ライフサイエンスコーパス: hypoxic response

1 at these signaling cascades may modulate the hypoxic response.

2 d certain metabolites, that can modulate the hypoxic response.

3 ork that functions to fine-tune the cellular hypoxic response.

4 se in VEGF expression at senescence is not a hypoxic response.

5 1alpha (HIF1alpha), the key molecule in the hypoxic response.

6 iptional regulators of genes involved in the hypoxic response.

7 ace each other in a feedback loop during the hypoxic response.

8 rhabditis elegans and, thus, differ from the hypoxic response.

9 a role in facilitating and/or sustaining the hypoxic response.

10 d greater than those produced by the natural hypoxic response.

11 is a global transcriptional regulator of the hypoxic response.

12 Oligomycin (2 microg) abolished the hypoxic response.

13 m-selective fashion and without triggering a hypoxic response.

14 s with a means to identify regulators of the hypoxic response.

15 or deletion of the HIF-1 site eliminated the hypoxic response.

16 oduce additional layers of complexity to the hypoxic response.

17 ndrial loss through oxo-nitrative stress and hypoxic response.

18 gene expression, cell survival and promoting hypoxic response.

19 a inhibits BK/Kv to initiate or maintain the hypoxic response.

20 CSM, opiorphins are master regulators of the hypoxic response.

21 mportant role in cellular oxygen sensing and hypoxic response.

22 factors (HIFs), the master regulators of the hypoxic response.

23 ent therapeutic strategies aim to target the hypoxic response.

24 criptional activators mediating the metazoan hypoxic response.

25 nt mechanism to control the magnitude of the hypoxic response.

26 le progression, signal transduction, and the hypoxic response.

27 levels in vitro and in vivo, to inhibit the hypoxic response.

28 rtant addition to models of the invertebrate hypoxic response.

29 heart tube or following induction of ectopic hypoxic responses.

30 tes transcription from the vegf locus during hypoxic responses.

31 a role in the species-related differences in hypoxic responses.

32 nine methyltransferases may be important for hypoxic responses.

33 nflammatory responses, matrix metabolism and hypoxic responses.

34 xic responses (20% increase) to pathological hypoxic responses (-14% decrease, P < 0.05).

35 Subsequently, we measured hypoxic responses after combined alpha- and beta-adrener

36 hat BETi dually targets angiogenesis and the hypoxic response, an effective combination at reducing t

37 ins may participate in signaling cascades of hypoxic response and angiogenesis.

38 for virulence and was sufficient to induce a hypoxic response and death in the absence of bacteria.

39 have important implications for the role of hypoxic response and HIF-1alpha in development, and in c

40 standing both the molecular mechanism of the hypoxic response and human adaptation to high altitude.

41 hypoxia, with hyperglycaemia suppressing the hypoxic response and hypoglycaemia stimulating it.

42 Hypoxic response and inflammation both involve the actio

43 To identify genes regulated by the hypoxic response and not other effects of chronic anemia

44 sm, the production of neurotransmitters, the hypoxic response and the biosynthesis of secondary metab

45 an clarify a possible connection between the hypoxic response and the stability of in-vitro preparati

46 mediators of gene networks implicated in the hypoxic response and the switch to glycolysis that occur

47 py of the VHL gene leads to up-regulation of hypoxic response and tumor formation within central nerv

48 including dysregulation of genes involved in hypoxic responses and angiogenesis.

49 e metabolic changes consistent with enhanced hypoxic responses and increased glycolysis.

50 on with hydroxyurea in SCD is independent of hypoxic responses and that genetic variation at SNP rs60

51 natural product biosynthesis, the mammalian hypoxic response, and DNA repair.

52 o growth and angiogenesis), immune function, hypoxic response, and oxidative modification of extracel

53 at low oxygen plays an important role in the hypoxic response, and the model indicates that the Ofd1

54 esistance to oxidative stress, regulation of hypoxic responses, and apoptosis.

55 Critical mediators of the hypoxic response are the hypoxia-inducible factors HIF-1

56 Thus, hypoxic responses are important for the establishment of

57 Many hypoxic responses are mediated by hypoxia-inducible fact

58 In diverse types of organisms, cellular hypoxic responses are mediated by prolyl 4-hydroxylases

59 ed during hypoxia, their individual roles in hypoxic responses are still poorly understood.

60 These findings define VHL-1 and the hypoxic response as an alternative longevity and protein

61 ession of components of the VEGF pathway and hypoxic responses as predictive markers for radiographic

62 onse element, GTAC, is required also for the hypoxic response, as is a trans-acting locus, CRR1.

63 , reaffirming the importance of CRR1 for the hypoxic response, but indicating also the contribution o

64 The A2R antagonist, CSC, inhibited the KDR hypoxic response by 42% +/- 7.8% (P = 0.008) at 10 micro

65 r studies that nitric oxide may regulate the hypoxic response by direct reaction with the HIF hydroxy

66 of G9a is a crucial factor in mediating the hypoxic response by down-regulating the expression of sp

67 iquitin ligase that negatively regulates the hypoxic response by promoting ubiquitination and degrada

68 The induction of a hypoxic response by VACV is reminiscent of the biochemic

69 tion of a key transcription factor mediating hypoxic responses by blocking the binding of HDACs.

70 In ISL1+ CPCs, induction of hypoxic responses caused CHD by repressing Isl1 and acti

71 Hypoxic responses (delta VE/delta SaO2) were significant

72 stress and potent induction of the cellular hypoxic response, despite normoxic conditions.

73 The role of the hypoxic response during metastasis was analysed in migra

74 lved in regulatory networks and the Enduring Hypoxic Response (EHR), hold promise for developing new

75 n of an abasic site at a key base within the hypoxic response element (HRE) of the vascular endotheli

76 Caco2 cells stably expressing a hypoxic response element (HRE)-driven luciferase promote

77 riptional complex forming on the VEGF gene's hypoxic response element and that the presence of Ref-1/

78 ucleotide-specific base modifications in the hypoxic response element of the VEGF gene in lung vascul

79 AP1 DNA recognition sequences present in the hypoxic response element of the VEGF gene.

80 Il22 promoter contains a putative conserved hypoxic response element suggesting that the transcripti

81 Overexpression of catalase abolishes hypoxic response element-luciferase expression during hy

82 on a 64-mer sequence encompassing a minimal hypoxic response element.

83 se reporter construct under the control of a hypoxic response element.

84 factor-1 (HIF1), the master regulator of the hypoxic response, enhances tumorigenesis and influences

85 that rapidly and efficiently attenuates the hypoxic response, even at modest CITED2 concentrations.

86 HIF1alpha, which in addition to its roles in hypoxic responses exerts an independent effect on radior

87 receptor nuclear translocator (ARNT) and the hypoxic response factor HIF-1alpha.

88 bsence of treatment and instead implicates a hypoxic response following the surgical biopsy.

89 the two copies of this motif upstream of the hypoxic response gene alpha-crystallin.

90 crease dramatically, and mRNA encoding other hypoxic response genes, such as those encoding hypoxia-i

91 of a transcriptional program that mimics the hypoxic response have been documented in cultured cells

92 f the major transcriptional regulator of the hypoxic response, HIF1alpha, is modulated by the interpl

93 lates the master transcription factor of the hypoxic response, hypoxia-inducible factor-alpha (HIF-al

94 One of the key mediators of the hypoxic response in animal cells is the hypoxia-inducibl

95 The hypoxic response in animals is mediated via the transcri

96 droxylases that act as oxygen sensors in the hypoxic response in animals.

97 We found that loss of the hypoxic response in astrocytes does not cause anemia in

98 ction is a virtually constant feature of the hypoxic response in both normal and transformed cells, r

99 The hypoxic response in cells and tissues is mediated by the

100 chondrial complex II substrate, restored the hypoxic response in cybrid cells, suggesting that electr

101 and nuclear import adaptor Nro1 regulate the hypoxic response in fission yeast by controlling activit

102 irect measure of oxygen supply and mediate a hypoxic response in fission yeast.

103 The hypoxic response in humans is regulated by the hypoxia-i

104 example of this is the relationship between hypoxic response in individual tissues, and the effect t

105 The chief mediator of hypoxic response in mammalian tissues is the transcripti

106 ctor 1 (HIF-1) is a central regulator of the hypoxic response in many cell types.

107 ndicate that MUC1 acts as a modulator of the hypoxic response in pancreatic cancer cells by regulatin

108 lly, discovery of a shared activation of the hypoxic response in pheochromocytomas with mutations in

109 that a regulatory protein that controls the hypoxic response in S. cerevisiae controls filamentous g

110 We postulated that the hypoxic response in sickle cell disease (SCD) contribute

111 genic specificity to the PGC-1alpha-mediated hypoxic response in skeletal muscle cells.

112 lism (glycolysis and respiration) are a core hypoxic response in some, but not all, fungal species.

113 ns of HO-2, including its involvement in the hypoxic response in the carotid body, which involves int

114 e-activated K(+) channel, is involved in the hypoxic response in the carotid body.

115 Many cell types undergo a hypoxic response in the presence of low oxygen, which ca

116 Spaceflight exposure appears to effect a hypoxic response in the roots of agar-grown plants that

117 echanism that is critical for regulating the hypoxic response in tumors.

118 To study the role of the transcriptional hypoxic response in vivo we have targeted the murine HIF

119 se findings reveal a second type of tracheal hypoxic response in which Sima activation conflicts with

120 us research efforts, the role of Plk3 in the hypoxic response induced by hypoxia or nickel is not com

121 CSN activities during normoxia and kept the hypoxic responses intact.

122 zheimer patients differentially affected the hypoxic response, involving the generation of AICD.

123 The hypoxic response is an ancient stress response triggered

124 The hypoxic response is controlled by a family of hypoxia-in

125 The need for hypoxic response is likely due to interrupted wound vasc

126 The hypoxic response is manifested in many pathophysiologica

127 The hypoxic response is mediated by the alpha-subunit of the

128 The finding that the metazoan hypoxic response is regulated by oxygen-dependent posttr

129 An important component of the hypoxic response is the activation of the hypoxia-induci

130 A critical issue in understanding the hypoxic response is the identification of hypoxia-regula

131 key question surrounding HIF-1alpha and the hypoxic response is the role of this transcription facto

132 One well-characterized component of the hypoxic response is transcriptional activation of genes

133 est that Hph, in addition to its function in hypoxic response, is a regulator of cellular growth and

134 restored" hypoxic response, like the control hypoxic response, is inhibited by the adenosine A(1) rec

135 or 1-alpha (HIF-1alpha), a key player in the hypoxic response, is kept under stringent regulation.

136 In conclusion, up-regulation of the hypoxic response leads to decreased expression of hepcid

137 This "restored" hypoxic response, like the control hypoxic response, is

138 n important physiological contributor to the hypoxic response, linking it to innate immunity and infl

139 evealed a direct interconnection between the hypoxic response, lipid catabolism, lipid anabolism and

140 tely balanced interplay between the cellular hypoxic response, mediated by hypoxia-inducible factor-1

141 nd 8-phenyltheophylline, did not inhibit the hypoxic response of KDR mRNA at A1R inhibitory concentra

142 The hypoxic response of respiratory neurones within the pre-

143 gainst Pur alpha also revealed a loss in the hypoxic response of the beta(2) integrin promoters.

144 HAF, thus, switches the hypoxic response of the cancer cell from HIF-1alpha-depe

145 two regulatory functions contributes to the hypoxic response of the cell.

146 hmic slice' is a good model for studying the hypoxic response of the respiratory network under in vit

147 he receptor is dispensable for the classical hypoxic response of transcriptional upregulation and sec

148 (HIF)-1alpha is an important mediator of the hypoxic response of tumor cells and controls the up-regu

149 important role for mir-210 in regulating the hypoxic response of tumor cells and tumor growth.

150 Understanding the spatially heterogeneous hypoxic response of tumors is critical.

151 The Siah E3 ubiquitin ligases regulate the hypoxic response pathway by modulating the turnover of t

152 racts with HIF1beta, and attenuates the HIF1 hypoxic response pathway.

153 ment of new agents targeting portions of the hypoxic response pathway.

154 ed as direct oxygen sensors in the mammalian hypoxic response pathway.

155 results have uncovered a previously unknown hypoxic-response pathway that may be conserved throughou

156 d vessels, leading to the activation of both hypoxic response pathways and oxidative stress pathways

157 ortantly, expression of GPD1L attenuates the hypoxic response, preventing complete HIF-1alpha inducti

158 identify regulatory elements involved in the hypoxic response, promoter regions of the mouse Flt-1 an

159 ding the evolutionary pressure to develop a 'hypoxic response' provides a framework to investigate th

160 ion of DNA repair is an integral part of the hypoxic response, providing molecular insights into the

161 mutant of dosR, which encodes the immediate hypoxic response regulator, failed to adapt to low-oxyge

162 ar mechanisms by which SUMOylation regulates hypoxic responses remain unclear.

163 ulmonary thromboembolism, or (3) upregulated hypoxic responses secondary to anemia, low O2 saturation

164 ha (HIF-1alpha) is the main regulator of the hypoxic response, the upstream mechanisms required for i

165 at independent of its function in regulating hypoxic response, the VHL gene plays a critical role in

166 but additional nutrient signals may tune the hypoxic response through control of unassembled Rps23 or

167 chanism that serves to maintain the cellular hypoxic response through HIF-alpha- and microRNA-depende

168 P1 plays a key role in the regulation of the hypoxic response through regulation of HIF1alpha stabili

169 Our findings link the innate immune hypoxic response to tumor progression through induction

170 biquitin ligase associated with the cellular hypoxic response, to be the ubiquitin E3 ligase that med

171 moting ubiquitination and degradation of the hypoxic response transcription factor HIF-1.

172 e investigated the need for a highly related hypoxic response transcription factor, HIF-2alpha.

173 ces pombe regulate lipid homeostasis and the hypoxic response under conditions of low sterol or oxyge

174 ucible factors (HIFs) activity and trigger a hypoxic response under normoxic conditions, such as iron

175 itor that stabilizes HIF-alpha and elicits a hypoxic response via a different mechanism, that is the

176 idence from these experiments indicates that hypoxic response via HIF-1alpha is an important positive

177 We show here how hypoxic response via the HIF transcription factors in on

178 During anemia, the hypoxic response via the transcription factor hypoxia-in

179 The hypoxic response was abolished while the response to U46

180 The hypoxic response was associated with reduced mitochondri

181 lated in pancreatic cancer cells even though hypoxic response was decreased in them.

182 More importantly, hypoxic response was improved by preconditioning islets

183 The hypoxic response was investigated by exposing normal (no

184 ioid system is involved in the regulation of hypoxic responses, we asked whether there are difference

185 Time-dependent hypoxic responses were assessed in the phrenic neurogram

186 In 5-d-old pups, early VE hypoxic responses were enhanced, and late VE were simila

187 These observations suggest that the hypoxic responses were selectively augmented in mutant m

188 n respiratory variables (baseline, hyperoxic/hypoxic responses) were not severely influenced by EMG+

189 essary for the yeast to quickly turn off its hypoxic response when oxygen is restored.

190 the epithelial-to-mesenchymal transition and hypoxic response, whereas down-regulation of the CPEB2A

191 period of depression and suppressed during a hypoxic response which we refer to as central apnoea.

192 role G9a plays as an epigenetic mediator of hypoxic response, which can be used as a diagnostic mark