ライフサイエンスコーパス: hypervariable region

1 arnesylated-methylated KRAS4b, including the hypervariable region.

2 obility analysis of the second envelope gene hypervariable region.

3 ha and Vbeta chain usage, and throughout the hypervariable region.

4 ed flanking domains and the other within the hypervariable region.

5 A gene sequences by more than 80% for the V4 hypervariable region.

6 r more p44 species were found within the p44 hypervariable region.

7 racterized by conserved sequences flanking a hypervariable region.

8 y charged lysine at position 12 of the first hypervariable region.

9 id pattern as well as a distinctive 16S rRNA hypervariable region.

10 ed except for sequence that encoded the MSP2 hypervariable region.

11 lyzed using 16S rRNA sequencing of the V3-V4 hypervariable region.

12 nt cells, and we mapped this activity to the hypervariable region.

13 regions, including splice site acceptors and hypervariable regions.

14 imilar magnitude were found in conserved and hypervariable regions.

15 have the same canonical structures in their hypervariable regions.

16 anonical structure in their first and second hypervariable regions.

17 ites for peptide-MHC complexes formed by six hypervariable regions.

18 arranged T cell receptor beta (TCRbeta) gene hypervariable regions.

19 not exclusively, directed against the hexon hypervariable regions.

20 is is further complicated by the presence of hypervariable regions.

21 of hepatitis C virus (HCV) contains several hypervariable regions.

22 Viral quasispecies in the second envelope hypervariable region 1 (E2/HVR1) and 5' untranslated reg

23 A population study of heteroplasmy in the hypervariable region 1 (HV1) portion of the human mtDNA

24 ne hypervariable region of mtDNA, designated hypervariable region 1 (HV1).

25 amino acid quasispecies complexities of the hypervariable region 1 (HVR-1) were less in the responde

26 Hypervariable region 1 (HVR1) (amino acids [aa] 384 to 4

27 edly reduced binding when amino acids within hypervariable region 1 (HVR1) and at sites approximately

28 Phylogenetic analysis of hypervariable region 1 (HVR1) and HCV genotyping were pe

29 In the mild fibrosis group, intrasample hypervariable region 1 (HVR1) genetic distance and nonsy

30 HCV internal ribosomal entry site (IRES) and hypervariable region 1 (HVR1) in autopsy-derived brain,

31 Hypervariable region 1 (HVR1) is genetically diverse and

32 A hyperimmune rabbit antiserum to an E2 hypervariable region 1 (HVR1) mimotope also exhibited an

33 Interestingly, the E2 hypervariable region 1 (HVR1) mutation T385P caused (i)

34 which we find maps to a specific site within hypervariable region 1 (HVR1) of AdV5 hexon, has no appa

35 f HCV and shielding of important epitopes by hypervariable region 1 (HVR1) of E2 are believed to be m

36 The hypervariable region 1 (HVR1) of hepatitis C virus (HCV)

37 Hypervariable region 1 (HVR1) of hepatitis C virus (HCV)

38 Furthermore, replacement of hypervariable region 1 (HVR1) of the Ad capsid proteins

39 studies suggested that genetic variation in hypervariable region 1 (HVR1) of the second envelope pro

40 Evolutionary rates in the hypervariable region 1 (HVR1) region of the E2 gene were

41 Remarkably, sequences of hypervariable region 1 (HVR1) remained stable for up to

42 to Huh7.5 cells to produce a quasispecies of hypervariable region 1 (HVR1) that mimicked that circula

43 Hypervariable region 1 (HVR1) variability is frequently

44 Hypervariable region 1 (HVR1) within viral envelope prot

45 notype-specific epitopes of HCV core, E1, E2 hypervariable region 1 (HVR1), E2 HVR1-plus-HVR2 consens

46 of cDNA that spanned the E1 gene and the E2 hypervariable region 1 (HVR1), followed by analysis of c

47 We obtained sequences from the HCV hypervariable region 1 (HVR1), using end-point limiting-

48 tensive mutations were not incorporated into hypervariable region 1 (HVR1).

49 ains a highly variable region referred to as hypervariable region 1 (HVR1).

50 instead of the well-known immunodominant E2 hypervariable region 1 (HVR1).

51 plotypes that had identical sequences in the hypervariable region 1 (HVR1).

52 s-immunoreactivity among variants of the HCV hypervariable region 1 (HVR1).

53 d, ranging from high diversity (the envelope hypervariable region 1 [HVR1]) to almost no diversity (t

54 te populations, we compared mtDNA (400 bp of hypervariable region 1 and 14 restriction site polymorph

55 paA/B proteins confirmed the central role of hypervariable region 1 in receptor binding and demonstra

56 h relapse were virtually identical, with the hypervariable region 1 of E2 appearing to be monoclonal,

57 on of SR-BI governed by specific residues in hypervariable region 1 of E2 leading to enhanced cell en

58 terized epitopes on E1/E2, especially to the hypervariable region 1 of E2.

59 out the envelope genes, primarily within the hypervariable region 1 of E2.

60 is virus (VSV)/HCV pseudotype model that the hypervariable region 1 of the HCV E2 envelope glycoprote

61 o 986 present-day human sequences located in hypervariable region 1 of the mitochondrion to estimate

62 Hypervariable region 1 of the second envelope gene was a

63 Most NAbs recognize hypervariable region 1 on E2, which undergoes frequent m

64 equence revealed amino acid substitutions in hypervariable region 1 that were responsible for a drama

65 yethylene glycol to a specific site in hexon hypervariable region 1 yielded vector particles that wer

66 Deletion of hypervariable region 1, a region previously proposed to

67 so generated serological responses to OMP-1g hypervariable region 1, indicating that humans and mice

68 cases, correlate also with antibodies to the hypervariable region 1, previously thought to be the pri

69 s, suggesting purifying selection, except in hypervariable region 1, where positive selection pressur

70 species diversity was analyzed by sequencing hypervariable region 1.

71 nfectivity of J6(2a) and J8(2b) with deleted hypervariable region 1.

72 lotype analysis and direct sequencing of the hypervariable regions 1 and 2 of the D-loop in muscle an

73 tes microbial communities, but sequencing of hypervariable regions 1-3 of the 16S rRNA gene provides

74 The HCV E2 hypervariable region-1 was amplified using nested revers

75 this finding with previous reports that the hypervariable region 3 (V3) of gp120 plays an important

76 We aligned time-stamped second hypervariable region (330 bp) of G-gene sequence data (g

77 uted the majority of binding energy, whereas hypervariable region 4 (HV4) and framework region 3 (FR3

78 Sequencing of hypervariable region 4 poorly captures skin commensal mi

79 a single immunization of chimeric rAd5 hexon hypervariable region 48 (rAd5HVR48) vectors expressing S

80 igen (PA) as a model antigen to characterize hypervariable region 5 (HVR5) of hexon as a site for pep

81 f P. aeruginosa OprF (Epi8) in loop 1 of the hypervariable region 5 of the hexon (AdZ.Epi8).

82 l with mutations in the surface glycoprotein hypervariable regions: a previously identified variant c

83 e for viral replication, and the nsp2 middle hypervariable region (aa 324 to 813) tolerated 100-aa or

84 MiSeq and Roche454 platforms using the V3-V4 hypervariable region also showed a high level of concord

85 oximately 30 to 35 kDa consisting of several hypervariable regions alternating with conserved regions

86 ue to a mixture of P44 proteins with diverse hypervariable region amino acid sequences expressed by a

87 kines was localized to 40 amino acids in the hypervariable region (amino acids 301-340) of the protei

88 Neisserial mod alleles also contained a hypervariable region and all mod alleles exhibited varia

89 Analysis of the szp gene hypervariable region and the 16S-23S rRNA intergenic spa

90 hanges both within the traditionally defined hypervariable regions and downstream, near the 3'-end of

91 sing from the crystal structure that include hypervariable regions and the epitope of a neutralizing

92 creased frequency of B cells with long third hypervariable regions, and distal J(kappa) gene segment

93 Inspection of the size of their hypervariable regions, and of sites that contain key res

94 r multiple markers such as the 16S rRNA gene hypervariable regions are available, MetAmp improves the

95 hout the primary amino acid sequence, with a hypervariable region at its C-terminus.

96 The hemagglutinin (H) gene and hypervariable region between the fusion and matrix genes

97 e, and -f were mapped within the nsp2 middle hypervariable region, but no conserved cleavage sites co

98 ive RNA splicing primarily in its N-terminal hypervariable region, but the functions of these isoform

99 3 million 16S rRNA sequences spanning the V4 hypervariable region by pyrosequencing.

100 n p44 conserved regions flanking the central hypervariable region by the TOPALi analysis.

101 the second constant region through the fifth hypervariable region (C2 to V5) of the surface envelope

102 While the hypervariable region CDR3 often mediates much of the spe

103 ts and the genes from the other intraspecies hypervariable regions contributes to a better assessment

104 The hypervariable region D2 and D3 domains appear to stabili

105 dies demonstrate that sequences in the third hypervariable region determine the specificity of corece

106 The hypervariable region determined to which membrane compar

107 Only the C-terminal hypervariable regions differ significantly.

108 We propose that this hypervariable region encodes the target recognition doma

109 monella typhimurium phase 1 flagellin, this "hypervariable" region encodes two solvent-exposed domain

110 cally infected individuals by sequencing the hypervariable regions encoding TCR alpha and beta polype

111 lysis indicated that most sites outside this hypervariable region experienced strong negative selecti

112 The p44 genes include a central hypervariable region flanked by conserved regions.

113 se pseudogenes encode unique surface-exposed hypervariable regions flanked by conserved domains, whic

114 extension containing a His- and Asp/Glu-rich hypervariable region followed by a highly conserved sequ

115 identified in at least two of five examined hypervariable regions for every virus, suggesting the ev

116 d for identification of the 16S rRNA gene V3 hypervariable region from Escherichia coli genomic DNA.

117 Partial deletion of the second hypervariable region from the envelope of the primary-li

118 g it into our Ad5 vector containing all nine hypervariable regions from Ad43, Ad5.H(43m-43), increase

119 the specific amplification of 18s rRNA gene hypervariable regions from eukaryotic microbes: anneal-i

120 two primer pairs demonstrated that the V3-V4 hypervariable region had significantly better capture of

121 etion variants of UreG demonstrated that the hypervariable region has a minor impact on activation ef

122 ta domains shows that their first and second hypervariable regions have one of three or four differen

123 by the novel gene p44-61 (p44-61/18), whose hypervariable region (hv) was a chimera of p44-20hv and

124 Second, in the two hypervariable regions HVa and HVb, thought to be involve

125 MSP2 has a central hypervariable region (HVR) flanked by highly conserved a

126 face protein 2 (MSP2), composed of a central hypervariable region (HVR) flanked by highly conserved r

127 me of the hepatitis E virus (HEV) contains a hypervariable region (HVR) in ORF1 that tolerates small

128 rnesylated and positively charged C-terminal hypervariable region (HVR) is critical to its oncogenic

129 sed on chromosomal DNA fingerprints (CDF), a hypervariable region (HVR) of a 5.6-kb plasmid, the rRNA

130 Signals in the carboxy-terminal hypervariable region (HVR) of Rho and Ras GTPases target

131 man ribosomal protein S17 (RPS17) within the hypervariable region (HVR) of the HEV ORF1 protein.

132 A hypervariable region (HVR) previously identified in the

133 n, predominately against the surface-exposed hypervariable region (HVR) rather than against the invar

134 Between these two ends is a hypervariable region (HVR) that is only poorly conserved

135 Comparative sequence analysis revealed a hypervariable region (HVR) with extensive sequence varia

136 st distribution of polymorphisms occurs in a hypervariable region (HVR) within the carboxy third of t

137 cently, insertions and rearrangements of the hypervariable region (HVR) within the HEV genome, allowi

138 -Ras4B is predominantly autoinhibited by its hypervariable region (HVR), whereas the GTP-bound state

139 genetic distance and entropy were highest in hypervariable region (HVR)-1.

140 of the HCV envelope gene including the first hypervariable region (HVR-1) was reverse transcription-P

141 egments from multiple alleles to form unique hypervariable regions (HVR).

142 elatively conserved and a second, so-called 'hypervariable region' (HVR).

143 Reactivity of antibody against the first hypervariable region (HVR1) of HCV in donor and recipien

144 quence diversity and complexity at the first hypervariable region (HVR1) of the second envelope prote

145 Replacing hypervariable regions (HVRs) 1, 2, 4, and 5 with the equ

146 ing antibodies typically recognize M protein hypervariable regions (HVRs) and confer narrow protectio

147 at CaM preferentially binds unfolded K-Ras4B hypervariable regions (HVRs) and not alpha-helical HVRs.

148 h substantial sequence homology in the hexon hypervariable regions (HVRs) and suppressed the immunoge

149 Since hypervariable regions (HVRs) are nonconserved among hexo

150 rface-exposed regions of the capsid, such as hypervariable regions (HVRs) I to IX of VP3.

151 maeric rAd5 vectors in which the seven short hypervariable regions (HVRs) on the surface of the Ad5 h

152 us catalytic domains and flexible C-terminal hypervariable regions (HVRs) that differ across Ras isof

153 amino acid sequence variations confirms four hypervariable regions (HVRs), separated by regions under

154 FX binds to the adenovirus hexon hypervariable regions (HVRs).

155 (NAbs) directed primarily against the hexon hypervariable regions (HVRs).

156 set in which the DNA sequence data come from hypervariable region I and the mutation of interest is t

157 -446 (epitope II), located downstream of the hypervariable region I within the HCV E2 protein.

158 Of 15 BDS strain clones, 1 had a hypervariable region identical to the region in a clone

159 Five regions of hypervariable region II (HVII) of the control region wer

160 60 million molecules) of human mitochondrial hypervariable region II amplicon was introduced into the

161 Here we show that the human mitochondrial hypervariable region II can function as a molecular fing

162 esent high-throughput sequencing analysis of hypervariable region II for spatial resolution of the co

163 the structural and physiological role of the hypervariable region in flagella assembly, stability and

164 ed sequence blocks throughout the MSP2 (P44) hypervariable region in reservoir hosts.

165 on-typeable H.influenzae isolates revealed a hypervariable region in the central portion of the mod g

166 e induction of Gal-3 expression requires the hypervariable region in the extracellular domain of beta

167 Pyrosequencing of amplicons for hypervariable regions in the 16S rRNA gene generated tax

168 oci within A. lyrata, sites corresponding to hypervariable regions in the Brassica S-loci (SLG and SR

169 Thus, for at least the first and second hypervariable regions in the currently known structures,

170 16S rRNA per cells and also the presence of hypervariable regions in the genes.

171 unique, sexually dimorphic motifs in the TCR hypervariable regions in the SjS(S) mice.

172 These hypervariable regions include sites with three segregati

173 conversion of the entire (nonsegmental) p44 hypervariable region including flanking regions with a c

174 sitive to GM-CSF, mutations within the N-Ras hypervariable region induced N-Ras mislocalization and a

175 that the P44 antigenic repertoire within the hypervariable region is restricted.

176 th most of the differences restricted to the hypervariable regions known to undergo sequence variatio

177 differences in the primary sequences of the hypervariable region manifest in different secondary str

178 genomic expression site encoding the central hypervariable region matched sequence polymorphisms in m

179 in primary structure within the immunogenic hypervariable region microdomains and tested whether the

180 QA1*0501, and DRB1 alleles sharing the first hypervariable region motif (9)EYSTS(13) were major risk

181 ted nanoclustering of H-ras helix alpha4 and hypervariable region mutants that have different bona fi

182 We further identified a hypervariable region of 15 residues and a beta-hairpin s

183 .1 M bacterial pyrotag sequences from the V6 hypervariable region of 16S rRNA genes from 38 influent

184 human hepatoma cells when inserted into the hypervariable region of a genotype 1 strain, but this ch

185 g a shift from recombination of the complete hypervariable region of a given pseudogene to complex mo

186 MSP2 contains a central hypervariable region of about 100 amino acids that encod

187 s recovered, 39 recognized an amino-terminal hypervariable region of an outer membrane protein (OMP),

188 plified by using primers specific for the V6 hypervariable region of bacterial 16s rRNA.

189 a crucial but commonly coded residue in the hypervariable region of CDR3 provide the basis for the s

190 anged p44Es revealed that the entire central hypervariable region of donor p44 pseudogenes or of dono

191 rough elevated signal produced to the unique hypervariable region of each - 2/114 in HL-60, 3/114 in

192 of the P28s were identified within the first hypervariable region of each P28 OMP.

193 The conservation of the hypervariable region of each p44 cDNA species of A. phag

194 oduplex tracking assay targeted to the V1/V2 hypervariable region of env.

195 utagenesis studies revealed that the central hypervariable region of flagellin is essential for the T

196 The hypervariable region of K-Ras4B binds specifically to th

197 tration calorimetry, we demonstrate that the hypervariable region of K-Ras4B contributes in a major w

198 nce for four short sequential changes in the hypervariable region of msp2 coupled with the identifica

199 histocompatibility antigens, we examined one hypervariable region of mtDNA, designated hypervariable

200 recognized a linear epitope within the first hypervariable region of OMP-1g.

201 topes within the amino terminus of the first hypervariable region of OMP-1g.

202 n the conserved regions flanking the central hypervariable region of p44 genes.

203 Development of antibody to the hypervariable region of P44-18 during the rickettsemia s

204 r results show that in the murine model, the hypervariable region of PilE is required to activate imm

205 nal structure-based antigen by replacing the hypervariable region of PilE with an aspartate-glutamine

206 ly bound to the CAAX motif in the C-terminal hypervariable region of Rac1, and then inhibited Rac1 me

207 ow that elements in the known domains in the hypervariable region of Ras (amino acids 170-189) intera

208 A mutation in the lysine repeat in the hypervariable region of Rsr1/Bud1 specifically abolished

209 The cDNA sequences of the central hypervariable region of several p44 genes were identical

210 zed by bar-coded pyrosequencing of the V3-V5 hypervariable region of the 16S rRNA gene, defining 662

211 ent study, using pyrosequencing of the V1-V2 hypervariable region of the 16S rRNA gene, reported find

212 Our study included the analysis of the D1/D2 hypervariable region of the 28S ribosomal gene and the i

213 We were able to assemble the D1-D2 hypervariable region of the 28S ribosomal RNA (rRNA) of

214 This virus was unusual in that the hypervariable region of the adapted virus contained a 17

215 idase subunit 1 gene of nematodes and the V3 hypervariable region of the bacterial 16 s ribosomal RNA

216 d a tag-sequencing strategy targeting the V6 hypervariable region of the bacterial small-subunit (16S

217 Furthermore, the E hypervariable region of the capsid protein appears to pl

218 ndings indicate that sequence variation in a hypervariable region of the degron affects JAZ stability

219 relatively small genomic segment, the first hypervariable region of the E2 gene, it is possible that

220 manifestations of disease are clustered in a hypervariable region of the genome termed the plasticity

221 rminants of macrophage infectivity to the V3 hypervariable region of the HIV-1 envelope glycoprotein.

222 s a 5-aa sequence motif in the third allelic hypervariable region of the HLA-DRbeta chain.

223 riable regions of Sic and the amino terminal hypervariable region of the M1 protein.

224 This residue is located in the C-terminal hypervariable region of the proteins and is not conserve

225 two attenuated viral variants differing in a hypervariable region of the spike protein.

226 al property variations of the NH(2)-terminal hypervariable region of TnT may have a role in tuning th

227 ligonucleotide gold nanoprobe for one of the hypervariable regions of 16S rRNA gene.

228 nd ESPRIT-Tree, sequence data from different hypervariable regions of 16S rRNA were used and binning

229 cultures of strains NY-31, NY-36, and NY-37, hypervariable regions of 450 deduced amino acid sequence

230 serotype 5 (Ad5) vector containing the hexon hypervariable regions of Ad serotype 48 (Ad48) and expre

231 hexon-modified vector that carried the hexon hypervariable regions of Ad48, indicating that the SP mu

232 o complex mosaics with segments derived from hypervariable regions of different pseudogenes.

233 In these hybrid glycoproteins the hypervariable regions of EHV-1 gG, a vCKBP, and the clos

234 Finally, features of the first and second hypervariable regions of gp120 (V1V2) may be critical fo

235 peptides representing the N- and C-terminal hypervariable regions of murine rab3D recognized a prote

236 oes is efficiently surveyed by sequencing of hypervariable regions of the 16s ribosomal RNA (rRNA) ge

237 lyzed by FLX+ pyrosequencing of the V1 to V4 hypervariable regions of the 16S rRNA gene and polymeras

238 Unique melt profiles generated from multiple hypervariable regions of the 16S rRNA gene for 100 clini

239 dot blot hybridization, by sequences of two hypervariable regions of the 16S rRNA gene, and by the p

240 DNA was amplified with primer pairs covering hypervariable regions of the 16S rRNA gene: primers 63F

241 iversity of sequence, primarily localized to hypervariable regions of the capsid protein, was detecte

242 The rates of evolution within hypervariable regions of the FCV capsid gene in individu

243 an interaction between the FX Gla domain and hypervariable regions of the hexon surface.

244 ensic identity testing by sequencing the two hypervariable regions of the human mtDNA control region.

245 Conventional genotyping methods target small hypervariable regions of the M. bovis genome and provide

246 is phosphorylated at sites clustered in two hypervariable regions of the protein.

247 The first and second hypervariable regions of Valpha and Vbeta domains are en

248 ences between D1 domains are concentrated in hypervariable regions on the front sheet strands of the

249 bit antisera raised against either the first hypervariable region or ectodomain of E2 showed limited

250 several single-nucleotide substitutions in a hypervariable region outside the SAM-binding core can al

251 g GC and AT rich motifs correlated well with hypervariable region recombination sites across the HAdV

252 The C terminus, also known as the hypervariable region (residues 166-189), of H-, N-, and

253 terminal conserved region and P44-18 central hypervariable region, respectively.

254 lagellin mutant composed of only the central hypervariable region retained substantial TNF-alpha-indu

255 Mutational analysis of the hypervariable region revealed that it contains two equal

256 quences follows the pattern of conserved and hypervariable regions seen in other S-RNases, but no reg

257 The hypervariable region sequence in the p44 expression locu

258 The K-Ras4A hypervariable region sequence is positively charged, in

259 elope protein (Env) by replacing part of its hypervariable region sequence with a sequence encoding t

260 ing more than 1.7 million bacterial 16S rRNA hypervariable region sequences from 52 to 56 samples per

261 Results obtained from the V3-V4 16S rRNA hypervariable region, sequencing on the MiSeq and Roche4

262 ive usage of each T-cell receptor beta chain hypervariable region subfamily.

263 method also identified 18 other intraspecies hypervariable regions, such as the capsule and lipooligo

264 key changes to the lipidation pattern of the hypervariable region, suggest that dimerization is a gen

265 rmining residues (SDRs), the residues of the hypervariable region that are most critical in Ag-Ab int

266 ermini flanking the central, surface-exposed hypervariable region that represents the variant B lymph

267 n that all serotypes have in common from the hypervariable regions that are responsible for capsid di

268 The sequences of several hypervariable regions that were > or = 97% similar to re

269 mice, suggesting that in the absence of the hypervariable region, the conserved regions of PilE alon

270 By looping out the hypervariable region, the porin structure is conserved a

271 a gonorrhoeae and contains a surface-exposed hypervariable region thought to be one feature of pili t

272 s in the mtDNA control region, including the hypervariable regions typically sequenced in a forensic

273 existence of a conserved region linked to a hypervariable region upstream of the 16S rRNA gene of H.

274 two species by pyrosequencing the 16S V1-V3 hypervariable regions using the 454 GS FLX Titanium plat

275 pected microbial profiles, sequencing of the hypervariable regions V1-V3 of the 16S ribosomal RNA gen

276 Previous studies have shown that the first hypervariable region (V1 loop) is immunogenic on soluble

277 ies (NAbs) that primarily targeted the first hypervariable region (V1 loop) of gp120, although SF162g

278 to potential N-linked glycosylation sites in hypervariable regions (V1 to V3) of the env gene of HIV

279 lope glycoproteins, the presence of all five hypervariable regions (V1 to V5) was required for optima

280 We used DNA from hypervariable regions (V1-V2) of 16S bacteria rRNA to de

281 The 16s rRNA hypervariable regions V3 and V6 were amplified from Kleb

282 had greater accuracy than sequencing of the hypervariable region V4 in determining genus and species

283 The 16S RNA hypervariable region V4 was sequenced on Illumina MiSeq.

284 sequencing based on the bacterial 16 S rRNA hypervariable region V4.

285 The hypervariable region was subdivided into five domains, i

286 ehrlichiosis (HGE) with primers flanking the hypervariable region, we show differential expression in

287 gG variants containing the EHV-1 hypervariable region were able to bind chemokines and we

288 No significant differences in the hypervariable region were found when we compared p44 seq

289 Complexity and diversity in the first hypervariable region were similar in the 2 groups.

290 d by genetic manipulation of the murine CC49 hypervariable regions were evaluated for their relative

291 bster strain clones were examined, 18 unique hypervariable regions were identified.

292 Substantial differences in the hexon hypervariable regions were noted between C68 and other k

293 units by the PKS modules is influenced by a "hypervariable region", which could be manipulated via co

294 ting phage binding were located in these two hypervariable regions, which are likely to be exposed on

295 analysis indicates that alternative 16S rRNA hypervariable regions will present similar challenges, w

296 -DR alleles sharing amino acids at the third hypervariable region with DRB1*0401(shared epitope) are

297 he majority of their genomes but contained a hypervariable region with extensive divergence.

298 pha segments and 90 % of Vbeta segments have hypervariable regions with a conformation of one of the

299 s identified as phage morons were located in hypervariable regions within individual SVMs, indicating

300 l seven HAdV species, confirmed the uniquely hypervariable regions within species.