ライフサイエンスコーパス: hypogonadal

1 le null mice (-/Y) developed testes but were hypogonadal.

2 o 96 years]); 71 (17.5%) of the 405 men were hypogonadal.

3 .04 L) older than 54 years; 38 patients were hypogonadal-a prevalence similar to that reported in the

4 Nineteen hypogonadal and 20 eugonadal men with COPD (FEV(1) 1.14

5 Mutant female mice are hypogonadal and demonstrate decreased levels of serum es

6 terans Short Form-36) were equivalent in the hypogonadal and eugonadal groups.

7 ysis showed a significant difference between hypogonadal and eugonadal men in time to diagnosed depre

8 Hypogonadal and eugonadal patients had equivalent limb m

9 g progressive inspiratory threshold loading, hypogonadal and eugonadal patients had similar respirato

10 by phrenic nerve stimulation, was similar in hypogonadal and eugonadal patients: 20.6 +/- 2.2 and 19.

11 Male Nhlh2-/- mice are microphallic, hypogonadal and infertile with alterations in circulatin

12 Patients were hypogonadal, and one of them also had type 2 diabetes me

13 ACE and TD would be observed when women were hypogonadal, and that treatment with estradiol would att

14 in an impaired healing model (mice rendered hypogonadal) associated with increased matrix deposition

15 roles of androgen and estrogen deficiency in hypogonadal bone loss are unclear.

16 Ascorbic acid may prevent FSH-induced hypogonadal bone loss by modulating the catabolic action

17 er, TNFalpha-deficient mice are resistant to hypogonadal bone loss despite having elevated FSH, sugge

18 We propose that hypogonadal bone loss is caused, at least in part, by en

19 lishes a role of gut microbiota in mediating hypogonadal bone loss.

20 We show that FSH is required for hypogonadal bone loss.

21 We suggest that high circulating FSH causes hypogonadal bone loss.

22 Female Nhlh2-/- mice reared alone are hypogonadal, but when reared in the presence of males, t

23 n associated with this therapy may lead to a hypogonadal condition that can have detrimental effects

24 y relevant mood symptoms during this induced hypogonadal condition.

25 or immunoreactivity (IR) in the brain of the hypogonadal (hpg) male mouse, genetically deficient in G

26 ophysectomized mice, gonadotrophin-deficient hypogonadal (hpg) mutant mice, and androgen receptor-def

27 n of GnRH, functions absent in patients with hypogonadal hypogonadism.

28 The prevalences that were based on FT (ie, hypogonadal < 52 pg/dL) and BAT (ie, hypogonadal < 95 ng

29 FT (ie, hypogonadal < 52 pg/dL) and BAT (ie, hypogonadal < 95 ng/dL) were 78% and 66%, respectively.

30 We tested here, using hypogonadal luteinizing hormone/choriongonadotropin rece

31 In the hypogonadal man whose only complaint is decreased libido

32 tudies suggested that tumors that develop in hypogonadal men are more aggressive.

33 Testosterone replacement therapy may offer hypogonadal men benefit, but long-term studies on its ef

34 at any site did not significantly differ in hypogonadal men compared with eugonadal men (for example

35 in postmenopausal women, but its efficacy in hypogonadal men is not known.

36 Hypogonadal men showed an increased incidence of depress

37 of diagnosed depressive illness was 21.7% in hypogonadal men vs 7.1% in others (chi2(1)=6.0, P=.01).

38 nt therapy increases bone mineral density in hypogonadal men, including men with hypopituitarism.

39 he prevention and perhaps treatment of AD in hypogonadal men.

40 of both overall QoL and sexual function for hypogonadal men.

41 d effective strategy to prevent bone loss in hypogonadal men.

42 n, but whether these changes represent early hypogonadal metabolic dysfunction warrants further inves

43 Hypogonadal mice (whether by castration or by treatment

44 , the same cell populations are increased in hypogonadal mice or male castrates.

45 Estrogen treatment of hypogonadal mice reduced precursors to normal.

46 wise, complexes isolated from the ovaries of hypogonadal mice, which lack circulating gonadotropins,

47 ly and not unexpectedly, probiotics reversed hypogonadal osteopenia in sex steroid-deficient mice by

48 Hypogonadal patients had decreased total QoL scores on F

49 (ie, TT < 300 ng/dL) was 48%, and mean TT in hypogonadal patients was 176 ng/dL.

50 The mean FT and BAT values in hypogonadal patients were 25 pg/dL and 45 ng/dL, respect

51 ith eugonadal patients, we hypothesized that hypogonadal patients with COPD have decreased respirator

52 store testosterone to the eugonadal range in hypogonadal patients with either unilateral or bilateral

53 likely contributes to the hypogonadotrophic hypogonadal phenotype in individuals with PWS.

54 lumbar punctures were performed during both hypogonadal (placebo) and testosterone-replaced conditio

55 ased sexual interest was observed during the hypogonadal state compared with both baseline and testos

56 In addition, the early hypogonadal state is characterized by decreased total li

57 y and withdrawal from these high levels to a hypogonadal state were simulated by inducing hypogonadis

58 ) to the healthy male volunteers, creating a hypogonadal state, and then either replaced testosterone

59 ass (adjusted for weight) are related to the hypogonadal state.

60 ead to expression of the alpha subunit and a hypogonadal state.

61 scanning genes in its vicinity in unrelated hypogonadal subjects, we have identified WDR11 as a gene

62 e efficacy of testosterone in alleviation of hypogonadal symptoms (diminished libido, depressed mood,

63 ssessed in six experiments performed on four hypogonadal women.

64 e sufficient to cause depressive symptoms in hypogonadal women.