ライフサイエンスコーパス: hypoxanthine-guanine phosphoribosyltransferase

1 e, which encodes the purine recycling enzyme hypoxanthine-guanine phosphoribosyltransferase.

2 disorder caused by deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase.

3 ntitative explanation for the specificity of hypoxanthine-guanine phosphoribosyltransferase, a key en

4 pectrum of clinical features associated with hypoxanthine-guanine phosphoribosyltransferase deficienc

5 e pathogenesis and diagnosis of all forms of hypoxanthine-guanine phosphoribosyltransferase deficienc

6 The coding region of the hypoxanthine (guanine) phosphoribosyltransferase gene wa

7 mutant fraction of 8 x 10(-3) in the nuclear hypoxanthine-guanine phosphoribosyltransferase gene, and

8 o the relatively stable mutation rate of the hypoxanthine-guanine phosphoribosyltransferase gene.

9 and induced cell death and mutations at the hypoxanthine-guanine phosphoribosyltransferase gene.

10 We here demonstrate that human hypoxanthine guanine phosphoribosyltransferase (HGPRT) c

11 ly been shown to be good inhibitors of human hypoxanthine-guanine phosphoribosyltransferase (HGPRT) a

12 donovani salvages purines primarily through hypoxanthine-guanine phosphoribosyltransferase (HGPRT) a

13 33% amino acid identity with the L. donovani hypoxanthine-guanine phosphoribosyltransferase (HGPRT) a

14 Homozygous null mutants of the hypoxanthine-guanine phosphoribosyltransferase (hgprt) a

15 osphate (IMP) complexes of Toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase (HGPRT) h

16 Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) i

17 Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) i

18 Antimutagenic activity was determined at the hypoxanthine-guanine phosphoribosyltransferase (HGPRT) l

19 Two isozymes of the purine salvage enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT) o

20 Crystal structures of hypoxanthine-guanine phosphoribosyltransferase (HGPRT) p

21 To dissect the contributions of hypoxanthine-guanine phosphoribosyltransferase (HGPRT),

22 e crystal structure of the Toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase (HGPRT)-x

23 y a deficiency of the purine salvage enzyme, hypoxanthine-guanine phosphoribosyltransferase (HGPRT).

24 thase (GMPS) or direct salvage of guanine by hypoxanthine-guanine phosphoribosyltransferase (HGPRT).

25 transferase (HGXPRT) and Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase (HGPRT).

26 l deficiency of the purine recycling enzyme, hypoxanthine-guanine phosphoribosyltransferase (HGprt).

27 Purine nucleoside phosphorylase (PNP) and hypoxanthine-guanine phosphoribosyltransferase (HGPRTase

28 alarial enzyme are similar to those of human hypoxanthine-guanine phosphoribosyltransferase (HGPRTase

29 Hypoxanthine-guanine phosphoribosyltransferase (HGPRTase

30 Hypoxanthine-guanine phosphoribosyltransferase (HGPRTase

31 ics (MD) simulations on two enzymes: a human hypoxanthine-guanine-phosphoribosyltransferase (HGPRTase

32 city and induced mutation frequencies at the hypoxanthine guanine phosphoribosyltransferase (HPRT) lo

33 genetic disorder caused by mutations of the hypoxanthine guanine phosphoribosyltransferase (HPRT) pu

34 gene encoding the purine biosynthetic enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT) ca

35 e transcriptional promoter and exon 1 of the hypoxanthine-guanine phosphoribosyltransferase (HPRT) ge

36 Somatic mutations in the hypoxanthine-guanine phosphoribosyltransferase (hprt) ge

37 junctions associated with cRSS sites at the hypoxanthine-guanine phosphoribosyltransferase (HPRT) lo

38 Here we present the hypoxanthine-guanine phosphoribosyltransferase (HPRT) re

39 ype, multiple mutations were detected in the hypoxanthine-guanine phosphoribosyltransferase (HPRT) re

40 way salvages guanine through the activity of hypoxanthine-guanine phosphoribosyltransferase (HPRT) to

41 frequency of somatic mutations (Mfs) at the hypoxanthine-guanine phosphoribosyltransferase (HPRT)-re

42 d by deficiency of the purine salvage enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT).

43 catalyzed by the X chromosome-linked enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT).

44 d in human lymphoblastoid cells in the human hypoxanthine-guanine-phosphoribosyltransferase (HPRT) ge

45 These genes included those for hypoxanthine-guanine phosphoribosyltransferase (hpt), ad

46 lpha) and two with 17alpha or Yalpha and the hypoxanthine guanine phosphoribosyltransferase locus (HP

47 single-copy transgene (Tg; inserted into the hypoxanthine-guanine phosphoribosyltransferase locus) th

48 One potential new target is hypoxanthine-guanine phosphoribosyltransferase (MtHGPRT)

49 We have generated a cell line derived from a hypoxanthine-guanine phosphoribosyltransferase negative

50 gle Mg2+ ion and Arg(63), in contrast to the hypoxanthine-guanine phosphoribosyltransferases, which u