ライフサイエンスコーパス: hypothermic

1 DKO were extremely cold-sensitive and became hypothermic.

2 lobal Et2 knockout mice were also profoundly hypothermic.

3 malnourished, underweight, hypoglycemic, and hypothermic.

4 ological deficit scores were observed in the hypothermic-2 hours animals.

5 ized into 4 groups (n=6 each): normothermic, hypothermic-2 hours, hypothermic-5 hours, and hypothermi

6 All the rats became equally hypothermic (28.9+/-1.2 degrees C [SEM]) at the end of t

7 Mild hypothermic (30 degrees C) culture of zygotes after micr

8 However, following hypothermic (30 degreesC) reperfusion, both respiration

9 al severity score, were randomized to either hypothermic (32-34 degrees C) or normothermic (37-39 deg

10 =6 each): normothermic, hypothermic-2 hours, hypothermic-5 hours, and hypothermic-8 hours.

11 METH under usual ambient (22 degrees C) and hypothermic (6 degrees C) temperature conditions, where

12 ypothermic-2 hours, hypothermic-5 hours, and hypothermic-8 hours.

13 A total of 192 patients (103 hypothermic, 89 nonhypothermic) were studied.

14 RPM8 channels (by cold) are required for the hypothermic action of M8-B.

15 anesthetics, questioning to what extent the hypothermic action of THC is specific (i.e., mediated vi

16 axis, inhibition of both the production and hypothermic action of TNF-alpha, and suppression of infl

17 or phenotype, delta1 or delta2, mediates the hypothermic actions of delta agonists.

18 ine, however, decreased the tolerance to the hypothermic actions of ethanol, when the ethanol was giv

19 That PAF possesses hypothermic activity and mediates LPS-induced hypothermi

20 examined the mechanisms responsible for the hypothermic activity of APAP.

21 The hypothermic activity was independent of TRPV1 since APAP

22 ts had reduced energy expenditure and became hypothermic after fasting or cold stress.

23 ust before rewarming commenced (hypotensive, hypothermic), after rewarming (hypotensive, normothermic

24 eceptor agonists and to exhibit CB1-mediated hypothermic and analgesic effects.

25 his antisense PNA specifically inhibited the hypothermic and antinociceptive activities of NT microin

26 Experiment 2 compared ethanol's initial hypothermic and delayed hyperthermic effect across age b

27 ys an important role in the induction of the hypothermic and hypometabolic torpid state in hibernatin

28 cating that GLP-1R activation contributes to hypothermic and hypophagic effects of hindbrain CART, wh

29 t a mean (SD) of 16 (5) and 15 (5) hours for hypothermic and noncooled groups, respectively.

30 Hypothermic and noncooled infants were term (mean [SD],

31 Sedative medications in both hypothermic and nonhypothermic patients may confound the

32 ery bypass grafting (CABG) (n = 6; low SOE), hypothermic and normothermic CABG (n = 3; moderate to lo

33 Mini-Mental State Examination scores in the hypothermic and normothermic groups were 27.4 +/- 3.8 an

34 rence in the incidence of impairment between hypothermic and normothermic groups.

35 ad good discrimination for mortality in both hypothermic and normothermic patients.

36 explore suspended animation potentials with hypothermic and pharmacologic strategies using aortic co

37 ic genetic ablation of HDAC3 become severely hypothermic and succumb to acute cold exposure.

38 It possesses analgesic, hypothermic, and antipsychotic-like properties.

39 A subpopulation of diabetic NOD mice became hypothermic, and tau hyperphosphorylation further extend

40 A subgroup of hypothermic animals (n = 12) were returned to normotherm

41 survive the reperfusion period, whereas all hypothermic animals and 11 of 12 of the hypothermic anim

42 expression of HSP 70 in the cerebellum while hypothermic animals experienced a significant decrease H

43 all hypothermic animals and 11 of 12 of the hypothermic animals that were returned to normothermic c

44 Hypothermic animals were kept under these temperature co

45 as maintained at 38 degrees C, except in the hypothermic animals, which were cooled to 30 degrees C t

46 hibition of PI3/Akt enlarged infarct size in hypothermic animals.

47 lular potassium ion activity was observed in hypothermic animals.

48 rol of 5-HT2AR, but its acute hypolocomotor, hypothermic, anxiogenic, and antinociceptive effects are

49 Of 38,520 patients, 1,921 (5.0%) were hypothermic at admission.

50 Both the hypothermic (at 20 degrees C) and febrile (at 30 degrees

51 During hypothermic blood cardioplegia, oxygen delivery to myocy

52 After the hypothermic bout, all animals showed a massive increase

53 perature), preproghrelin knockout mice enter hypothermic bouts associated with reduced sleep, culmina

54 laboratory studies identifying mechanisms of hypothermic brain protection are reviewed.

55 ent increases tissue oxygenation during deep hypothermic bypass and after circulatory arrest.

56 white cell/endothelial activation after deep hypothermic bypass and circulatory arrest.

57 ukocyte/endothelial cell interactions during hypothermic bypass are mild with both alpha-stat and pH-

58 s: control (n=3); CPB (n=5), femoral-femoral hypothermic bypass for 1 hour; LPS (n=7), sham bypass fo

59 egarding the optimal pH strategy during deep hypothermic bypass in children.

60 opulmonary bypass, followed by 75 minutes of hypothermic cardioplegia (13 degrees C) with either BC (

61 ystolic and diastolic function after 3 hr of hypothermic cardioplegic arrest (114+/-4 mm Hg vs. 83+/-

62 One rationale for hemodilution during hypothermic cardiopulmonary bypass (CPB) has been improv

63 ere quantified before, during and after deep hypothermic cardiopulmonary bypass (CPB) in nine neonate

64 r in neonates after heart surgery using deep hypothermic cardiopulmonary bypass (dhCPB) and circulato

65 r in animals treated with epinephrine during hypothermic cardiopulmonary resuscitation when compared

66 t when it is administered during therapeutic hypothermic cardiopulmonary resuscitation.

67 -0.61%]), and highest with on-pump CABG with hypothermic circulatory arrest (5.3% [95% CI, 2.0%-11%])

68 ry following cardiopulmonary bypass and deep hypothermic circulatory arrest (CPB/DHCA) in a pediatric

69 strategies to minimize the duration of deep hypothermic circulatory arrest (DHCA) and efforts to ame

70 of 10%, 20%, or 30%, followed by 1-hour deep hypothermic circulatory arrest (DHCA) and rewarming on C

71 The technique of deep hypothermic circulatory arrest (DHCA) for cardiothoracic

72 r, aortic arch repair, requiring either deep hypothermic circulatory arrest (DHCA) or antegrade cereb

73 cerebral perfusion (ACP) compared with deep hypothermic circulatory arrest (DHCA).

74 7 involving cardiopulmonary bypass with deep hypothermic circulatory arrest (DHCA).

75 lie SCP strategies as an alternative to deep hypothermic circulatory arrest (DHCA).

76 CU stay (P=0.08), and cumulative duration of hypothermic circulatory arrest (HCA) (P=0.09) approached

77 Hypothermic circulatory arrest (HCA) provides neuroprote

78 aoperative transesophageal echocardiography; hypothermic circulatory arrest (HCA) with retrograde cer

79 a cerebral metabolic deficit observed after hypothermic circulatory arrest (HCA).

80 ent coarctation surgery with the use of deep hypothermic circulatory arrest (HCA).

81 No evidence exists that profound hypothermic circulatory arrest (PHCA) improves survival

82 nary bypass to 18 degrees C followed by deep hypothermic circulatory arrest for 120 mins.

83 rdiopulmonary bypass before instituting deep hypothermic circulatory arrest for 45 minutes.

84 ith resection of the intimal tear and use of hypothermic circulatory arrest for distal anastomosis re

85 grade cerebral perfusion (RCP) with profound hypothermic circulatory arrest has been subject to much

86 he advent of cardiopulmonary bypass and deep hypothermic circulatory arrest have allowed the open rep

87 between regional cerebral perfusion and deep hypothermic circulatory arrest on 1-year outcomes; no di

88 ds of replacing the aortic arch without deep hypothermic circulatory arrest or even cardiopulmonary b

89 The use of RCP with profound hypothermic circulatory arrest was associated with a red

90 Hypothermic circulatory arrest was used in 52 patients (

91 levels after cardiopulmonary bypass and deep hypothermic circulatory arrest with calpain inhibition w

92 t, on-pump with arrested heart, on-pump with hypothermic circulatory arrest).

93 hophysiologic process in a rat model of deep hypothermic circulatory arrest, and that intestinal inju

94 en employing cardiopulmonary bypass and deep hypothermic circulatory arrest, is associated with syste

95 0 mins after cardiopulmonary bypass and deep hypothermic circulatory arrest, p = .05).

96 stinal mast cells as central players in deep hypothermic circulatory arrest-associated responses, and

97 rrier function were preserved following deep hypothermic circulatory arrest.

98 een low-flow cardiopulmonary bypass and deep hypothermic circulatory arrest.

99 Previously, PtK1 cells in hypothermic conditions (23 degrees C) were shown to have

100 reperfusion (Normothermic), or given 1 h of hypothermic conditions (28 degrees C) either during the

101 was induced by cell stress under hypoxic or hypothermic conditions and prevented by specific removal

102 in which primary human HSPCs cultured under hypothermic conditions are maintained in a quiescent sta

103 ption factors Fos and pCREB under normal and hypothermic conditions in this neonatal model of focal i

104 fferences in simple behaviors or growth, all hypothermic conditions significantly reduced mortality r

105 e prevented and/or more easily treated under hypothermic conditions.

106 ed pressures and under both normothermic and hypothermic conditions.

107 o ischemia-reperfusion under normothermic or hypothermic conditions.

108 In this study, we used hypothermic continuous machine perfusion preservation to

109 iopulmonary resuscitation when compared with hypothermic controls.

110 After shunt closure, hypothermic CPB (25 degrees C) was performed for 2 hours

111 The DHCA group received surgery, deep hypothermic CPB for 40 mins, and circulatory arrest for

112 The dhCPB group received surgery and deep hypothermic CPB for 40 mins.

113 prospectively randomized to mild or moderate hypothermic CPB for elective CABG to determine the incid

114 ation in the moderate compared with the mild hypothermic CPB group.

115 tween both variables is observed during deep hypothermic CPB in all subjects.

116 Hypothermic CPB increased both mean pulmonary arterial p

117 eferable relative to lower Hct values during hypothermic CPB, particularly if DHCA is used.

118 significantly decreased CBF and CMRO2 during hypothermic CPB.

119 or moderate (28 degrees C [82.4 degrees F]) hypothermic CPB.

120 sruption of the Dio2 gene (Dio2(-/-)) become hypothermic due to impaired BAT thermogenesis and surviv

121 ne levels to 50% of control in mice becoming hypothermic during dosing in a 13 degrees C environment.

122 3-30 min following injection with a maximal hypothermic effect of -1.3 degrees C.

123 ure studies on the clinical potential of the hypothermic effect.

124 WT mice, tolerance developed to CB1-mediated hypothermic effects of CP55,940 earlier than to antiallo

125 her wild-type or FAAH(-/-) mice enhanced the hypothermic effects of exogenous anandamide, a response

126 completely abolished the sleep-promoting and hypothermic effects of glycine.

127 mice are hypersensitive to the sedative and hypothermic effects of systemic ethanol administration,

128 pinephrine; hypothermic placebo control; and hypothermic epinephrine.

129 Three groups (n=6) were studied: hypothermic EPR (H-EPR; 0 degrees C flush; target temper

130 When compared with febrile patients, the hypothermic group has an amplified response with respect

131 96-hr cerebral performance categories of the hypothermic group were significantly lower than control

132 For patients in the hypothermic group, 54.5% were impaired on at least one t

133 In the hypothermic group, the concentrations of glutamate remai

134 n the normothermic groups compared with both hypothermic groups (p < .01).

135 Animals in the hypothermic groups received rapid cooling, which was sta

136 xygen consumption, which were normal in both hypothermic groups.

137 mperature was significantly decreased in the hypothermic groups.

138 (Cu+) pups, copper-deficient (Cu-) pups were hypothermic, had lower brain copper levels and markedly

139 ly shorter, less branched, and less spiny in hypothermic hamsters compared with active animals.

140 These results suggest that 24-hour hypothermic HMP may help preservation of hepatocyte func

141 Following 24-hour hypothermic HMP with University of Wisconsin (UW) soluti

142 ted, and randomized to normothermic (Nor) or hypothermic (Hy) conditions.

143 Hypothermic hyperkalemic cardioplegia results in signifi

144 roreflex control of RSNA could contribute to hypothermic hypotension and may primarily reflect an eff

145 We conclude that the improved recovery after hypothermic hypoxia is at least in part due to the atten

146 nt hypothermia within 60 min and exhibited a hypothermic induction profile analogous to 3-iodothyrona

147 The primary outcome occurred in 19 of 78 hypothermic infants (24.4%) and 22 of 79 noncooled infan

148 Eighty-three hypothermic infants were maintained at 33.5 degrees C (a

149 ellular ice formation and to protect against hypothermic injury.

150 chemia and orthotopic liver transplantation (hypothermic ischemia).

151 Hypothermic kidney storage causes preservation injury an

152 Hypothermic machine organ perfusion (HMP) offers opportu

153 occurring within the preserved kidney during hypothermic machine perfusion (HMP) are not well charact

154 Clinical trial data suggest that continuous hypothermic machine perfusion (HMP) during the entire pr

155 Hypothermic machine perfusion (HMP) for preservation led

156 Dynamic preservation of organ grafts by hypothermic machine perfusion (HMP) has regained broader

157 The mechanism through which oxygenated hypothermic machine perfusion (HMP) improves viability o

158 There is increasing support for the use of hypothermic machine perfusion (HMP) in an attempt to red

159 regarding the outcomes of kidneys undergoing hypothermic machine perfusion (HMP) in patients in the U

160 Hypothermic machine perfusion (HMP) is in its infancy in

161 Although hypothermic machine perfusion (HMP) preservation has bee

162 Hypothermic machine perfusion (MP) has the potential to

163 Hypothermic machine perfusion (MP) preservation is used

164 PNF and DGF in 335 DCD kidneys preserved by hypothermic machine perfusion at our center between 1 Ja

165 to determine whether a novel, oxygenated and hypothermic machine perfusion device (HMP Airdrive syste

166 sure renovascular circulating volumes during hypothermic machine perfusion of donor kidneys.

167 UW solution used with continuous hypothermic machine perfusion preservation can rescue ca

168 Hypothermic machine perfusion preservation has the poten

169 Hypothermic machine perfusion pretreatment facilitated d

170 ing specialized pressurized chambers; during hypothermic machine perfusion; with the addition of oxyg

171 jected to 60 min of warm ischemia before the hypothermic machine preservation during 22 hr.

172 uring in situ preservation (ISP) rather than hypothermic machine preservation.

173 pressure and a decrease in cerebral edema in hypothermic meningitic animals.

174 indings could be explained by the effects of hypothermic modified Euro-Collins solution on pulmonary

175 diately after pulmonary artery flushing with hypothermic modified Euro-Collins solution.

176 Hypothermic myocardial arrest is necessary to complete m

177 These results indicate that hypothermic neuroprotection is more efficacious during t

178 bute to the greater benefit of intraischemic hypothermic neuroprotection.

179 uld buy time for transport and repair during hypothermic no flow followed by resuscitation, or it cou

180 e IRI have mainly focused on ways to improve hypothermic organ preservation and reduce the nephrotoxi

181 to the endothelium of corneal grafts during hypothermic organ preservation.

182 Although hypothermic oxygenated machine perfusion performed using

183 We aimed to determine whether hypothermic oxygenated machine perfusion would improve o

184 Hypothermic oxygenated perfusion (HOPE) was designed to

185 A novel perfusion approach, hypothermic oxygenated perfusion (HOPE), used for DCD li

186 s pretreated with the new machine perfusion "Hypothermic Oxygenated PErfusion" (HOPE) in an attempt t

187 s a durable measure in both normothermic and hypothermic patient groups.

188 lpha and IL-6 were significantly elevated in hypothermic patients compared with febrile patients.

189 Base deficit in hypothermic patients did not discriminate between patien

190 Hypothermic patients did not have an increased incidence

191 Compared with the nonhypothermic patients, hypothermic patients had higher 28-day (50.0% vs 24.9%,

192 These data suggest that hypothermic patients should be warmed to febrile range t

193 otropic drugs are frequently administered in hypothermic patients to support an assumed inadequate ci

194 In hypothermic patients treated with ibuprofen, there was a

195 Hypothermic patients were 3 times more likely than normo

196 For hypothermic patients, 16.8% were impaired from their Com

197 e mortality rate was significantly higher in hypothermic patients, 70% vs. 35% for febrile patients.

198 eas TP hearts received three cycles of 2 min hypothermic perfusion (26 degrees C) interspersed by 3 m

199 Other hearts received a single 6 min hypothermic perfusion (SHP) before ischaemia.

200 preconditioning (TP), induced by short-term hypothermic perfusion and rewarming, may protect hearts

201 Oxygenated hypothermic perfusion enables the evaluation of kidneys

202 support the use of active oxygenation during hypothermic perfusion of kidneys from donors with intact

203 The inclusion of liver hypothermic perfusion permits safe TVE.

204 be detected in the ureteral effluent during hypothermic perfusion preservation (HPP) and; 2) to dete

205 elin (ET), is significantly increased during hypothermic perfusion preservation (HPP) of kidneys subj

206 findings suggest that full portability in a hypothermic perfusion preservation device seems feasible

207 hosphate (ATP) resynthesis during oxygenated hypothermic perfusion was compared to evaluate the "ex v

208 ation by 32% when measured at the end of the hypothermic period.

209 With arterial hypotension, postarrest, hypothermic piglets had a significant decrease in the pe

210 c placebo control; normothermic epinephrine; hypothermic placebo control; and hypothermic epinephrine

211 resections performed using standard TVE with hypothermic portal perfusion and venovenous bypass betwe

212 Liver resection using standard TVE with hypothermic portal perfusion and venovenous bypass is as

213 sion of suspended animation by ultraprofound hypothermic preservation (0 degrees to 5 degrees C) with

214 n of molecular tools to study the effects of hypothermic preservation and reperfusion and to screen n

215 The allografts were subjected to 4-hr hypothermic preservation and transplanted to the fully m

216 ules and in a canine autotransplant model of hypothermic preservation injury.

217 metabolism in a large animal model of renal hypothermic preservation injury.

218 Supplementing the kidney with oxygen during hypothermic preservation is not common practice.

219 Both methods of hypothermic preservation of kidneys currently used clini

220 in its minimally altered state by combining hypothermic preservation with targeted strategies that c

221 In the second model (hypothermic preservation), IPC was not protective.

222 EPR uses a cold aortic flush to induce deep hypothermic preservation, followed by resuscitation with

223 After 24-hour hypothermic preservation, HMP livers showed lower releas

224 ts on renal graft function are described for hypothermic preservation.

225 ine did not block depletions by altering the hypothermic profiles from that observed during METH only

226 this hypothesis, we evaluated the effects of hypothermic pulmonary artery flushing on the pulmonary c

227 Hypothermic pulmonary artery flushing transiently increa

228 II (in situ flush), we harvested lungs after hypothermic pulmonary artery flushing with modified Euro

229 oup I (controls), we harvested lungs without hypothermic pulmonary artery flushing, and measured Kfc

230 to evaluate transient changes in Kfc during hypothermic pulmonary artery flushing.

231 eness of static cold storage in ice (CS) and hypothermic pulsatile machine perfusion (MP) as methods

232 All kidneys underwent continuous hypothermic pulsatile machine perfusion until transplant

233 During hypothermic pulsatile perfusion preservation (HPPP), oxy

234 All MP kidneys were preserved by continuous hypothermic pulsatile perfusion using Belzer-MPS or Belz

235 hine-perfused using the Newcastle continuous-hypothermic pulsatile preservation system before transpl

236 mperatures that remained entirely within the hypothermic range (e.g., from 32.5 to 35.5 degrees C).

237 Hypothermic rats had a quicker recovery of EEG activity

238 Hypothermic rats had lower serum potassium and higher bl

239 hemic values within 1 min of reperfusion but hypothermic rats had more sustained hyperemia.

240 Hypothermic rats showed improved neurologic recovery at

241 Hypothermic rats were rewarmed gradually over 1 hr.

242 In hypothermic rats, brain temperature was reduced immediat

243 ncture, we observed that mice became rapidly hypothermic reaching a threshold temperature of 28 degre

244 tire preservation period or only for 2 hr of hypothermic reconditioning (HR) subsequent to convention

245 e machine perfusion after cold storage (CS) (hypothermic reconditioning) has been proposed as a conve

246 2 min during the period of cold ischemia and hypothermic reperfusion (HtR).

247 injections of NT69L resulted in a diminished hypothermic response and a diminished anticataleptic eff

248 Stimulation produced a strong hypothermic response in 62% (13/21) of mice (core temper

249 This partial attenuation of the hemorrhagic hypothermic response indicates that an intact POAH is ne

250 Supracollicular decerebration eliminated the hypothermic response observed in intact rats to hindbrai

251 r preproghrelin gene product, attenuates the hypothermic response of preproghrelin knockout mice.

252 The hypothermic response of the f/f rats was markedly prolon

253 h2 knockin mice, indicating that the blunted hypothermic response relates directly to the low 5-HT(Ex

254 is were uninvolved in the attenuation of the hypothermic response to a high, shock-inducing dose of L

255 This study evaluated whether the hypothermic response to bacterial lipopolysaccharide (LP

256 , the COX-1 inhibitor resulted in a profound hypothermic response to LPS and blocked LPS-induced Fos-

257 The prolonged hypothermic response to LPS in the f/f rats was accompan

258 tassium (GIRK) channels, we investigated the hypothermic response to several of these agents on Girk2

259 mg/kg, sc), a delta antagonist, blocked the hypothermic response to SNC-80 (35 mg/kg, im).

260 The hypothermic response to TNF-alpha (80 microg/kg iv) was

261 LPS-induced hypothermic response, infiltration of inflammatory cells

262 lated in an attempt to alter the hemorrhagic hypothermic response.

263 els also are involved in the alcohol-induced hypothermic response.

264 AH significantly exacerbated the hemorrhagic hypothermic response.

265 Hypothermic responses of rodents to the peripheral or in

266 tures, cocaine induced both hyperthermic and hypothermic responses.

267 onary bypass (CP/CPB) subjects myocardium to hypothermic reversible ischemic injury that can impair c

268 onary bypass with heat exchanger or a single hypothermic saline flush into the aorta, which proved su

269 cking this transporter are protected against hypothermic sepsis and bacteremia developing as a result

270 either kept normothermic or rendered mildly hypothermic shortly after MCA occlusion for 2 h.

271 Some mammals can enter a severe hypothermic state during hibernation in which metabolic

272 An acute hypothermic stimulus, disinhibition of a brainstem therm

273 Loss of protein synthesis due to hypothermic storage appears biphasic.

274 Prolonged hypothermic storage causes ischemia-reperfusion injury (

275 Prolonged hypothermic storage elicits severe ischemia-reperfusion

276 During hypothermic storage in standard preservation solution, C

277 Hypothermic storage preservation causes disruption of ke

278 tabilize membranes and cells in vitro during hypothermic storage, probably by interacting with the pl

279 protect lungs from the effects of prolonged hypothermic storage.

280 and enhances graft survival after prolonged hypothermic storage.

281 y allograft injury associated with prolonged hypothermic storage.

282 Monocyte incubation at hypothermic temperatures (34 degrees C) reduced HLA-DR s

283 uction of transplantation and routine use of hypothermic temperatures for kidney preservation, there

284 ma of body temperature (that is, became less hypothermic), than did animals with fewer social partner

285 on of A1ARs to be used in the induction of a hypothermic, therapeutically beneficial state in humans.

286 s with asphyxial encephalopathy who received hypothermic therapy had improved neurologic outcomes at

287 Whether hypothermic therapy improves neurodevelopmental outcomes

288 iation, hyperbaric oxygen therapy, hyper- or hypothermic therapy, and photodynamic therapy.

289 ent temperatures and food restriction induce hypothermic (torpor) bouts and characteristic metabolic

290 These findings demonstrate that a deeply hypothermic, torpor-like state can be pharmacologically

291 R agonist N6-cyclohexyladenosine to induce a hypothermic, torpor-like state in the (nonhibernating) r

292 Our goal was to decipher the effect of hypothermic total liquid ventilation on the systemic and

293 rker of brain injury, were reduced by 69% in hypothermic treated animals.

294 bjecting the human muscle fiber fragments to hypothermic treatment successfully enriches the cultures

295 omes were observed in children who underwent hypothermic treatment with a 66% increase in mortality (

296 ntly, unwarmed anaesthetised patients become hypothermic, typically by 1-2 degrees C.

297 Contusion volume was larger in hypothermic vs. normothermic rats (44.3 +/- 4.2 vs. 28.6

298 were increased at the end of hypothermia in hypothermic (vs. normothermic) rats (p <.05), indicating

299 serum fentanyl concentrations were higher in hypothermic (vs. normothermic) rats at the end of both h

300 n addition, Lmx1b(f/f/p) mice rapidly became hypothermic when exposed to an ambient temperature of 4