ライフサイエンスコーパス: hypoblast

1 does not require paracrine support from the hypoblast.

2 formation but suppresses development of the hypoblast.

3 th a riboprobe for Crescent, a marker of the hypoblast.

4 only parietal endoderm, a derivative of the hypoblast.

5 the segmental plate, epiblast, mesoderm, and hypoblast.

6 ation development: trophoblast, epiblast and hypoblast.

7 wth factor from the extraembryonic endoderm (hypoblast, a cell layer unique to amniotes) directs the

8 To reevaluate the role of the hypoblast/ADE (lower layer) in patterning the chick ecto

9 ith or without tissue replacement), that the hypoblast/ADE (lower layer) is required and sufficient f

10 The spreading of the hypoblast also directs cell movements in the adjacent ep

11 e failed to demonstrate a clear role for the hypoblast and anterior definitive endoderm (ADE) in patt

12 in which they are expressed, the pregastrula hypoblast and anterior lateral endoderm, respectively.

13 Hypoblast and endoblast (a second lower layer formed und

14 esizing retinoids are expressed in the avian hypoblast and in tissues directly involved in head patte

15 e cardiac-inducing capacities of pregastrula hypoblast and stage 5 anterior lateral endoderm.

16 Finally, the relationship between the hypoblast and the definitive endoderm was defined by fol

17 embryo, has focused on Koller's sickle, the hypoblast and the posterior marginal zone.

18 ose induced by an extraembryonic tissue, the hypoblast, and are normally expressed in the pregastrula

19 d inhibition by Cerberus from the underlying hypoblast, and finally a late inhibition from Lefty emit

20 Epiblasts were separated from the mesoderm, hypoblast, and primitive streak, dissociated to produce

21 yngeal endodermal precursors of the anterior hypoblast, anticipating both temporally and spatially th

22 s, we show that the node, head mesoderm, and hypoblast are interchangeable to begin any of these indu

23 ocysts, implying segregation of epiblast and hypoblast, as in rodent embryos.

24 We report that the hypoblast can induce a set of very early markers that ar

25 calation at its interface with the displaced hypoblast cells.

26 udies suggest a signaling cascade in which a hypoblast-derived activin/TGFbeta signal is required pri

27 s regulating cardiac myogenesis in avians, a hypoblast-derived signal acting on epiblast and mediated

28 These findings suggest that the hypoblast-derived signal likely acts upstream of propose

29 is underway by stage 3, indicating that the hypoblast-derived signal occurs shortly before specifica

30 A goosecoid-expressing hypoblast did not form under the induced streak, indicat

31 lium, or in the presence of the mesoderm and hypoblast, did not undergo myogenesis.

32 In the human embryo, hypoblast differentiation has not previously been charac

33 However, the hypoblast does induce transient expression of the early

34 We show that the hypoblast does not fit the criteria for a head organizer

35 sen's node as a cell monolayer that replaces hypoblast during chick gastrulation.

36 se observations indicate that segregation of hypoblast from the bipotent ICM is dependent on FGF/Erk

37 ising influences of the organiser, the chick hypoblast has been suggested to be the homologue of the

38 rdiac mesodermal precursors in the zebrafish hypoblast immediately following gastrulation.

39 n is strongly expressed in the yolk cell and hypoblast in the early gastrula, just preceding the appe

40 of Hoxa-1 message during gastrulation in the hypoblast in the head region.

41 However, the formation of hypoblast in the human is apparently not dependent upon

42 l differences in epiblast responsiveness and hypoblast inductiveness restrict appearance of cardiac m

43 Here we argue that the chick hypoblast is equivalent to the mouse VE, based on fate,

44 This dual role of the hypoblast is more consistent with the Nieuwkoop model th

45 al plate or a forebrain, suggesting that the hypoblast is not a head organizer and that other signals

46 express ndr1, while ndr2 RNA is found in the hypoblast layer of the shield and later in notochord, pr

47 These cells involute to join the deeper hypoblast layer where they adopt a migratory, mesenchyma

48 iation of cells toward the trophectoderm and hypoblast lineages compared with that for control embryo

49 After gastrulation, the hypoblast might protect prospective forebrain cells from

50 cells of the gastrula that involute into the hypoblast, motility appears wild-type.

51 However, neither the hypoblast nor any of these factors or combinations there

52 the absence of axial-expressing cells in the hypoblast of oep mutants.

53 The hypoblast possessed broad capacity to induce heart muscl

54 Here we explore the role of the hypoblast (the chick equivalent of the AVE) in the early

55 One such tissue, the hypoblast (visceral endoderm in mouse), acquired a role

56 eriments demonstrated that a signal from the hypoblast was required to induce cardiac myogenesis in t