ライフサイエンスコーパス: hypo-

1 nsor response may be customized to cover the hypo- (0-80 mg/dL), normo- (80-120 mg/dL), and hyperglyc

2 nce of normal first-pass signal enhancement (HYPO), (2) normal first pass signal followed by hyperenh

3 week 1, %S was depressed in HYPER, COMB, and HYPO (9+/-8%, 7+/-6%, and 5+/-4%, respectively) and were

4 nd a normal oncogenic Nras allele (Nras G12D(hypo) and Nras G12D, respectively) to create a gene dose

5 The stages of hyper-, hypo-, and hyper-methylation patterns of the CDX1 promot

6 iving Scale), potential prediagnostic motor (hypo- and bradykinesia, tremor, rigidity, postural imbal

7 re up-regulated in L-NCoRDeltaID mice in the hypo- and euthyroid state, there was little effect seen

8 ation, ranging from 4 to100 mM (covering the hypo- and hyper-glycemia range, useful in diabetes).

9 n(2+)-binding pocket generated variants both hypo- and hyper-resistant to zinc starvation, and both m

10 A wild-type strain outcompeted both hypo- and hyperaccumulating strains, suggesting that gly

11 During dietary-induced hypo- and hypercalcemia (0.59+/-0.06 and 1.58+/-0.12 mM

12 PTH-iCa curves were constructed by inducing hypo- and hypercalcemia through alterations in dialysate

13 ASR) gene and cause human autosomal dominant hypo- and hypercalcemic disorders.

14 aR) that are associated with inherited human hypo- and hypercalcemic disorders.

15 w Pico2 measurements during induced systemic hypo- and hypercapnia.

16 econciled seemingly disparate themes of both hypo- and hyperconnectivity in the ASD literature; both

17 c value in treating disorders resulting from hypo- and hyperdopaminergic activity, without the side e

18 c value in treating disorders resulting from hypo- and hyperdopaminergic activity, without the side e

19 yT1+/-), to determine how constitutive NMDAR hypo- and hyperfunction, respectively, affect the glutam

20 This study was designed to determine whether hypo- and hyperglycaemia modulate the hypoxic ventilator

21 show for the first time that PHHs exposed to hypo- and hyperglycemia can remain highly functional, bu

22 olling glucagon and insulin secretion during hypo- and hyperglycemia, respectively, the dose-response

23 y, whereas areas of regeneration appeared as hypo- and hyperintense.

24 Dietary hypo- and hyperkalemia (2.8 +/- 0.1 and 6.8 +/- 0.3 mM)

25 sants, a combination of glucose and insulin, hypo- and hyperkalemia, hypercalcemia, and alcohol and c

26 disorders (periodic ataxia with myokymia and hypo- and hyperkalemic periodic paralysis) are due to mu

27 mGlu receptor ligands for treatment of both hypo- and hyperkinetic disorders of basal ganglia origin

28 ing software (SPM5) was used to identify all hypo- and hypermetabolic regions in patients with HD rel

29 atients showed a nearly identical pattern of hypo- and hypermetabolism in groups 1 and 2.

30 les of females; (v) the general dichotomy of hypo- and hypermethylated alleles persisted over the 5 y

31 nexpectedly, the sequence characteristics of hypo- and hypermethylated domains in cerebellum were dis

32 We discover pancancer hypo- and hypermethylated genes and identify novel methy

33 t that exploit this vast dataset to identify hypo- and hypermethylated genes in cancer.

34 tion levels, thus the dual stability of both hypo- and hypermethylated genomic regions, and (3) spora

35 e maternally and paternally derived ICRs are hypo- and hypermethylated, respectively, with the former

36 Age-associated hypo- and hypermethylation events occur at distinct regu

37 s this an attractive technique to study both hypo- and hypermethylation of regions of the genome like

38 gene sequences was studied as a hallmark of hypo- and hypermethylation, respectively.

39 Ingestion of water and food are major hypo- and hyperosmotic challenges.

40 , we assess the sensitivity of TRPM7 to both hypo- and hyperosmotic conditions and explored the invol

41 perturbation of COPI function, because both hypo- and hyperosmotic conditions slowed brefeldin A-ind

42 rent magnitude, as well as under consecutive hypo- and hyperosmotic conditions.

43 ase (39%) in glutamine uptake in response to hypo- and hyperosmotic exposure, respectively.

44 changes in glycogen synthesis resulting from hypo- and hyperosmotic exposure.

45 (i) The relative amounts of hypo- and hyperphosphorylated EF-1delta in Vero cells in

46 plication and virion assembly, and exists in hypo- and hyperphosphorylated forms.

47 2A, resulting in dynamic equilibrium between hypo- and hyperphosphorylated isoforms of CLK.

48 ve and regulated pre-mRNA splicing; yet both hypo- and hyperphosphorylation of SR proteins are known

49 The patients presented with hypo- and hyperpigmented macules over the body, resembli

50 he cilial protein Evc in mice causes various hypo- and hyperplasia defects during molar development.

51 changes in aortic cross-sectional area with hypo- and hypertension did not appreciably improve the p

52 Both the hypo- and hyperthermia phases were associated with a red

53 vivo, we expressed a biotinylated TRbeta1 in hypo- and hyperthyroid mouse livers, used ChIP-seq to id

54 we examined T3-regulated gene expression of hypo- and hyperthyroid transgenic mice.

55 rine dysfunctions such as Graves disease and hypo- and hyperthyroidism.

56 om Necturus basolateral membranes respond to hypo- and hypertonic challenge monotonically around an i

57 DV volume and pH changes upon ATP depletion, hypo- and hypertonic shock, and rapid withdrawal of perf

58 inistration of CO(2) as well as by voluntary hypo- and hyperventilation at rest and during steady-sta

59 plitudes were quite variable with some being hypo- and others hypermetric.

60 suggesting that the specific cause of vermal hypo-/aplasia precedes this defect.

61 e, anterior hypothalamic (hypo.) n., lateral hypo. area (most extensive and dense message), periventr

62 In exosome mutants, hypo- as well as hyperadenylated mRNAs are released and

63 Rpd3 and Hda1 overlap extensively with Lys 4 hypo- but not hypermethylated regions.

64 engineered betaTrCP was capable of selecting hypo- but not hyperphosphorylated forms of retinoblastom

65 Mice expressing Nras G12D(hypo)/G12D(hypo) develop normally and are tumor-free, whereas early

66 lower in the ANTE HYPO group versus the ANTE HYPO + DHEA-S group (2.0 +/- 0.2 vs. 3.3 +/- 0.6 nmol/l;

67 us the ANTE EUG, ANTE EUG + DHEA-S, and ANTE HYPO + DHEA-S groups (13 +/- 5 vs. 32 +/- 3, 38 +/- 7, a

68 us the ANTE EUG, ANTE EUG + DHEA-S, and ANTE HYPO + DHEA-S groups (57 +/- 8 vs. 22 +/- 5, 18 +/- 6, a

69 us the ANTE EUG, ANTE EUG + DHEA-S, and ANTE HYPO + DHEA-S groups (P < 0.05).

70 travenous infusion of DHEA-S (30 mg/kg; ANTE HYPO + DHEA-S).

71 mice with 1% of wild-type St14 levels (St14(hypo/-)) display aberrant processing of profilaggrin and

72 evidence that genome-wide cancer hyper- and hypo- DNA methylation patterns are independent processes

73 poglycemia (2.8 +/- 0.1 mmol/l; n = 12; ANTE HYPO), euglycemia (6.2 +/- 0.1 mmol/l; n = 12; ANTE EUG)

74 Mice expressing Nras G12D(hypo)/G12D(hypo) develop normally and are tumor-free, wh

75 Moreover, CD18(hypo) gammadelta T cells induced allogeneic CD4(+) T cel

76 Areas of cortical lobar hypo (hyper)-metabolism in the cerebrum that were 2 SDx

77 roperties, block of particular channels, and hypo-/hyperkalemia.

78 (2VO) or 2VO plus systemic hypotension (2VO+Hypo; mean arterial pressure=30+/-2 mmHg) for 10-20 min.

79 7,537 differentially (46.6% hyper- and 53.4% hypo-) methylated regions.

80 erns of statistically significant hyper- and hypo- methylation in comparisons involving any number of

81 ylogeny and community structure between St14(hypo/-) mice and control littermates.

82 St14(hypo/-) mice have a selective shift in resident skin mic

83 St14(hypo/-) mice provide early evidence that the cutaneous m

84 e pallial commissure, anterior hypothalamic (hypo.) n., lateral hypo. area (most extensive and dense

85 po. n., stratum cellulare externum, inferior hypo. n., infundibular hypo. n., median eminence, three

86 xtensive and dense message), periventricular hypo. n., lateral to the paraventricular n., ventromedia

87 re externum, inferior hypo. n., infundibular hypo. n., median eminence, three layers within the strat

88 eral to the paraventricular n., ventromedial hypo. n., stratum cellulare externum, inferior hypo. n.,

89 al cell and astrocyte production of NO under hypo-, normo- and hypercapnic conditions.

90 Here, we exposed MPCCs to hypo-, normo- and hyperglycemic culture media for ~3 wee

91 ase from cerebral microvessels isolated from hypo-, normo- and hyperkalemic rats (2.3+/-0.1, 3.9+/-0.

92 poglycemia (2.8 +/- 0.1 mmol/l; n = 12; ANTE HYPO), or 4) hyperinsulinemic hypoglycemia (2.8 +/- 0.1

93 6% of the mutations screened as putative FSC hypo- or hyper-competitors, respectively.

94 ep output of each locus being either equal-, hypo- or hyper-methylated locus without further post-hoc

95 The hypo- or hyper-methylation of the human genome is one of

96 with alanine (9A) or aspartate (9D) to mimic hypo- or hyper-phosphorylation, respectively.

97 ivo environment, certain cell subsets became hypo- or hyper-responsive, showed profound differences i

98 iveness and through this mechanism intrinsic hypo- or hyperactive adrenal medullas in some individual

99 levels of trachea displacement under either hypo- or hypercapnic conditions.

100 , whereas chronic infection can cause either hypo- or hyperchlorhydria, depending on the distribution

101 Whether these neuroadaptations lead to a hypo- or hyperdopaminergic state during abstinence is a

102 entifying an underlying cause and correcting hypo- or hyperfunction of an endocrine gland, however, c

103 locorticoid bioactivity in patients who have hypo- or hyperkalemia.

104 ose that the methylation pattern and status (hypo- or hypermethylation) of genomic DNA may determine

105 Hypo- or hypermethylation-mediated oncogene activation,

106 ontent, are common and ascertained by plasma hypo- or hypernatremia, respectively.

107 slices were exposed to different degrees of hypo- or hyperosmolality 15 min prior to and during a 15

108 red, leaving patients vulnerable to cerebral hypo- or hyperperfusion.

109 Cells with either hypo- or hyperphosphorylation of DNA-PKcs at these sites

110 re induced by early drug exposure, producing hypo- or hyperresponsiveness to environmental or pharmac

111 Individuals with hypo- or hyperthyroidism showed various changes in elect

112 uggable targets for therapeutic treatment of hypo- or hyperthyroidism.

113 )-diabetic (diabetic), and STZ-diabetic kept hypo- or normoglycemic with insulin pellets (diabetic-no

114 esent investigation, Tregs derived from CD18(hypo) PL/J mice were analyzed for their propensity to di

115 23/p19 depletion, injection of diseased CD18(hypo) PL/J mice with anti-gammadeltaTCR Abs significantl

116 the psoriasiform dermatitis observed in CD18(hypo) PL/J mice.

117 In the CD18(hypo) PL/J mouse model of psoriasis, reduced expression

118 Severity of CD18(hypo) PL/J psoriasiform dermatitis correlated with a los

119 Using the polygenic CD18(hypo) PL/J psoriasis mouse model spontaneously developin

120 Adoptively transferred CD18(hypo) PL/J Tregs were more inclined toward conversion in

121 t manner similar to conversion rates of CD18(hypo) PL/J Tregs.

122 in whether recurrent nonsevere hypoglycemia (Hypo) results in long-term cognitive impairment in type

123 ntinuous, preimplantation) and temperatures (hypo-, sub, or normothermic).

124 During 2VO+Hypo, the EEG became isoelectric in all animals.

125 Consistent with this hypo- thesis, the ATPgammaS effects were both time- and

126 c regions, and (3) sporadic transitions from hypo- to hypermethylated equilibria as a result of methy

127 hosphorylation of PERIOD (PER) proteins from hypo- to hyperphosphorylated species, events that are hi

128 This transition from hypo- to hyperproliferation presents an intriguing parad

129 ons were small, homogeneously enhancing, and hypo- to isointense on T1-weighted images and iso- to sl

130 mice (Control and Nrf2(-/-) +/- T1D and +/- Hypo) were subject to recurrent, twice-weekly, insulin o