ライフサイエンスコーパス: hypoxic condition

1 pathway was activated in myeloma cells under hypoxic condition.

2 epatoma cell increased gene expression under hypoxic condition.

3 der normoxia and in the mature neurons under hypoxic condition.

4 reducing the expression of FAK and PKC under hypoxic condition.

5 ulosis meets its nutrient requirements under hypoxic conditions.

6 NLRX1 significantly reduced apoptosis under hypoxic conditions.

7 X, contributes to cancer cell survival under hypoxic conditions.

8 acid and cholesterol metabolism genes under hypoxic conditions.

9 ecific signaling pathways under normoxic and hypoxic conditions.

10 rticles for monitoring lactate levels during hypoxic conditions.

11 endothelial cells cultured under normoxic or hypoxic conditions.

12 nfection and downregulated during anemia and hypoxic conditions.

13 rete proregenerative exosomes in response to hypoxic conditions.

14 reby stabilizing HIF under both normoxic and hypoxic conditions.

15 ytic metabolic switch and was enhanced under hypoxic conditions.

16 er, neurological deficits are abundant under hypoxic conditions.

17 uman placenta and cultured under standard or hypoxic conditions.

18 regulate an enhanced sensory response under hypoxic conditions.

19 some cell types continue to replicate under hypoxic conditions.

20 e efficiently than other phytoplankton under hypoxic conditions.

21 veal altered miRNA maturation in cells under hypoxic conditions.

22 model system of mammalian cell growth under hypoxic conditions.

23 maintenance of cell-cycle progression under hypoxic conditions.

24 unction, was significantly upregulated under hypoxic conditions.

25 sponses and rescued functional parameters in hypoxic conditions.

26 gnaling and cell fate decisions triggered by hypoxic conditions.

27 esting that the pathogen requires Msh1 under hypoxic conditions.

28 -1alpha does not activate this program under hypoxic conditions.

29 in vitro migration, and tumorigenicity under hypoxic conditions.

30 it promotes increased HIF degradation under hypoxic conditions.

31 a potential application of the biosensor in hypoxic conditions.

32 mide mustard, is preferentially activated in hypoxic conditions.

33 lator of ECM remodeling by fibroblasts under hypoxic conditions.

34 for inhibiting cardiomyocyte apoptosis under hypoxic conditions.

35 skeletal muscle homeostasis under otherwise hypoxic conditions.

36 eterminant of acute thrombotic events during hypoxic conditions.

37 feeding with special formula and exposure to hypoxic conditions.

38 role in mediating the effects of IL-11 under hypoxic conditions.

39 production of IL-11 in cells cultured under hypoxic conditions.

40 al changes of microencapsulated islets under hypoxic conditions.

41 oting and sustaining protein synthesis under hypoxic conditions.

42 l epithelium under normal, inflammatory, and hypoxic conditions.

43 l progenitors, released erythropoietin under hypoxic conditions.

44 ne-induced replication stress is enhanced in hypoxic conditions.

45 tabolic dysfunction in adipose tissues under hypoxic conditions.

46 lets and adenomas cultured under normoxic or hypoxic conditions.

47 n of several genes and a growth defect under hypoxic conditions.

48 duced by anticancer drugs or radiation under hypoxic conditions.

49 ve resting skeletal muscle homeostasis under hypoxic conditions.

50 e degradation of aromatic hydrocarbons under hypoxic conditions.

51 afforded the heart by Txnip deficiency under hypoxic conditions.

52 g high levels of ROS under both normoxic and hypoxic conditions.

53 or cap-dependent translation of IGFBP3 under hypoxic conditions.

54 f hepatocellular carcinoma (HCC) cells under hypoxic conditions.

55 rine-acting factors primarily released under hypoxic conditions.

56 sustains mitochondrial ATP production under hypoxic conditions.

57 nd various processes by which cells adapt to hypoxic conditions.

58 dren were not reparative unless subjected to hypoxic conditions.

59 fectively reduced the level of Su-OCT4 under hypoxic conditions.

60 photobleaching-based dosimetry failed under hypoxic conditions.

61 human HCC cell lines (Huh7 and Hep3B) under hypoxic conditions.

62 F-1alpha protein which occurs normally under hypoxic conditions.

63 supply to increased metabolic demands under hypoxic conditions.

64 on when ATP supply is low, presumably due to hypoxic conditions.

65 which is associated with the ribosome under hypoxic conditions.

66 ecretion of VEGF protein, specifically under hypoxic conditions.

67 mRNA may permit continuous translation under hypoxic conditions.

68 he important oxidoreductases expressed under hypoxic conditions.

69 ke, CBF, and CMRO(2) under both normoxic and hypoxic conditions.

70 tive oxygen species (ROS) and sickling under hypoxic conditions.

71 oxicity than cisplatin or tirapazamine under hypoxic conditions.

72 d promoted cell migration and invasion under hypoxic conditions.

73 ning citrate synthesis and cell growth under hypoxic conditions.

74 tabilization and transcriptional activity in hypoxic conditions.

75 ng, which promotes hepatocyte survival under hypoxic conditions.

76 (ROS), which can be rescued by growth under hypoxic conditions.

77 to melanoma cell lines in both normoxic and hypoxic conditions.

78 a marked delay in cell death observed under hypoxic conditions.

79 ell as the improved anticancer effects under hypoxic conditions.

80 on at both the mRNA and protein levels under hypoxic conditions.

81 cancer cell proliferation via ANGPTL4 under hypoxic conditions.

82 t inhibits PGE(2) induction of ANGPTL4 under hypoxic conditions.

83 is regulation occurs under both normoxic and hypoxic conditions.

84 ble factor (HIF) transcription factors under hypoxic conditions.

85 al but more pronounced differentiation under hypoxic conditions.

86 ed by wild-type animals only when exposed to hypoxic conditions.

87 still able to induce cancer cell death under hypoxic conditions.

88 ould be rescued by JNK1 reconstitution under hypoxic conditions.

89 following knockdown of HEF1 expression under hypoxic conditions.

90 nction in cancer cell lines under normal and hypoxic conditions.

91 levels in live cancer cells under normal and hypoxic conditions.

92 tained an enhanced level of HIF-1alpha under hypoxic conditions.

93 requirement for GSH to maintain growth under hypoxic conditions.

94 iple negative breast cancer cells only under hypoxic conditions.

95 mucosa permeability and in inflammatory and hypoxic conditions.

96 me activation and curtailed thrombosis under hypoxic conditions.

97 myocytes and skeletal muscle in ischemic and hypoxic conditions.

98 highest growth performance when subjected to hypoxic conditions.

99 proliferation of host progenitor cells under hypoxic conditions.

100 as a switch to augment Notch signaling under hypoxic conditions.

101 trated to be repressed and less efficient in hypoxic conditions.

102 alnexin prevents fission and mitophagy under hypoxic conditions.

103 ell as sickling of SCD erythroid cells under hypoxic conditions.

104 tection of (19)F signal in cells grown under hypoxic conditions.

105 umulation of lipid inclusions in response to hypoxic conditions.

106 itize them to drugs that are activated under hypoxic conditions.

107 causing increased O2 release from heme under hypoxic conditions.

108 molecule's cytotoxicity in both normoxic and hypoxic conditions.

109 wth, and development under both normoxic and hypoxic conditions.

110 drial fission and subsequent mitophagy under hypoxic conditions.

111 tosis, which abrogated BCSC enrichment under hypoxic conditions.

112 ng that they retain high activity even under hypoxic conditions.

113 t cellular functions under both normoxic and hypoxic conditions.

114 unction of EM CD4(+) T cells in normoxic and hypoxic conditions.

115 2-aminoimidazoles through bioreduction under hypoxic conditions.

116 to be biologically relevant, particularly in hypoxic conditions.

117 ronal stem cells to keep proliferating under hypoxic conditions.

118 MTX release, and cellular MTX delivery under hypoxic conditions.

119 n by IL-10-deficient Th1 cells stimulated in hypoxic conditions.

120 hole-body plethysmography under normoxic and hypoxic conditions.

121 newborn rat preparations under normoxic and hypoxic conditions.

122 es and U251 cells under normal and stressed (hypoxic) conditions.

123 was stimulated by acute neuronal injury and hypoxic conditioning.

124 ceramide species elicited by a wide range of hypoxic conditions (0.2-5% oxygen).

125 In this study, under hypoxic conditions (1% O2), we examined the effect of PE

126 hypertrophy response under both normoxic and hypoxic conditions (26% lower than control surgery, p <

127 Under hypoxic conditions, a decrease in the IC50 of MTX and MT

128 the auxin efflux carrier PIN2 is reduced at hypoxic conditions, a response that is suppressed by RAP

129 e by dietary intervention under normoxic and hypoxic conditions; a moderate dose of nitrate administe

130 This temperature rise resulted in hypoxic conditions across the entire Baltic sea as revea

131 We hypothesized that MM-associated hypoxic conditions activate EMT-related proteins and pro

132 rotected Salmonella grown under normoxic and hypoxic conditions against the bacteriostatic activity o

133 in both ALCL and NSCLC, we found that under hypoxic conditions, ALK directly regulated the abundance

134 Here, we demonstrate that hypoxic conditions alone enhance permeability and giant

135 Extreme hypoxic conditions along the coast, leading to what are

136 gene expression of which is increased under hypoxic conditions, also increased the Pck anaplerotic a

137 enhanced HIF-1alpha protein stabilization in hypoxic conditions, an effect insensitive to antioxidant

138 e survival of hepatocyte cell lines grown in hypoxic conditions, an effect that is overcome by preind

139 hat are known ERBB2 targets, suggesting that hypoxic conditions and ERBB2 overexpression share both p

140 embrane enzyme, mediates cell survival under hypoxic conditions and is overexpressed in solid maligna

141 dependent on activin A both under basal and hypoxic conditions and that the expression of the EGLN3-

142 individuals appear to be less able to resist hypoxic conditions and this is the size range that is th

143 observed when ARPE-19 cells are grown under hypoxic conditions and when pre-treated with lutein prio

144 n E7-mediated G1 checkpoint abrogation under hypoxic condition, and the function could possibly be in

145 mammary epithelial cells under normoxic and hypoxic conditions, and applying in silico mathematical

146 bolism and provides a growth advantage under hypoxic conditions, and HIF-1 knockdown abrogates this a

147 increasing sRBC occlusion under normoxic and hypoxic conditions, and increasing sRBC adhesion in our

148 lls move through capillaries under transient hypoxic conditions, and offer novel possibilities for de

149 PK pathway, impairs cellular migration under hypoxic conditions, and regulates a set of genes related

150 SRC, glycolytic reserve was not tapped under hypoxic conditions, and, under hypoxia, glucose metaboli

151 ncluding cell proliferation, viability under hypoxic condition, anti-apoptotic properties, resistance

152 mechanisms of fungal growth in these in vivo hypoxic conditions are poorly understood.

153 Although hypoxic conditions are present in IPF, hypoxia's role as

154 Here we show that hypoxic conditions, as are often found in subregions of

155 The hypoxic conditions at high altitudes present a challenge

156 ionally, VO2 of the tissue was maintained in hypoxic conditions at rest and during exercise, despite

157 Instead, we show that in hypoxic conditions ATMIN expression is repressed.

158 es in normoxic tissues but is retained under hypoxic conditions because of reduction and binding to m

159 n of MTA1, HSP90 and HIF1alpha complex under hypoxic condition but not under normoxic condition.

160 ased by RA synovial fibroblasts (RASF) under hypoxic conditions but not under normoxia or TNF-alpha t

161 d to drive HIF1-depedent tumorigenesis under hypoxic conditions, but also has HIF-independent activit

162 HNSCC cells expressing wild-type EGFR under hypoxic conditions, but not in EGFRvIII-expressing HNSCC

163 ized HIF-1alpha protein in both normoxic and hypoxic conditions by blocking its proteasomal degradati

164 mydomonas reinhardtii adapts to anaerobic or hypoxic conditions by developing a complex fermentative

165 BACKGROUND & AIMS: Tumor cells survive hypoxic conditions by inducing autophagy.

166 ls and tissues; it inhibited autophagy under hypoxic conditions by suppressing the conversion of LC3I

167 d to a fluorescent product selectively under hypoxic conditions by the one-electron reducing enzyme N

168 excessive accumulation of unfolded proteins, hypoxic conditions, calcium imbalance, and other stress

169 neovascularization at the graft surface, but hypoxic conditions cause cell death at the core.

170 In this study, we show that hypoxic conditions cause the primary root to grow sidewi

171 hypoxia requires JMY, as depleting JMY under hypoxic conditions causes decreased cell motility.

172 Under hypoxic conditions, cellular damage (lactate dehydrogena

173 s can catalyze this reductive reaction under hypoxic conditions comparable with those in solid tumors

174 P-ODD-VEGF protein at increased levels under hypoxic conditions compared to normoxic conditions.

175 indicate a diminished level of DNA damage at hypoxic conditions compared with those at normal conditi

176 Parallel experiments using cells grown under hypoxic conditions confirmed that a compromised ETC and

177 F-1alpha protein levels in both normoxic and hypoxic conditions, consistent with a role for MKK1 and

178 Only under hypoxic conditions could luciferase activity be detected

179 Growth of trypanosomes in hypoxic conditions decreases JBP1 and -2 activity, resul

180 Hypoxic conditions, defined as dissolved oxygen (DO) con

181 h of cells cultured under chemically induced hypoxic conditions, displaying a specific activity again

182 ustain high levels of aerobic activity under hypoxic conditions (e.g., birds that fly at high altitud

183 se findings indicate that ANDV infection and hypoxic conditions enhance mTOR signaling responses, res

184 ificantly higher levels of association under hypoxic conditions for 2-nitroimidazole-containing BB2r-

185 Moreover, under hypoxic conditions found in the tumour microenvironment,

186 However, both under normoxic and hypoxic conditions, glucose was critical for EM CD4(+) T

187 We found that hypoxic conditions had strong negative effects on extent

188 Hypoxic conditions have been widely used as an in vitro

189 Hypoxic conditions have profound effects on the differen

190 In severely hypoxic condition, HIF-1alpha-mediated induction of Pdk1

191 Under hypoxic conditions, HIF-1alpha levels are greatly increa

192 As under hypoxic conditions hypoxia-inducible factor-1alpha (HIF-

193 We observed that under hypoxic conditions, IDH1-mutant cells exhibited increase

194 Our results indicate that under hypoxic conditions, immune response genes are differenti

195 Submersion and hypoxic conditions impede AhR-dependent Ccno induction.

196 ability is drastically affected in PC, under hypoxic condition in a hypoxia inducible factor 1alpha (

197 we found OPN expression to be upregulated by hypoxic condition in PC-3 prostate tumor cells.

198 nd increase survival of melanoma cells under hypoxic condition in vivo.

199 that inhibits proangiogenic signaling under hypoxic conditions in breast cancer cells.

200 n was decreased by histone acetylation under hypoxic conditions in cancer cells.

201 ns and enhances HIF1alpha accumulation under hypoxic conditions in cells.

202 TG7 and impairs viability of HCC cells under hypoxic conditions in culture and in mice.

203 n ganglioside metabolism, is activated under hypoxic conditions in cultured skeletal muscle cells (C2

204 king in concert with DRP1 and calnexin under hypoxic conditions in mammalian cells.

205 rategy was evaluated under both normoxic and hypoxic conditions in normal tissues as well as in a mur

206 K promoter constructs were then tested under hypoxic conditions in PC-12 cells, where NFkappaB is not

207 at MITF expression is potently reduced under hypoxic conditions in primary melanocytes and melanoma a

208 rate of oxygen (CMRO(2)) under normoxic and hypoxic conditions in rats.

209 Hypoxic conditions in the cornea affect epithelial funct

210 n measurements showed no oxygen depletion or hypoxic conditions in the microwell.

211 hether training or sleeping under normobaric hypoxic conditions in the weeks before the ascent would

212 ay is activated in breast cancer cells under hypoxic conditions in vitro and in sunitinib-treated mou

213 ebral cortical neurons previously exposed to hypoxic conditions in vitro or experimental cerebral isc

214 d not improve EDL muscle contractility under hypoxic conditions in vitro.

215 on by dbcAMP was significantly reduced under hypoxic conditions in which cell fusion is impaired.

216 Hypoxic conditions increased expression of genes previou

217 Hypoxic conditions increased fermentation of glucose to

218 Under hypoxic conditions, increases in H3K9me3 occur in an oxy

219 to these MCT-disrupted cells in normoxic and hypoxic conditions induced a rapid drop in cellular ATP-

220 Here, we investigated how hypoxic conditions influence human T cell functions and

221 Here, we show that hypoxic conditions inhibit anoikis and block expression

222 Consistent with these data, hypoxic conditions inhibit luminal clearing during morph

223 Moreover, under hypoxic conditions, inhibition of prolyl hydroxylase sig

224 esting that primary root growth direction at hypoxic conditions is antagonistically regulated by hypo

225 sponse of eukaryotic microbes to low-oxygen (hypoxic) conditions is strongly regulated at the level o

226 SCD pathology is erythrocyte sickling under hypoxic conditions, leading to vaso-occlusion and hemoly

227 Loss of KDM4A in hypoxic conditions leads to a decreased HIF-1alpha media

228 infiltration and low oxygen tension, yet how hypoxic conditions may affect innate immune cells and th

229 Hypoxic conditioning of NK cells may thus benefit their

230 The cold, hypoxic conditions of high-altitude habitats impose seve

231 The widespread hypoxic conditions of the tumor microenvironment can imp

232 ncerning the effects of acute versus chronic hypoxic conditions on DNA replication and genomic stabil

233 Correspondingly, hypoxic conditions or HIF1alpha stabilization achieved b

234 of FDG uptake by any cell (upregulated under hypoxic conditions or other microenvironmental factors),

235 are necessary for full promoter activity in hypoxic conditions or upon Cu starvation.

236 Under hypoxic conditions, overexpression of SUMO1gg (the activ

237 Under hypoxic conditions, p53 loss promoted MCT1 expression an

238 erbate the intracellular acidity produced by hypoxic conditions, perhaps compromising cell growth and

239 The ability to sense and adapt to hypoxic conditions plays a pivotal role in neuronal surv

240 The apparent establishment of stable hypoxic conditions prior to AD 1900 highlights the chall

241 der low-glucose and combined low-glucose and hypoxic conditions, proline catabolized by POX was used

242 In the presence of functional p53, hypoxic conditions promote apoptosis; however, the p53-d

243 itioning of ASCs using ascorbic acid (AA) or hypoxic conditions provided additional benefit.

244 hypoxia-inducible factor (HIF) 1alpha under hypoxic conditions providing a molecular basis for the d

245 93 cells coexpressing STIM1 and Orai1, acute hypoxic conditions rapidly blocked store-operated Ca(2+)

246 ria of an oxygen sensor across physiological hypoxic conditions, regulating the balance between biolo

247 During hypoxic conditions, regulon induction was attenuated by

248 ndingly, of internalized radioactivity under hypoxic conditions relative to 34.8%, 35.3%, 33.2%, and

249 In certain hypoxic conditions, replication stress occurs in the abs

250 e upregulation of HIF1alpha and HIF2alpha in hypoxic conditions required ALK activity and its downstr

251 Importantly, succinate metabolism under hypoxic conditions restores membrane potential and ATP l

252 t exposure of ANDV-infected MECs and LECs to hypoxic conditions resulted in a 3- to 6-fold increase i

253 nally, applying CPOs against cancer cells in hypoxic conditions resulted in the dose dependent releas

254 ANDV infection in combination with hypoxic conditions resulted in the enhancement of hypoxi

255 rofile and genomewide binding of EglN2 under hypoxic conditions reveal nuclear respiratory factor 1 (

256 Under normoxic or hypoxic conditions, SAD inhibited cell survival through

257 wever, GAD67-EGFP knock-in mice reared under hypoxic conditions showed no changes in total number of

258 Under hypoxic conditions, stabilized hypoxia-inducible factor

259 cting the mouse to alternating hyperoxic and hypoxic conditions, strong and weak functional connectiv

260 und that miR-630, which is upregulated under hypoxic conditions, targets and downregulates Dicer expr

261 of endothelial cells more efficiently under hypoxic conditions than normoxic conditions.

262 Hypoxic conditions that are known to induce EMT in MDA-M

263 s) are highly migratory predators adapted to hypoxic conditions that may be deleterious to their comp

264 d that in the presence of LPS or exposure to hypoxic conditions the cells produce higher C3 mRNA as w

265 In addition to measurements in hypoxic conditions, the detection limit of this biosenso

266 Under hypoxic conditions, the HIF1alpha subunit accumulates be

267 Under hypoxic conditions, the trophoblast-like cell line JAR s

268 Here we demonstrate that under hypoxic conditions, the ubiquitin ligase Siah (seven in

269 Under hypoxic conditions there was an increase in GlcAT-1 expr

270 Under hypoxic conditions, this posttranslational modification

271 Sox9 allows the survival of OC cells upon hypoxic condition, through the activation of betaIII-tub

272 reatly increased in the cetacean liver under hypoxic conditions, thus implicating FGF23 in low bone d

273 We used an in vitro assay under hypoxic condition to observe an increase of protein expr

274 We created short-term and long-term hypoxic conditions to simulate normal and retarded trans

275 Under hypoxic conditions, transcript levels of 18S rRNA decrea

276 During hypoxic conditions, treatment of HT29 cells with the AR

277 fter 72 h of incubation in both normoxic and hypoxic conditions, unlike sulfonamide CA inhibitors tha

278 Under hypoxic conditions, upregulation of EMP2 promoted vascul

279 CA IX and XII was tested under normoxic and hypoxic conditions, using 2D and 3D in vitro cellular mo

280 Estuarine hypoxic conditions varied spatially and temporally and w

281 Under hypoxic conditions, VEGF increased Dll4 expression in th

282 old higher hydroxyl radicals than TiO2 under hypoxic conditions via N3-facilitated electron-hole redu

283 vidence that HIF1alpha can be degraded under hypoxic conditions via the 26 S proteasome and that MDM2

284 S100P elevation under hypoxic conditions was abrogated by silencing of Cav1 or

285 nary artery endothelial cell migration under hypoxic conditions was also reduced by pretreatment with

286 d 5-fluorouracil on cell proliferation under hypoxic conditions was demonstrated.

287 PA-824, active against M. tuberculosis under hypoxic conditions, was also evaluated.

288 ors that control VEGF mRNA translation under hypoxic conditions we established an in vitro translatio

289 nd because apoptosis is greatly increased in hypoxic conditions, we decided to investigate whether th

290 Proinflammatory M1-polarizing stimuli and hypoxic conditions were responsible for enhanced NFAT5 e

291 tion, cell lines cultured under normoxic and hypoxic conditions were used.

292 a positive inotrope, especially under acidic/hypoxic conditions, whereas cTnI facilitates faster rela

293 of CDCP1 impairs cancer cell migration under hypoxic conditions, whereas overexpression of HIF-2alpha

294 e glucose transporters SGLT1 and SGLT2 under hypoxic conditions which implies a possible correlation

295 We demonstrate that under hypoxic conditions, which induce p53 activity, the negat

296 s in rat cortical neurons under normoxic and hypoxic conditions with major differences between the im

297 ve also been shown to be highly active under hypoxic conditions, with the activities of some complexe

298 nd soluble guanylyl cyclase activation under hypoxic conditions, with this process regulated by pH, o

299 Leukemogenesis occurs under hypoxic conditions within the bone marrow (BM).

300 tic stem cell (HSC) pool is maintained under hypoxic conditions within the bone marrow microenvironme