ライフサイエンスコーパス: icilin

1 s C and cooling compounds such as menthol or icilin.

2 al compounds such as the supercooling agent, icilin.

3 ng oppose the behavioral stimulant effect of icilin.

4 incidence of shaking elicited by 2.5mg/kg of icilin.

5 d and chemical agonists, such as menthol and icilin.

6 activated by the cooling agents menthol and icilin.

7 10-200microM) nor intrathecal application of icilin (0.1nM to 1microM) affected tactile allodynia or

8 Rats injected with icilin (0.5, 1, 2.5, 5mg/kg, i.p.) displayed dose-relate

9 nhanced the shaking induced by a low dose of icilin (0.5mg/kg).

10 Icilin (10 nM-10 microM) produced a concentration-relate

11 educed dose dependently (0.002-200microM) by icilin (18-80%).

12 The effects of icilin, a TRPM8 and TRPA1 agonist, on intracellular Ca(2

13 In contrast, icilin activates TRPM8 with extremely variable latency f

14 TRPM8 channel behavior upon menthol and icilin activation was distinguishable, and the effect of

15 ly increased by ENaC delta subunit agonists (icilin and capsazepine).

16 residue (L1008), but was independent of the icilin and menthol binding site residue Y745 and, essent

17 eptor activation inhibits shaking induced by icilin and that increases in peripheral, as well as cent

18 8 degrees C) and cooling compounds (menthol, icilin) and are implicated in sensing unpleasant cold st

19 a wide range of stimuli, including menthol, icilin, and cold temperatures (<25 degrees C).

20 , inhibited the activation of TRPM8 by cold, icilin, and menthol.

21 so lack behavioral response to cold-inducing icilin application and display an attenuated response to

22 (DRG) neurons, and the analgesic efficacy of icilin applied topically to the paws or intrathecally wa

23 t study was to investigate the usefulness of icilin as a pharmacological tool to study primary affere

24 Further, TRPM8 activation by icilin blocked capsaicin-triggered calcitonin-gene-relat

25 ation was distinguishable, and the effect of icilin depended on the presence of calcium on the intrac

26 Intraplantar injection of icilin did not evoke firing of WDR neurones in naive, sh

27 .) and 2-BFI (7 mg/kg, i.p.), did not affect icilin-evoked shaking.

28 TRPV1 agonist capsaicin or the TRPM8 agonist icilin had no effect on intracellular Ca(2+) concentrati

29 o and to investigate the analgesic effect of icilin in a neuropathic pain model in vivo.

30 ntial mechanism for the analgesic effects of icilin in other pain models.

31 he modulation of ICa(V) by the TRPM8-agonist icilin in vitro and to investigate the analgesic effect

32 Icilin increased both innocuous (sham-operated and SNL r

33 etrahydrothienopyridine 4 as an inhibitor of icilin-induced calcium influx in CHO cells expressing re

34 deficiencies in certain behaviors, including icilin-induced jumping and cold sensation, as well as a

35 We conclude that the icilin-induced modulation of ICa(V) in DRG neurons is un

36 at alpha(2)-adrenoceptor activation inhibits icilin-induced WDS.

37 pecific in vivo coverage models in rats (the icilin-induced wet dog shake model and the cold pressor

38 acodynamic model measuring the prevention of icilin-induced wet-dog shakes (WDS).

39 Icilin is a transient receptor potential cation channel

40 The vigorous shaking associated with icilin is dependent on NMDA receptor activation and nitr

41 nk with the channel activity, sensitivity to icilin, menthol and cold, and impact on channel oligomer

42 Our data suggests that icilin modulates the mechanosensitivity of dorsal horn n

43 The differing effects of ice and icilin on dorsal horn neurones indicate different mechan

44 The effects of icilin on ICa(V) were not significantly different in non

45 ere, we show that, to achieve full efficacy, icilin requires simultaneous elevation of cytosolic Ca2+

46 Determinants of icilin sensitivity map to a region of TRPM8 that corresp

47 treated systemically with the TRPM8 agonist, icilin showed an attenuation of chemically induced colit

48 Furthermore, icilin treatment reduced the 2,4,6-trinitrobenzenesulfon

49 ehavior caused by a fixed dose (2.5mg/kg) of icilin was also inhibited in a dose-related manner by cl

50 TRPM8 responses to cold and the agonist icilin were abolished by inhibitors of the calcium-indep