ライフサイエンスコーパス: hypochlorous acid

1 l react with approximately 3.5 to 4.0 mol of hypochlorous acid.

2 peroxidase that catalyzes the production of hypochlorous acid.

3 ut were inactive against the related oxidant hypochlorous acid.

4 e repair of periplasmic proteins oxidized by hypochlorous acid.

5 potentially mutagenic pathway by generating hypochlorous acid.

6 s, including the highly microbicidal species hypochlorous acid.

7 ing with an antibody to proteins modified by hypochlorous acid, a characteristic product of the enzym

8 Human neutrophils synthesize hypochlorous acid, a nonradical oxidant, as one of the a

9 dent oxidation of chloride anion to generate hypochlorous acid, a potent antimicrobial agent.

10 s hydrogen peroxide and chloride to generate hypochlorous acid, a potent bactericidal oxidant in vitr

11 The reactive chlorinating species, hypochlorous acid and chlorine gas, both attacked the vi

12 n chloride and hydrogen peroxide to generate hypochlorous acid and other reactive compounds that have

13 DPPH, superoxide and hydroxyl radicals, and hypochlorous acid), and inhibitory activity against chol

14 Hydrogen peroxide (H2O2), hypochlorous acid, and azurophilic granule proteins had

15 richia coli cells against hydrogen peroxide, hypochlorous acid, and chloramines.

16 t in the rheumatoid joint (hydroxyl radical, hypochlorous acid, and peroxynitrite) were used for modi

17 actions between primary aliphatic amines and hypochlorous acid (aqueous Cl2).

18 Reactive chlorine species (RCS) such as hypochlorous acid are powerful antimicrobial oxidants.

19 ed myeloperoxidase, inhibiting production of hypochlorous acid by 50% at 25 nm.

20 ng chronic inflammation, neutrophil-secreted hypochlorous acid can damage nearby cells inducing the g

21 from mast cells and the oxidation of HDL by hypochlorous acid can impair the function of phospholipi

22 s (ROS; peroxyl radical, superoxide radical, hypochlorous acid), cytotoxicity assay (MTT) and quantif

23 icate that electrolysis reactions generating hypochlorous acid from chloride are likely a main contri

24 vely modified by peroxynitrite (ONOO(-)) and hypochlorous acid (HOCl) and by activated monocytes and

25 gh protein degradation by neutrophil-derived hypochlorous acid (HOCl) and eosinophil-derived hypobrom

26 Furthermore, oxidation of WWOM by hypochlorous acid (HOCl) and molecular ozone also result

27 e the biologic effects of exposure of IgG to hypochlorous acid (HOCl) and peroxynitrite (ONOO).

28 specific end product of the reaction between hypochlorous acid (HOCl) and tyrosine residues of protei

29 roxide (O2(.-)), hydroxyl radicals (.OH) and hypochlorous acid (HOCl) assays, and their potential as

30 rate to form the highly microbicidal species hypochlorous acid (HOCl) at neutral pH.

31 d cyt c was reacted with an excess amount of hypochlorous acid (HOCl) at pH 7.4, the peroxidase activ

32 operoxidase generates significant amounts of hypochlorous acid (HOCl) at sites of inflammation to inf

33 uction of potent halogenating agents such as hypochlorous acid (HOCl) by the myeloperoxidase-hydrogen

34 Solutions of hypochlorous acid (HOCl) decay over time.

35 xidation product of nitric oxide (.NO), with hypochlorous acid (HOCl) forms reactive intermediate spe

36 It has been reported that topical hypochlorous acid (HOCl) formulations lead to relief of

37 Hypochlorous acid (HOCl) from activated neutrophils at s

38 microbial role, hydrogen peroxide (H2O2) and hypochlorous acid (HOCl) function as inflammatory mediat

39 However, hypochlorous acid (HOCl) generated by the myeloperoxidas

40 A major new finding is that hypochlorous acid (HOCl) in its neutral form is especial

41 Production of hypochlorous acid (HOCl) in neutrophils, a critical oxid

42 02 and chloride, and was mimicked by reagent hypochlorous acid (HOCl) in the absence of enzyme, sugge

43 recently showed that the neutrophil oxidant hypochlorous acid (HOCl) inhibits VWF proteolysis by ADA

44 Hypochlorous acid (HOCl) is an important component of th

45 Hypochlorous acid (HOCl) is by far the most abundant age

46 The myeloperoxidase-derived oxidant hypochlorous acid (HOCl) is thought to contribute to end

47 scrimination between changes in H(2)O(2) and hypochlorous acid (HOCl) levels in live RAW264.7 macroph

48 CuO was effective to catalyze hypochlorous acid (HOCl) or hypobromous acid (HOBr) deca

49 by reaction with the inflammatory mediators hypochlorous acid (HOCl) or myeloperoxidase.

50 One potential pathway involves hypochlorous acid (HOCl) produced by myeloperoxidase (MP

51 Hypochlorous acid (HOCl) produced via the enzyme myelope

52 etric method was developed and validated for hypochlorous acid (HOCl) scavenging activity estimation

53 MPO produces hypochlorous acid (HOCl) that oxidizes the genomic DNA i

54 obe (Hypo-SiF) designed for the detection of hypochlorous acid (HOCl) using a silicon analogue of flu

55 idase required H2O2 and Cl-, suggesting that hypochlorous acid (HOCl) was an intermediate in the reac

56 se uses hydrogen peroxide (H2O2) to generate hypochlorous acid (HOCl), a potent cytotoxic oxidant.

57 interaction of TIMPs with MMPs might involve hypochlorous acid (HOCl), a potent oxidant produced by t

58 or controlling enzyme activity might involve hypochlorous acid (HOCl), a potent oxidant produced by t

59 e is the only human enzyme known to generate hypochlorous acid (HOCl), a potent oxidizing agent, at p

60 roxide (H(2)O(2)), myeloperoxidase generates hypochlorous acid (HOCl), a powerful oxidant.

61 We previously showed that hypochlorous acid (HOCl), a specific product of myeloper

62 a combination of molecular chlorine (Cl(2)), hypochlorous acid (HOCl), and hypochlorite (OCl(-))) are

63 as a specific product when HE was exposed to hypochlorous acid (HOCl), chloramines, MPO/H2O2/chloride

64 ygen species within the phagosome, including hypochlorous acid (HOCl), formed by the oxidation of chl

65 n of alpha-amino acids to aldehydes requires hypochlorous acid (HOCl), formed from H2O2 and chloride

66 In the current studies, we show that hypochlorous acid (HOCl), generated by the myeloperoxida

67 Hypochlorous acid (HOCl), generated from H2O2 and Cl- by

68 olonization on mucosal barrier epithelia are hypochlorous acid (HOCl), hypobromous acid (HOBr) and hy

69 trite, can be oxidized by monochloramine and hypochlorous acid (HOCl), potentially leading to rapid m

70 We exposed ADAMTS13 to hypochlorous acid (HOCl), produced by a myeloperoxidase-

71 Hypochlorous acid (HOCl), the active component of househ

72 Hypochlorous acid (HOCl), the active ingredient in house

73 Hypochlorous acid (HOCl), the active ingredient of house

74 Hypochlorous acid (HOCl), the major oxidant generated by

75 The reaction is mediated by hypochlorous acid (HOCl), the major oxidant generated by

76 Furthermore, hypochlorous acid (HOCl), the major strong oxidant gener

77 s investigated in wild-type BALB/c mice with hypochlorous acid (HOCl)-induced SSc by ELISA and Wester

78 Hypochlorous acid (HOCL)-modified LDL, a specific biomar

79 system that produces the potent microbicide hypochlorous acid (HOCl).

80 t nanoprobe for the ratiometric detection of hypochlorous acid (HOCl).

81 g superoxide radical, hydrogen peroxide, and hypochlorous acid (HOCl).

82 rophils produce high local concentrations of hypochlorous acid (HOCl).

83 gocytes, such as peroxynitrite (ONOO(-)) and hypochlorous acid (HOCl).

84 rophages, uses hydrogen peroxide to generate hypochlorous acid (HOCl).

85 idase that produces the pro-oxidant species, hypochlorous acid (HOCl).

86 d in BALB/c mice by daily s.c. injections of hypochlorous acid (HOCl).

87 -) to generate the chlorinating intermediate hypochlorous acid (HOCl).

88 (ONOO(-)) and myeloperoxidase (MPO) mediated hypochlorous acid (HOCl/OCl(-)) production.

89 1% wt/vol) effectively scavenges the oxidant hypochlorous acid (HOCl; 1 to 7.5 mM) in vitro, and prot

90 n of potent antimicrobial oxidants including hypochlorous acid, human myeloperoxidase (MPO) plays a c

91 uding H2O2, hydroxyl radical, peroxynitrite, hypochlorous acid, hypobromous acid, and hypothiocyanous

92 II, we reacted hydrogen peroxide (H(2)O(2)), hypochlorous acid/hypochlorite (HOCl/OCl(-)), and single

93 scission is a strong function of exposure to hypochlorous acid, (iii) the ratio between amide links b

94 radical, reactive nitrogen intermediates and hypochlorous acid in LDL oxidation and lesion formation

95 osyl radical, reactive nitrogen species, and hypochlorous acid in LDL oxidation in the human artery w

96 ially produced from plasmalogen treated with hypochlorous acid in the presence of NaBr.

97 incubation with tert-butyl hydroperoxide and hypochlorous acid in vitro, we identified additional cov

98 trols for all the tested methods, except for hypochlorous acid, in which lemon juice displayed higher

99 Hypochlorous acid is only generated by the phagocytic en

100 MPO-specific biomarkers 3-chlorotyrosine and hypochlorous acid-modified proteins increase in the brai

101 Exposure to either hypochlorous acid or tetranitromethane (pH 6) inhibited

102 We find that treatment with hypochlorous acid preferentially oxidizes specific methi

103 xidation of low-density lipoprotein (LDL) by hypochlorous acid produces a modified form (HOCl-LDL) ca

104 d by five common virucidal agents (heat, UV, hypochlorous acid, singlet oxygen, and chlorine dioxide)

105 Hypochlorous acid stimulated apoptosis in both HL-60 and

106 ide ion and little affected by scavengers of hypochlorous acid, suggesting that the reactive agent is

107 myeloperoxidase-containing leukocyte-derived hypochlorous acid targeting the vinyl ether bond of plas

108 acid that interacts with the potent oxidant hypochlorous acid to form the less toxic and more stable

109 zed the sites of chlorination at tyrosine in hypochlorous acid-treated hemoglobin by an accurate mass

110 chieve inactivation: UV, singlet oxygen, and hypochlorous acid treatments generally render the genome

111 ively produced toxicity in bacteria, whereas hypochlorous acid was nonselectively toxic to both bacte

112 Hypochlorous acid was the apparent oxidizing intermediat

113 idase converting H(2)O(2) to highly reactive hypochlorous acid, we hypothesized that gene variants co

114 otonated conjugates (i.e., neutral water and hypochlorous acid), which are much weaker but more predo