ライフサイエンスコーパス: hyphal

1 differential localization of slr1Delta/Delta hyphal and yeast morphologies within the kidney.

2 of concentrated endocytosis just behind the hyphal apex (the "endocytic collar"); and small, rapidly

3 ed dwelling times for MTs after reaching the hyphal apex.

4 nspicuous appearance at the MT ends near the hyphal apex.

5 of specific mRNAs play an important role in hyphal apical growth.

6 n oogonium shape, size, spine morphology and hyphal attachment between the Permian forms from the Pri

7 somes, followed by establishment of multiple hyphal branches elsewhere in the cell, revealing a profo

8 trunk and in some cases, a few initial thick hyphal branches.

9 Sch9) was defective in aerial hyphal growth, hyphal branching and conidial germination.

10 During normal growth, AfsK regulates hyphal branching by modulating branch-site selection and

11 ation of parasitic plant seeds, they enhance hyphal branching of arbuscular mycorrhizal fungi of the

12 During hyphal, but not yeast growth, secretory vesicles accumul

13 idue S584 was necessary for Sec2p to support hyphal, but not yeast growth.

14 14 retention on phagosomes was prolonged for hyphal cargo and was directly proportional to hyphal len

15 was indistinguishable, even though yeast and hyphal cell lengths differ by two- to fivefold, demonstr

16 pathogen Candida albicans, GlcNAc stimulates hyphal cell morphogenesis, virulence genes, and the gene

17 In the elongated hyphal cell of the fungus Ustilago maydis, Higuchi et al

18 ure of beta-glucan and chitin content on the hyphal cell surface, but diminished TNF production by bo

19 cture, we extracted glucans from C. albicans hyphal cell walls.

20 Intriguingly, hyphal cells display a slr1-6SA-GFP focus at the tip nea

21 The hyphal cells of filamentous fungi concentrate both exocy

22 tosis are strictly segregated at the ends of hyphal cells of filamentous fungi, with a collar of endo

23 Rim101, and genes characteristic of invasive hyphal cells.

24 ut are intermittently present throughout all hyphal cells; the region of concentrated endocytosis jus

25 ssil root nodules contain fungal arbuscules, hyphal coils, and vesicles in their cortex.

26 can interconnect plant root systems through hyphal common mycorrhizal networks, which may influence

27 tive dynamics of gene expression with single hyphal compartment resolution in response to carbon sour

28 Septation in Fgcdc14 was reduced and hyphal compartments contained multiple nuclei, indicatin

29 een trafficking long distances in nearly all hyphal compartments.

30 chitin, and beta-glucan are not the relevant hyphal components; instead, the recently identified fung

31 ability to adopt a non-branching vegetative hyphal conformation and rapidly transverse solid surface

32 were readily cotransmitted horizontally via hyphal contact to different vegetative compatibility gro

33 gorous ability to proliferate and spread via hyphal contact.

34 Hyphal contaminant dispersal may provide an untapped pot

35 sensing molecule that prevents the yeast to hyphal conversion.

36 logy characterized by poor hyphal extension, hyphal curvature and limited formation of conidia.

37 equire Fn and ERK but not ROS, and result in hyphal destruction.

38 Recent studies suggest that hyphal development in C. albicans requires two temporall

39 Hyphal development requires two temporally linked change

40 aling system with similarity to processes of hyphal development that are linked with virulence in rel

41 rg1 recruits Hda1 to promoters for sustained hyphal development, and BRG1 expression is a readout of

42 HIR operates as a crucial modulator of hyphal development, since genetic ablation of the HIR co

43 To better understand hyphal development, we examined the role of GlcNAc metab

44 ynamics, impaired endocytosis, and defective hyphal development, whereas a nonphosphorylatable Sla1 h

45 e expression of NRG1, the major repressor of hyphal development.

46 ly not possible due to the limited amount of hyphal differentiation.

47 Quantitative analysis of hyphal dimensions showed that the mycelial architecture

48 to inflammatory foci, leading to widespread hyphal dissemination to lung blood vessels.

49 atin-remodeling does not disrupt C. albicans hyphal elongation and virulence during invasive infectio

50 genetic screen for mutants that can sustain hyphal elongation in rich media, we found hog1, ssk2, an

51 Virulence and hyphal elongation in vivo are attenuated only when the p

52 CO2, but neither condition alone, maintains hyphal elongation, even in mutants lacking the nutrient-

53 phosphatases to activate BRG1 expression for hyphal elongation.

54 sition and size of the nuclei occur prior to hyphal entry into the cortical cells and do not require

55 necessary to enable hyphopodium formation or hyphal entry into the root but is essential to support a

56 mination in macrophages and also resulted in hyphal escape.

57 tributions to MT dynamics and unidirectional hyphal expansion in filamentous fungi.

58 Ascomycetes and EM fungi with short-contact hyphal exploration types.

59 of normal Golgi organization stops polarized hyphal extension and triggers de-polarization of the hyp

60 sents an adaptation that is as important for hyphal extension as is the presence of a Spitzenkorper.

61 Here we demonstrate that regulation of hyphal extension results at least in part, from an impor

62 an abnormal morphology characterized by poor hyphal extension, hyphal curvature and limited formation

63 of growth and exocytosis during intercalary hyphal extension, subapical branch initiation, septum fo

64 During hyphal extension, the growing tip may be separated from

65 ed by Cdk1, which is necessary for efficient hyphal extension.

66 Galpha proteins GNA-1 and GNA-3 to regulate hyphal extension.

67 class V myosin (myoE) is required for proper hyphal extension; deletion of myoE resulted in hyperbran

68 Addition of geldanamycin does not result in hyphal extensions at 30 degrees C in the gpr1Delta/gpr1D

69 ducted to determine the direct impact of AMF hyphal exudates on growth of the PSB.

70 (2) occurs concomitant with emergence of the hyphal filament.

71 In the fungal Ascomycota, CM is based on hyphal filaments and arose in the Pezizomycotina.

72 al transition from yeast to pseudohyphal and hyphal filaments, which is required for virulence.

73 Although mechanisms that regulate hyphal forces on the substrate during expansion have bee

74 switching from the yeast to the filamentous hyphal form following phagocytosis by macrophages, facil

75 ediating NF-kappaB activation induced by the hyphal form of C. albicans hyphae (Hyphae) but not by it

76 cells to discriminate between the yeast and hyphal form of C. albicans.

77 ctin-2 in response to the stimulation by the hyphal form of Candida albicans, an opportunistic pathog

78 icans cells more efficiently in their mature hyphal form than in their yeast form.

79 he phagosome in the presence of the invasive hyphal form, which favors fungal survival and escape.

80 es the number of fungal cells present in the hyphal form.

81 ce of SR-like RNA-binding protein Slr1 slows hyphal formation and decreases virulence in a systemic c

82 The impact of SLR1 deletion on hyphal formation and function thus may be partially due

83 Hyphal formation is a type of polarized growth, and memb

84 Hyphal formation is controlled by a multilayer regulator

85 biofilm formation through the inhibition of hyphal formation, a critical virulence trait.

86 ts in a delay in alkalinization, a defect in hyphal formation, and a reduction in the amount of ammon

87 enes required for suppression of C. albicans hyphal formation.

88 f fungus in FFPE tissues, demonstrating both hyphal forms and granular fungal antigens, and PCR ident

89 ible morphological changes between yeast and hyphal forms in response to environmental cues.

90 effectively discriminates between yeast and hyphal forms of C. albicans.

91 with dimorphic transition between yeast and hyphal forms, switching between white and opaque cells,

92 reater binding by Dectin-1 in both yeast and hyphal forms.

93 Germinated (hyphal) forms of the fungus evoke secretion of inflammat

94 Restoration of growth in hyphal fragments of both wild-type and ftsZ mutant hypha

95 perate in many filamentous fungi to regulate hyphal fusion between genetically dissimilar individuals

96 cluding immune defense, neuronal connection, hyphal fusion, and sexual reproduction.

97 Conidial melanin and hydrophobin as well as hyphal galactosaminogalactan represent important pathoge

98 rity-complex dynamics was investigated using hyphal galvanotropic and thigmotropic responses as repor

99 a and dfg16Delta mutants to form hyphae, but hyphal gene expression was partially defective.

100 ng the complex transcriptional regulation of hyphal gene expression.

101 between alkalinization and GlcNAc to induce hyphal genes involves the Rim101 pH-sensing pathway; Glc

102 Ac could induce the triple mutant to express hyphal genes when the medium was buffered to a higher pH

103 to form hyphae without obvious induction of hyphal genes.

104 linked glucans and C. albicans yeast glucan, hyphal glucan has a unique cyclical or "closed chain" st

105 Hyphal glucan induced robust immune responses in human p

106 lso demonstrated the capacity of C. albicans hyphal glucan, but not yeast glucan, to induce IL-1beta

107 ll GTPase, Cdc42, is essential for polarized hyphal growth and Ca(2+) influx is required for the trop

108 Deletion of AfSUN1 negatively affected hyphal growth and conidiation.

109 cleavage site led to more rapid induction of hyphal growth and delayed hypha-to-yeast transitions.

110 Specific cyclophilin mutants showed impaired hyphal growth and differential effects on conidiation an

111 beta chain (GM-CSFRbeta) developed invasive hyphal growth and exhibited impaired survival after pulm

112 protein DivIVA is a critical determinant of hyphal growth and localizes in foci at hyphal tips and s

113 tes produced by Aspergillus during invasive, hyphal growth and may prove diagnostically useful.

114 r hyphae, localize to the nucleus and affect hyphal growth and morphology.

115 stage, possibly as a result of adaptation to hyphal growth and multinuclearity.

116 lpqB cells displayed hyphal growth and polyploidism, reminiscent of the morph

117 stigate the contribution of CnaA and CnaB to hyphal growth and septation, DeltacnaB and DeltacnaADelt

118 le for the calcineurin complex in regulating hyphal growth and septation.

119 Moreover, C. albicans hyphal growth factor HWP1 as well as ALS1 and ALS3, whic

120 Invasive hyphal growth following rice cell ingress is thus depend

121 y to switch between yeast, pseudohyphal, and hyphal growth forms (polymorphism) is one of the most in

122 o the morphological transition from yeast to hyphal growth forms is critical for its pathogenesis.

123 al pathogen Candida albicans from budding to hyphal growth has been implicated in its ability to caus

124 l actin patch dynamics between the yeast and hyphal growth in Candida albicans.

125 nal Spitzenkorper and maintenance of regular hyphal growth in Neurospora crassa.

126 d host cuticles like wild type, but invasive hyphal growth in rice cells was restricted and elicited

127 G protein signaling is essential for normal hyphal growth in the filamentous fungus Neurospora crass

128 We observed that IAA also induced hyphal growth in the human pathogen Candida albicans and

129 red ability to inhibit Aspergillus fumigatus hyphal growth in vitro and in infected corneas in a muri

130 ound that calcium chelation severely impedes hyphal growth indicating a critical requirement for this

131 remains largely unknown in C. lusitaniae but hyphal growth is fundamental to C. albicans virulence.

132 Hyphal growth is however essential for successful leaf i

133 Alternatively, maintenance of hyphal growth may increase the farnesol response thresho

134 glucan which led to damage and inhibition of hyphal growth of Aspergillus in vitro and in vivo.

135 Hyphal growth of filamentous fungi requires microtubule-

136 sed species reduced Artemia survivorship and hyphal growth of Fusarium during the immature and mature

137 However, virus infection suppressed hyphal growth of most germinating conidia of B. cinerea

138 of two vertebrate-dispersed species reduced hyphal growth of Phoma.

139 Toxicity was measured as reduced hyphal growth of two fungal pathogens, Phoma sp. and Fus

140 ow that AnBud3 is not required for polarized hyphal growth per se, but is involved in septum formatio

141 mechanistic understanding of a novel mode of hyphal growth regulation that may be widely employed.

142 FungiDB contains cell cycle microarray data, hyphal growth RNA-sequence data and yeast two hybrid int

143 ophils to interfere with Aspergillus species hyphal growth was impaired after HSCT.

144 l keratitis; however, the ability to inhibit hyphal growth was restored in S100A9(-/-) mice by inject

145 served roles in regulating stress responses, hyphal growth, and possibly secondary metabolism.

146 rease soil available P, the PSB enhanced AMF hyphal growth, and PSB activity was also stimulated by t

147 constitutive high levels, to drive complete hyphal growth, but does not cause a reduction in UME6 tr

148 RP27 or TrpC promoter resulted in defects in hyphal growth, conidiation, appressorium penetration and

149 ts were examined for effects on conidiation, hyphal growth, cyclosporine and stress resistance, and i

150 mutant (DeltaFgSch9) was defective in aerial hyphal growth, hyphal branching and conidial germination

151 reas Axl2 appears to have no obvious role in hyphal growth, it is required for the regulation of phia

152 N-glycosylation in regulating the switch to hyphal growth, possibly as a consequence of maintaining

153 ch is known to be particularly important for hyphal growth, represents an effective target for hyphae

154 S1 deletion mutants are severely impaired in hyphal growth, sexual reproduction, melanin pigmentation

155 epl1 was predominantly expressed during hyphal growth, whereas epl2 was mainly expressed during

156 dida albicans can transition from budding to hyphal growth, which promotes biofilm formation and inva

157 A pathway, influences primary metabolism and hyphal growth, while represses sexual development in A.

158 n Candida albicans to switch from budding to hyphal growth.

159 other downstream morphogenetic factors from hyphal growth.

160 inhibited rust spore germination and reduced hyphal growth.

161 aA genes confer FK506 resistance and restore hyphal growth.

162 mation, and the induction and maintenance of hyphal growth.

163 ught about by the highly polarized nature of hyphal growth.

164 n hyphal induction and remains so throughout hyphal growth.

165 rns a morphogenetic switch between yeast and hyphal growth.

166 uired to maintain cellular health needed for hyphal growth.

167 dergo yeast-like growth but cannot switch to hyphal growth.

168 ll as other physiological adaptation such as hyphal growth.

169 ggested that cAMP signaling is essential for hyphal growth.

170 a role in glucose uptake and the recovery of hyphal growth.

171 to neutralize the phagolysosome and initiate hyphal growth.

172 in morphogenesis, making it unclear whether hyphal inducers must stimulate cAMP, or if normal basal

173 Sla1 is rapidly dephosphorylated upon hyphal induction and remains so throughout hyphal growth

174 Hyphal initiation also requires inoculation of a small a

175 Hyphal initiation and maintenance depend on host environ

176 Here, we show that farnesol inhibits hyphal initiation mainly through blocking the protein de

177 Hyphal initiation requires a rapid but temporary disappe

178 Therefore, hyphal initiation requires both the cAMP-PKA pathway-dep

179 Hyphal initiation requires the activation of the cAMP-PK

180 transiently activated on inoculation during hyphal initiation, and overexpression of SOK1 overcomes

181 play altered transcriptional amplitudes upon hyphal initiation, suggesting that Hir1 affects transcri

182 vercomes the farnesol-mediated inhibition of hyphal initiation.

183 Neither pathway alone is sufficient for hyphal initiation.

184 gesting that Hir1 impacts the early phase of hyphal initiation.

185 is specifically recruited to the macrophage-hyphal interface but not the macrophage-spore interface

186 oribund animals revealed massive C. albicans hyphal invasion coupled with S. aureus deep tissue infil

187 l candidiasis specifically, characterized by hyphal invasion of oral mucosal tissue, is the most comm

188 tifying fungal pressures on substrate during hyphal invasions under normal and pathophysiological gro

189 Using C. albicans yeast and hyphal kinesin-5 (Kip1p) heterozygotes (KIP1/kip1), we f

190 penic lung correlated with fungal burden and hyphal length but not induction of GT biosynthetic genes

191 Relative hyphal length is dependent upon soil temperature and moi

192 Hyphal length was high, but stable during winter in mois

193 iferation, AM colonization and extramatrical hyphal length) across 14 coexisting AM subtropical tree

194 productivity and ECM root tips but decreased hyphal length, whereas interspecific richness had no eff

195 yphal cargo and was directly proportional to hyphal length.

196 ver, growth and exocytosis commonly occur at hyphal locations other than tips.

197 Hyphal maintenance in vitro requires chromatin remodelin

198 Hyphal maintenance requires active sensing of the surrou

199 transcription factor Ume6, which facilitates hyphal maintenance, rescues filamentation defects of hir

200 hips among farnesol, germ tube formation and hyphal maintenance.

201 grown with an organic source of P, with the hyphal matrix serving to localize the resultant uranium

202 while enclosed in host-derived extrainvasive hyphal membrane.

203 oryzae in vitro, using multiple methods (ie, hyphal metabolic and fluorescent vital dye reduction ass

204 These results demonstrate that hyphal morphogenesis and gene expression can be regulate

205 oformans requires the PUF protein, Pum1, for hyphal morphogenesis during sexual development.

206 ysis revealed that the inhibition of Candida hyphal morphogenesis is mediated via RadD and Flo9 prote

207 Previous studies suggested that hyphal morphogenesis is stimulated by transcriptional in

208 F. nucleatum ATCC 23726 inhibits growth and hyphal morphogenesis of C. albicans SN152 in a contact-d

209 e F. nucleatum-induced inhibition of Candida hyphal morphogenesis promotes C. albicans survival and n

210 everal compounds that specifically inhibited hyphal morphogenesis were identified.

211 ynthesis and Ras signaling (which determines hyphal morphogenesis).

212 ans was due to the inhibition of C. albicans hyphal morphogenesis, a developmental program crucial to

213 nce, including cell wall synthesis, invasive hyphal morphogenesis, and nutrient uptake.

214 ven neutralization of the phagosome promotes hyphal morphogenesis, sufficient for induction of caspas

215 To identify compounds able to inhibit hyphal morphogenesis, we screened libraries of existing

216 C. albicans with ergosterol biosynthesis and hyphal morphogenesis.

217 tions of the vesicle supply center model for hyphal morphogenesis.

218 nce of the Nrg1 transcriptional repressor of hyphal morphogenesis.

219 ly implicated in regulation of adherence and hyphal morphogenesis.

220 ar pH, both in vitro and in vivo and induces hyphal morphogenesis.

221 ion of adenylyl cyclase to form cAMP induces hyphal morphogenesis.

222 bal perspective on their respective roles in hyphal morphogenesis.

223 ultured human epithelial cells, the yeast-to-hyphal morphological transition, induction of the hyphal

224 y of C. albicans to switch between yeast and hyphal morphologies is considered its central virulence

225 factors NRG1 and UME6, to maintain yeast and hyphal morphologies, respectively, confirmed the importa

226 bicans reversibly switches between yeast and hyphal morphologies, with hyphae being associated with v

227 is, cell death, sterigmatocystin production, hyphal morphology and size, and mitochondrial superoxide

228 ding those regulating penicillin production, hyphal morphology, and conidial formation.

229 These new roles include regulation of hyphal morphology, asexual development, as well as amino

230 llioides (Deltaubl1) influenced conidiation, hyphal morphology, pigmentation and amylolysis.

231 ngle mutant strain did not affect colony and hyphal morphology.

232 e daily change in hyphal production, but not hyphal mortality.

233 ction thus may be partially due to a role in hyphal mRNA transport.

234 aciens insertional mutagenesis to screen for hyphal mutants.

235 mented regions within the sample deposit and hyphal negative control extracts of A. niger were not in

236 able: we observed inhibition of the RFS soil hyphal network and significant reductions in M. racemosu

237 multigenomic lifestyles, the adaptation of a hyphal network for mixing nuclear material provides a pr

238 ss fibers (used as a model to mimic a fungal hyphal network) resulted in (i) increased bacterial surf

239 ws of nuclei at all length scales within the hyphal network.

240 ting responses are associated with larger AM hyphal networks, and structural advances in vascular pla

241 ients foraged in the soil by their intricate hyphal networks.

242 found in intracellular vacuoles later during hyphal outgrowth.

243 culture system for histologic evaluation of hyphal penetration.

244 ort by cytoplasmic streaming of the hyphae ('hyphal pipelines').

245 s across an interfacial zone consisting of a hyphal plasma membrane, a specialized interfacial matrix

246 myoE resulted in hyperbranching and loss of hyphal polarity.

247 Hyphal polarized growth is supported by tip-directed tra

248 espiration is related to the daily change in hyphal production, but not hyphal mortality.

249 Hyphal proliferation inside of the nematode coelom was o

250 riptional profile of the C. albicans reverse hyphal-pseudohyphal-yeast transition and demonstrate tha

251 With autumn monsoons, rapid hyphal re-growth occurred following each event.

252 nzymes and adhesion molecules from subapical hyphal regions is also discussed.

253 ndent signals contribute to the induction of hyphal responses.

254 ungi that catch nematodes using constricting hyphal rings.

255 promoted mycorrhizal and A. euteiches early hyphal root colonization, while rhizobial infection was

256 S. reilianum localized to the extracellular hyphal space.

257 This action of Cdk1 depends on the hyphal-specific cyclin Hgc1, the homologue of G1 cyclins

258 l morphological transition, induction of the hyphal-specific HWP1 promoter, biofilm formation on sili

259 n involves not only down-regulation of known hyphal-specific, genes but also differential expression

260 erest, spindle organization in the yeast and hyphal states was indistinguishable, even though yeast a

261 s and showed defects in colony pigmentation, hyphal surface hydrophobicity, cell wall integrity, auto

262 ranium and phosphorus-containing minerals on hyphal surfaces, and these were identified by X-ray powd

263 e yeast cell wall and is further enriched on hyphal surfaces.

264 ungal anti-oxidative mediators that regulate hyphal survival during infection.

265 ries of existing drugs for inhibition of the hyphal switch under stringent conditions.

266 ngi), which are concentrated just behind the hyphal tip but are intermittently present throughout all

267 compartments are spatially segregated within hyphal tip cells in a manner that depends upon the integ

268 Hyphal tip cells of the fungus Aspergillus nidulans are

269 The presence of slr1-6SA-GFP hyphal tip foci is reduced in the absence of the mRNA-tr

270 Mycologists have put extreme emphasis on hyphal tip growth as the primary mode of growth in filam

271 amples of this polarised growth form include hyphal tip growth in actinobacteria and filamentous fung

272 es (MTs) serve as a rate-limiting factor for hyphal tip growth in the filamentous fungus Aspergillus

273 p of early endosomes that move away from the hyphal tip in the mutant, the average speed of movement

274 diated early endosome movement away from the hyphal tip occurs at a significantly reduced frequency.

275 lization patterns of exocyst subunits at the hyphal tip suggest the dynamic formation of two assembli

276 d the localization of dynein-dynactin to the hyphal tip where early endosomes abnormally accumulate b

277 ormal accumulation of early endosomes at the hyphal tip, where microtubule plus ends are located.

278 s required for directional tip growth at the hyphal tip.

279 xtension and triggers de-polarization of the hyphal tip.

280 rus infection by cycloheximide treatment and hyphal tipping.

281 Lcc1) is highly expressed in the specialized hyphal tips (gongylidia) that the ants preferentially ea

282 to root tips (rhizosphere), soil adjacent to hyphal tips (hyphosphere), and bulk soil.

283 idiation, melanin and chitin accumulation in hyphal tips and lesion expansion on wounded hosts, but s

284 Thr protein kinase, AfsK, which localizes to hyphal tips and phosphorylates DivIVA.

285 nt of hyphal growth and localizes in foci at hyphal tips and sites of future branch development.

286 eltatrx2 mutant rarely formed appressoria on hyphal tips and were defective in invasive growth after

287 nes adjacent to the PAM around the arbuscule hyphal tips where it interacts with Vapyrin, a plant-spe

288 but cardiolipin itself showed enrichment at hyphal tips, branch points and anucleate regions.

289 s1 mutants are able to form appressoria from hyphal tips, but these are unable to re-polarize, and ri

290 Overexpression of clsA resulted in weakened hyphal tips, misshaped aerial hyphae and anucleate spore

291 n with fungal-derived superoxide produced at hyphal tips.

292 l as supporting polarized growth at existing hyphal tips.

293 the exocytosis of extracellular enzymes from hyphal tips.

294 methylprednisolone acetate results in robust hyphal tissue invasion and a significant reduction in im

295 ations for initiation and maintenance of the hyphal transcriptional program.

296 gnal that regulates virulence traits such as hyphal transition in pathogenic fungi.

297 like those of diploids, including the yeast-hyphal transition, chlamydospore formation and a white-o

298 to drive the C. albicans yeast-pseudohyphal-hyphal transition.

299 albicans to PMMA is morphology dependent, as hyphal tubes had increased adhesion compared with yeast

300 he existence of a root/mycorrhizal exudation-hyphal uptake pathway was supported.