophilia, mucus hypersecretion, and airway hyperreactivity.

60 cterized by eosinophilic inflammation, mucus hypersecretion, and airway hyperresponsiveness (AHR).

61 that is characterized by inflammation, mucus hypersecretion, and airway hyperresponsiveness.

62 hyperresponsiveness, gene expression, mucus hypersecretion, and airway inflammation was assessed by

63 However, goblet cell metaplasia, mucus hypersecretion, and airway obstruction are integral feat

64 g antibody attenuated ILC2 expansion, mucous hypersecretion, and airways responsiveness.

65 l and microbial agents causing inflammation, hypersecretion, and epithelial necrosis.

66 reduced airway hyperreactivity (AHR), mucus hypersecretion, and fibrosis.

67 cell maturation phenotypes, including IL-12 hypersecretion, and higher major histocompatibility comp

68 allergen-induced airway inflammation, mucus hypersecretion, and hyperresponsiveness in the hGX-sPLA(

69 ated with a reduction in eosinophilia, mucus hypersecretion, and IL-5 and IL-13 production upon the a

70 a therapeutic target for inflammation, mucus hypersecretion, and structural lung damage and indicate

71 ovalbumin-induced airway eosinophilia, mucus hypersecretion, and Th2 cytokine production (IL-4/IL-5/I

72 g to eosinophilic airway inflammation, mucus hypersecretion, and Th2 cytokine production in response

73 velopment of AHR, airway eosinophilia, mucus hypersecretion, and TH2 cytokine production without chan

74 ized by airway epithelial cell damage, mucus hypersecretion, and Th2 cytokine production.

75 Eosinophil recruitment and mucus hypersecretion are characteristic of asthmatic airway in

76 n leading to airflow obstruction, and mucous hypersecretion are clinical hallmarks of asthma.

77 Goblet cell metaplasia and mucus hypersecretion are important features in the pathogenesi

78 r, the signalling pathways regulating MUC5AC hypersecretion are not fully characterised.

79 Calcium bursts and hypersecretion are reversed by mutations in the ryanodin

80 ced inflammatory cell infiltration and mucus hypersecretion as observed in lung sections, and mRNA ex

81 es a molecular basis for biliary cholesterol hypersecretion as the mechanism for cholesterol gallston

82 values underestimate the degree of hydrolase hypersecretion as these enzymes were rapidly cleared fro

83 ere examined for cell infiltration and mucus hypersecretion, as well as the expression of antioxidant

84 rway diseases associated with chronic mucous hypersecretion.Bcl-2 interacting killer (Bik) decreases

85 FDRs to maintain their compensatory insulin hypersecretion beyond 18 h of hyperglycemia.

86 so diminished goblet cell hyperplasia, mucus hypersecretion, bronchoalveolar lavage eosinophilia, alt

87 gen-induced airway hyperreactivity and mucus hypersecretion but not for fibroblast or alternative mac

88 However, IL-6 is essential for mucus hypersecretion by airway epithelial cells triggered in r

89 ity that adenosine also contributes to mucus hypersecretion by airway epithelial cells.

90 Lyn overexpression ameliorated airway mucus hypersecretion by down-regulating STAT6 and its binding

91 ated that M. pneumoniae induces airway mucus hypersecretion by modulating the STAT/EGFR-FOXA2 signali

92 IL-1beta hypersecretion by monocytes involves decreased mitochond

93 The mechanism of gastric acid hypersecretion by NGASP was investigated in rats.

94 ho-A/Rho kinase inhibitor, affects the mucus hypersecretion by suppressing MUC5AC via signal transduc

95 chanism by which M. pneumoniae induces mucus hypersecretion by using M. pneumoniae infection of mouse

96 beta-cell excitability: the expected initial hypersecretion can progress to undersecretion and glucos

97 Chronic mucus hypersecretion (CMH) is common among smokers and is asso

98 s minimally perturbed, demonstrating insulin hypersecretion compensated for insulin resistance.

99 f further medical conditions associated with hypersecretion components is prevented partly because th

100 Goblet cell hyperplasia and mucous hypersecretion contribute to the pathogenesis of chronic

101 ersion to CSCs via MEC co-culture (e.g., MMP hypersecretion, decreased PTEN).

102 therapeutic potential for treatment of human hypersecretion diseases.

103 subjects showed higher glycemia and insulin hypersecretion due to greater beta-cell glucose and rate

104 partakes in biliary phosphatidylcholine (PC) hypersecretion during cholesterol cholelithogenesis.

105 educed airway eosinophil infiltration, mucus hypersecretion, edema, and IL-4 levels in a mouse asthma

106 rway hyperreactivity, T(H)2 responses, mucus hypersecretion, eosinophil infiltration, and collagen de

107 ted airway hyperresponsiveness, glycoprotein hypersecretion, eosinophilia, and lung IL-4 responses.

108 usion criteria included evidence of lacrimal hypersecretion, eyelid malposition, and punctal or canal

109 ronchoalveolar lavage eosinophilia and mucus hypersecretion following the secondary challenge protoco

110 pheral blood insulin levels, despite insulin hypersecretion from pancreatic beta cells.

111 d-type enteropathogenic Escherichia coli and hypersecretion from sepL and sepD mutants.

112 filtration with concomitant epithelial mucus hypersecretion, goblet cell metaplasia, subepithelial fi

113 While the etiology is not well understood, hypersecretion has been linked to the presence of cytoki

114 trin-releasing peptide that could cause acid hypersecretion; however, Zollinger-Ellison syndrome (ZES

115 diated goblet cell differentiation and mucus hypersecretion in a murine model of allergic lung diseas

116 ver, its function in modulating airway mucus hypersecretion in asthma remains undefined.

117 ecretory drugs for treatment of airway mucus hypersecretion in asthma.

118 licate NKCC1 in the pathophysiology of mucus hypersecretion in asthma.

119 ell hyperplasia may lead to sustained mucous hypersecretion in chronic diseases.

120 Parenteral control of gastric acid hypersecretion in conditions such as Zollinger-Ellison s

121 function, and thereby reverse glucocorticoid hypersecretion in depression.

122 y inflammation and hyperreactivity and mucus hypersecretion in house dust mite-challenged mice.

123 184 or PF-3845 blocked naloxone-precipitated hypersecretion in morphine-dependent small intestinal ti

124 ed to treat symptoms associated with hormone hypersecretion in neuroendocrine tumors; however, data o

125 Medical control of acid hypersecretion in patients with sporadic ZES is highly e

126 that propofol (Diprivan) may stimulate mucus hypersecretion in patients without pulmonary disease.

127 there was no goblet cell metaplasia or mucus hypersecretion in response to OVA, even in the presence

128 okine production in the peritoneum, or mucus hypersecretion in the gastrointestinal tract.

129 diators of the eosinophilic influx and mucus hypersecretion in the lungs in a murine model of asthma.

130 minished eosinophilic inflammation and mucus hypersecretion in the lungs of allergen-sensitized and a

131 UC5AC production and IL-1beta-induced Muc5ac hypersecretion in tracheas from wild-type but not from C

132 in may potentiate each other to produce acid hypersecretion in ulcerogenic pancreatic tumor syndrome.

133 g-chain omega-3 fatty acids reversed insulin hypersecretion in vivo, and the effect of long-term high

134 In a cohort of patients with gastric acid hypersecretion in whom acid secretion status was monitor

135 es of the disease such as selective cytokine hypersecretion, increased neutrophil recruitment and cli

136 AT(1) receptor blocker, losartan, inhibited hypersecretion induced by C. difficile toxin A (mean vol

137 Previously, we reported that mucin hypersecretion induced by human neutrophil elastase invo

138 y abnormalities of COPD/CF, including mucous hypersecretion, inflammatory and emphysematous phenotype

139 glucose but results in compensatory glucagon hypersecretion involving expansion of pancreatic alpha-c

140 Mucus hypersecretion is a common characteristic of asthma.

141 Airway mucus hypersecretion is a feature of many patients with asthma

142 Mucus hypersecretion is a hallmark of asthma that contributes

143 Airway mucus hypersecretion is a key pathophysiologic feature in a nu

144 Airway mucus hypersecretion is a key pathophysiological feature in as

145 Mucous hypersecretion is a major cause of airway obstruction in

146 Mucin hypersecretion is a major pathological feature of many r

147 Mucus hypersecretion is a prominent manifestation in patients

148 Mucus hypersecretion is a prominent manifestation in patients

149 Airway hypersecretion is a serious and presently untreatable sy

150 Mucous hypersecretion is an important feature of obstructive ai

151 Because mucus hypersecretion is common in purulent rhinitis, we questi

152 on syndrome (ZES) or idiopathic gastric acid hypersecretion is necessary perioperatively or when oral

153 Cortisol hypersecretion is one of the most reliable biological ab

154 y, not only because medical therapy for acid hypersecretion is so effective, but also in large part b

155 ther, these results indicate that adenoma GH hypersecretion is the result of STAT3-dependent GH induc

156 Dysregulated growth hormone (GH) hypersecretion is usually caused by a GH-secreting pitui

157 ystem hyperreactivity, presumably due to CRF hypersecretion, is a persistent consequence of childhood

158 pogenesis, induced in hepatocytes by insulin hypersecretion, is followed by beta-cell destruction in

159 ts such as epithelial desquamation and mucus hypersecretion leading to airway obstruction, subepithel

160 Consequently, mucin hypersecretion likely produces mucus stasis, which contr

161 ge, inflammatory cell recruitment, and mucus hypersecretion may be associated with substantial argina

162 d by loss-of-function mutations) and hormone hypersecretion (McCune-Albright syndrome caused by gain-

163 did not cause a comparable decrease in mucus hypersecretion, Muc 5ac gene expression, or the level of

164 ences of hypergastrinemia, including rebound hypersecretion of acid, and possible development of vari

165 receptors on the MMP-1 promoter and leads to hypersecretion of active MMP-1 enzyme and degradation of

166 on by CLA of MEK/ERK signaling was linked to hypersecretion of adipocytokines interleukin-6 and inter

167 Hypersecretion of airway mucin characterizes numerous re

168 Hypersecretion of amylin is common in individuals with p

169 Hypersecretion of basal cortisol, in conjunction with bl

170 eases in bile salt hydrophobicity and not to hypersecretion of biliary cholesterol per se, such as oc

171 ation normalized bile salt reabsorption, and hypersecretion of bilirubin was abolished.

172 lly associated with systemic symptoms due to hypersecretion of biogenic amines from metastatic lesion

173 t diarrheal illnesses mediated by intestinal hypersecretion of chloride.

174 pituitary-adrenal axis activity secondary to hypersecretion of corticotropin-releasing hormone.

175 Hypersecretion of cortisol can be detected in asymptomat

176 Although hypersecretion of cortisol has frequently been reported

177 In this form of hyperplasia, hypersecretion of cortisol suppresses the release of cor

178 IVH-induced hypersecretion of CSF is mediated by TLR4-dependent acti

179 Hypersecretion of cytokines by innate immune cells is th

180 n addition, we hypothesized that concomitant hypersecretion of glucagon and insulin was also contribu

181 is due to alpha-cell hyperplasia with gross hypersecretion of glucagon, which according to recent gr

182 aracrine mechanisms is believed to cause the hypersecretion of glucagon.

183 r depression, which is often associated with hypersecretion of glucocorticoids; and (3) posttraumatic

184 e AIP gene and are sometimes associated with hypersecretion of growth hormone.

185 pletion of STX10 leads to MPR missorting and hypersecretion of hexosaminidase.

186 T helper 1 cells show slight but significant hypersecretion of IFN-gamma in Grail(-/-) mice whereas T

187 We find that hypersecretion of IL-1beta and IL-18 requires reactive o

188 ammasome activation, thereby contributing to hypersecretion of IL-1beta in mevalonate kinase deficien

189 and their targets in real time, we show that hypersecretion of IL-2, TNF, IFN-gamma, and various chem

190 oxin, at sub nM concentrations, can suppress hypersecretion of IL-8 from cultured CF lung epithelial

191 lymphoplasmacytic lymphoma characterized by hypersecretion of immunoglobulin M (IgM) protein and tum

192 mmatory phenotype in HRMPs, characterized by hypersecretion of inflammatory and angiogenic mediators.

193 were identified as having MHSs involving the hypersecretion of insulin (5 patients), vasoactive intes

194 TP) channels in transgenic (AAA) mice causes hypersecretion of insulin and enhanced glucose tolerance

195 By 12 weeks of age, hypersecretion of insulin at 5.0 mmol/l glucose was obse

196 r of childhood associated with inappropriate hypersecretion of insulin by the pancreas.

197 ls leads to fasting-induced hypoglycemia and hypersecretion of insulin during GSIS.

198 athways do not contribute to the early-onset hypersecretion of insulin from islets of ob/ob mice.

199 Hypersecretion of insulin from the pancreas is among the

200 This inappropriate hypersecretion of insulin in the face of profound hypogl

201 The hypersecretion of insulin may be explained by a loss of

202 KC signaling system within islets to prevent hypersecretion of insulin.

203 tory pathway in pancreatic islets to prevent hypersecretion of insulin.

204 to obesity-associated insulin resistance is hypersecretion of insulin.

205 This phenotype was characterized by hypersecretion of interferon (IFN)-gamma and interleukin

206 activated chloride secretion, and suppresses hypersecretion of interleukin-8 (IL-8).

207 suggest that, in addition to activation and hypersecretion of matrix components, fibroblasts from pa

208 f MECs and NSCs rapidly (</= 3 weeks) caused hypersecretion of MMPs and marked suppression of the tum

209 CB is caused by overproduction and hypersecretion of mucus by goblet cells, which leads to

210 Hypersecretion of mucus is an important component of air

211 ration with decreased transport velocity and hypersecretion of mucus.

212 Significant hypersecretion of nitric oxide (NO) was observed in thio

213 h could account for the previously described hypersecretion of procathepsin D induced by wortmannin.

214 Dexamethasone at various potencies blocked hypersecretion of several proteins.

215 As hypersecretion of the stress neuromediator, corticotropi

216 The likely underlying mechanism is hypersecretion of vascular endothelial growth factor sec

217 Importantly, the hypersecretion of VLDL-TG from the liver induced by a mo

218 Finally, DVC glycine normalized the hypersecretion of VLDL-TG induced by high-fat feeding.

219 Yersinia-containing vacuoles (YCVs) requires hypersecretion of Yersinia translocon proteins.

220 Airway inflammation and mucus hypersecretion/overproduction/obstruction are pathophysi

221 ncy state may be involved in the actual ACTH hypersecretion phenomenon.

222 ) mice displayed a cell-autonomous IL-1alpha hypersecretion phenotype, whereas T cells showed propens

223 tudies of the mechanisms responsible for the hypersecretion produced by cholera toxin (CT) have shown

224 al mechanism supporting compensatory insulin hypersecretion rather than exacerbating metabolic diseas

225 tumors (PNETs) may evolve and cause hormonal hypersecretion-related symptoms that were not present at

226 wever, regulatory mechanisms that promote GH hypersecretion remain elusive.

227 h includes recruitment of eosinophils, mucus hypersecretion, Th2 cytokine production, and airways hyp

228 al. show, in a mouse model of chronic mucous hypersecretion, that ciliated epithelial cell apoptosis

229 ation, airway hyperresponsiveness, and mucus hypersecretion to a similar degree as detected in mast c

230 responsiveness, lung inflammation, and mucus hypersecretion to the degree observed in wild-type mice.

231 previously unrecognized contribution of CSF hypersecretion to the pathogenesis of PHH, demonstrate a

232 ocytes, eosinophils, IL-13, IL-5, and mucous hypersecretion to wild-type levels, whereas eotaxin and

233 Mucus hypersecretion upon Pofut1 inactivation is accompanied b

234 investigated the role of PKC delta in mucin hypersecretion using both primary human bronchial epithe

235 thways that underlie MKD-associated IL-1beta hypersecretion using human cell cultures, Rac1 and RhoA

236 ined the hypothesis that LTB(4) causes nasal hypersecretion via neutrophil elastase.

237 Cholera toxin induces hypersecretion via release of mucosal serotonin and over

238 s signaling cascade is relevant to asthmatic hypersecretion was indicated by results showing that muc

239 nnervation, the authors discovered that GABA hypersecretion was required for the induction of mucin M

240 -12-myristate-13-acetate (PMA)-induced mucin hypersecretion was significantly attenuated by rottlerin

241 ivation/inflammation, high SNS tone, and CRH hypersecretion, which are all consistent with insufficie

242 zed by airway eosinophilia, as well as mucus hypersecretion, which can lead to airflow obstruction.

243 hopefully lead to novel therapies for mucin hypersecretion, which is an important cause of morbidity

244 Whether amelioration of basal insulin hypersecretion will prevent diabetes remains to be eluci

245 ic inflammation, an immune response, and IgA hypersecretion with an osmotic effect, all contributing

246 ive hormones and relieve symptoms of hormone hypersecretion with functional NETs.

247 flammation, Th2 cell accumulation, and mucus hypersecretion with mucus metaplasia.

248 hypertrophy and hyperplasia as well as mucus hypersecretion with subsequent airflow obstruction.

249 ppressed AHR, airway eosinophilia, and mucus hypersecretion without any reduction in TH2 cytokine pro