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1 their DNA structure and primary sequence are hypervariable.
3 inical isolates by pyrosequencing within the hypervariable A region of the 16S rRNA gene was compared
4 ecies revealed that the N-terminal domain is hypervariable among species yet is conserved with regard
5 e NH2-terminal region of troponin T (TnT) is hypervariable among the muscle type-specific isoforms an
8 pheral peptide residues and the roles of the hypervariable and germline CDR loops in engaging peptide
11 Using universal primers that amplify the hypervariable bacterial 16 S rRNA gene as a model system
12 thin filament proteins, and its sequence is hypervariable between fiber type and developmental isofo
14 e-directed mutagenesis now indicate that the hypervariable C-terminal region of beta5 plays no role i
17 CD1d affinities are further modulated by the hypervariable CDR3 beta loop, thereby defining a functio
18 receptor then contacts the peptide using the hypervariable CDR3 loops as the transition state decays
19 C ligand derives largely from the juxtaposed hypervariable CDR3 regions on the TCRalpha and TCRbeta c
21 , it is unclear if affinity mutations in the hypervariable CDRs generally impact antibody stability a
23 variations and the presence and structure of hypervariable chromosomal elements indicate that there i
26 R amplification and sequence analysis of the hypervariable D1/D2 region of the 26S rRNA gene for the
30 ese nonstructural proteins, nsP3, contains a hypervariable domain (HVD), which demonstrates very low
31 of nsp2 (the PLP2 protease domain [OTU], the hypervariable domain [HV], the putative transmembrane do
33 ylation, and amino acid sequence of the V1V2 hypervariable domain of gp120, while the recipient Envs
35 A filaments and identified a surface-exposed hypervariable domain that contains the immunodominant Es
36 ar domains: a conserved N-terminal domain, a hypervariable domain, and an acidic C-terminal domain.
37 rved N-terminal domain of VP90 but lacks the hypervariable domain, which forms the capsid surface spi
38 those of other teams have demonstrated that hypervariable domains (HVDs) of the alphavirus nsP3 prot
39 e receptor and the surface (SU) glycoprotein hypervariable domains are required for binding affinity
40 t population turnover of the V1-V2 and V4-V5 hypervariable domains of the human immunodeficiency viru
41 tudy, acquisition of length in the Env gp120 hypervariable domains was shown to correlate with resist
42 zation, chimeras containing heterologous Rab hypervariable domains were generated, and their ability
46 and gene copy number variation (CNV) at the hypervariable DRB locus within the MHC region to HPV ser
48 mutations by acting like a blanket over the hypervariable epitope, thereby providing effective viral
50 de a transmembrane receptor protein with two hypervariable extracellular regions similar to immunoglo
54 three variable island regions, with the most hypervariable genes concentrated at one end of the genom
56 t strains identified, with (except for a few hypervariable genes) the EEHV2, EEHV3, and EEHV6 strains
57 by less than 1% within populations, even in hypervariable genome regions, and by 42-71% between popu
58 ndings uncover a novel and cryptic source of hypervariable genomic diversity with global regulatory c
63 Kupffer cell interaction is mediated by the hypervariable (HVR) loops of the virus hexon protein, we
64 Adaptive immunity in humans is provided by hypervariable Ig-like molecules on the surface of B and
66 These studies reveal sequences upstream, hypervariable in the human population (HVR3), and downst
68 BorreliaBase allows online identification of hypervariable lipoprotein genes, potential regulatory el
73 ns of Africa was therefore surprising as one hypervariable loop contains the entire collagen-binding
74 eir concave surface, in addition to a unique hypervariable loop in the C-terminal LRR capping module.
75 ht chains, the majority of CDR-L3 [the third hypervariable loop of the light chain variable domain (V
76 ally divergent face of the protein formed by hypervariable loop segments, confirming that TRIM5alpha
77 ity (together with the local dynamics of the hypervariable loop within domain 3) could facilitate rec
78 P.falciparum isolates demonstrates that the hypervariable loop within Stevor and Pfmc-2TM proteins p
80 Neutralization epitopes localize to three hypervariable loops in the distal portion of the protrud
82 ity in structure is most apparent in the six hypervariable loops of the complementarity-determining r
84 Antibodies recognize antigens through six hypervariable loops, five of which have a limited set of
85 e heavy and light chain each providing three hypervariable loops, which are varied to generate divers
87 The haplotigs accurately characterized the hypervariable major histocompatability complex region as
91 study reveals that a previously undescribed hypervariable molecule bearing three extracellular domai
92 orphisms within the Helicobacter pylori CagL hypervariable motif (CagLHM) in gastric cancer-associate
98 al fusion of a reporter lacZ fragment to the hypervariable poly-Psi domain facilitated measurement of
100 e for viral replication, and the nsp2 middle hypervariable region (aa 324 to 813) tolerated 100-aa or
101 kines was localized to 40 amino acids in the hypervariable region (amino acids 301-340) of the protei
102 me of the hepatitis E virus (HEV) contains a hypervariable region (HVR) in ORF1 that tolerates small
103 rnesylated and positively charged C-terminal hypervariable region (HVR) is critical to its oncogenic
104 sed on chromosomal DNA fingerprints (CDF), a hypervariable region (HVR) of a 5.6-kb plasmid, the rRNA
105 man ribosomal protein S17 (RPS17) within the hypervariable region (HVR) of the HEV ORF1 protein.
107 n, predominately against the surface-exposed hypervariable region (HVR) rather than against the invar
109 Comparative sequence analysis revealed a hypervariable region (HVR) with extensive sequence varia
110 cently, insertions and rearrangements of the hypervariable region (HVR) within the HEV genome, allowi
111 -Ras4B is predominantly autoinhibited by its hypervariable region (HVR), whereas the GTP-bound state
112 Previous studies have shown that the first hypervariable region (V1 loop) is immunogenic on soluble
113 ies (NAbs) that primarily targeted the first hypervariable region (V1 loop) of gp120, although SF162g
115 amino acid quasispecies complexities of the hypervariable region 1 (HVR-1) were less in the responde
117 edly reduced binding when amino acids within hypervariable region 1 (HVR1) and at sites approximately
120 which we find maps to a specific site within hypervariable region 1 (HVR1) of AdV5 hexon, has no appa
121 f HCV and shielding of important epitopes by hypervariable region 1 (HVR1) of E2 are believed to be m
126 to Huh7.5 cells to produce a quasispecies of hypervariable region 1 (HVR1) that mimicked that circula
133 d, ranging from high diversity (the envelope hypervariable region 1 [HVR1]) to almost no diversity (t
134 on of SR-BI governed by specific residues in hypervariable region 1 of E2 leading to enhanced cell en
137 is virus (VSV)/HCV pseudotype model that the hypervariable region 1 of the HCV E2 envelope glycoprote
138 o 986 present-day human sequences located in hypervariable region 1 of the mitochondrion to estimate
141 equence revealed amino acid substitutions in hypervariable region 1 that were responsible for a drama
142 yethylene glycol to a specific site in hexon hypervariable region 1 yielded vector particles that wer
144 s, suggesting purifying selection, except in hypervariable region 1, where positive selection pressur
147 a single immunization of chimeric rAd5 hexon hypervariable region 48 (rAd5HVR48) vectors expressing S
148 igen (PA) as a model antigen to characterize hypervariable region 5 (HVR5) of hexon as a site for pep
149 MiSeq and Roche454 platforms using the V3-V4 hypervariable region also showed a high level of concord
150 ue to a mixture of P44 proteins with diverse hypervariable region amino acid sequences expressed by a
151 Neisserial mod alleles also contained a hypervariable region and all mod alleles exhibited varia
158 lysis indicated that most sites outside this hypervariable region experienced strong negative selecti
159 extension containing a His- and Asp/Glu-rich hypervariable region followed by a highly conserved sequ
160 d for identification of the 16S rRNA gene V3 hypervariable region from Escherichia coli genomic DNA.
161 two primer pairs demonstrated that the V3-V4 hypervariable region had significantly better capture of
162 etion variants of UreG demonstrated that the hypervariable region has a minor impact on activation ef
164 60 million molecules) of human mitochondrial hypervariable region II amplicon was introduced into the
165 Here we show that the human mitochondrial hypervariable region II can function as a molecular fing
166 esent high-throughput sequencing analysis of hypervariable region II for spatial resolution of the co
167 the structural and physiological role of the hypervariable region in flagella assembly, stability and
169 on-typeable H.influenzae isolates revealed a hypervariable region in the central portion of the mod g
170 e induction of Gal-3 expression requires the hypervariable region in the extracellular domain of beta
171 sitive to GM-CSF, mutations within the N-Ras hypervariable region induced N-Ras mislocalization and a
172 in primary structure within the immunogenic hypervariable region microdomains and tested whether the
173 ted nanoclustering of H-ras helix alpha4 and hypervariable region mutants that have different bona fi
174 .1 M bacterial pyrotag sequences from the V6 hypervariable region of 16S rRNA genes from 38 influent
175 human hepatoma cells when inserted into the hypervariable region of a genotype 1 strain, but this ch
177 a crucial but commonly coded residue in the hypervariable region of CDR3 provide the basis for the s
178 anged p44Es revealed that the entire central hypervariable region of donor p44 pseudogenes or of dono
179 rough elevated signal produced to the unique hypervariable region of each - 2/114 in HL-60, 3/114 in
182 tration calorimetry, we demonstrate that the hypervariable region of K-Ras4B contributes in a major w
183 histocompatibility antigens, we examined one hypervariable region of mtDNA, designated hypervariable
184 r results show that in the murine model, the hypervariable region of PilE is required to activate imm
185 nal structure-based antigen by replacing the hypervariable region of PilE with an aspartate-glutamine
186 ly bound to the CAAX motif in the C-terminal hypervariable region of Rac1, and then inhibited Rac1 me
187 zed by bar-coded pyrosequencing of the V3-V5 hypervariable region of the 16S rRNA gene, defining 662
188 ent study, using pyrosequencing of the V1-V2 hypervariable region of the 16S rRNA gene, reported find
191 idase subunit 1 gene of nematodes and the V3 hypervariable region of the bacterial 16 s ribosomal RNA
192 d a tag-sequencing strategy targeting the V6 hypervariable region of the bacterial small-subunit (16S
193 ndings indicate that sequence variation in a hypervariable region of the degron affects JAZ stability
195 This residue is located in the C-terminal hypervariable region of the proteins and is not conserve
196 several single-nucleotide substitutions in a hypervariable region outside the SAM-binding core can al
197 g GC and AT rich motifs correlated well with hypervariable region recombination sites across the HAdV
199 ing more than 1.7 million bacterial 16S rRNA hypervariable region sequences from 52 to 56 samples per
200 a gonorrhoeae and contains a surface-exposed hypervariable region thought to be one feature of pili t
201 had greater accuracy than sequencing of the hypervariable region V4 in determining genus and species
205 -DR alleles sharing amino acids at the third hypervariable region with DRB1*0401(shared epitope) are
207 e, and -f were mapped within the nsp2 middle hypervariable region, but no conserved cleavage sites co
209 Results obtained from the V3-V4 16S rRNA hypervariable region, sequencing on the MiSeq and Roche4
210 key changes to the lipidation pattern of the hypervariable region, suggest that dimerization is a gen
211 mice, suggesting that in the absence of the hypervariable region, the conserved regions of PilE alon
221 monella typhimurium phase 1 flagellin, this "hypervariable" region encodes two solvent-exposed domain
224 ing antibodies typically recognize M protein hypervariable regions (HVRs) and confer narrow protectio
225 at CaM preferentially binds unfolded K-Ras4B hypervariable regions (HVRs) and not alpha-helical HVRs.
226 h substantial sequence homology in the hexon hypervariable regions (HVRs) and suppressed the immunoge
228 maeric rAd5 vectors in which the seven short hypervariable regions (HVRs) on the surface of the Ad5 h
229 us catalytic domains and flexible C-terminal hypervariable regions (HVRs) that differ across Ras isof
232 to potential N-linked glycosylation sites in hypervariable regions (V1 to V3) of the env gene of HIV
234 tes microbial communities, but sequencing of hypervariable regions 1-3 of the 16S rRNA gene provides
235 hanges both within the traditionally defined hypervariable regions and downstream, near the 3'-end of
236 r multiple markers such as the 16S rRNA gene hypervariable regions are available, MetAmp improves the
237 ts and the genes from the other intraspecies hypervariable regions contributes to a better assessment
239 cally infected individuals by sequencing the hypervariable regions encoding TCR alpha and beta polype
240 identified in at least two of five examined hypervariable regions for every virus, suggesting the ev
241 g it into our Ad5 vector containing all nine hypervariable regions from Ad43, Ad5.H(43m-43), increase
242 the specific amplification of 18s rRNA gene hypervariable regions from eukaryotic microbes: anneal-i
247 nd ESPRIT-Tree, sequence data from different hypervariable regions of 16S rRNA were used and binning
248 serotype 5 (Ad5) vector containing the hexon hypervariable regions of Ad serotype 48 (Ad48) and expre
249 hexon-modified vector that carried the hexon hypervariable regions of Ad48, indicating that the SP mu
251 Finally, features of the first and second hypervariable regions of gp120 (V1V2) may be critical fo
252 oes is efficiently surveyed by sequencing of hypervariable regions of the 16s ribosomal RNA (rRNA) ge
253 lyzed by FLX+ pyrosequencing of the V1 to V4 hypervariable regions of the 16S rRNA gene and polymeras
254 Unique melt profiles generated from multiple hypervariable regions of the 16S rRNA gene for 100 clini
255 DNA was amplified with primer pairs covering hypervariable regions of the 16S rRNA gene: primers 63F
258 Conventional genotyping methods target small hypervariable regions of the M. bovis genome and provide
260 ences between D1 domains are concentrated in hypervariable regions on the front sheet strands of the
261 s in the mtDNA control region, including the hypervariable regions typically sequenced in a forensic
262 two species by pyrosequencing the 16S V1-V3 hypervariable regions using the 454 GS FLX Titanium plat
263 pected microbial profiles, sequencing of the hypervariable regions V1-V3 of the 16S ribosomal RNA gen
265 analysis indicates that alternative 16S rRNA hypervariable regions will present similar challenges, w
266 s identified as phage morons were located in hypervariable regions within individual SVMs, indicating
268 method also identified 18 other intraspecies hypervariable regions, such as the capsule and lipooligo
279 alyzed 815,377 autosomal SNPs, mitochondrial hypervariable segments I and II, and 36 Y-chromosome STR
280 r 32 lineage-defining mitochondrial SNPs and hypervariable sequence (HVS) 1, Tamil castes have higher
281 The custom database was generated using the hypervariable sequences of the internal transcribed spac
285 ison, deletion of loop 2, which contains the hypervariable splice region, did not reduce the ability
291 composition through the use of 16S rRNA gene hypervariable tag sequencing has profound health implica
292 t microbial populations were generated using hypervariable tag sequencing of the V3-V5 region of the
294 this family of genes are characterized by a hypervariable "toxin" region capable of encoding a wide
295 rived from next-generation sequencing of the hypervariable V3 region of the 16S ribosomal RNA gene sh
296 acer using two approaches, pyrosequencing of hypervariable V3-V5 regions of the 16S rRNA gene and who
297 f linear peptides corresponding to the third hypervariable (V3) loop of gp120 failed to inhibit serum
298 Pro(313)-Gly(314)-Arg(315) arch of the third hypervariable (V3) loop of the HIV-1 surface glycoprotei
299 associated multigene families, including the hypervariable var genes, is broadly conserved, but P. fa
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