ライフサイエンスコーパス: hypomorph

1 issue polarity as it is deleted in a weak fy hypomorph.

2 P1 expression and therefore generated a NRP1 hypomorph.

3 s shown by mig-38 RNAi with the mig-15(rh80) hypomorph.

4 xpression pattern using heterozygosity and a hypomorph.

5 ng partner Csk, unmasks the risk allele as a hypomorph.

6 t ventral branch migration in the breathless hypomorph.

7 was compromised in neurons cultured from the hypomorphs.

8 equency of vascular defects reported in Fgf8 hypomorphs.

9 solated new vn mutations including nulls and hypomorphs.

10 crepancies between receptor mutants and Ntn1 hypomorphs.

11 for persistent attraction to the midline in hypomorphs.

12 um channel are markedly increased in the 10% hypomorphs.

13 e in inflammatory cytokine expression in the hypomorphs.

14 d this phosphorylation is compromised in CK2 hypomorphs.

15 source of lethality in irradiated Smc5-Smc6 hypomorphs.

16 -associated Six3 mutant proteins function as hypomorphs.

17 ation when breaks are reduced in yeast spo11 hypomorphs.

18 proach was used to generate a series of Plk1 hypomorphs.

19 nstrated by the myeloerythroid bias in Dnmt1 hypomorphs, a comprehensive DNA methylation map of haema

20 permorphs at age 12 wk to 400% normal in the hypomorphs accompanied with proportionate changes in pla

21 and male reproductive tract, but served as a hypomorph allele in the development of the appendicular

22 bly, the reduced Elmo1 expression in the 30% hypomorphs almost abolishes the pathological features of

23 y defects, the mutant protein is both a mild hypomorph and a potent antimorph as determined by the ef

24 We have combined Twist1 null, hypomorph and conditional alleles to generate a Twist1 a

25 Homozygous Sno hypomorph and null mutant mice are viable without gross

26 idence that the aphakia allele of Pitx3 is a hypomorph and that Pitx3 is required for the regulation

27 is indicated protein-coding alterations in 8 hypomorphs and 6 amorphs, with mild-moderate phenotypes

28 , moderate, umbrous-like, severe) for the 18 hypomorphs and a single category for the 7 amorphs (null

29 penetrance of mutant phenotypes in signaling hypomorphs and explains available experiments with no ad

30 Vegfa hypomorphs and isoform-specific (medium/long) morphants

31 ison of the mutant phenotypes of dpp and gbb hypomorphs and null clones shows that both BMPs act loca

32 Ten hypomorphs and one null demonstrated wild-type coding po

33 homozygous lethal in midgestation, but Mpc1 hypomorphs and tissue-specific deletion of Mpc1 presente

34 s stages up through metamorphosis (synthetic hypomorphs) and displayed prepupal and pupal phenotypes

35 us: a 5' deletion, with reduced Sno protein (hypomorph), and an exon 1 deletion removing half the pro

36 The kcc(DHS1) allele is a hypomorph, and its seizure-like phenotype reflects reduc

37 ies: inactivation of tumor suppressor genes (hypomorph, antimorph or amorph) or activation of oncogen

38 phs showed only slight G2/M arrest, a medium hypomorph arrested with 4N DNA content, followed later b

39 It was deduced to be a hypomorph, as Pax3 protein expression is reduced by 80%

40 NA-mediated silencing to generate epiallelic hypomorphs associated with KIF14 depletion.

41 icant improvement in serum creatinine in the hypomorphs at 3 and 10 days after injury, and renal fibr

42 TP1, NQO1) revealed higher expression in the hypomorphs at baseline.

43 otes but also partially complement other dpp hypomorphs at low temperatures.

44 uppress the DNA damage sensitivity of Smc5/6 hypomorphs but not that of HR mutants and remarkably dec

45 ro, suggesting that the mutants are actually hypomorphs, but must be above certain concentration to e

46 dated peptides were largely absent in strong hypomorphs, but peptide precursors, a nonamidated neurop

47 rescue of the innervation phenotype of FasII hypomorphs by over expressing FasII in glia.

48 ve previously reported generation of an Orc2 hypomorph cell line (Delta/-) that expresses very low le

49 genetically disrupted for DNMT1 (DNMT1(-/-) hypomorph cells).

50 The Eya1(bor) mutant hypomorph contains an intracisternal A particle insertio

51 ional exposure, the patent DV in AHR or ARNT hypomorphs could be efficiently closed by dioxin exposur

52 expression is reduced by 80% and homozygote hypomorphs die postnatally.

53 scued by L. major glf, which behave as glf-1 hypomorphs, display resistance to infection by Microbact

54 A global reduction of Fgf8 in hypomorph embryos leads to an early loss of placode-deri

55 In JIL-1 hypomorphs, euchromatic regions of polytene chromosomes

56 toxicity studies demonstrated that the ARNT hypomorphs exhibited resistance to the end points of dio

57 inked to pseudopod extension, whereas a PTEN hypomorph exhibits elevated RacB activation.

58 In Nav2 hypomorphs, fewer granule cells migrate out of cerebella

59 function and that Tgfb1(C33S/C33S) mice are hypomorphs for active TGF-beta1.

60 While the HSP82 hypomorph grows normally in vitro at 37 degrees C and un

61 The diabetic 10% hypomorphs had comparable creatinine clearance and album

62 which we believe is either a null or severe hypomorph, has an IRES-lacZ-neomycin resistance cassette

63 ver perfusion studies demonstrated that ARNT hypomorphs have a patent ductus venosus, identical to th

64 Foxc1 homozygous hypomorphs have CVH with medial fusion and foliation def

65 Fgf8 hypomorphs have hypoplastic SMGs, whereas conditional mu

66 Here we show that alpha-SNAP hypomorph, hydrocephalus with hopping gait, Napa(hyh/hyh

67 As in the hypomorph, IFE proliferation was stimulated and expressi

68 This also occurs in Smc5/6 hypomorphs in the fission yeast Schizosaccharomyces pomb

69 Altered phenotypes in the NR1 hypomorphs include marked deficits in species-typical be

70 ssion from low to high in the tubules of the hypomorphs increased their albumin excretion more than 1

71 ion and dMYC-dependent overgrowth in the Hfp hypomorph is further impaired in the C-terminal Hay/XPB

72 The altered phenotypic landscape in our adar hypomorph is paralleled by an unexpected dichotomous res

73 ean number of supercoil domains, this gyrase hypomorph is prone to fork collapse and topological chao

74 The hypertension in the 10% hypomorphs is corrected by spironolactone or amiloride a

75 Characterization of the SV40 miRNA hypomorph, K661, shows that it is inhibited at the early

76 blp hypomorph larvae had a 35% decreased number of plasmatoc

77 s LDH-A and rescue expression of a catalytic hypomorph LDH-A mutant, Y10F, demonstrate increased resp

78 showed that the BALB/c allele of Ube2l6 is a hypomorph leading to the lack of UBE2L6 protein expressi

79 hat B. burgdorferi-infected hearts from CD18 hypomorph mice express increased levels of MCP-1 RNA com

80 CD18 hypomorph mice expressing reduced levels of the common b

81 increased severity of Lyme carditis in CD18 hypomorph mice is caused by deficiency in CD11a or CD11c

82 e demonstrate that dendritic cells from CD18 hypomorph mice secrete higher levels of monocyte/macroph

83 B. burgdorferi-infected CD18 hypomorph mice showed an increased macrophage infiltrati

84 In Trip13(Gt/Gt)hypomorph mice treated with unilateral renal IRI, persis

85 Similarly to CD18 hypomorph mice, CD11c-/- mice expressed higher levels of

86 the beta2 integrins was investigated in CD18 hypomorph mice, which express low levels of CD18.

87 In a Dll1 hypomorph mutant that survives until birth, hair follicl

88 ENU mutagenesis screen and generated a Brg1 hypomorph mutation in the ATPase domain.

89 Hypomorph mutations in sld3 are suppressed by a mcm4 reg

90 Here, we identify COII(G177S), a mtDNA hypomorph of cytochrome oxidase II, which specifically i

91 anscription of Sema3c in the OFT, whereas, a hypomorph of Tbx1, a key SHF transcription factor, resul

92 The Hoxb2 mutant phenotype is a hypomorph of the Hoxb1 mutant phenotype, consistent with

93 imilar to defects observed in knock-outs and hypomorphs of the Notch ligand Serrate-2.

94 R localization in metaphase-II Mater(tm/tm) (hypomorph) oocytes and found ER clusters to be less abun

95 sion of phosphorylation-deficient, catalytic hypomorph PDHK1 mutants in cancer cells leads to decreas

96 ons, showing that MLL translocations cause a hypomorph phenotype of RUNX1/CBFbeta.

97 Orai1 gene-trap mutant mouse which may be a hypomorph rather than a true null.

98 tinct from RAG nullizygosity, the RAG1-S723C hypomorph results in aberrant DNA double-strand breaks w

99 Natural and synthetic PHM hypomorphs revealed phenotypes that resembled those of a

100 RNA interference targeting Rac hypomorphs revealed synergistic interactions between the

101 otype induced in the PV myocardium in Nkx2-5 hypomorphs reverted back to a working myocardial phenoty

102 In HeLa cells, two weak hypomorphs showed only slight G2/M arrest, a medium hypo

103 We found that 4 hypomorphs significantly reduced MMS to varying degrees.

104 posis Coli 2 (APC2) rescued GSC loss in chic hypomorphs, suggesting an additive role of APC2 and F-ac

105 pression was attenuated or reversed in Keap1 hypomorphs, suggesting that protection in these mice was

106 throid maturation was deficient in these Scl hypomorphs, supporting that Scl was required both for th

107 passenger complex (CPC), AURKC p.C229Y is a hypomorph that cannot fully support cell-cycle progressi

108 an N-terminal GFP-Foxp3 fusion protein, is a hypomorph that causes profoundly accelerated autoimmune

109 , with NPC1, we have generated a murine NPC2 hypomorph that expresses 0-4% residual protein in differ

110 One allele is a hypomorph that generates less protein and exhibits struc

111 In Fas II hypomorphs, the number of contact points is increased, a

112 Consequently, we used a BMP4 hypomorph to investigate the role of BMP4 in regulating

113 lizability of our findings, we subjected the hypomorphs to unilateral ureteral obstruction (UUO) and

114 genetic model of brd2 lo mice, a BET protein hypomorph, to show that Brd2 is essential for proinflamm

115 llowed later by apoptosis, and a strong Plk1 hypomorph underwent serious mitotic catastrophe.

116 ion defect of a smk1-2 temperature-sensitive hypomorph were isolated.

117 mRNA enhances the Daf-c phenotype of a daf-4 hypomorph, whereas the same transgene with a nonsense mu

118 the 300% hypermorphs to six times in the 10% hypomorphs, which have elevated blood pressure.

119 strongly enhanced phenotype relative to Ntn1 hypomorphs, which retain many axons with normal trajecto

120 e-trap mouse (Pikfyve(beta-geo/beta-geo)), a hypomorph with ~10% of the normal level of Pikfyve prote

121 amage, since the synthetic lethality of smc6 hypomorphs with a topoisomerase II mutant, defective in

122 ectrolytes are markedly decreased in the 10% hypomorphs without significant change in the glomerular