ライフサイエンスコーパス: hypoxic

1 However, the skeletal muscle remained hypoxic.

2 n pro-inflammatory cytokines, and profoundly hypoxic.

3 d from chronic infections, where tissues are hypoxic.

4 randomly assigned to a normoxic (21% O2) and hypoxic (10% O2) trial with measurements performed at re

5 HyP-1 exhibits selectivity for hypoxic activation in vitro, in living cells, and in mul

6 PHD3 silencing decreased hypoxic activation of HIF-1alpha C-terminal transactivat

7 distinct mechanisms by which RRM2B maintains hypoxic activity and identified responsible residues in

8 portant pathway in regulating glycolysis and hypoxic adaptation in tumor cells.

9 and the two formulations displayed a higher hypoxic: air cytotoxicity ratio compared to the pro-drug

10 While the data support the existence of hypoxic and acidic regions in TME, the most dramatic dif

11 ervoir for NO generation, particularly under hypoxic and acidosis conditions.

12 ity to process the neural activity to detect hypoxic and gastric extension events from the glossophar

13 demonstrate that CD8(+) TILs reprogram under hypoxic and hypoglycemic conditions, regaining effector

14 Thus, hypoxic and metabolic pathways may modulate TNF response

15 statistically improved function in neonatal hypoxic and neonatal normoxic groups compared with salin

16 odels using treatment/control comparisons in hypoxic and nonhypoxic areas produce null results, but w

17 ts previously associated with well-perfused, hypoxic and/or necrotic tumor compartments.

18 l pigmented epithelial cells under normoxic, hypoxic, and lutein-pretreated conditions in a similar m

19 int of 140 mEq/L, chronic liver disease, and hypoxic/anoxic episode.

20 neages, allowing animals to obtain oxygen in hypoxic aquatic environments.

21 n is expected to produce an 18% reduction in hypoxic area over the long term.

22 fore there is 95% certainty of observing any hypoxic area reduction between consecutive 5-y assessmen

23 pi River nitrogen load is required to reduce hypoxic area to 5,000 km(2) The interim goal of a 20% lo

24 FMISO-positive patients, the contours of the hypoxic area were transferred to the radiation oncologis

25 MiR-210 was increased in hypoxic areas of CRC tissues and hypoxia-responsive miR-

26 MiR-210 as a hypoxic biomarker, and the targeting of miR-21 and miR-3

27 overexpression and stabilization within the hypoxic BM microenvironment promotes disease progression

28 In the retina of DM/hypoxic C57BL/6 mice, abnormal a-wave and b-wave activit

29 Hypoxic cancer cells (CCs) stimulate blood vessel sprout

30 to increased ROS production and apoptosis in hypoxic cancer cells as well as impaired growth of tumor

31 o establish a therapeutic strategy targeting hypoxic cancer cells in gastric carcinoma (GC).

32 d droplet (LD) accumulation is a hallmark of hypoxic cancer cells, yet how LDs form and function duri

33 process for ultrasound mediated treatment of hypoxic cancer cells.

34 re highly effective in inducing apoptosis in hypoxic cancer cells.

35 ery strategy for more effective treatment of hypoxic cancer cells.

36 Donor rats sustained a hypoxic cardiac arrest, followed by variable acirculator

37 owed that YC-1 shifted glucose metabolism in hypoxic cells from anaerobic glycolysis to oxidative pho

38 ic burden of pH regulation is offloaded from hypoxic cells onto metabolically altruistic normoxic nei

39 ted by HAL, TPZ was activated and killed the hypoxic cells, but spared the normoxic cells.

40 atic tumors are renowned for their extremely hypoxic centers, resulting in upregulation of a number o

41 An acute hypoxic challenge decreased CBF (P < 0.05) in untrained

42 We designed and created isobaric hypoxic chambers able to maintain pregnant sheep for pro

43 ion to air-breathing at birth using isobaric hypoxic chambers without alterations to maternal food in

44 ed rabbit hearts to test the hypothesis that hypoxic changes would be more severe in left ventricular

45 5 years several lines of research into acute hypoxic chemotransduction mechanisms have focused on the

46 n of MTA1, HSP90 and HIF1alpha complex under hypoxic condition but not under normoxic condition.

47 n E7-mediated G1 checkpoint abrogation under hypoxic condition, and the function could possibly be in

48 hypertrophy response under both normoxic and hypoxic conditions (26% lower than control surgery, p <

49 This temperature rise resulted in hypoxic conditions across the entire Baltic sea as revea

50 Extreme hypoxic conditions along the coast, leading to what are

51 observed when ARPE-19 cells are grown under hypoxic conditions and when pre-treated with lutein prio

52 Although hypoxic conditions are present in IPF, hypoxia's role as

53 In this study, we show that hypoxic conditions cause the primary root to grow sidewi

54 n was decreased by histone acetylation under hypoxic conditions in cancer cells.

55 rategy was evaluated under both normoxic and hypoxic conditions in normal tissues as well as in a mur

56 n measurements showed no oxygen depletion or hypoxic conditions in the microwell.

57 esting that primary root growth direction at hypoxic conditions is antagonistically regulated by hypo

58 Loss of KDM4A in hypoxic conditions leads to a decreased HIF-1alpha media

59 of FDG uptake by any cell (upregulated under hypoxic conditions or other microenvironmental factors),

60 itioning of ASCs using ascorbic acid (AA) or hypoxic conditions provided additional benefit.

61 d that in the presence of LPS or exposure to hypoxic conditions the cells produce higher C3 mRNA as w

62 old higher hydroxyl radicals than TiO2 under hypoxic conditions via N3-facilitated electron-hole redu

63 Proinflammatory M1-polarizing stimuli and hypoxic conditions were responsible for enhanced NFAT5 e

64 Under hypoxic conditions, a decrease in the IC50 of MTX and MT

65 the auxin efflux carrier PIN2 is reduced at hypoxic conditions, a response that is suppressed by RAP

66 increasing sRBC occlusion under normoxic and hypoxic conditions, and increasing sRBC adhesion in our

67 lls move through capillaries under transient hypoxic conditions, and offer novel possibilities for de

68 Here we show that hypoxic conditions, as are often found in subregions of

69 Under hypoxic conditions, HIF-1alpha levels are greatly increa

70 reatly increased in the cetacean liver under hypoxic conditions, thus implicating FGF23 in low bone d

71 esting that the pathogen requires Msh1 under hypoxic conditions.

72 eterminant of acute thrombotic events during hypoxic conditions.

73 l epithelium under normal, inflammatory, and hypoxic conditions.

74 ulosis meets its nutrient requirements under hypoxic conditions.

75 g high levels of ROS under both normoxic and hypoxic conditions.

76 dren were not reparative unless subjected to hypoxic conditions.

77 he important oxidoreductases expressed under hypoxic conditions.

78 tive oxygen species (ROS) and sickling under hypoxic conditions.

79 ell as the improved anticancer effects under hypoxic conditions.

80 al but more pronounced differentiation under hypoxic conditions.

81 iple negative breast cancer cells only under hypoxic conditions.

82 mucosa permeability and in inflammatory and hypoxic conditions.

83 me activation and curtailed thrombosis under hypoxic conditions.

84 as a switch to augment Notch signaling under hypoxic conditions.

85 t cellular functions under both normoxic and hypoxic conditions.

86 MTX release, and cellular MTX delivery under hypoxic conditions.

87 NLRX1 significantly reduced apoptosis under hypoxic conditions.

88 er, neurological deficits are abundant under hypoxic conditions.

89 gulate the acid-base balance of cells at the hypoxic core of connexin-coupled tumor growths.

90 GEC spontaneously form a network within the hypoxic core, consistent with published experimental fin

91 d then transmitted passively to cells at the hypoxic core.

92 during light-controlled H(+) uncaging at the hypoxic core.

93 The high infiltration of immune cells in the hypoxic cores of advanced solid tumors leads to a chain

94 th miR-21 and miR-30d antagonists sensitized hypoxic CRC cells to 5-FU.

95 echanism that could be harnessed to minimize hypoxic damage in human disease.

96 se findings support a potential role for PNS hypoxic damage in the motor impairment that results from

97 s system are well known, the contribution of hypoxic damage to the peripheral nervous system (PNS) ha

98 the fetal heart and circulation directly in hypoxic development via mechanisms including decreased o

99 protects the fetal cardiovascular system in hypoxic development, and that the mechanisms of sildenaf

100 so protects fetal cardiovascular function in hypoxic development.

101 Unlike cells adapted to a hypoxic environment (1% O2), those cultured in 5% O2 sti

102 We observed that sUA is released in a hypoxic environment and is able to induce IL-1beta relea

103 However, the hypoxic environment in tumor tissue prevents the formati

104 Exposure to antibiotics and hypoxic environment resulted in higher oxidative shift i

105 nerated CAR T-cells that are responsive to a hypoxic environment, a hallmark of certain tumors.

106 (ROS) diminishes the therapeutic effect in a hypoxic environment, such as solid tumors.

107 Liver regeneration occurs in a hypoxic environment.

108 r maintaining satellite cell self-renewal in hypoxic environments.

109 (BL)], during, and 15 min after three 5 min hypoxic episodes (11% O2, H1-H3).

110 creased excitatory cross-correlations during hypoxic episodes (34%) compared with BL (19%; p < 0.0001

111 Here we document an unprecedented hypoxic event on the Caribbean coast of Panama and asses

112 Hypoxic events in the tropics and associated mortality e

113 abitats that routinely experience pronounced hypoxic events.

114 at the dephosphorylation of Akt after 2 h of hypoxic exposure might deactivate RNA-binding protein BR

115 t-transcriptional regulation within hours of hypoxic exposure, where PI3K-Akt signalling was suggeste

116 ents revealed 70% mortality after 6 hours of hypoxic exposure.

117 hages (IMs) at baseline and after 4 and 14 d hypoxic exposure.

118 makers developed goals to reduce the area of hypoxic extent because of its ecological, economic, and

119 tioxidant therapy to protect the chronically hypoxic fetus in adverse pregnancy.

120 Pericyte ablation also led to hypoxic focal and subclinical tubular injury, reflected

121 In vivo, B20-4.1.1 increased hypoxic foci and invasiveness, as seen in GBM patients r

122 dose YC-1 + GI is a unique therapy targeting hypoxic GC cells that generates lethal ROS via forced ac

123 is that inhibition of complex II facilitates hypoxic gene expression in monocytes using an integrativ

124 the stabilization of HIF-1alpha and reduces hypoxic gene expression in transformed cell lines.

125 binding Sre1, which is then free to activate hypoxic gene expression.

126 genetically increases CA, and HIF-1alpha and hypoxic gene signature expression correlate with CA and

127 Overexpression of LncHIFCAR induces pseudo-hypoxic gene signature, whereas knockdown of LncHIFCAR i

128 1alpha explains the persistent expression of hypoxic genes upon complex II inactivation.

129 ting ROX1, which encodes a repressor of many hypoxic genes, or by overexpressing HEM3 or HEM12 induce

130 d then analyzed for cellular responses to 3D hypoxic gradients and to elucidate the underlying mechan

131 reased fibrosis and improved angiogenesis in hypoxic groups compared with controls.

132 ypoxia, we performed RNA-Seq of normoxic and hypoxic head and neck cancer cells.

133 This complex repressed Isl1 in the hypoxic heart tube or following induction of ectopic hyp

134 n-regulated in association with a decline in hypoxic HIF-1alpha protein expression downstream of sile

135 Protein-level adaptations to hypoxic high-altitude conditions have been identified in

136 s nutrients for prolonged persistence within hypoxic host microenvironments.

137 Collectively, these findings indicate that hypoxic HPV-positive cancer cells can induce a reversibl

138 o interfered with the senescence response of hypoxic HPV-positive cancer cells toward prosenescent ch

139 Premature birth terminates the hypoxic in utero environment and supply of maternal horm

140 Hypoxic incubation (3 kPa) caused (i) stabilization of H

141 Hypoxic incubation increased oxidative stress (4-hydroxy

142 Further, because hypoxic inflamed tissues are associated with the overexp

143 ma membrane during the recovery phase from a hypoxic injury and that binding of neuronal uPA to astro

144 tic recovery in neurons that have suffered a hypoxic injury by a mechanism that does not require plas

145 geted H2 S donor, AP39, during in vitro cold hypoxic injury improved the protective capacity of H2 S

146 overy in neurons that have suffered an acute hypoxic injury via a mechanism mediated by astrocytic th

147 ma membrane during the recovery phase from a hypoxic injury.

148 output that supports prenatal growth in the hypoxic intrauterine environment, to the postnatal state

149 to a neonatal mouse model of cerebral palsy (Hypoxic-Ischaemic Encephalopathy).

150 s showed well demarcated zones of oedema and hypoxic-ischaemic neuronal injury, consistent with acute

151 stem (adjusted HR, 46.4; 95% CI, 42.2-51.0), hypoxic ischemic encephalopathy (adjusted HR, 23.6; 95%

152 atal cerebral sinovenous thrombosis, 11 with hypoxic ischemic encephalopathy, and 5 with neonatal art

153 Placental pathologies of inflammatory, hypoxic, ischemic/hypertensive, infectious and thromboti

154 rocyte precursor cell (OPC) production after hypoxic-ischemic (HI) injury, the downstream functional

155 iddle cerebral artery occlusion, or neonatal hypoxic-ischemic brain injury, Mn preferentially accumul

156 al in neonates (>/=36 weeks' gestation) with hypoxic-ischemic encephalopathy at 18 US centers in the

157 reduces death or disability for infants with hypoxic-ischemic encephalopathy at 36 weeks' or later ge

158 ' or later gestation with moderate or severe hypoxic-ischemic encephalopathy enrolled at 6 to 24 hour

159 less than or equal to 17 mug/L argue against hypoxic-ischemic encephalopathy incompatible with reawak

160 for 72 hours at 33.5 degrees C for neonatal hypoxic-ischemic encephalopathy reduces death or disabil

161 Among term neonates with moderate or severe hypoxic-ischemic encephalopathy, cooling for longer than

162 Among term infants with hypoxic-ischemic encephalopathy, hypothermia initiated a

163 r disability at 18 months among infants with hypoxic-ischemic encephalopathy.

164 disability at age 18 months in infants with hypoxic-ischemic encephalopathy.

165 g/L who died had a cause of death other than hypoxic-ischemic encephalopathy.

166 n innovative therapeutic target for treating hypoxic-ischemic human diseases and organ transplantatio

167 xygen gradients that drive the heterogeneous hypoxic landscapes in solid tumors.

168 Hypoxic lipid accumulation and storage of oxidized LDL,

169 h cardiac output from arteriovenous fistula, hypoxic lung diseases, and metabolic derangements associ

170 hypoxia in mice and accounts for erythrocyte hypoxic memory and faster acclimatization.

171 However, the role of hypoxic metabolism in IBD is unclear.

172 regulation of B-cell malignancies in chronic hypoxic microenvironment have not been studied.

173 A hypoxic microenvironment is a hallmark for solid tumors.

174 We hypothesized that the hypoxic microenvironment within the GC facilitates an ex

175 ity to support growth and proliferation in a hypoxic microenvironment.

176 tilize its survival pathways for adapting to hypoxic microenvironment.

177 d O2-controllable hydrogels that can provide hypoxic microenvironments in vitro.

178 therapeutic resistance of GBM cells to RT in hypoxic microenvironments through enhanced activation of

179 euron production and that restoration of the hypoxic milieu or estrogen treatment might reverse inter

180 n this study we utilize in vitro and in vivo hypoxic models of DWMI to investigate whether the ISR is

181 We recently showed that SDHB mRNAs in hypoxic monocytes gain a stop codon mutation by APOBEC3A

182 In this study, we used a hypoxic murine model of PH in combination with FACS to q

183 intracellular accumulation of HIF-1alpha of hypoxic nasopharyngeal carcinoma cells and mediates the

184 To study the impact of hypoxic necrosis on the efficacy of antimycobacterials a

185 Hypoxic necrotizing lesions rendered moxifloxacin less a

186 cells as microbial defence uniformly develop hypoxic necrotizing lung lesions, widely observed in hum

187 that, via this route, normoxic cells supply hypoxic neighbors with acid-neutralizing HCO3(-) ions.

188 Indeed, apoptosis was increased in hypoxic neutrophils from AMPKalpha2(DeltaMC) mice, fewer

189 ing glioma stem-like cells (GSCs) within the hypoxic niche, although the molecular mechanisms linking

190 ocial and subterranean lifestyle generates a hypoxic niche.

191 Infected human tissues are hypoxic or anoxic.

192 art defects were isolated and cultured under hypoxic or normoxic conditions.

193 evels (19-21%), culturing chondrocytes under hypoxic oxygen levels (</=8%) promotes the chondrogenic

194 ally accumulate at sites that are relatively hypoxic, particularly during periods of inflammation, th

195 ol species were the most prominent lipids in hypoxic pellets.

196 es with a shorter protocol that excluded the hypoxic periods was demonstrated.

197 the therapeutic targeting of macrophages in hypoxic PH and potentially other inflammatory lung disea

198 t the pathogenesis of vascular remodeling in hypoxic PH involves an early compartment-independent act

199 At the hypoxic phase, caffeine reduced microglial activation an

200 ented in polysomes isolated from control and hypoxic plants.

201 Hypoxic pneumonia fell from 13.1 to 5.7 cases per 1000 p

202 d substantial reductions of pneumococcal and hypoxic pneumonia in young children.

203 imilar to those measured in human fetuses of hypoxic pregnancy.

204 ephrine pre-constricted UtA from normoxic or hypoxic pregnant mice to dilate and this dilatation was

205 vated and displays nuclear expression in the hypoxic proximal tubules exhibiting high levels of autop

206 tial to avoid life-threatening hypoxemia via hypoxic pulmonary vasoconstriction (HPV) which matches p

207 perfusion, which is proposed to result from hypoxic pulmonary vasoconstriction (HPV).

208 can selectively invade and colonize in tumor hypoxic regions (THRs) and deliver therapeutic products

209 ouse xenograft tumor, PDK1 is accumulated in hypoxic regions and activates glycolysis to promote stem

210 Hypoxic regions exist within most solid tumors and often

211 activated EZH2, whereas mesenchymal GSCs in hypoxic regions expressed BMI1 protein, which promoted c

212 at 5-methylcytosine (5mC) hypomethylation in hypoxic regions of a tumor can be reverted to enhance ca

213 nable their activation at lower pH values in hypoxic regions of solid tumours.

214 fts robust BIRC3 expression was noted within hypoxic regions of the tumor.

215 l angiotensin II predominantly exists in the hypoxic regions of tumor formed by nasopharyngeal carcin

216 anobubbles were developed for mitigating the hypoxic regions of tumors to weaken the hypoxia-driven p

217 lar regions showing a proneural profile, and hypoxic regions showing a mesenchymal pattern.

218 Solid tumors often contain hypoxic regions which are resistant to standard chemothe

219 in vivo, where its expression corresponds to hypoxic regions.

220 enal transplantation (RTx) and in vitro cold hypoxic renal injury.

221 increase in ventilation that counteracts the hypoxic respiratory depression.

222 of G9a is a crucial factor in mediating the hypoxic response by down-regulating the expression of sp

223 and nuclear import adaptor Nro1 regulate the hypoxic response in fission yeast by controlling activit

224 example of this is the relationship between hypoxic response in individual tissues, and the effect t

225 us research efforts, the role of Plk3 in the hypoxic response induced by hypoxia or nickel is not com

226 The hypoxic response is mediated by the alpha-subunit of the

227 but additional nutrient signals may tune the hypoxic response through control of unassembled Rps23 or

228 ces pombe regulate lipid homeostasis and the hypoxic response under conditions of low sterol or oxyge

229 We show here how hypoxic response via the HIF transcription factors in on

230 lated in pancreatic cancer cells even though hypoxic response was decreased in them.

231 hat BETi dually targets angiogenesis and the hypoxic response, an effective combination at reducing t

232 that rapidly and efficiently attenuates the hypoxic response, even at modest CITED2 concentrations.

233 biquitin ligase associated with the cellular hypoxic response, to be the ubiquitin E3 ligase that med

234 the epithelial-to-mesenchymal transition and hypoxic response, whereas down-regulation of the CPEB2A

235 role G9a plays as an epigenetic mediator of hypoxic response, which can be used as a diagnostic mark

236 ork that functions to fine-tune the cellular hypoxic response.

237 m-selective fashion and without triggering a hypoxic response.

238 oduce additional layers of complexity to the hypoxic response.

239 gene expression, cell survival and promoting hypoxic response.

240 a inhibits BK/Kv to initiate or maintain the hypoxic response.

241 criptional activators mediating the metazoan hypoxic response.

242 e metabolic changes consistent with enhanced hypoxic responses and increased glycolysis.

243 In ISL1+ CPCs, induction of hypoxic responses caused CHD by repressing Isl1 and acti

244 heart tube or following induction of ectopic hypoxic responses.

245 Hypoxic root bending is inhibited by the group VII ethyl

246 We also demonstrated spatially-resolved hypoxic signaling in cancer cells through immunostaining

247 aggressiveness of ovarian cancer, including hypoxic signaling mechanisms.

248 roviding a secondary mechanism to extend the hypoxic signalling response.

249 ing pressure overload, both hypertrophic and hypoxic signals can stimulate angiogenesis, both of whic

250 ated by correlation of its expression with a hypoxic signature in patient samples and its roles in tu

251 ccumulation of myeloid cells at ischemic and hypoxic sites results from a lack of chemotactic respons

252 ht into RNR biology, highlighting RRM2B as a hypoxic-specific, anti-cancer therapeutic target.

253 A hypoxic state is critical to the metastatic and invasive

254 is fine-tuned to allow cells to recover from hypoxic stress and adapt to heterogeneous or fluctuating

255 is up-regulated both in an in vitro model of hypoxic stress and in a mouse model of M. tuberculosis i

256 We emphasize mechanisms of manipulating hypoxic stress and its associated pathways, which may su

257 Our results suggest that hypoxic stress compromises CPC function by inducing quie

258 Hypoxic stress has a strong impact on tumor cell biology

259 echanisms involved in CPC protection against hypoxic stress is essential to maximize their cardioprot

260 In mammals, hypoxic stress management is under the control of the Hy

261 We investigated the effects of hypoxic stress on CPCs and found significant reduction i

262 tor is an important regulator of osmotic and hypoxic stress responses in plants.

263 Cells adjust to hypoxic stress within the tumor microenvironment by down

264 er cells respond to nutrient deprivation and hypoxic stress, two hallmarks of the tumor microenvironm

265 ntification of the roles of angiogenesis and hypoxic stress.

266 t compositional tumor heterogeneity involves hypoxic stress.

267 genes that underpins one of the most extreme hypoxic survival strategies among vertebrates and that i

268 ncers and its translational implications for hypoxic-targeted therapy.

269 cumulation of plasma adenosine to counteract hypoxic tissue damage in mice.

270 e (H2 S), is a novel molecule that mitigates hypoxic tissue injury.

271 ogenesis and essential to the oxygenation of hypoxic tissues.

272 tion increased fibronectin deposition in the hypoxic TME.

273 ion within biofilms is regulated by the SrbA hypoxic transcription factor and that without SrbA, MTs

274 Glucocorticoid (GC) and hypoxic transcriptional responses play a central role in

275 l respiratory inhibition in induction of the hypoxic transcriptome in monocytes and suggest that inhi

276 rmoxic conditions mimics hypoxia and induces hypoxic transcripts as well as APOBEC3A-mediated RNA edi

277 tumorigenesis in a mouse xenograft model of hypoxic triple negative breast cancer.

278 iotensin II in regulating radioresistance of hypoxic tumor cells.

279 molecular pathway that promotes survival of hypoxic tumor cells.

280 Targeting the hypoxic tumor microenvironment has a broad impact in can

281 tion of therapeutic targets derived from the hypoxic tumor microenvironment is of major importance.

282 ost-tumor interactions in the context of the hypoxic tumor microenvironment may be important in preve

283 astoma stem cells (GSCs) are enriched in the hypoxic tumor microenvironment, and that monocarboxylate

284 anscription factors during adaptation to the hypoxic tumor microenvironment.

285 Energetic resources in hypoxic tumor regions are constrained by low-yielding gl

286 ivo tumor analysis confirmed the presence of hypoxic tumor regions that nevertheless exhibited relati

287 Hypoxic tumors exhibit increased resistance to radiation

288 ) contribute significantly to the aggressive hypoxic tumour phenotype.

289 ic of most solid cancerous tumours, treating hypoxic tumours using PDT can be a challenge.

290 T to superficial lesions, inability to treat hypoxic tumours, and incomplete tumour damage.

291 sms underlying red blood cell (RBC)-mediated hypoxic vasodilation remain controversial, with separate

292 ntified as the dominant mechanism underlying hypoxic vasodilation.

293 of AOPCP in vivo significantly decreased the hypoxic ventilatory response (Delta VE control 74 +/- 6%

294 ABSTRACT: The hypoxic ventilatory response (HVR) is biphasic, consisti

295 derstanding of the mechanisms underlying the hypoxic ventilatory response and highlight the significa

296 -CHF rats exhibited a significantly enhanced hypoxic ventilatory response compared to AV-CHF rats.

297 ly, inhibition of CD73 in vivo decreased the hypoxic ventilatory response, reduced the hypoxia-induce

298 rated that cells in the mouse heart tube are hypoxic, while cardiac progenitor cells (CPCs) expressin

299 oA levels, leading to more ROS generation in hypoxic YC-1-treated cells.

300 ieving the goal of a 5,000-km(2) 5-y average hypoxic zone and set an interim load target of a 20% red