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1 l-vein bleeding time, which were reversed by idarucizumab.
3 m analysis included 90 patients who received idarucizumab (51 patients in group A and 39 in group B).
4 for dTT was 1.01 with placebo, 0.26 with 1 g idarucizumab (74% reduction), 0.06 with 2 g idarucizumab
5 idarucizumab (74% reduction), 0.06 with 2 g idarucizumab (94% reduction), 0.02 with 4 g idarucizumab
6 idarucizumab (94% reduction), 0.02 with 4 g idarucizumab (98% reduction), and 0.01 with 5 g plus 2.5
9 ombotic event occurred within 72 hours after idarucizumab administration in a patient in whom anticoa
12 o determine the safety of 5 g of intravenous idarucizumab and its capacity to reverse the anticoagula
13 5 g plus 2.5 g idarucizumab groups (nine to idarucizumab and three to placebo in each group), and 11
16 roved humanized monoclonal antibody fragment idarucizumab for reversing the effects of dabigatran, th
17 ability, and efficacy of increasing doses of idarucizumab for the reversal of anticoagulant effects o
18 ch group), and 11 were enrolled into the 4 g idarucizumab group (eight to idarucizumab and three to p
19 and hot flushes), one in the 5 g plus 2.5 g idarucizumab group (epistaxis); one receiving placebo (i
20 ported in seven participants: one in the 1 g idarucizumab group (infusion site erythema and hot flush
21 into each of the 1 g, 2 g, or 5 g plus 2.5 g idarucizumab groups (nine to idarucizumab and three to p
27 n within 4 hours after the administration of idarucizumab, on the basis of the determination at a cen
28 n within 4 hours after the administration of idarucizumab, on the basis of the diluted thrombin time
29 mly assigned within groups in a 3:1 ratio to idarucizumab or placebo using a pseudorandom number gene
34 tudy to determine whether 5 g of intravenous idarucizumab would be able to reverse the anticoagulant
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