ライフサイエンスコーパス: hypoxia-inducible factor 1

1 regulated by the transcription factor HIF-1 (hypoxia-inducible factor 1).

2 regulates Complex II expression and opposes hypoxia-inducible factor-1.

3 sion is mediated by the transcription factor hypoxia-inducible factor-1.

4 lly mediated at the transcriptional level by hypoxia-inducible factor-1.

5 riptional activator, which was identified as hypoxia-inducible factor-1.

6 In this study, we demonstrate that hypoxia-inducible factor 1 activates the transcription o

7 phage glucose metabolism pathway via the Vpr-hypoxia inducible factor 1 alpha (HIF-1 alpha) axis to i

8 The promoter of the hypoxia inducible factor 1 alpha (HIF-1alpha) gene has a

9 protein levels in macrophages and T cells of hypoxia inducible factor 1 alpha (HIF-1alpha), the regul

10 entified in this screen, only one candidate, hypoxia inducible factor 1 alpha (Hif1alpha), did not ha

11 from hydroxylating the transcription factor hypoxia inducible factor 1 alpha (HIF1alpha), targeting

12 The hypoxia inducible factor 1 alpha subunit (HIF1A) directl

13 found that E2 and PPT induced the binding of hypoxia inducible factor 1 alpha subunit (HIF1A) in the

14 ine production of VEGF with the induction of hypoxia inducible factor-1 alpha (HIF-1 alpha) and survi

15 control, and immunohistochemical staining of hypoxia inducible factor-1 alpha (HIF-1 alpha), vascular

16 of PI-3 kinase, reactive oxygen species and hypoxia inducible factor-1 alpha (HIF-1 alpha).

17 nd it was accompanied by decreased levels of hypoxia inducible factor-1 alpha (HIF-1alpha) and Bcl-2.

18 Given that both AR and hypoxia inducible factor-1 alpha (HIF-1alpha) are key re

19 mpaired activity of the transcription factor hypoxia inducible factor-1 alpha (HIF-1alpha).

20 However, hypoxia inducible factor-1 alpha is naturally degraded b

21 trol, inhibition of PHD2 increased levels of hypoxia inducible factor-1 alpha protein and several dow

22 th shPHD2 had significantly higher levels of hypoxia inducible factor-1 alpha protein.

23 During hypoxia, upregulation of hypoxia inducible factor-1 alpha transcriptional factor

24 ationship for the VHL tumor suppressor gene, hypoxia inducible factor-1 alpha, and vascular endotheli

25 Hypoxia-inducible factor 1 alpha (HIF-1 alpha) is a prot

26 erminal phosphorylation, and the presence of hypoxia-inducible factor 1 alpha (HIF-1 alpha), the oxyg

27 oenvironments where the stabilization of the hypoxia-inducible factor 1 alpha (Hif-1alpha) subunit is

28 posttranscriptional control of expression of hypoxia-inducible factor 1 alpha (HIF-1alpha), a critica

29 not only that LOXL2 was regulated by hypoxia/hypoxia-inducible factor 1 alpha (HIF-1alpha), but also

30 ial cells that have pathologic expression of hypoxia-inducible factor 1 alpha (HIF-1alpha).

31 ressed in neurons and is markedly induced by hypoxia-inducible factor 1 alpha (HIF-1alpha).

32 Hypoxia-inducible factor 1 alpha (HIF1-alpha), which is

33 ty to the cell death phenotype observed when hypoxia-inducible factor 1 alpha (Hif1a) expression was

34 Hypoxia-inducible factor 1 alpha (HIF1alpha) is an essen

35 Levels of hypoxia-inducible factor 1 alpha (HIF1alpha) mRNA, a tar

36 sents a common pathway for the regulation of hypoxia-inducible factor 1 alpha (HIF1alpha)-dependent V

37 nd STAT6 phosphorylation, and down-regulated hypoxia-inducible factor 1 alpha and its downstream targ

38 activity associated with induction of tumor hypoxia-inducible factor 1 alpha expression and marked i

39 utyrate (SB) may indirectly (through reduced hypoxia-inducible factor 1 alpha stabilization) decrease

40 lower expression of lactate dehydrogenase 5, hypoxia-inducible factor 1 alpha subunit, and vascular e

41 opalisading cells show nuclear expression of hypoxia-inducible factor 1 alpha, consistent with their

42 terodimeric transcription factor, comprising hypoxia-inducible factor-1 alpha (HIF-1 alpha) and ARNT.

43 ealed that mTOR controls the accumulation of hypoxia-inducible factor-1 alpha (HIF-1 alpha) and the c

44 asts were hypersensitive to the induction of hypoxia-inducible factor-1 alpha (HIF-1 alpha) under hyp

45 EP1 receptor up-regulates the expression of hypoxia-inducible factor-1 alpha (HIF-1 alpha), which ca

46 ctly associated with a low oxygen responder, hypoxia-inducible factor-1 alpha (HIF-1 alpha).

47 The protein stability of hypoxia-inducible factor-1 alpha (Hif-1alpha) and Hif-2a

48 Hypoxia-inducible factor-1 alpha (HIF-1alpha) is an impo

49 conditions, HEXIM1 inhibits estrogen-induced hypoxia-inducible factor-1 alpha (HIF-1alpha) protein ex

50 that robustly and persistently expresses the hypoxia-inducible factor-1 alpha (HIF-1alpha) therapeuti

51 ng that cetuximab reduces cellular levels of hypoxia-inducible factor-1 alpha (HIF-1alpha), a transcr

52 hypoxic/ischemic retinal ganglion cells in a hypoxia-inducible factor-1 alpha (HIF-1alpha)-dependent

53 pimonidazole, macrophage marker RAM-11, and hypoxia-inducible factor-1 alpha subunit [HIF-1alpha]).

54 ding IGF1, B cell CLL/lymphoma 2 (BCL2), and hypoxia inducible factor 1, alpha subunit (HIF1A).

55 ene targeting to examine the contribution of hypoxia-inducible factor 1, alpha subunit (HIF-1alpha) t

56 ion by phosphorylation of Akt, which induces hypoxia inducible factor 1-alpha (HIF-1alpha).

57 , vascular endothelial growth factor (VEGF), hypoxia-inducible factor 1-alpha (HIF-1alpha) and erythr

58 that the expression of NLRP3 is mediated by hypoxia-inducible factor 1-alpha (HIF-1alpha) during the

59 s to test whether constitutive expression of hypoxia-inducible factor 1-alpha (HIF-1alpha) influences

60 a mutated (ATM)-dependent phosphorylation of hypoxia-inducible factor 1-alpha (HIF-1alpha) on serine(

61 The hypoxia-inducible factor 1-alpha (HIF-1alpha), a key pla

62 in physiological oxygen conditions through a hypoxia-inducible factor 1-alpha (HIF-1alpha)-dependent

63 We demonstrate that hypoxia-inducible factor 1-alpha (HIF1A) inhibition in l

64 miR-210 transcription was activated in an hypoxia-inducible factor 1-alpha (Hif1a)-dependent manne

65 nsiently increasing the transcription factor hypoxia-inducible factor 1-alpha (HIF1alpha) is required

66 mutant mice did not display accumulation of hypoxia-inducible factor 1-alpha (HIF1alpha), and deleti

67 ation and decreased nuclear translocation of hypoxia-inducible factor 1-alpha and vascular endothelia

68 ivin in endothelial cells and down-regulated hypoxia-inducible factor 1-alpha and VEGF expression in

69 TLR-primed cells was dependent, in part, on hypoxia-inducible factor 1-alpha and was essential for i

70 e kinase release spectrophotometrically, and hypoxia-inducible factor 1-alpha by Western blotting.

71 Importantly, both VHL and the hypoxia-inducible factor 1-alpha gene are experimentally

72 tors nuclear factor of activated T cells and hypoxia-inducible factor 1-alpha in PAH-PASMCs, previous

73 Mechanistically, 1,25-VitD3 increased hypoxia-inducible factor 1-alpha through binding to its

74 Hypoxia-inducible factor 1-alpha was elevated but not ma

75 Hypoxia-regulated hypoxia-inducible factor 1-alpha, (HIF-1alpha) may regul

76 y, Leu increases the intracellular levels of hypoxia-inducible factor 1-alpha, a repressor of endocri

77 eration, up-regulation of AKT signaling, and hypoxia-inducible factor 1-alpha-related angiogenesis.

78 ngiopoietin-1, matrix metalloprotease-2, and hypoxia-inducible factor 1-alpha.

79 ys and knockout and inhibitory strategies of hypoxia-inducible factor 1-alpha.

80 04, nuclear factor of activated T cells, and hypoxia-inducible factor 1-alpha.

81 ered to express tumor-necrosis-factor-alpha, hypoxia-inducible-factor-1-alpha antibodies, interleukin

82 d stress-induced activation of cardiomyocyte hypoxia inducible factor 1 and the release of vascular e

83 Results show accumulation of hypoxia inducible factors 1 and 2alpha (HIF-1 and 2alpha

84 rect transcriptional target of oxygen-labile hypoxia-inducible factor 1 and 2 that accentuates the fo

85 expression of their transcriptional factors hypoxia-inducible factor-1 and c-Myc.

86 owth factor (VEGF) and blocked activation of hypoxia-inducible factor-1 and nuclear factor-kappaB in

87 E were dependent on the transcription factor hypoxia-inducible factor-1 and on formation of a single-

88 Hypoxia-inducible factors 1 and 2 (HIF-1 and -2) control

89 Hypoxia, via the hypoxia-inducible factors 1 and 2 (HIF-1 and HIF-2), upr

90 Hypoxia-inducible factors 1 and 2 (HIF-1 and HIF-2, resp

91 Hypoxia-inducible factors 1 and 2 (HIF1 and HIF2) are he

92 Hypoxia-inducible factors 1 and 2 constitute important c

93 ated their ability to respond to hypoxia via hypoxia-inducible factors 1 and 2, tumor relapse was una

94 up-regulating such transcription factors as hypoxia-inducible factors 1 and 2, which in turn activat

95 ression, in part through the presence of the hypoxia-inducible factor-1-binding site, leading to an a

96 he novel GPx-3 promoter identified Sp-1- and hypoxia-inducible factor-1-binding sites, as well as the

97 We found that wild-type p53 and hypoxia-inducible factor 1 co-regulate hDBR1 expression,

98 2 (A2) gene through the direct action of the hypoxia-inducible factor-1 complex.

99 reased expression of ErbB3 and inhibition of hypoxia-inducible factor-1-dependent responses to hypoxi

100 Hypoxia-inducible factor-1 directly regulated TrkB expre

101 ith higher VEGF (3.65 vs. 5.98; P = 0.01) or hypoxia-inducible factor 1 expression (3.63 vs. 5.48; P

102 ar endothelial growth factor but upregulated hypoxia-inducible factor 1 expression.

103 glucose transporter protein 1 (Glut-1), and hypoxia-inducible factor 1 expression.

104 ntly, we demonstrated that factor-inhibiting hypoxia-inducible factor 1 (FIH-1) diminished glycogen s

105 n undergo hydroxylation by factor-inhibiting hypoxia-inducible factor 1 (FIH-1); however, the biologi

106 Factor inhibiting hypoxia-inducible factor 1 (FIH-1; official symbol HIF1A

107 iRNA, negatively regulates factor inhibiting hypoxia-inducible factor-1 (FIH-1).

108 iCl(2) exposure leads to marked induction of hypoxia inducible factor 1 (HIF-1) in human osteosarcoma

109 Hypoxia inducible factor 1 (HIF-1) is a key player in ca

110 full expression of the transcription factor hypoxia inducible factor 1 (HIF-1).

111 lpha (AMPKalpha) degradation, (ii) increased hypoxia inducible factor-1 (HIF-1) alpha expression, and

112 ators have been identified for its promoter: hypoxia inducible factor-1 (HIF-1) and signal transducer

113 nical data provides evidence for the role of hypoxia inducible factor-1 (HIF-1) as a crucial mediator

114 Hypoxia inducible factor-1 (HIF-1) initiates key cellula

115 Hypoxia inducible factor-1 (HIF-1) is a heterodimeric tr

116 Hypoxia inducible factor-1 (HIF-1) is a master regulator

117 Hypoxia inducible factor-1 (HIF-1) is considered a cruci

118 Hypoxia inducible factor-1 (HIF-1) regulates changes in

119 with tumor resistance to therapy and express hypoxia inducible factor-1 (HIF-1), a transcription fact

120 The transcription factor, hypoxia inducible factor-1 (HIF-1), plays a significant

121 stimulates tumor angiogenesis by activating hypoxia inducible factor-1 (HIF-1)-induced proangiogenic

122 Overexpression of hypoxia inducible factor-1 (HIF-1)alpha, which is common

123 activated mTORC1 and downstream upregulated hypoxia inducible factor-1 (HIF-1alpha) expression.

124 Hypoxia-inducible factor 1 (HIF-1) activates transcripti

125 Hypoxia-inducible factor 1 (HIF-1) activates transcripti

126 Tumor hypoxia and hypoxia-inducible factor 1 (HIF-1) activation are associ

127 irst marine natural product shown to inhibit hypoxia-inducible factor 1 (HIF-1) activation.

128 alpha-ketoglutarate antagonist that induces hypoxia-inducible factor 1 (HIF-1) activity, results in

129 Hypoxia-inducible factor 1 (HIF-1) and activator protein

130 Hypoxia activates hypoxia-inducible factor 1 (HIF-1) and induces autocrine

131 Hilpda proved to be a target of hypoxia-inducible factor 1 (Hif-1) and peroxisome prolif

132 ROS production, we showed that ROS regulated hypoxia-inducible factor 1 (HIF-1) and vascular endothel

133 Here, we confirmed the presence of a hypoxia-inducible factor 1 (HIF-1) binding site within t

134 We tested the hypothesis that hypoxia-inducible factor 1 (HIF-1) expression, an O(2)-s

135 Hypoxia-inducible factor 1 (HIF-1) functions as a master

136 response to hypoxia in many cell types, and hypoxia-inducible factor 1 (HIF-1) has been implicated i

137 Hypoxia-inducible factor 1 (HIF-1) has been recognized a

138 Hypoxia-inducible factor 1 (HIF-1) has been suggested to

139 equent studies identified a binding site for hypoxia-inducible factor 1 (HIF-1) in the CD18 gene.

140 Stabilization of the hypoxia-inducible factor 1 (HIF-1) increases life span a

141 rus encoding a constitutively active form of hypoxia-inducible factor 1 (HIF-1) induced VEGFR1 mRNA a

142 Hypoxia-inducible factor 1 (HIF-1) is a central regulato

143 Here, we demonstrate that hypoxia-inducible factor 1 (HIF-1) is a critical regulat

144 Here, we demonstrate that hypoxia-inducible factor 1 (HIF-1) is a critical regulat

145 Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric ba

146 Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric tr

147 Hypoxia-inducible factor 1 (HIF-1) is a master regulator

148 Hypoxia-inducible factor 1 (HIF-1) is a master regulator

149 Hypoxia-inducible factor 1 (HIF-1) is a master transcrip

150 Hypoxia-inducible factor 1 (HIF-1) is a master transcrip

151 Hypoxia-inducible factor 1 (HIF-1) is a transcription fa

152 Hypoxia-inducible factor 1 (HIF-1) is a transcription fa

153 Hypoxia-inducible factor 1 (HIF-1) is a transcription fa

154 Hypoxia-inducible factor 1 (HIF-1) is a transcription fa

155 Hypoxia-inducible factor 1 (HIF-1) is a transcription fa

156 Hypoxia-inducible factor 1 (HIF-1) is a transcription fa

157 Hypoxia-inducible factor 1 (HIF-1) is a ubiquitously exp

158 Hypoxia-inducible factor 1 (HIF-1) is the central mediat

159 recent work delineating mechanisms by which hypoxia-inducible factor 1 (HIF-1) mediates adaptive met

160 Hypoxia-inducible factor 1 (HIF-1) mediates transcriptio

161 Here we report that the hypoxia-inducible factor 1 (HIF-1) pathway is establishe

162 The transcription factor Hypoxia-inducible factor 1 (HIF-1) plays a central role

163 We recently showed that hypoxia-inducible factor 1 (HIF-1) plays a crucial role

164 The transcription factor hypoxia-inducible factor 1 (HIF-1) plays a pivotal role

165 Hypoxia-inducible factor 1 (HIF-1) plays a role in tumou

166 Being key regulator of oxygen homeostasis hypoxia-inducible factor 1 (HIF-1) plays significant rol

167 y demonstrated that the transcription factor hypoxia-inducible factor 1 (HIF-1) promotes the onset of

168 der conditions of reduced O(2) availability, hypoxia-inducible factor 1 (HIF-1) reciprocally regulate

169 Here we show that hypoxia-inducible Factor 1 (HIF-1) regulates allelic var

170 Hypoxia-inducible factor 1 (HIF-1) regulates transcripti

171 r concentrations of thioredoxin 1 (Trx1) and hypoxia-inducible factor 1 (HIF-1) than cells from unsup

172 EN increases the transcriptional activity of hypoxia-inducible factor 1 (HIF-1) through the inactivat

173 , a topoisomerase I (Top 1) poison, inhibits hypoxia-inducible factor 1 (HIF-1) transcriptional activ

174 The hypoxia-inducible factor 1 (HIF-1) transcriptional compl

175 ated, our results point to the activation of hypoxia-inducible factor 1 (HIF-1) upon HIV-1 infection

176 Numerous studies link activation of hypoxia-inducible factor 1 (HIF-1) with tumor angiogenes

177 uestion and reveal that orexin activates the hypoxia-inducible factor 1 (HIF-1), a heterodimeric tran

178 Here, we show that hypoxia-inducible factor 1 (HIF-1), a key metabolic sens

179 Factor inhibiting hypoxia-inducible factor 1 (HIF-1), FIH1, is derepressed

180 ia-induced amoeboid detachment was driven by hypoxia-inducible factor 1 (HIF-1), followed the downreg

181 ons requires transcription through activated hypoxia-inducible factor 1 (HIF-1), increased mRNA stabi

182 g the relationship between the activation of hypoxia-inducible factor 1 (HIF-1), the primary transcri

183 Transcriptional activity of hypoxia-inducible factor 1 (HIF-1), which drives VEGF ex

184 rs increased production of erythropoietin by hypoxia-inducible factor 1 (HIF-1), which is a transcrip

185 A low dose of either H2S or HCN can activate hypoxia-inducible factor 1 (HIF-1), which is required fo

186 hypoxic pulmonary hypertension (HPH) include hypoxia-inducible factor 1 (HIF-1)-dependent transactiva

187 cin and daunorubicin as potent inhibitors of hypoxia-inducible factor 1 (HIF-1)-mediated gene transcr

188 that PKM2 gene transcription is activated by hypoxia-inducible factor 1 (HIF-1).

189 oxygen-sensitive master transcription factor hypoxia-inducible factor 1 (HIF-1).

190 poxia) is the regulation of transcription by hypoxia-inducible factor 1 (HIF-1).

191 d transcriptional response driven largely by hypoxia-inducible factor 1 (HIF-1).

192 s have demonstrated that copper up-regulates hypoxia-inducible factor 1 (HIF-1).

193 trials or use was screened for inhibitors of hypoxia-inducible factor 1 (HIF-1).

194 effects of hypoxia also were independent of hypoxia-inducible factor 1 (HIF-1).

195 ed in ischemic brain preconditioning (PC) by hypoxia-inducible factor 1 (HIF-1).

196 es the induction of the transcription factor hypoxia-inducible factor 1 (HIF-1).

197 gene is transactivated by the heterodimeric hypoxia-inducible factor 1 (HIF-1).

198 Metformin also reduced hypoxic activation of hypoxia-inducible factor 1 (HIF-1).

199 pathway can increase VEGF expression via the hypoxia-inducible factor 1 (HIF-1); however, our results

200 ion regulates glycolysis in cancer cells via hypoxia-inducible factor 1 (HIF-1alpha) and its transcri

201 own-regulated sFlt1 production by inhibiting hypoxia-inducible factor 1 (HIF-1alpha) protein expressi

202 troversy in the literature as to the role of hypoxia-inducible factor-1 (HIF-1) and HIF-1 target gene

203 Hypoxia-inducible factor-1 (Hif-1) and Hif-2 are key med

204 Here, we report that balanced activity of hypoxia-inducible factor-1 (HIF-1) and HIF-2 is critical

205 of the KRAS mutations and for expression of hypoxia-inducible factor-1 (HIF-1) and minichromosome ma

206 The hypoxia-inducible factor-1 (HIF-1) binding site located

207 In this report, we address the dynamics of hypoxia-inducible factor-1 (HIF-1) binding to the vascul

208 Hypoxia-inducible factor-1 (HIF-1) can activate expressi

209 We further demonstrate that the hypoxia-inducible factor-1 (HIF-1) constitutes an import

210 of this study was to establish the effect of hypoxia-inducible factor-1 (HIF-1) directly on tumor gro

211 importance of the transcriptional regulator hypoxia-inducible factor-1 (HIF-1) for adaptive hypoxia

212 Hypoxia-inducible factor-1 (HIF-1) has been suggested to

213 ion is regulated by the transcription factor hypoxia-inducible factor-1 (HIF-1) in endothelial cells,

214 to accumulation of the transcription factor hypoxia-inducible factor-1 (HIF-1) in skeletal muscle ce

215 (NF-kappaB), activator protein-1 (AP-1), and hypoxia-inducible factor-1 (HIF-1) in the hypoxic regula

216 Here we report that 1 h of HT activates hypoxia-inducible factor-1 (HIF-1) in tumors and its dow

217 Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric tr

218 Hypoxia-inducible factor-1 (HIF-1) is a key gene regulat

219 Hypoxia-inducible factor-1 (HIF-1) is a known cancer pro

220 Hypoxia-inducible factor-1 (HIF-1) is a potent cellular

221 Hypoxia-inducible factor-1 (HIF-1) is a primary regulato

222 Hypoxia-inducible factor-1 (HIF-1) is a transcription fa

223 Hypoxia-inducible factor-1 (HIF-1) is a transcription fa

224 Hypoxia-inducible factor-1 (HIF-1) is a transcription fa

225 Hypoxia-inducible factor-1 (HIF-1) is a transcriptional

226 Hypoxia-inducible factor-1 (HIF-1) is a transcriptional

227 Hypoxia-inducible factor-1 (HIF-1) is a well-studied tra

228 a potent stimulator of VEGF expression, and hypoxia-inducible factor-1 (HIF-1) is considered to be c

229 Hypoxia-inducible factor-1 (HIF-1) is the master regulat

230 The transcriptional activator hypoxia-inducible factor-1 (HIF-1) mediates a broad rang

231 and inhibition of tumor angiogenesis via the hypoxia-inducible factor-1 (HIF-1) pathway.

232 Hypoxia-inducible factor-1 (HIF-1) plays a central role

233 Hypoxia-inducible factor-1 (HIF-1) plays an essential ro

234 However, Pdcd4 did not affect hypoxia-inducible factor-1 (HIF-1) protein expression or

235 Hypoxia-inducible factor-1 (HIF-1) regulates the transcr

236 The transcription factor hypoxia-inducible factor-1 (HIF-1) represents an importa

237 Hypoxia-inducible factor-1 (HIF-1) stabilization is a pi

238 o hypoxia, characterized by the induction of hypoxia-inducible factor-1 (HIF-1) target genes.

239 ated during hypoxia due to direct binding by hypoxia-inducible factor-1 (HIF-1) to HIF-1 response ele

240 LOX in colorectal cancer synergizes with hypoxia-inducible factor-1 (HIF-1) to promote tumor prog

241 ion of gene expression occurs mainly via the hypoxia-inducible factor-1 (HIF-1) transcription factor

242 ntial feature of tumor angiogenesis, and the hypoxia-inducible factor-1 (HIF-1) transcription factor

243 Digoxin and other cardiac glycosides inhibit hypoxia-inducible factor-1 (HIF-1) transcriptional activ

244 rubicin (DXR) and daunorubicin (DNR) inhibit hypoxia-inducible factor-1 (HIF-1) transcriptional activ

245 the effects of pharmacological inhibition of hypoxia-inducible factor-1 (HIF-1), a critical regulator

246 To examine the role of hypoxia-inducible factor-1 (HIF-1), a key mediator of ce

247 These tumor cells are hypoxic and express hypoxia-inducible factor-1 (HIF-1), a prosurvival transc

248 rimary factor mediating this response is the hypoxia-inducible factor-1 (HIF-1), an oxygen-sensitive

249 -kappaB), STAT3, activator protein-1 (AP-1), hypoxia-inducible factor-1 (HIF-1), and tumor protein 53

250 suppresses hypoxia-sensitive genes, e.g. via hypoxia-inducible factor-1 (HIF-1), but mutations in Com

251 ecular key players in tumor hypoxia, such as hypoxia-inducible factor-1 (HIF-1), have been discovered

252 cellular response, the transcription factor hypoxia-inducible factor-1 (HIF-1), is correlated with p

253 bunit of the host cell transcription factor, hypoxia-inducible factor-1 (HIF-1), is up-regulated by i

254 n angiogenesis during hypoxia is mediated by hypoxia-inducible factor-1 (HIF-1), it was conceivable t

255 gene delivery and small molecules targeting hypoxia-inducible factor-1 (HIF-1), we evaluated the imp

256 tivation in transcription are dependent upon hypoxia-inducible factor-1 (HIF-1), whereas others are H

257 y and voltage dependency as full-length, was hypoxia-inducible factor-1 (HIF-1)-dependent and could b

258 Hypoxia-induced angiogenesis is mediated by hypoxia-inducible factor-1 (HIF-1)-dependent transcripti

259 Up-regulation of NPM is hypoxia-inducible factor-1 (HIF-1)-dependent.

260 suppressor (VHL), which negatively regulates hypoxia-inducible factor-1 (HIF-1).

261 o hypoxia respond by increasing the level of hypoxia-inducible factor-1 (HIF-1).

262 The primary mediating factor is the hypoxia-inducible factor-1 (HIF-1).

263 iogenesis and tumor growth by activating the hypoxia-inducible factor-1 (HIF-1).

264 to be regulated by the transcription factor hypoxia-inducible factor-1 (HIF-1).

265 nds the functional NF-kappaB binding site in hypoxia-inducible factor-1 (HIF-1alpha) promoter and res

266 Exposure to SB also suppressed hypoxia-inducible factor-1 (HIF-1alpha) stabilization an

267 tidinyl hydroxylase FIH-1 (factor inhibiting hypoxia-inducible factor 1 [HIF-1]), the lysyl hydroxyla

268 alt chloride (CoCl(2), a chemical inducer of hypoxia-inducible factor 1, HIF-1), suggesting a regulat

269 elanoma and clear cell sarcoma cells through hypoxia inducible factor 1 (HIF1)-mediated induction of

270 form the heterodimeric transcription factor hypoxia inducible factor 1 (HIF1).

271 The transcription factor hypoxia-inducible factor 1 (HIF1) facilitates the induct

272 The role of hypoxia and hypoxia-inducible factor 1 (HIF1) in the development of

273 Hypoxia-inducible factor 1 (HIF1) is a heterodimeric tra

274 Hypoxia-inducible factor 1 (HIF1) is up-regulated in mos

275 is increased by pharmacologic inhibition of hypoxia-inducible factor 1 (HIF1) or its target gene pyr

276 family of transcription factors, among which hypoxia-inducible factor 1 (HIF1) plays a major role.

277 In exercise, as well as cancer and ischemia, hypoxia-inducible factor 1 (HIF1) transcriptionally acti

278 the metabolic reprogramming associated with hypoxia-inducible factor 1 (HIF1), as constitutive activ

279 cancer cells was under strict control of the hypoxia-inducible factor 1 (HIF1), which drove redox- an

280 phorylation of Akt followed by activation of hypoxia-inducible factor 1 (HIF1).

281 ssor VHL, driving constitutive activation of hypoxia-inducible factor-1 (HIF1) and HIF2.

282 Hypoxia-inducible factor-1 (HIF1) is a transcription fac

283 Hypoxia-inducible factor-1 (HIF1), the master regulator

284 ic breast cancer cells through the action of hypoxia-inducible factor-1 (HIF1).

285 n of TIGAR depended on mitochondrial HK2 and hypoxia-inducible factor 1 (HIF1alpha) activity.

286 ption, lactate production, and expression of Hypoxia-inducible factor 1 (HIF1alpha) target genes, sug

287 by an oxygen-sensitive transcription factor, hypoxia-inducible factor-1 (HIF1alpha), which becomes ac

288 ilization of the transcription factor HIF-1 (hypoxia-inducible factor 1) in neurons and muscle.

289 cIH induced systemic insulin resistance in a hypoxia-inducible factor 1-independent manner and impair

290 ent chemotherapy, antiangiogenic agents with hypoxia-inducible factor-1 inhibitors, tissue-selective

291 in mild hypoxia (0.25-1 kPa O(2)) through a hypoxia-inducible factor 1-mediated response, cannot sur

292 P=9.8x10(-10)) and HIF1AN (factor inhibiting hypoxia-inducible factor-1; P=5.7x10(-9)) polymorphisms

293 dermal growth factor receptor-MAP/ERK kinase-hypoxia-inducible factor 1 signaling but on RhoA pathway

294 cation arrest and is entirely independent of hypoxia-inducible factor 1 status.

295 t of a transcriptional complex involving the hypoxia-inducible factor-1 transcription factor, p300, R

296 d by mTORC1 regulate the expression of HIF1 (hypoxia-inducible factor 1) transcription factor complex

297 y foci, evidencing induction of an epidermal hypoxia-inducible factor-1 transcriptional program, and

298 Another trophic factor regulated by hypoxia-inducible factor-1, vascular endothelial growth

299 f asTF is mediated via the activation of the hypoxia-inducible factor-1/vascular endothelial growth f

300 erodimeric, functional transcription factor, hypoxia-inducible factor-1, which activates a gene progr