ライフサイエンスコーパス: identical-by-descent

1 fspring by causing parts of the genome to be identical by descent.

2 ted sibling pairs than on regions not shared identical by descent.

3 n long stretches of genomic sharing that are identical by descent.

4 Mamu-B*17-containing MHC haplotypes that are identical by descent.

5 of identical base composition that were not identical by descent.

6 ffected breeds indicated that the allele was identical by descent.

7 e-sex sibling pairs will share fewer alleles identical by descent.

8 siblings did not share two HLA-DRB1 alleles identical by descent.

9 ohort will often share long-range haplotypes identical-by-descent.

10 ere homozygous for a mutant allele inherited identical-by-descent.

11 iblings who do not share both MHC haplotypes identical-by-descent.

12 irs (7.6%) did not share parental haplotypes identical by descent across the MHC, suggesting that onl

13 mples revealed that they were homozygous and identical by descent across their genome.

14 ch allows for differences in sharing alleles identical-by-descent across different types of ARPs.

15 stimation demonstrated that this mutation is identical by descent among horse breeds.

16 air of individuals sharing a haplotype tract identical by descent and (iii) assembly of polyploid gen

17 available SNPs to locate genes that are not identical by descent and that contain nonsynonymous codi

18 s based on sibling amount of sharing that is identical by descent are widely available, for both auto

19 ere HD affected, estimates of allele sharing identical by descent at and around the HD locus were adj

20 y sampled sib pairs share half their alleles identical by descent at any locus, whereas a critical as

21 ted proportion of alleles shared by brothers identical by descent at each marker location.

22 method uses the proportion of alleles shared identical by descent at genotyped loci to estimate IBD s

23 n the estimated proportion of alleles shared identical-by-descent at each marker position.

24 dia) showed higher levels of allele sharing, identical by descent, at RGS4.

25 ve-pair studies, the distribution of alleles identical by descent between pairs of affected relatives

26 teroduplexes, likely representing DNA shared identical by descent between the two individuals, are re

27 Homozygosity for a haplotype that was identical by descent between two of the affected individ

28 e majority of restriction fragments that are identical by descent between two related humans.

29 xtended chromosomal segments that are shared identical by descent between very distantly related indi

30 t of affected horses to detect a homozygous, identical-by-descent block spanning approximately 2.5 Mb

31 ess the expected proportions of genes shared identical by descent by a sib pair, in terms of the gene

32 should be found more often on regions shared identical by descent by affected sibling pairs than on r

33 ysis of common disease and in the search for identical-by-descent chromosome regions that carry an ae

34 , during the haplotyping process, from their identical-by-descent copies.

35 alized appropriately, show which alleles are identical by descent despite the presence of untyped ind

36 NA microarray technology to map the selected identical by descent DNA fragments.

37 ty (BMI > or = 40; n = 59) shared haplotypes identical-by-descent for the region containing the OB ge

38 dentified 45 sib-pairs that were concordant (identical by descent) for a locus on chromosome 2 which

39 which the mutant alleles are expected to be identical by descent from a common founder and the regio

40 idual inherits chromosomal segments that are identical by descent from each parent.

41 insertion polymorphisms will prove useful as identical by descent genetic markers for the study of hu

42 ed Alu insertion polymorphisms will serve as identical-by-descent genetic markers for the study of hu

43 mportant genomic features that manifest when identical-by-descent haplotypes are inherited from paren

44 DR3/4-DQ8 siblings of patients with T1D for identical-by-descent HLA haplotype sharing (the number o

45 ling pairs who inherited both apo(a) alleles identical by descent (IBD) (r = .85) than in those that

46 aracterizing genomic regions that are shared identical by descent (IBD) among individuals can yield i

47 Allele sharing identical by descent (IBD) and multipoint maximum likeli

48 to estimate the proportion of allele sharing identical by descent (IBD) and the probability of sharin

49 fference of sib pairs with the shared allele identical by descent (IBD) at marker locus for linkage t

50 to identify an approximately 12-Mbp interval identical by descent (IBD) between the affected individu

51 kage as measured by increased allele sharing identical by descent (IBD) by affected family members.

52 of unconditional probability of genes shared identical by descent (IBD) by relatives can be very diff

53 The proportion of alleles identical by descent (IBD) determines the genetic covari

54 correlation analyses based on alleles shared identical by descent (IBD) for independent obese affecte

55 The detection of genetic segments of Identical by Descent (IBD) in Genome-Wide Association St

56 high proportion (57%-62%) of alleles shared identical by descent (IBD), with P values of .049-.0008

57 We adopt the identical by descent (IBD)-based variance component meth

58 ithm to identify chromosomal segments shared identical-by-descent (IBD) and compared homozygosity at

59 Widespread sharing of long, identical-by-descent (IBD) genetic segments is a hallmar

60 We detected unusually high amount of shared identical-by-descent (IBD) genomic segments between seve

61 se allele heterogeneity and a high degree of identical-by-descent (IBD) haplotype sharing in this fou

62 Direct identical-by-descent (IBD) mapping is a technique, that

63 Inference of identical-by-descent (IBD) probabilities is the key in f

64 eling covariance between individuals, due to identical-by-descent (IBD) QTL alleles, on the basis of

65 e number of sequence differences observed in identical-by-descent (IBD) segments together with a reco

66 genotyped samples by harnessing long (>4-cM) identical-by-descent (IBD) tracts shared among distantly

67 marker D5S500 (proportion of alleles shared identical by descent [ibd] = 0.68 +/- 0.05 [mean +/- SE]

68 20S119, D20S178, and D20S197 (allele sharing identical-by-descent [IBD], 0.56 for all three; P = 0.00

69 he realized proportion of the genome that is identical by descent (IBDG) is predicted better by the p

70 kage screen revealed a single locus that was identical by descent in affected children in both famili

71 The mutated BLM gene is inherited identical by descent in BS persons whose parents are cou

72 imating the probabilities of sharing alleles identical by descent in multipoint calculations and henc

73 Regions potentially shared identical by descent in patients were further characteri

74 dentified those regions most commonly shared identical by descent in patients with psoriasis.

75 iated with dark pigmentation in Africans are identical by descent in South Asian and Australo-Melanes

76 jor histocompatibility complex (MHC) that is identical-by-descent in 85% of patient chromosomes.

77 e was assessed by estimating allele sharing (identical by descent) in affected sibling pairs.

78 stimated proportion of marker alleles shared identical by descent is first partitioned into a compone

79 iers and 168 mutation carriers) carrying the identical-by-descent KCNQ1 p.Ala341Val (A341V) mutation

80 for strong and widespread selection against identical-by-descent marker homozygotes.

81 ertion presence or absence and will serve as identical-by-descent markers for the study of human evol

82 ther is the size of the most common class of identical-by-descent mutants in the sample, again tested

83 type consistent with a founder effect and an identical-by-descent mutation.

84 arently similar introgressions and CNVs were identical by descent or recurrent, we also performed who

85 enome for which both chromosomes were shared identical-by-descent, reducing the search space for caus

86 pproximately 67% of any AJ genome with long, identical-by-descent segments.

87 algorithm, DASH, which builds upon pairwise identical-by-descent shared segments to infer clusters o

88 conversion, and efficiently outputs pairwise identical-by-descent sharing data.

89 ed on multiplex sibship data, conditional on identical-by-descent sharing statuses.

90 nally and paternally derived alleles through identical-by-descent sharing, thus allowing for the disc

91 a parametric representation for the expected identical-by-descent statistic at an arbitrary locus, co

92 ving cases and controls, may share sequences identical-by-descent stretching on the order of 10s to 1

93 orphic L1 elements represent a new source of identical-by-descent variation for the study of human ev

94 is selectively neutral and if all copies are identical by descent with a copy that either was carried

95 ulated to have inherited chromosome segments identical-by-descent with exception of the mutated posit

96 histocompatibility complex (MHC) haplotypes identical-by-descent with their proband siblings have a

97 region of the genome, more genetic material identical by descent, with and without the presence of a