ライフサイエンスコーパス: hypoxia-inducible factor

1 tiple molecular switches, including mTOR and hypoxia-inducible factor.

2 ia-induced MDSC infiltration is dependent on hypoxia-inducible factors.

3 protein levels in macrophages and T cells of hypoxia inducible factor 1 alpha (HIF-1alpha), the regul

4 from hydroxylating the transcription factor hypoxia inducible factor 1 alpha (HIF1alpha), targeting

5 The hypoxia inducible factor 1 alpha subunit (HIF1A) directl

6 found that E2 and PPT induced the binding of hypoxia inducible factor 1 alpha subunit (HIF1A) in the

7 ding IGF1, B cell CLL/lymphoma 2 (BCL2), and hypoxia inducible factor 1, alpha subunit (HIF1A).

8 Tumor hypoxia and hypoxia-inducible factor 1 (HIF-1) activation are associ

9 Hilpda proved to be a target of hypoxia-inducible factor 1 (Hif-1) and peroxisome prolif

10 Hypoxia-inducible factor 1 (HIF-1) has been recognized a

11 Hypoxia-inducible factor 1 (HIF-1) has been suggested to

12 recent work delineating mechanisms by which hypoxia-inducible factor 1 (HIF-1) mediates adaptive met

13 ia-induced amoeboid detachment was driven by hypoxia-inducible factor 1 (HIF-1), followed the downreg

14 ed in ischemic brain preconditioning (PC) by hypoxia-inducible factor 1 (HIF-1).

15 Levels of hypoxia-inducible factor 1 alpha (HIF1alpha) mRNA, a tar

16 utyrate (SB) may indirectly (through reduced hypoxia-inducible factor 1 alpha stabilization) decrease

17 We found that wild-type p53 and hypoxia-inducible factor 1 co-regulate hDBR1 expression,

18 , vascular endothelial growth factor (VEGF), hypoxia-inducible factor 1-alpha (HIF-1alpha) and erythr

19 that the expression of NLRP3 is mediated by hypoxia-inducible factor 1-alpha (HIF-1alpha) during the

20 in physiological oxygen conditions through a hypoxia-inducible factor 1-alpha (HIF-1alpha)-dependent

21 We demonstrate that hypoxia-inducible factor 1-alpha (HIF1A) inhibition in l

22 mutant mice did not display accumulation of hypoxia-inducible factor 1-alpha (HIF1alpha), and deleti

23 TLR-primed cells was dependent, in part, on hypoxia-inducible factor 1-alpha and was essential for i

24 e kinase release spectrophotometrically, and hypoxia-inducible factor 1-alpha by Western blotting.

25 Hypoxia-inducible factor 1-alpha was elevated but not ma

26 cIH induced systemic insulin resistance in a hypoxia-inducible factor 1-independent manner and impair

27 Hypoxia-inducible factors 1 and 2 (HIF-1 and -2) control

28 ated their ability to respond to hypoxia via hypoxia-inducible factors 1 and 2, tumor relapse was una

29 activated mTORC1 and downstream upregulated hypoxia inducible factor-1 (HIF-1alpha) expression.

30 Given that both AR and hypoxia inducible factor-1 alpha (HIF-1alpha) are key re

31 mpaired activity of the transcription factor hypoxia inducible factor-1 alpha (HIF-1alpha).

32 Hypoxia-inducible factor-1 (HIF-1) is a key gene regulat

33 LOX in colorectal cancer synergizes with hypoxia-inducible factor-1 (HIF-1) to promote tumor prog

34 the effects of pharmacological inhibition of hypoxia-inducible factor-1 (HIF-1), a critical regulator

35 -kappaB), STAT3, activator protein-1 (AP-1), hypoxia-inducible factor-1 (HIF-1), and tumor protein 53

36 ecular key players in tumor hypoxia, such as hypoxia-inducible factor-1 (HIF-1), have been discovered

37 The primary mediating factor is the hypoxia-inducible factor-1 (HIF-1).

38 to be regulated by the transcription factor hypoxia-inducible factor-1 (HIF-1).

39 Exposure to SB also suppressed hypoxia-inducible factor-1 (HIF-1alpha) stabilization an

40 ssor VHL, driving constitutive activation of hypoxia-inducible factor-1 (HIF1) and HIF2.

41 hypoxic/ischemic retinal ganglion cells in a hypoxia-inducible factor-1 alpha (HIF-1alpha)-dependent

42 pimonidazole, macrophage marker RAM-11, and hypoxia-inducible factor-1 alpha subunit [HIF-1alpha]).

43 Here, we show that hypoxia inducible factor-1a (HIF-1alpha) controls the ov

44 ffect through ROS-dependent stabilization of hypoxia-inducible factor-1A and reduced pyruvate kinase

45 ion of the ET-1 gene occurs by activation of hypoxia inducible factor 1alpha (HIF-1alpha) and posttra

46 a hypoxia-induced pathway that utilizes the Hypoxia Inducible Factor 1alpha (HIF-1alpha) transcripti

47 affected in PC, under hypoxic condition in a hypoxia inducible factor 1alpha (HIF-1alpha)-independent

48 multiple mechanisms, including activation of hypoxia inducible factor 1alpha (HIF1alpha).

49 lysis, as evidenced by the downregulation of hypoxia inducible factor 1alpha and failure to upregulat

50 s T-cell factor, forkhead box protein O, and hypoxia inducible factor 1alpha to regulate the expressi

51 We show that endothelial hypoxia-inducible factor 1alpha (HIF-1alpha) controls gl

52 Here we show that hypoxia-inducible factor 1alpha (HIF-1alpha) controls mu

53 Our previous studies indicate that hypoxia-inducible factor 1alpha (HIF-1alpha) cooperates

54 d growth, blood vessel density, and VEGF and hypoxia-inducible factor 1alpha (HIF-1alpha) expression

55 We hypothesized that hypoxia via hypoxia-inducible factor 1alpha (HIF-1alpha) might contr

56 Ectopic expression of miR-211 reduced hypoxia-inducible factor 1alpha (HIF-1alpha) protein lev

57 Inhibition of PDK1 or knockout of hypoxia-inducible factor 1alpha (HIF-1alpha) reversed th

58 HRG are mediated by the transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha) via ErbB3 a

59 In addition, Tip110 regulated hypoxia-inducible factor 1alpha (HIF-1alpha), likely thr

60 m a wide variety of partners, including p53, hypoxia-inducible factor 1alpha (HIF-1alpha), NF-kappaB,

61 Additionally, the expression of hypoxia-inducible factor 1alpha (Hif-1alpha), Snail1, Sl

62 Augmented hypoxia-inducible factor 1alpha (HIF-1alpha)-induced gly

63 ignal-regulated kinase 1/2 (ERK1/2) pathway, hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated va

64 by the oxygen-sensitive transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha).

65 ow that Parkin is an E3 ubiquitin ligase for hypoxia-inducible factor 1alpha (HIF-1alpha).

66 santin including NF-kappaB, MAPK, STAT3, and hypoxia-inducible factor 1alpha (HIF-1alpha).

67 of pathological cardiac hypertrophy through hypoxia-inducible factor 1alpha (HIF1alpha) activation o

68 We identified hypoxia-inducible factor 1alpha (HIF1alpha) as a key tra

69 EM expansion in hypoxia corresponded to high hypoxia-inducible factor 1alpha (HIF1alpha) expression a

70 Hypoxia-inducible factor 1alpha (HIF1alpha) is a crucial

71 %), and overexpression of oxygen-insensitive hypoxia-inducible factor 1alpha (Hif1alpha) or its downs

72 nscription is upregulated by hypoxia through hypoxia-inducible factor 1alpha (Hif1alpha) stabilizatio

73 Overexpression of hypoxia-inducible factor 1alpha (HIF1alpha), glucose tra

74 Expression of hypoxia-inducible factor 1alpha and heme oxygenase 1 in

75 protein analysis of hippocampal samples for hypoxia-inducible factor 1alpha and heme oxygenase 1, an

76 Furthermore, adipose tissue hypoxia-inducible factor 1alpha expression and inflammat

77 VHL mutation and hypoxia-inducible factor 1alpha expression may be predic

78 greater macrophage chemotactic protein-1 and hypoxia-inducible factor 1alpha expression.

79 Hypoxia-inducible factor 1alpha immunostaining was highe

80 High hypoxia-inducible factor 1alpha protein expression was a

81 itor cells was not because of alterations in hypoxia-inducible factor 1alpha signaling or the oxygena

82 stochemistry staining, mRNA, and protein for hypoxia-inducible factor 1alpha were upregulated within

83 t in addition to matrix metalloproteinase 9, hypoxia-inducible factor 1alpha, and cleaved AMPKalpha,

84 ic molecules and the accumulation of retinal hypoxia-inducible factor 1alpha, indicating hypoxia.

85 genous RNA sequesters miRNA let-7 to release Hypoxia-inducible factor 1alpha, leading to an increase

86 Regarding the mechanism of action, hypoxia-inducible factor 1alpha-induced heme oxygenase 1

87 was associated with decreased expression of hypoxia-inducible factor 1alpha.

88 ver, PlGF induced the expression of ET-1 via hypoxia-inducible factor 1alpha.

89 oxia and oxidative stress with expression of hypoxia-inducible factors 1alpha and 2alpha, heat shock

90 HIF (hypoxia-inducible factor)-1alpha is a major determinant

91 (PAECs), expression of transcription factor hypoxia inducible factor-1alpha (HIF-1alpha) is increase

92 nstrate that MUC1-regulated stabilization of hypoxia inducible factor-1alpha (HIF-1alpha) mediates su

93 Overexpression of gankyrin decreases hypoxia inducible factor-1alpha (HIF-1alpha) protein lev

94 The transcription factor hypoxia inducible factor-1alpha (HIF-1alpha) was recentl

95 DF-induced metabolic reprogramming required hypoxia inducible factor-1alpha (HIF-1alpha), downstream

96 roxymethylation of the Oct4 promoter and was hypoxia inducible factor-1alpha (HIF-1alpha, encoded by

97 Mechanistically, hypoxia inducible factor-1alpha (HIF1alpha) mediated thi

98 Here we demonstrate that Hypoxia inducible factor-1alpha (Hif1alpha), a key media

99 ression in all S-HB, while 4/5 showed either Hypoxia Inducible Factor-1alpha or 2alpha upregulation.

100 Loss of smooth muscle cell hypoxia inducible factor-1alpha underlies increased vasc

101 lular metabolism, including up-regulation of hypoxia inducible factor-1alpha's downstream processes a

102 The elucidation of the VHL-HIF-1alpha (hypoxia inducible factor-1alpha)-VEGF (vascular endothel

103 ruvate dehydrogenase kinase-3, and levels of hypoxia inducible factor-1alpha.

104 cell motility and matrix remodeling through hypoxia-inducible factor-1alpha (HIF-1alpha) activation.

105 tress-induced p53 physically interacted with hypoxia-inducible factor-1alpha (HIF-1alpha) and attenua

106 sion of epithelial injury markers, including hypoxia-inducible factor-1alpha (HIF-1alpha) and plasmin

107 s, matrix gene expression, and expression of hypoxia-inducible factor-1alpha (HIF-1alpha) and TGF-bet

108 responses to oxygen deprivation by mediating hypoxia-inducible factor-1alpha (HIF-1alpha) hydroxylati

109 kappaB or Sp1 inhibitors, but was blocked by hypoxia-inducible factor-1alpha (HIF-1alpha) inhibition

110 Hypoxia-inducible factor-1alpha (HIF-1alpha) is a transc

111 study, we show that the transcription factor hypoxia-inducible factor-1alpha (HIF-1alpha) is an essen

112 cidated, although it has been suggested that hypoxia-inducible factor-1alpha (HIF-1alpha) mediates in

113 ular responses to hypoxia with shRNA, namely hypoxia-inducible factor-1alpha (HIF-1alpha) or HIF-2alp

114 rotein-1-like (HSPA1L) expression stabilized hypoxia-inducible factor-1alpha (HIF-1alpha) protein and

115 diated PHLPP1 transcriptional inhibition and hypoxia-inducible factor-1alpha (HIF-1alpha) protein tra

116 The role of C/EBPbeta and hypoxia-inducible factor-1alpha (HIF-1alpha) signaling w

117 ro, rHDL increased key mediators involved in hypoxia-inducible factor-1alpha (HIF-1alpha) stabilizati

118 Hypoxia-inducible factor-1alpha (HIF-1alpha), which accu

119 and degradation of the transcription factor hypoxia-inducible factor-1alpha (HIF-1alpha).

120 common genes, among which are those encoding hypoxia-inducible factor-1alpha (HIF1A) and VEGFA.

121 sm is elevated tumor hypoxia and upregulated hypoxia-inducible factor-1alpha (HIF1alpha) caused by an

122 eport that miR-210 expression is elevated by hypoxia-inducible factor-1alpha (HIF1alpha) in MDSC loca

123 Stabilisation of hypoxia-inducible factor-1alpha (HIF1alpha) in tumours c

124 n of the profibrotic markers fibronectin and hypoxia-inducible factor-1alpha and reversed TGF-beta1-i

125 e regulated by hypoxia-inducible factor, and hypoxia-inducible factor-1alpha induction was attenuated

126 in greater sensitivity to inhibition of the hypoxia-inducible factor-1alpha pathway, suggesting that

127 In addition, there was reduced expression of hypoxia-inducible factor-1alpha relevant in the pathogen

128 h inhibition related to an interference with hypoxia-inducible factor-1alpha signaling pathways and i

129 a2 regulates alpha-ketoglutarate generation, hypoxia-inducible factor-1alpha stability, and neutrophi

130 pha-ketoglutarate, which negatively regulate hypoxia-inducible factor-1alpha stability, were attenuat

131 s accompanied by nonheme iron deposition and hypoxia-inducible factor-1alpha upregulation in the rena

132 , and immunoblotting (nuclear factor-kappaB, hypoxia-inducible factor-1alpha, heme oxygenase-1, induc

133 nd that sustained RUNX2 expression activates hypoxia-inducible factor-1alpha, leading to aberrant pro

134 pectedly, its specific transcription factor, hypoxia-inducible factor-1alpha, was shown of no signifi

135 ncreases proliferation via ROS-dependent but hypoxia-inducible factor-1alpha-independent mechanisms.

136 n levels that was prevented by knocking down hypoxia-inducible factor-1alpha.

137 (ROS), leading to lactate production through hypoxia-inducible factor-1alpha.

138 : IL-1R-associated kinase-M, NFkB2/p100, and hypoxia-inducible factor-1alpha.

139 Its role in regulating hypoxia-inducible factors-1alpha (HIF-1alpha) and -2alph

140 Hypoxia-inducible factor 2 (HIF-2) controls EPO synthesi

141 yl hydroxylase gene (PHD) 1 and 2 and in the hypoxia-inducible factor 2 alpha (HIF2A) were also found

142 Decreases of renal pO2 promote hypoxia-inducible factor 2-mediated (HIF-2-mediated) ind

143 ongoing with the reduction in hepatocellular hypoxia inducible factor 2a (Hif2a).

144 ariant mapped to the EPAS1 gene encoding the hypoxia inducible factor 2alpha.

145 ression of Bcl2-like12 (Bcl2L12), c-Met, and hypoxia-inducible factor 2alpha (HIF2A) is of central im

146 The hypoxia-inducible factor 2alpha (HIF2alpha), an oncogeni

147 Interestingly, this response was executed by hypoxia-inducible factor 2alpha (HIF2alpha), which contr

148 og forms a complex with the oxygen-regulated hypoxia-inducible factor 2alpha and can escape translati

149 of rapamycin complex 1 (eIF4E-dependent) or hypoxia-inducible factor 2alpha expression (eIF4E2-depen

150 ypoxia contributes to tumor progression in a hypoxia inducible factor-2alpha (HIF-2alpha)-dependent m

151 ), leading to inappropriate stabilization of hypoxia-inducible factor-2alpha (HIF-2alpha).

152 gln1 and Hif1a or Egln1 and Hif2a identified hypoxia-inducible factor-2alpha as the critical mediator

153 Thus, targeting PHD2/hypoxia-inducible factor-2alpha signaling is a promising

154 th muscle cell proliferation in part through hypoxia-inducible factor-2alpha-activated CXCL12 express

155 We further found that hypoxia-inducible factors activate the transcription of

156 R overexpressing carcinoma cells induce HIF (hypoxia-inducible factor) activation with increased gluc

157 n TET expression, proliferation, metabolism, hypoxia-inducible factor activity or reactive oxygen spe

158 ) are molecular oxygen sensors that regulate hypoxia-inducible factor activity, but their functions i

159 We show that the Drosophila hypoxia inducible factor alpha (HIFalpha) ortholog Simil

160 in mammals that posttranslationally modifies hypoxia-inducible factor alpha (HIF-alpha) and targets i

161 Although LSD1-induced hypoxia-inducible factor alpha (HIF1alpha) demethylation

162 dent prolyl hydroxylase (PHD) reaction, with hypoxia-inducible factor alpha (HIFalpha) being its most

163 tent of deregulation of the alpha subunit of hypoxia-inducible factor alpha, a well established targe

164 ve retained proper binding and regulation of hypoxia-inducible factor alpha, showed a severe defect i

165 understanding how dysregulation of the many hypoxia-inducible factor alpha-dependent and -independen

166 hat during human sepsis monocytes upregulate hypoxia-inducible factor-alpha (HIF1-alpha) activity and

167 We characterized the responsiveness of hypoxia inducible factors and found this correlated with

168 gh dysregulated signaling pathways involving hypoxia-inducible factors and angiogenic factors like VE

169 y angiogenic growth factors are regulated by hypoxia-inducible factor, and hypoxia-inducible factor-1

170 ascular endothelial growth factor (VEGF) and hypoxia-inducible factor by using a histone deacetylase

171 The hypoxia-inducible factor complex (HIF-alpha.aryl hydroca

172 1 (EPAS1), a regulatory alpha subunit of the hypoxia-inducible factor complex, during angiotensin II-

173 Hypoxia-inducible factors coordinately regulate expressi

174 ing differentiation into HLA-G(+) EVTs in an hypoxia-inducible, factor-dependent manner.

175 ssociated with increased fibrosis, decreased hypoxia-inducible factor expression, and decreased micro

176 ional program, mediated predominantly by the hypoxia inducible factor family of transcription factors

177 s including the heat shock factor hsf-1, the hypoxia-inducible factor hif-1, and the insulin/IGF-1 pa

178 the breast tumor kinase, Brk (PTK6), via the hypoxia-inducible factors HIF-1alpha and HIF-2alpha.

179 during early development, we stabilized the hypoxia inducible factor (HIF) pathway under normoxia us

180 Hypoxia inducible factor (HIF) transcription factors res

181 The role of prolyl hydroxylase (PHD)-3 as a hypoxia inducible factor (HIF)-1alpha cofactor is contro

182 Over-activation of hypoxia inducible factor (HIF)-1alpha has been implicate

183 a (RCC) cell lines expressing high levels of Hypoxia Inducible Factor (HIF)-2alpha are more sensitive

184 r 24 hours, or by APC specific deficiency in hypoxia inducible factor (HIF)-2alpha, an oxygen labile

185 echanisms by which hypoxia and activation of hypoxia inducible factor (HIF)-dependent signaling promo

186 geted therapeutics, such as those abrogating hypoxia inducible factor (HIF)/vascular endothelial grow

187 a regulatory feedback circuit consisting of hypoxia-inducible factor (HIF) 1 alpha, microRNA-210 (mi

188 ces for associations between hypoxia and the hypoxia-inducible factor (Hif) 1 signaling and glycolysi

189 udy was to investigate whether cell-specific hypoxia-inducible factor (HIF) 1alpha regulates cancer-a

190 Hypoxia-inducible factor (HIF) activation associated wit

191 of the arginine-degrading agent ADI-PEG20 on hypoxia-inducible factor (HIF) activation, the hypoxia-i

192 ore, because acidic pH is known to stabilize hypoxia-inducible factor (HIF) and 2-HG is a known inhib

193 nalysis revealed relative down-regulation of hypoxia-inducible factor (HIF) and vascular endothelial

194 On the one hand, knockdown of hypoxia-inducible factor (HIF) beta in the VHL-deficient

195 aptations are mediated primarily through the hypoxia-inducible factor (HIF) complex.

196 ghts have been gained through studies of the hypoxia-inducible factor (HIF) hydroxylase system.

197 The hypoxia-inducible factor (HIF) hydroxylases regulate hyp

198 Here we uncovered a role for intestinal hypoxia-inducible factor (HIF) in hepatic steatosis.

199 The hypoxia-inducible factor (HIF) is a key regulator of the

200 Hypoxia-inducible factor (HIF) is a key transcriptional

201 As the most studied O2 "sensor," hypoxia-inducible factor (HIF) is regarded as an importa

202 The hypoxia-inducible factor (HIF) is the master regulator o

203 While the Hypoxia-Inducible Factor (HIF) is the primary driver of

204 xia sensing, putatively via an action on the hypoxia-inducible factor (HIF) pathway.

205 xadustat (FG-4592) is an orally bioavailable hypoxia-inducible factor (HIF) prolyl hydroxylase inhibi

206 yclic)pyrimidine-5-carboxamide inhibitors of hypoxia-inducible factor (HIF) prolyl hydroxylases (PHD)

207 in chondrocytes elevated mRNA expression of hypoxia-inducible factor (HIF) signaling molecules inclu

208 mes (PHDs) sense cellular oxygen upstream of hypoxia-inducible factor (HIF) signaling, leading to HIF

209 ygen-induced retinopathy (OIR, ROP model) by hypoxia-inducible factor (HIF) stabilization via HIF pro

210 The hypoxia-inducible factor (HIF) system orchestrates cellu

211 toma cells and the expression levels of some hypoxia-inducible factor (HIF) target genes via TET inhi

212 s known to activate the transcription factor hypoxia-inducible factor (HIF) that increases lactate ef

213 Egln1, which senses oxygen and regulates the hypoxia-inducible factor (HIF) transcription factor, cou

214 Although the hypoxia-inducible factor (HIF) transcriptional pathway t

215 demethylating RACK1 protein, a component of hypoxia-inducible factor (HIF) ubiquitination machinery,

216 IF (FIH), confers oxygen-dependence upon the hypoxia-inducible factor (HIF), a master regulator of th

217 n regulates cellular function is through the hypoxia-inducible factor (HIF), a transcription factor c

218 consumption and results in stabilization of hypoxia-inducible factor (HIF), a transcription factor c

219 The hypoxia-inducible factor (HIF), HIF-1, is a central regu

220 lular transcriptional responses, mediated by hypoxia-inducible factor (HIF), is common in many types

221 Hypoxia activates the hypoxia-inducible factor (HIF), promoting glycolysis and

222 Hypoxia-inducible factor (HIF)-1 mediates hypoxia- and c

223 nit of glutamate-cysteine ligase (GCLM) in a hypoxia-inducible factor (HIF)-1-dependent manner, leadi

224 The hypoxia-inducible factor (Hif)-1alpha (Hif-1alpha) and H

225 factors GATA-binding protein 4 (GATA-4) and hypoxia-inducible factor (HIF)-1alpha and -2alpha in res

226 intestine, the hypoxic transcription factors hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha are

227 Under hypoxic conditions, stabilized hypoxia-inducible factor (HIF)-1alpha downregulates Daxx

228 r atpenin A5 in normoxia robustly stabilizes hypoxia-inducible factor (HIF)-1alpha in primary monocyt

229 Hypoxia-inducible factor (HIF)-1alpha is a transcription

230 lability decreases, the transcription factor hypoxia-inducible factor (HIF)-1alpha is stabilized and

231 that a key angiogenic transcriptional factor hypoxia-inducible factor (HIF)-1alpha is stabilized by G

232 Consistent herewith, hypoxia-inducible factor (HIF)-1alpha levels controlled

233 t the hypoxic cellular response, mediated by hypoxia-inducible factor (HIF)-1alpha, is required to pr

234 found that burn injury activated mTORC1 and hypoxia-inducible factor (HIF)-1alpha, which paralleled

235 ffects in other contexts have been linked to hypoxia-inducible factor (HIF)-1alpha, which was enhance

236 R pathway, which synergizes the induction of hypoxia-inducible factor (HIF)-2alpha expression.

237 Our data demonstrate that the intestine via hypoxia-inducible factor (HIF)-2alpha is an essential re

238 ypoxic response via the transcription factor hypoxia-inducible factor (HIF)-2alpha is highly activate

239 Hypoxia-inducible factor (HIF)-alpha isoforms regulate k

240 creased production of red blood cells due to hypoxia-inducible factor (HIF)-mediated induction of ery

241 the expression of Ephrin-A3 through a novel hypoxia-inducible factor (HIF)-mediated mechanism.

242 ransduction is transcriptionally mediated by hypoxia-inducible factor (HIF).

243 We hypothesized that hypoxia-inducible factor (HIF)1alpha promotes proliferat

244 me of hypoxia-targeted therapeutics, such as hypoxia-inducible factor (HIF-1) inhibitors and hypoxia-

245 he only amino acids from those to activate a hypoxia-inducible factor (HIF-1) reporter strain.

246 ization and degradation of proteins, such as hypoxia-inducible factor (HIF; via Cullin-2).

247 Hypoxia-inducible factors (HIF) are heterodimeric transc

248 One important function of hypoxia and the hypoxia-inducible factors (HIF) is the maintenance of ca

249 of pVHL is to regulate the stability of the hypoxia-inducible factors (HIF), which become constituti

250 l transition (EMT) transcription factors and hypoxia-inducible-factor (HIF)-1 gene signature.

251 onses to hypoxia are largely mediated by the hypoxia-inducible factors, Hif-1 and Hif-2.

252 timescale WR-1065 induced expression of the Hypoxia Inducible Factor HIF1alpha, lactate dehydrogenas

253 The alpha-subunits of hypoxia-inducible factors (HIF1alpha and HIF2alpha) prom

254 tegies to using small molecules to stimulate hypoxia inducible factors (HIFs) activity and trigger a

255 Hypoxia inducible factors (HIFs) are alpha/beta heterodi

256 Hypoxia inducible factors (HIFs) are centrally involved

257 Hypoxia inducible factors (HIFs) are ubiquitously expres

258 which targets hydroxylated alpha subunit of hypoxia inducible factors (HIFs) for ubiquitination and

259 As such as microRNA (miR)-210 that regulates hypoxia inducible factors (HIFs).

260 Hypoxia-inducible factors (HIFs) 1 and 2 are dimeric alp

261 idative bioenergetic pathways and suppressed hypoxia-inducible factors (HIFs) and phosphorylation of

262 ly to occur, in part, through suppression of hypoxia-inducible factors (HIFs) and vascular endothelia

263 tion in response to oxygen fluctuations, and hypoxia-inducible factors (HIFs) are central mediators o

264 Hypoxia and stabilization of hypoxia-inducible factors (HIFs) are hallmark features o

265 their role in cellular responses to hypoxia, hypoxia-inducible factors (HIFs) are involved in innate

266 in the VHL tumor suppressor stabilizing the hypoxia-inducible factors (HIFs) are the most prevalent

267 fect of high altitude hypoxia on the RAS and hypoxia-inducible factors (HIFs) by measuring mRNA and p

268 nsive changes in gene expression mediated by Hypoxia-Inducible Factors (HIFs) contribute significantl

269 The hypoxia-inducible factors (HIFs) coordinate cellular ada

270 brafish that identifies GCs as activators of hypoxia-inducible factors (HIFs) in the liver.

271 Oxygen-sensing pathways executed by the hypoxia-inducible factors (HIFs) induce a cellular adapt

272 Hypoxia-inducible factors (HIFs) regulate the production

273 NAs is accelerated post-transcriptionally by hypoxia-inducible factors (HIFs) through HIF-Drosha inte

274 ation to oxygen deficiency is the binding of hypoxia-inducible factors (HIFs) to hypoxia response ele

275 tations to sustained hypoxia are mediated by hypoxia-inducible factors (HIFs) to regulate downstream

276 SPC number and intracellular content of hypoxia-inducible factors (HIFs) were evaluated by flow

277 oiesis and leukemogenesis are dependent upon hypoxia-inducible factors (HIFs), a family of essential

278 ecules including proteins that interact with hypoxia-inducible factors (HIFs), transcription factors

279 an cancer and leads to increased activity of hypoxia-inducible factors (HIFs), which regulate the exp

280 on of the VHL gene leads to stabilization of hypoxia-inducible factors (HIFs).

281 tly of Notch by antagonizing the activity of hypoxia-inducible factors (HIFs).

282 suppressor pVHL is an E3 ligase that targets hypoxia-inducible factors (HIFs).

283 ion of a transcriptional program mediated by hypoxia-inducible factors (HIFs).

284 maging probe, and analyzed the expression of hypoxia-inducible factors (HIFs).

285 ffected by pharmacological interference with hypoxia-inducible factors (HIFs).

286 t function off the transcription factor HIF (hypoxia-inducible factor) in the regulation of key targe

287 investigations defined basic mechanisms for hypoxia-inducible factor induction of EPO expression, an

288 ligand 26 production in cancer cells by the hypoxia-inducible factor inhibitor digoxin or blockade o

289 s of ion channels, as well as members of the hypoxia-inducible factors pathway.

290 r transactivation and downstream signalling, hypoxia-inducible factors, positive feedback between Src

291 Hypoxia-inducible factor prolyl hydroxylase inhibitors s

292 ore the relationship between the dose of the hypoxia-inducible factor-prolyl hydroxylase inhibitor GS

293 in-5-yl}benzonitrile-based inhibitors of the hypoxia-inducible factor prolylhydroxylase domain-1 (PHD

294 T cells, achieved by conditional deletion of hypoxia-inducible factor regulator Vhl, accelerated CD8(

295 with a focus on its relations with VEGF and hypoxia inducible factor related angiogenesis pathways,

296 l hydroxylase inhibitors stabilize levels of hypoxia-inducible factor that upregulate transcription o

297 prolyl and asparaginyl hydroxylation of the hypoxia-inducible factors that play important roles in t

298 Stabilization of hypoxia-inducible factors under hypoxia resulted in most

299 Chetomin, an inhibitor of hypoxia-inducible factors, was found to strongly increas

300 tress management is under the control of the Hypoxia Inducible Factors, whose activity depends on the