ライフサイエンスコーパス: hypogonadism

1 f the hypothalamic-pituitary unit (secondary hypogonadism).

2 nction, delayed puberty and hypogonadotropic hypogonadism).

3 g recognized in males and is associated with hypogonadism.

4 erlapping features of impaired olfaction and hypogonadism.

5 ann syndrome and idiopathic hypogonadotropic hypogonadism.

6 he rare adult-onset form of hypogonadotropic hypogonadism.

7 ransplant recipients should be evaluated for hypogonadism.

8 and delayed puberty due to hypogonadotropic hypogonadism.

9 germ cells to progress through meiosis I and hypogonadism.

10 ced effect on the prostate in a rat model of hypogonadism.

11 the hypothalamus as well as hypogonadotropic hypogonadism.

12 SHR) null mice have bone loss despite severe hypogonadism.

13 ivation therapy (ADT), resulting in profound hypogonadism.

14 ypothalamic amenorrhea, and hypogonadotropic hypogonadism.

15 loss of sense of smell and hypogonadotrophic hypogonadism.

16 y adrenal insufficiency and hypogonadotropic hypogonadism.

17 hormone replacement therapy as indicated for hypogonadism.

18 lative effect of estrogen status compared to hypogonadism.

19 d primary hypogonadism and two had secondary hypogonadism.

20 rrhea, hypothyroidism, and hypergonadotropic hypogonadism.

21 a, uterine hypoplasia, and hypergonadotropic hypogonadism.

22 beta gene, which causes Q54 to be R, causes hypogonadism.

23 health in relation to testosterone and male hypogonadism.

24 aracterized by anosmia and hypogonadotrophic hypogonadism.

25 upted vaginal cycling, and hypergonadotropic hypogonadism.

26 ctions, such as potency and libido, to avoid hypogonadism.

27 cts of the medications as opposed to chronic hypogonadism.

28 and pubertal failure due to hypogonadotropic hypogonadism.

29 range and reported no increased symptoms of hypogonadism.

30 g ADT and in elderly men with age-associated hypogonadism.

31 steoporosis caused by chronic opioid-induced hypogonadism.

32 hs, that underlies typical hypogonadotrophic hypogonadism.

33 rophin deficiency known as hypogonadotrophic hypogonadism.

34 tigate the pathogenesis of hypogonadotrophic hypogonadism.

35 y, intellectual disability, polydactyly, and hypogonadism.

36 unctions absent in patients with hypogonadal hypogonadism.

37 ase, although it is often in part related to hypogonadism.

38 um criteria necessary to identify late-onset hypogonadism.

39 bnormal reproductive hormones: 4 had primary hypogonadism, 2 had secondary hypogonadism, and 1 develo

40 ta suggest that in aging men with late-onset hypogonadism, 6 months of TRT normalizes serum androgen

41 enes involved in idiopathic hypogonadotropic hypogonadism, a congenital form of GnRH deficiency, are

42 of GPR54 causes idiopathic hypogonadotropic hypogonadism, a disorder characterized by delayed pubert

43 nsipidus, growth hormone deficiency, primary hypogonadism, adrenal insufficiency, and hypothyroidism.

44 infertility accompanied by hypergonadotropic hypogonadism after 30 weeks of age.

45 mong 50 men with idiopathic hypogonadotropic hypogonadism after a mean (+/-SD) duration of treatment

46 y hyperphagia, obesity and hypogonadotrophic hypogonadism, all highly suggestive of hypothalamic dysf

47 der that is associated with hypogonadotropic hypogonadism also.

48 In conclusion, hypogonadism, although common among men older than 54 ye

49 Hypogonadism, an acquired endocrine deficiency state cha

50 adotropes is delayed, resulting in transient hypogonadism and a delay in the onset of puberty.

51 include Kallmann syndrome (hypogonadotropic hypogonadism and anosmia), stereotyped midface hypoplasi

52 POF presents as hypergonadotropic hypogonadism and can be part of a syndrome or occur in i

53 e disease characterized by hypogonadotrophic hypogonadism and cardiomyopathy.

54 mild of form of FA-like phenotypes including hypogonadism and cellular sensitivity to the crosslinker

55 reminiscent of isolated LH-hypogonadotropic hypogonadism and corpus luteum insufficiency in humans.

56 pectrum of endocrine abnormalities including hypogonadism and feminization, with elevated serum estra

57 , as well as severe germline defects such as hypogonadism and germ cell depletion.

58 for fat-free mass, partial hypogonadotropic hypogonadism and growth failure.

59 al bilateral anophthalmia, hypogonadotrophic hypogonadism and growth hormone deficiency.

60 formation leading to high bone mass despite hypogonadism and hypercortisolism.

61 ic disease characterized by hypogonadotropic hypogonadism and impaired sense of smell.

62 is in GnRH neurons leads to hypogonadotropic hypogonadism and infertility in mice.

63 set of puberty and leads to hypogonadotropic hypogonadism and infertility.

64 ecocious germline differentiation leading to hypogonadism and infertility.

65 iss1r (Kiss1r(d/d)) display hypogonadotropic hypogonadism and infertility.

66 ice lacking miR-7a2 develop hypogonadotropic hypogonadism and infertility.

67 cross-sectional study examines prevalence of hypogonadism and its correlation with QoL and sexual dys

68 luding causes of idiopathic hypogonadotropic hypogonadism and Kallmann syndrome.

69 Both hypogonadism and low estrogen levels adversely affect bo

70 MSG treatments induced hypogonadism and obesity, retain-->and markedly reduced

71 ess, and the use of testosterone in men with hypogonadism and obesity.

72 astatic prostate cancer are at risk for both hypogonadism and osteoporosis.

73 in an individual with hyperphagia, obesity, hypogonadism and other features associated with PWS, whi

74 Treatment with GnRH reversed the hypogonadism and restored fertility in each of the five

75 ssive loss of male fertility, accompanied by hypogonadism and seminal vesicle agenesis/hypodysplasia.

76 y syndrome associated with hypergonadotropic hypogonadism and short stature.

77 ith CSF measures of androsterone during both hypogonadism and testosterone replacement (r = -0.76 and

78 sal of normosmic idiopathic hypogonadotropic hypogonadism and the Kallmann syndrome was noted after d

79 ression models to examine the association of hypogonadism and time to depression diagnosis, adjusting

80 e of hypogonadism pre-PTX: three had primary hypogonadism and two had secondary hypogonadism.

81 4 had primary hypogonadism, 2 had secondary hypogonadism, and 1 developed hyperestrogenemia with ele

82 g resolution of type 2 diabetes mellitus and hypogonadism, and beneficial effects on ingestive and no

83 which includes hyperphagia, severe obesity, hypogonadism, and impaired immunity, has provided insigh

84 y, congenital malformations of the skeleton, hypogonadism, and increased risk of leukemia.

85 gies, including hyperphagia-induced obesity, hypogonadism, and learning and memory deficits.

86 phenotypes are hyperphagic obesity, central hypogonadism, and low growth hormone (GH).

87 one parameters, menstrual cycle, symptoms of hypogonadism, and offspring were evaluated.

88 oxicity, neurotoxicity, decreased fertility, hypogonadism, and psychosocial problems.

89 tional risk factors such as low body weight, hypogonadism, and smoking, as well as direct effects of

90 te, testicular, or male breast cancer; known hypogonadism; and HIV.

91 associated with idiopathic hypogonadotropic hypogonadism are found in women with hypothalamic amenor

92 mutants from patients with hypogonadotropic hypogonadism are frequently misrouted proteins that exer

93 ciency, central diabetes insipidus, and male hypogonadism as new features of PCSK1 insufficiency.

94 ined reversal of idiopathic hypogonadotropic hypogonadism as the presence of normal adult testosteron

95 palatal abnormalities, ventriculomegaly, and hypogonadism as well as additional findings such as bone

96 e randomly assigned 1199 men with primary or hypogonadism-associated osteoporosis who were 50 to 85 y

97 The syndrome of hypogonadotropic hypogonadism, ataxia, and dementia can be caused by inac

98 An alternate definition of hypogonadism based only on a mean testosterone level les

99 ted PRL may not only improve infertility and hypogonadism but also have a positive effect on the meta

100 Late-onset hypogonadism can be defined by the presence of at least

101 ia of prepubertal onset and hypogonadotropic hypogonadism caused by elevated estrogen levels.

102 (NKB) and its receptor show hypogonadotropic hypogonadism characterised by failure to progress throug

103 ptor, NK3 (NK3R), result in hypogonadotropic hypogonadism, characterized by an absence of pubertal de

104 thus raising the hypothesis that ADT-induced hypogonadism could potentially lead to acute kidney inju

105 eficient in PC1 display hyperphagic obesity, hypogonadism, decreased GH, and hypoinsulinemic diabetes

106 Short-term hypogonadism did not affect VLDL triglyceride (TG) secre

107 We recently reported that hypogonadism does not affect respiratory muscle performa

108 In conclusion, hypogonadism does not decrease respiratory or limb muscl

109 nactivation of Kiss1 causes hypogonadotropic hypogonadism, Donato et al., in this issue of the JCI, a

110 rogeneous and manifests as hypergonadotropic hypogonadism either as part of a syndrome or in isolatio

111 ale fertility are multifactorial and include hypogonadism, erectile dysfunction, sperm abnormalities,

112 dy androgen receptor (AR)-knockout mice with hypogonadism exhibit insulin resistance.

113 ation (GnRHR E(90)K) causes hypogonadotropic hypogonadism (failed puberty associated with low or apul

114 n a patient with ataxia and hypogonadotropic hypogonadism, followed by targeted sequencing of candida

115 Hypogonadism, found in about one-third of patients with

116 la, malignant hyperthermia, hypogonadotropic hypogonadism, growth retardation, hypoglycemia, myopathy

117 sufficiency and associated hypogonadotrophic hypogonadism had a measurable response to gonadotropin-r

118 iency, men with adult-onset hypogonadotropic hypogonadism had larger mean (+/-SD) testicular volumes

119 or pituitary hypoplasia and hypogonadotropic hypogonadism, has been reported in patients carrying SOX

120 oplasia congenita (AHC) and hypogonadotropic hypogonadism (HH).

121 oplasia congenita (AHC) and hypogonadotropic hypogonadism (HH).

122 Hypogonadotropic hypogonadism (HHG) has been identified as a component of

123 ilar to patients with AS, including obesity, hypogonadism, hyperinsulinemia, retinal dysfunction and

124 splay growth deficiencies as adolescents and hypogonadism, hyperphagia, and obesity as adults.

125 ormal glucose homeostasis, hypogonadotrophic hypogonadism, hypocortisolism and elevated plasma proins

126 nally observed include acanthosis nigricans, hypogonadism, hypothyroidism, alopecia, short stature an

127 The crude prevalence of hypogonadism (ie, TT < 300 ng/dL) was 48%, and mean TT i

128 er consisting of idiopathic hypogonadotropic hypogonadism (IHH) and anosmia, and is most commonly due

129 Idiopathic hypogonadotropic hypogonadism (IHH) due to defects of gonadotropin-releas

130 Idiopathic hypogonadotropic hypogonadism (IHH) is a condition characterized by failu

131 Idiopathic hypogonadotropic hypogonadism (IHH) with anosmia (Kallmann syndrome; KS)

132 in families with idiopathic hypogonadotropic hypogonadism (IHH).

133 associated with idiopathic hypogonadotropic hypogonadism in 55 women with hypothalamic amenorrhea an

134 hypogonadal state were simulated by inducing hypogonadism in euthymic women-eight with and eight with

135 short-term estradiol withdrawal and induced hypogonadism in healthy premenopausal women.

136 t to describe the effects on mood of induced hypogonadism in healthy young men, suggest that short-te

137 osomal recessive idiopathic hypogonadotropic hypogonadism in humans and mice, suggesting that this re

138 or deletions of GPR54 cause hypogonadotropic hypogonadism in humans and mice.

139 in the FSHB/Fshb gene cause hypogonadotropic hypogonadism in humans and mice.

140 The prevalence of symptomatic hypogonadism in male patients with cancer exceeds that f

141 r adrenal insufficiency and hypogonadotropic hypogonadism in males affected by adrenal hypoplasia con

142 strophy, deafness, mandibular hypoplasia and hypogonadism in males.

143 recognition of adult-onset hypogonadotropic hypogonadism in men as a distinct disorder expands the s

144 lated testosterone deficiency and late-onset hypogonadism in men remains a controversial concept.

145 short-term treatment of symptoms of clinical hypogonadism in men with symptomatic human immunodeficie

146 the approach to evaluation and management of hypogonadism in men.

147 , and acute treatment substantially corrects hypogonadism in mice starved for 2 d without affecting b

148 ation for the occurrence of hypogonadotropic hypogonadism in patients with inactivating mutations in

149 However, treating hypogonadism in the aging male has resulted in discrepan

150 ce-based criteria for identifying late-onset hypogonadism in the general population on the basis of a

151 tients had hypothyroidism, hypergonadotropic hypogonadism (in men), pulmonary insufficiency, swallowi

152 ry, and swallowing function; muscle atrophy; hypogonadism (in men); retinopathy; vascular and cerebra

153 vere obesity, mild learning difficulties and hypogonadism, in whom diagnostic tests for Prader-Willi

154 f growth-hormone deficiency, hypothyroidism, hypogonadism, infertility, and cataracts.

155 including kyphosis, uncoordinated movement, hypogonadism, infertility, severe skeletal muscle wastin

156 Male hypogonadism is a clinical syndrome that results from fa

157 Hypogonadism is a major risk factor.

158 Because male hypogonadism is a risk factor for metabolic syndrome and

159 Although a high prevalence of hypogonadism is associated with opioid use, HIV and tran

160 The clinical diagnosis of hypogonadism is made on the basis of signs and symptoms

161 to assess reversibility of hypogonadotropic hypogonadism is reasonable.

162 n healthy young men, suggest that short-term hypogonadism is sufficient to precipitate depressive sym

163 cancer, diabetes mellitus, hypogonadotrophic hypogonadism, joint disease, and cardiomyopathy.

164 Hypogonadism may arise from testicular disease (primary

165 nia, childhood obesity, dysmorphic features, hypogonadism, mental retardation, and behavioral problem

166 oly/syn/brachydactyly, retinal degeneration, hypogonadism, mental retardation, obesity, diabetes, and

167 = 2), myelodysplastic syndrome (n = 2), and hypogonadism (n = 4).

168 nd whether specific symptoms associated with hypogonadism (nighttime hot flushes and disturbed sleep)

169 her as normosmic idiopathic hypogonadotropic hypogonadism (nIHH) or with anosmia [Kallmann syndrome (

170 for osteoporotic fracture, the influence of hypogonadism on bone mineral density remains unclear, as

171 ngly, we determined prevalence and impact of hypogonadism on health-related quality of life in men wi

172 m may arise from testicular disease (primary hypogonadism) or dysfunction of the hypothalamic-pituita

173 myelination, Hypodontia and Hypogonadotropic Hypogonadism) or RNA polymerase III (POLR3)-related leuk

174 , including kyphosis, severe muscle wasting, hypogonadism, osteopenia, emphysema, uncoordinated movem

175 tion in TACR3 for idiopathic hypogonatrophic hypogonadism (p.W275X) is associated with 1.25-year-late

176 erone levels were significantly lower during hypogonadism (P=.002, .04, and .046, respectively), but

177 f opioids rather than chronic opioid-induced hypogonadism play a key role in fracture risk.

178 Two men had secondary hypogonadism pre-PTX with resolution in one and persiste

179 Five of the ten women had evidence of hypogonadism pre-PTX: three had primary hypogonadism and

180 ogen receptors; and (2) such alcohol-induced hypogonadism precedes changes in hepatic sex hormone hom

181 30 days of alcohol exposure, suggesting that hypogonadism precedes liver feminization.

182 scular calcification, severe muscle wasting, hypogonadism, pulmonary emphysema, distention of intesti

183 levels between testosterone replacement and hypogonadism (r = -0.68; P<.05).

184 In elderly men, hypogonadism related to aging has little influence on bo

185 ce, a syndrome emerged with delayed puberty, hypogonadism, relative macrocephaly, moderate short stat

186 Controlling for all covariates, hypogonadism remained significantly associated with depr

187 by retinal dystrophy, polydactyly, obesity, hypogonadism, renal abnormalities, and mental retardatio

188 besity, pigmentary retinopathy, polydactyly, hypogonadism, renal and cardiac abnormalities, and cogni

189 y, hepatic dysfunction, hypothyroidism, male hypogonadism, short stature and mild to moderate develop

190 deficient mice had isolated hypogonadotropic hypogonadism (small testes in male mice and a delay in v

191 ing, is characterized by neonatal hypotonia, hypogonadism, small hands and feet, hyperphagia and obes

192 Age-associated hypogonadism (testosterone deficit) occurs in 30% of men

193 No cases of secondary hypogonadism that developed or resolved post-PTX were re

194 lt-onset form of idiopathic hypogonadotropic hypogonadism that develops after puberty.

195 re a novel genetic model of hypogonadotropic hypogonadism that establishes essential role(s) of SF1 i

196 When it comes to managing men with hypogonadism, the benefit of testosterone replacement th

197 nverse energy, such as inducing hypothalamic hypogonadism to prevent fertilization.

198 adult onset of obesity and hypogonadotropic hypogonadism to study effects of gonadotropin releasing

199 Among older men with symptomatic hypogonadism, treatment with testosterone gel for 1 year

200 unadjusted hazard ratio for depression with hypogonadism was 3.5 (95% confidence interval, 1.3-9.4)

201 Relative to baseline, induced hypogonadism was associated with significantly decreased

202 Hypogonadism was defined as a mean testosterone level le

203 ted proband with idiopathic hypogonadotropic hypogonadism was determined to have two separate mutatio

204 The combination of ataxia and hypogonadism was first described more than a century ago

205 Idiopathic hypogonadotropic hypogonadism was previously thought to require lifelong

206 plasia congenita (AHC) with hypogonadotropic hypogonadism was recently shown to be caused by mutation

207 Among those whose hypogonadism was reversed, the mean serum level of endog

208 whom reversal of idiopathic hypogonadotropic hypogonadism was sustained after discontinuation of horm

209 The prevalence of hypogonadism was unexpectedly high.

210 Hypogonadism was untreated in 50% of men and 20% of wome

211 A similar model that adjusted for hypogonadism was used to examine the association of estr

212 tal development (idiopathic hypogonadotropic hypogonadism) was examined for mutations in a candidate

213 P > 0.2), even when alternate definitions of hypogonadism were used.

214 Idiopathic hypogonadotropic hypogonadism, which may be associated with anosmia (the

215 to testosterone) and symptoms suggestive of hypogonadism who were enrolled in the Testosterone Trial

216 The association of hypogonadism with bone mineral density was examined with

217 sing hormone (GnRH) that is characterized by hypogonadism with delayed or absent puberty and dysfunct

218 PR54 genes cause idiopathic hypogonadotropic hypogonadism with normal olfaction (nIHH).

219 patients who had idiopathic hypogonadotropic hypogonadism without GPR54 mutations.