ライフサイエンスコーパス: hypochlorous

1 actions between primary aliphatic amines and hypochlorous acid (aqueous Cl2).

2 vely modified by peroxynitrite (ONOO(-)) and hypochlorous acid (HOCl) and by activated monocytes and

3 gh protein degradation by neutrophil-derived hypochlorous acid (HOCl) and eosinophil-derived hypobrom

4 Furthermore, oxidation of WWOM by hypochlorous acid (HOCl) and molecular ozone also result

5 e the biologic effects of exposure of IgG to hypochlorous acid (HOCl) and peroxynitrite (ONOO).

6 specific end product of the reaction between hypochlorous acid (HOCl) and tyrosine residues of protei

7 roxide (O2(.-)), hydroxyl radicals (.OH) and hypochlorous acid (HOCl) assays, and their potential as

8 rate to form the highly microbicidal species hypochlorous acid (HOCl) at neutral pH.

9 d cyt c was reacted with an excess amount of hypochlorous acid (HOCl) at pH 7.4, the peroxidase activ

10 operoxidase generates significant amounts of hypochlorous acid (HOCl) at sites of inflammation to inf

11 uction of potent halogenating agents such as hypochlorous acid (HOCl) by the myeloperoxidase-hydrogen

12 Solutions of hypochlorous acid (HOCl) decay over time.

13 xidation product of nitric oxide (.NO), with hypochlorous acid (HOCl) forms reactive intermediate spe

14 It has been reported that topical hypochlorous acid (HOCl) formulations lead to relief of

15 Hypochlorous acid (HOCl) from activated neutrophils at s

16 microbial role, hydrogen peroxide (H2O2) and hypochlorous acid (HOCl) function as inflammatory mediat

17 However, hypochlorous acid (HOCl) generated by the myeloperoxidas

18 A major new finding is that hypochlorous acid (HOCl) in its neutral form is especial

19 Production of hypochlorous acid (HOCl) in neutrophils, a critical oxid

20 02 and chloride, and was mimicked by reagent hypochlorous acid (HOCl) in the absence of enzyme, sugge

21 recently showed that the neutrophil oxidant hypochlorous acid (HOCl) inhibits VWF proteolysis by ADA

22 Hypochlorous acid (HOCl) is an important component of th

23 Hypochlorous acid (HOCl) is by far the most abundant age

24 The myeloperoxidase-derived oxidant hypochlorous acid (HOCl) is thought to contribute to end

25 scrimination between changes in H(2)O(2) and hypochlorous acid (HOCl) levels in live RAW264.7 macroph

26 CuO was effective to catalyze hypochlorous acid (HOCl) or hypobromous acid (HOBr) deca

27 by reaction with the inflammatory mediators hypochlorous acid (HOCl) or myeloperoxidase.

28 One potential pathway involves hypochlorous acid (HOCl) produced by myeloperoxidase (MP

29 Hypochlorous acid (HOCl) produced via the enzyme myelope

30 etric method was developed and validated for hypochlorous acid (HOCl) scavenging activity estimation

31 MPO produces hypochlorous acid (HOCl) that oxidizes the genomic DNA i

32 obe (Hypo-SiF) designed for the detection of hypochlorous acid (HOCl) using a silicon analogue of flu

33 idase required H2O2 and Cl-, suggesting that hypochlorous acid (HOCl) was an intermediate in the reac

34 se uses hydrogen peroxide (H2O2) to generate hypochlorous acid (HOCl), a potent cytotoxic oxidant.

35 interaction of TIMPs with MMPs might involve hypochlorous acid (HOCl), a potent oxidant produced by t

36 or controlling enzyme activity might involve hypochlorous acid (HOCl), a potent oxidant produced by t

37 e is the only human enzyme known to generate hypochlorous acid (HOCl), a potent oxidizing agent, at p

38 roxide (H(2)O(2)), myeloperoxidase generates hypochlorous acid (HOCl), a powerful oxidant.

39 We previously showed that hypochlorous acid (HOCl), a specific product of myeloper

40 a combination of molecular chlorine (Cl(2)), hypochlorous acid (HOCl), and hypochlorite (OCl(-))) are

41 as a specific product when HE was exposed to hypochlorous acid (HOCl), chloramines, MPO/H2O2/chloride

42 ygen species within the phagosome, including hypochlorous acid (HOCl), formed by the oxidation of chl

43 n of alpha-amino acids to aldehydes requires hypochlorous acid (HOCl), formed from H2O2 and chloride

44 In the current studies, we show that hypochlorous acid (HOCl), generated by the myeloperoxida

45 Hypochlorous acid (HOCl), generated from H2O2 and Cl- by

46 olonization on mucosal barrier epithelia are hypochlorous acid (HOCl), hypobromous acid (HOBr) and hy

47 trite, can be oxidized by monochloramine and hypochlorous acid (HOCl), potentially leading to rapid m

48 We exposed ADAMTS13 to hypochlorous acid (HOCl), produced by a myeloperoxidase-

49 Hypochlorous acid (HOCl), the active component of househ

50 Hypochlorous acid (HOCl), the active ingredient in house

51 Hypochlorous acid (HOCl), the active ingredient of house

52 The reaction is mediated by hypochlorous acid (HOCl), the major oxidant generated by

53 Hypochlorous acid (HOCl), the major oxidant generated by

54 Furthermore, hypochlorous acid (HOCl), the major strong oxidant gener

55 s investigated in wild-type BALB/c mice with hypochlorous acid (HOCl)-induced SSc by ELISA and Wester

56 Hypochlorous acid (HOCL)-modified LDL, a specific biomar

57 system that produces the potent microbicide hypochlorous acid (HOCl).

58 t nanoprobe for the ratiometric detection of hypochlorous acid (HOCl).

59 g superoxide radical, hydrogen peroxide, and hypochlorous acid (HOCl).

60 rophils produce high local concentrations of hypochlorous acid (HOCl).

61 gocytes, such as peroxynitrite (ONOO(-)) and hypochlorous acid (HOCl).

62 rophages, uses hydrogen peroxide to generate hypochlorous acid (HOCl).

63 idase that produces the pro-oxidant species, hypochlorous acid (HOCl).

64 d in BALB/c mice by daily s.c. injections of hypochlorous acid (HOCl).

65 -) to generate the chlorinating intermediate hypochlorous acid (HOCl).

66 (ONOO(-)) and myeloperoxidase (MPO) mediated hypochlorous acid (HOCl/OCl(-)) production.

67 1% wt/vol) effectively scavenges the oxidant hypochlorous acid (HOCl; 1 to 7.5 mM) in vitro, and prot

68 The reactive chlorinating species, hypochlorous acid and chlorine gas, both attacked the vi

69 n chloride and hydrogen peroxide to generate hypochlorous acid and other reactive compounds that have

70 Reactive chlorine species (RCS) such as hypochlorous acid are powerful antimicrobial oxidants.

71 ed myeloperoxidase, inhibiting production of hypochlorous acid by 50% at 25 nm.

72 ng chronic inflammation, neutrophil-secreted hypochlorous acid can damage nearby cells inducing the g

73 from mast cells and the oxidation of HDL by hypochlorous acid can impair the function of phospholipi

74 icate that electrolysis reactions generating hypochlorous acid from chloride are likely a main contri

75 radical, reactive nitrogen intermediates and hypochlorous acid in LDL oxidation and lesion formation

76 osyl radical, reactive nitrogen species, and hypochlorous acid in LDL oxidation in the human artery w

77 ially produced from plasmalogen treated with hypochlorous acid in the presence of NaBr.

78 incubation with tert-butyl hydroperoxide and hypochlorous acid in vitro, we identified additional cov

79 Hypochlorous acid is only generated by the phagocytic en

80 Exposure to either hypochlorous acid or tetranitromethane (pH 6) inhibited

81 We find that treatment with hypochlorous acid preferentially oxidizes specific methi

82 xidation of low-density lipoprotein (LDL) by hypochlorous acid produces a modified form (HOCl-LDL) ca

83 Hypochlorous acid stimulated apoptosis in both HL-60 and

84 myeloperoxidase-containing leukocyte-derived hypochlorous acid targeting the vinyl ether bond of plas

85 acid that interacts with the potent oxidant hypochlorous acid to form the less toxic and more stable

86 chieve inactivation: UV, singlet oxygen, and hypochlorous acid treatments generally render the genome

87 ively produced toxicity in bacteria, whereas hypochlorous acid was nonselectively toxic to both bacte

88 Hypochlorous acid was the apparent oxidizing intermediat

89 DPPH, superoxide and hydroxyl radicals, and hypochlorous acid), and inhibitory activity against chol

90 s (ROS; peroxyl radical, superoxide radical, hypochlorous acid), cytotoxicity assay (MTT) and quantif

91 otonated conjugates (i.e., neutral water and hypochlorous acid), which are much weaker but more predo

92 scission is a strong function of exposure to hypochlorous acid, (iii) the ratio between amide links b

93 ing with an antibody to proteins modified by hypochlorous acid, a characteristic product of the enzym

94 Human neutrophils synthesize hypochlorous acid, a nonradical oxidant, as one of the a

95 dent oxidation of chloride anion to generate hypochlorous acid, a potent antimicrobial agent.

96 s hydrogen peroxide and chloride to generate hypochlorous acid, a potent bactericidal oxidant in vitr

97 Hydrogen peroxide (H2O2), hypochlorous acid, and azurophilic granule proteins had

98 richia coli cells against hydrogen peroxide, hypochlorous acid, and chloramines.

99 t in the rheumatoid joint (hydroxyl radical, hypochlorous acid, and peroxynitrite) were used for modi

100 n of potent antimicrobial oxidants including hypochlorous acid, human myeloperoxidase (MPO) plays a c

101 uding H2O2, hydroxyl radical, peroxynitrite, hypochlorous acid, hypobromous acid, and hypothiocyanous

102 trols for all the tested methods, except for hypochlorous acid, in which lemon juice displayed higher

103 d by five common virucidal agents (heat, UV, hypochlorous acid, singlet oxygen, and chlorine dioxide)

104 ide ion and little affected by scavengers of hypochlorous acid, suggesting that the reactive agent is

105 idase converting H(2)O(2) to highly reactive hypochlorous acid, we hypothesized that gene variants co

106 MPO-specific biomarkers 3-chlorotyrosine and hypochlorous acid-modified proteins increase in the brai

107 zed the sites of chlorination at tyrosine in hypochlorous acid-treated hemoglobin by an accurate mass

108 l react with approximately 3.5 to 4.0 mol of hypochlorous acid.

109 peroxidase that catalyzes the production of hypochlorous acid.

110 ut were inactive against the related oxidant hypochlorous acid.

111 e repair of periplasmic proteins oxidized by hypochlorous acid.

112 potentially mutagenic pathway by generating hypochlorous acid.

113 s, including the highly microbicidal species hypochlorous acid.

114 II, we reacted hydrogen peroxide (H(2)O(2)), hypochlorous acid/hypochlorite (HOCl/OCl(-)), and single

115 tent with the modification of collagen IV by hypochlorous (HOCl) and hypobromous acids.