ライフサイエンスコーパス: i.t.

1 i.t. DC administration combined with RT induces a potent

2 i.t. injections were delivered to L1 as sympathetic neur

3 selective CCKB receptor antagonist L-365260 i.t. dose-dependently inhibited mustard oil hyperalgesia

4 dose (0.01-0.001 microg) goat anti-rat IL-6 i.t. administration (P=0.025) significantly decreased al

5 hresholds are elevated by approximately 70%, i.t. nociceptin substantially attenuates jump thresholds

6 The administration of TNF70-80 i.t. to CBA/J mice 7 days prior to, but not concomitantl

7 d-type, but not TLR9(-/-), mice administered i.t. reconstituted anti-legionella immunity and restored

8 Morphine, administered i.t. at a maximally effective dose (80 micrograms), inhi

9 is a much more potent antihyperalgesic after i.t. as compared to s.c. administration.

10 hoalveolar lavage (BAL) cells 1-3 days after i.t. challenge with hapten in the HIPIF lung, but not lu

11 ookhaven Medical Research Reactor 24 h after i.t. injection, which was timed to coincide with 2.5 h a

12 +CD25+Foxp3+ Tregs as late as 24 hours after i.t. LPS normalized resolution in Rag-1-/- mice.

13 d P-selectin-deficient (E(-)P(-)) mice after i.t. SRBC challenge.

14 d to directly measure target occupancy after i.t. dosing.

15 compartment, were much more pronounced after i.t. than after i.v. challenge.

16 without effect on the tail-flick test after i.t. injection in mice.

17 d a significant growth delay of tumors after i.t. injection of Ad5/Ad35.IR-E1A/TRAIL, whereas adenovi

18 An i.t. co-injection of reactive red 2 (100 micrograms) and

19 FR) or F98(WT) tumor cells, rats received an i.t. injection of BSD-EGF (approximately 60 microg (10)B

20 c receptor antagonist phentolamine (i.p. and i.t.) but not by the opioid receptor antagonist naloxone

21 tion was combined with radiation therapy and i.t. AdsGRP94 injections, local tumor growth and pulmona

22 tly evident starting from day 14 in i.v. and i.t. rUCMS cell-transplanted rats compared with sham-tra

23 m spacer exhibited profound antinociception (i.t. ED50 = 0.0146 pmol/mouse) that was 2000x greater th

24 body refractoriness to systemic LPS, because i.t. administration followed by i.p. administration did

25 hdrawal, an effect differentially altered by i.t. pretreatment with monoaminergic antagonists (100 nm

26 of HBO2 was also significantly attenuated by i.t. pretreatment with a rabbit antiserum against rat dy

27 cement of formalin-induced pain behaviors by i.t. bicuculline is not secondary to enhanced peripheral

28 these effects were differentially blocked by i.t. pretreatment with the nAChR antagonists mecamylamin

29 The granulomatous inflammation elicited by i.t. challenge predominantly involved alveolar spaces an

30 Pulmonary LPS tolerance was induced by i.t. administration of 100 ng LPS at time 0 and 48 h.

31 -3 activity, an increase that was reduced by i.t. BDFMK administration.

32 nmol of NMDA in rats prepared with a chronic i.t. cannula.

33 A(B)), and no significant effects of chronic i.t. morphine treatment were observed in brain sections.

34 In conclusion, i.t. or i.v. challenge with C. parvum in sensitized rats

35 In contrast, i.t. application of the micro-selective antagonist D-Phe

36 In contrast, i.t. instillation of LT-HDM-pulsed DCs induced a similar

37 In contrast, i.t. pretreatment with 3 microg of naltriben (NTB), a de

38 Conversely, i.t. administration of TGF-beta1 potently inhibited neur

39 were treated for 7 days with 0.11 mg/kg/day i.t. morphine, and receptor activation of G-proteins was

40 gliomas compared with 33.2%ID/g after direct i.t. injection and 12.3%ID/g in F98(WT) gliomas.

41 Our data indicate that direct i.t. injection can selectively deliver BSD-EGF to EGFR-p

42 tomatic CNS therapy that consisted of either i.t. methotrexate (MTX) and CRT or intensified i.t. MTX

43 ptomatic CNS therapy that consists of either i.t. MTX plus CRT or intensified i.t. MTX alone results

44 ized to receive systemic therapy with either i.t. MTX and CRT (regimen A, n = 317) or intensified i.t

45 Following i.t. injection of 131I-BSD-EGF, 21.8% of the injected do

46 algesic actions of these compounds following i.t. administration are not observed in non-pregnant or

47 In contrast, following i.t. injection of BSD-EGF, only 0.01-0.1% ID/g was local

48 phocyte recruitment into the lungs following i.t.-SRBC challenge is subset specific and time dependen

49 day after implantation mice were tested for i.t. [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin (DAMGO)

50 Furthermore, i.t. DC plus RT treatment of s.c. tumor in mice bearing

51 Furthermore, i.t. oncolytic adenovirus injection resulted in suppress

52 Given i.t., A-85380 (1 and 10 nmol/rat) decreased the latency

53 ver, when CAP-treated rats sensitized to HEL i.t. at day 0 were rechallenged with HEL i.t. at day 14,

54 HEL i.t. at day 0 were rechallenged with HEL i.t. at day 14, the lungs showed decreased numbers of OX

55 Following highest i.t. dose of nociceptin employed (20 nmol), the gestatio

56 Increased susceptibility in i.t. infection was associated with higher brain CFU, low

57 No tolerance was induced i.t., but marginal tolerance (3-fold) was observed via t

58 Conversely, injection (i.t.) of purified recombinant Wnt5a stimulates the expre

59 pidly up-regulated by intrathecal injection (i.t.) of gp120.

60 Furthermore, intensified i.t. MTX may protect against late bone marrow relapse.

61 and CRT (regimen A, n = 317) or intensified i.t. MTX alone (regimen B, n = 319).

62 s of either i.t. MTX plus CRT or intensified i.t. MTX alone results in a similar 5-year EFS outcome.

63 t. methotrexate (MTX) and CRT or intensified i.t. MTX alone.

64 Interestingly, i.t. administration of CART (55-102) significantly enhan

65 Treg transfer into i.t. LPS-exposed Rag-1-/- mice also corrected the elevat

66 Intrathecal (i.t.) administration of the delta opiate receptor-select

67 Intrathecal (i.t.) administration of the gamma-aminobutyric acid (GAB

68 Intrathecal (i.t.) administration of the non-selective cholecystokini

69 Intrathecal (i.t.) application of reactive red 2 (6-200 micrograms) c

70 Intrathecal (i.t.) injection of 3 or 10 micrograms of CGP 35348 antag

71 Intrathecal (i.t.) pre-treatment with the test compounds 5-methyl-3-p

72 Intrathecal (i.t.) pretreatment with 1 microg of 7-benzylidinenaltrex

73 die in 12.1 +/- 2.1 days after intrathecal (i.t.) implantation of 5 x 10(5) 9L rat gliosarcoma cells

74 stration of normal goat IgG and intrathecal (i.t.) administration of IL-6 neutralizing antibody, norm

75 st that concurrent systemic and intrathecal (i.t.) therapy may be more effective than i.t. therapy al

76 In the mouse tail-flick assay, intrathecal (i.t.) NNTA produced antinociception that was ~100-fold g

77 was sensitive to antagonism by intrathecal (i.t.) pretreatment with the kappa- and mu-selective opio

78 In contrast, intrathecal (i.t.) yohimbine pretreatment (30 microg) completely bloc

79 that can be elicited following intrathecal (i.t.) application of 5-HT to an in situ'isolated' spinal

80 Intensified intrathecal (i.t.) chemotherapy without cranial radiation therapy (CR

81 e, we demonstrate that a local, intrathecal (i.t.) injection of bone marrow stromal cells (BMSCs) fol

82 t study evaluated the effect of intrathecal (i.t.) and intracerebroventricular (i.c.v.) injection of

83 nt study examined the effect of intrathecal (i.t.) morphine administration on receptor/G-protein coup

84 In rats, intrathecal (i.t.) administration of nociceptin is without effect on

85 The results indicate that intrathecal (i.t.) administration of the COX-2 inhibitor, SC58238, an

86 els of acute pain whereas their intrathecal (i.t.) administration has been reported to be antinocicep

87 Rats were implanted with intrathecal (i.t.) catheters for drug delivery and DC-compatible elec

88 stimulus used was peri-spinal (intrathecal, i.t.) application of the Human Immunodeficiency Virus ty

89 lumbosacral subarachnoid space (intrathecal; i.t.).

90 Administration of A-134974 intrathecally (i.t.) was more potent (ED(50)=10 nmol) in relieving tact

91 ylketone (BDFMK) administered intrathecally (i.t.) in a reversible spinal cord ischemia model (RSCIM)

92 When administered intrathecally (i.t.) to the lumbar spinal cord, GSK189254 produced robu

93 oses of 0.001 and 0.003 nmol, intrathecally (i.t.) blocked the hyperalgesia induced by 11.1 nmol of N

94 spinal cord (10 or 25 microg intrathecally [i.t.] in 5 microl saline) induced pupillary dilatation w

95 del, we examined the effects of intrathymic (i.t.) injection of P5-primed alloreactive T cells on gra

96 Intratracheal (i.t.) administration of 10(6) CFU of L. pneumophila indu

97 model of ALI, we administered intratracheal (i.t.) LPS to mice and observed peak lung injury 4 days a

98 nary LPS tolerance induced by intratracheal (i.t.) administration of LPS.

99 epsis, followed 24 h later by intratracheal (i.t.) administration of PSEUDOMONAS: aeruginosa.

100 ged after 2 weeks with either intratracheal (i.t.) or i.v. C. parvum.

101 cited in the lung by a single intratracheal (i.t.) challenge in mice sensitized with hapten (2,4,6-tr

102 Specifically, intratracheal (i.t.) administration of CpG ODN (30 microg) 48 h before

103 oduced in C57BL/6 mice by the intratracheal (i.t.) administration of bleomycin (BLM).

104 al studies, we found that the intratracheal (i.t.) administration of L. pneumophila to mice deficient

105 sham surgery, followed by the intratracheal (i.t.) administration of P. aeruginosa or saline.

106 onia, we hypothesize that the intratracheal (i.t.) administration of TNF70-80 would augment lung inna

107 stration of c-di-GMP prior to intratracheal (i.t.) challenge with Klebsiella pneumoniae stimulates pr

108 ce were highly susceptible to intratracheal (i.t.) Cryptococcus neoformans infection relative to BALB

109 imed and then challenged with intratracheal (i.t.) SRBC.

110 stores, and then challenged intratracheally (i.t.) with hen egg lysozyme (HEL).

111 R4(-/-), or MyD88(-/-) mice intratracheally (i.t.) with recombinant cHSP60 (50 microg), UV-killed C.

112 FU of Klebsiella pneumoniae intratracheally (i.t.), resulting in the time-dependent expression of IL-

113 (i.n.) plus orally and then intratracheally (i.t.), followed by envelope protein boosting, elicits br

114 lus recombinant IL-33, were intratracheally (i.t.) administered to induce allergic airway inflammatio

115 ution studies rats received an intratumoral (i.t.) injection of (125)I-labeled BSD-EGF and were eutha

116 improve the intracerebral and intratumoral (i.t.) uptake of a heavily boronated macromolecule (dendr

117 raft model (Granta 519 cells), intratumoral (i.t.) vector administration alone had high oncolytic eff

118 Our results indicate that only intratumoral (i.t.) injections of CpG-ODN induce an antitumor response

119 e rats received either i.v. or intratumoral (i.t.) injection of 131I-labeled boronated starburst dend

120 We showed that systemic or intratumoral (i.t.) injection of adenovirus vectors into mice increase

121 lso tested our hypothesis that intratumoral (i.t.) delivery of dendritic cells that had been transduc

122 Two intratumoral (i.t.) injections of (10)B-enriched N5-2OH were administe

123 CT26 tumors were treated with intratumoral (i.t.) injections of a recombinant NDV modified to contai

124 rcoma tumors were treated with intratumoral (i.t.) injections of bone marrow-derived unpulsed DCs in

125 n relieving the OA pain (ED(50)=0.0027 mg/kg i.t.).

126 ppression of primary and metastatic lesions, i.t. replication and necrosis, vector entrance into the

127 malin nociceptive test, 0.001 nmol LY235959 (i.t.) significantly reduced the number of Phase 2 flinch

128 Thus, LY235959 (i.t. or s.c.) has NMDA receptor antagonist activity as d

129 5-Tyr (Me)2-Orn8]-Vasotocin [OTA]; 25 microg i.t. in 5 microl saline) significantly attenuated the pu

130 Pretreatment with 0.3 microg i.t. bicuculline neither enhanced nor suppressed formali

131 Low doses (0.01-0.001 microg) i.t. normal goat and rat IgG significantly attenuated me

132 Chronic morphine (10 microg, i.t.; twice daily for 6 d) induced a time-dependent upre

133 Moreover, i.t. BMSCs reduced CCI-induced spontaneous pain and axon

134 -650394 (an SGK1 antagonist; 100 nm, 10 mul, i.t.) not only exhibited effects similar to the kalirin

135 nal kalirin mRNA expression (10 mug, 10 mul; i.t.) reduced SNL-induced allodynia, kalirin and pNR2B e

136 d these studies to compare the standard i.n./i.t. regimen with additional mucosal administration rout

137 y (3.4 nmol, i.c.v.) and spinally (4.3 nmol, i.t.).

138 The i.p., but not i.t., administration of IL-10 Abs given just before P. a

139 he present study investigated the effects of i.t. and systemic administration of A-85380, a novel nAC

140 s, and this upregulation caused migration of i.t.-injected BMSCs to DRGs through the CXCL12 receptor

141 Combination treatment of i.t. DCs plus RT was superior to s.c. injections of tumo

142 studies and a reconsideration of the use of i.t. chemotherapy for patients with neoplastic meningiti

143 the right caudate nucleus of normal rats or i.t. in rats bearing either F98(EGFR) or F98 wild-type (

144 shed when co-administered with phentolamine (i.t.).

145 earing F98(EGFR) gliomas, which had received i.t. BSD-EGF and BNCT, had a MST of 45 +/- 5 days compar

146 tumors (P = 0.0032), and rats that received i.t. BSD-EGF in combination with i.v. BPA had a MST of 5

147 Similarly, i.t. co-injection of almost equipotent dosages of reacti

148 y of the PDGFR kinase domain, after a single i.t. dose and has efficacy at 0.03 mg/kg, in the rat mon

149 rol tumors, apoptosis induction and a single i.t. injection of virus produced an interconnected and d

150 e group of 15 patients treated with standard i.t. MTX during the same time interval.

151 t comparable to those achieved with standard i.t. therapy.

152 ve concluded that CED is more effective than i.t. injection as a way to deliver boronated EGF to EGFR

153 al (i.t.) therapy may be more effective than i.t. therapy alone.

154 ive T cells on graft survival and found that i.t. administration of the P5-primed T cells on day -7 a

155 We report here that i.t. delivery of protocells, with modified chemistry sup

156 These findings indicate that i.t. administration of CpG ODN can stimulate multiple co

157 These results reveal that i.t. application of morphine affects specific subpopulat

158 The present study shows that i.t. administration of BDFMK reduced caspase-3 activity,

159 The i.t. administration of bacteria to CLP-, but not sham-,

160 The i.t. administration of fasudil, a Rho kinase inhibitor,

161 ce undergoing CLP followed 24 h later by the i.t. administration of saline or P. aeruginosa was 58% a

162 The kappa-antagonist, norBNI, decreased the i.t. potency, and the activity was virtually abolished i

163 Finally, the i.t., but not intraperitoneal, administration of the TLR

164 Furthermore, the i.t. GSK189254 effect was abolished when co-administered

165 In the i.t. model using CBA/J mice, low Ab doses were disease e

166 oup was 13.8 months versus 2.3 months in the i.t. MTX group (P = .003).

167 dialysis, levels of 5-HT, but not NE, in the i.t. space of the lumber region of the spinal cord were

168 le for the slower growth of recurrences; the i.t. injection of collagenase increased the growth rate

169 We also show that the i.t. injection of HSV after caspase-8 activation or pacl

170 ys prior to, but not concomitantly with, the i.t. delivery of 3 x 10(3) CFU of K. pneumoniae resulted

171 mal hyperalgesia and mechanical allodynia to i.t. gp120 were blocked by spinal pretreatment with drug

172 Rag-1-/- and C57BL/6 WT mice were exposed to i.t. LPS.

173 gitation tests) were observed in response to i.t. gp120.

174 n Klebsiella pneumonia, animals were treated i.t. with 5 x 10(8) PFU of a nonreplicating adenoviral v

175 cal refractory state can be induced with two i.t. LPS exposures.

176 to Aspergillus fumigatus and challenged via i.t. instillation with live A. fumigatus conidia.

177 te pulmonary clearance of L. pneumophila, we i.t. administered 5 x 10(8) PFU of a recombinant adenovi

178 dings support a paracrine mechanism by which i.t. BMSCs target CXCL12-producing DRGs to elicit neurop

179 d in treating leptomeningeal metastases with i.t. administered 125IUdR.

180 ts in bacterial clearance were observed with i.t. recombinant IFN-gamma treatment.

181 ations were maintained much longer than with i.t. dosing.

182 Splenocytes from mice treated with i.t. DCs plus RT contained significantly more tumor-spec

183 Mice bearing s.c. CT26 tumors treated with i.t. injections of recombinant NDV expressing IL-2 showe

184 Treatment with i.t. administered 125IUdR (500 microCi/rat) significantl