ライフサイエンスコーパス: idiotype

1 seem to induce antibodies that bind the OKT3 idiotype.

2 demonstrated significant bias toward the VH3 idiotype.

3 drophobic patch (HP) responsible for the 9G4 idiotype.

4 on suggesting that this is a public (common) idiotype.

5 he B-cell receptor (BCR), otherwise known as idiotype.

6 immunodominant epitopes in autologous tumor idiotype.

7 e in the regulation of autoantibodies, their idiotypes.

8 xclusively producing chimeric Abs with human idiotypes.

9 RNP) as well as reactivity against the 16/6 idiotype (16/6 Id).

10 Anti-idiotype 3H1 mimics a distinct and specific epitope of C

11 mature dendritic cells (DC) loaded with anti-idiotype 3H1 or CEA could reverse CEA unresponsiveness a

12 Here, we have combined the anti-idiotype 3H1 with the CTL peptides of CEA to augment bot

13 In this study, we identify an idiotype (44.1-Id) that dominates the PPS14-specific IgG

14 eby providing membrane expression of the 5H7 idiotype (5H7scFv-GPI).

15 b (ADX40) chemically conjugated to the tumor idiotype A20 and tested it in a murine lymphoma model.

16 n increase in the PC response and in TEPC 15 idiotype(+) Ab production.

17 a from 40 of 47 patients showed an anti-anti-idiotype (Ab3) response.

18 T15-idiotype Abs, whose heavy (H) chain variable region is e

19 irst practical clinical application of cross-idiotype analysis.

20 ated anti-idiotype antibody induces a strong idiotype and antigen-specific response in mice.

21 cteria lack affinity maturation use the 44.1-idiotype and are dependent on marginal zone B cells.

22 cells demonstrated reconstitution of the 5H7 idiotype and binding to soluble HLA-A2.

23 light-chain variable-region (VL)-associated idiotype and had functional activities similar to those

24 ondary response highly enriched for the 44.1-idiotype and lacking affinity maturation.

25 oximated the SCA derivative in terms of both idiotype and metatype, confirming identical active site

26 ration of a family of antibodies with common idiotypes and affinities for fluorescein ranging over fi

27 ons that induce the production of regulatory idiotypes and that the presence or absence of these idio

28 ly defined cross-reactive human anti-Hib PRP idiotypes and was biased towards lambda light-chain expr

29 Anti-idiotype (anti-Id) antibody can induce tumor dormancy in

30 We developed a murine monoclonal anti-idiotype (anti-Id) antibody, 3H1, which mimics a specifi

31 Tumor-specific anti-idiotype (anti-Id) monoclonal antibodies (MoAbs) to B-ce

32 o CP and PNAG bound together via an apparent idiotype-anti-idiotype interaction.

33 nti-cardiolipin antibodies (the latter by an idiotype-anti-idiotype reaction).

34 in autoimmunity through a network involving idiotype-anti-idiotype reactions termed 'autoantigen com

35 ooled sera of multiple donors resulting from idiotype/anti-idiotype (Id/anti-Id) interactions.

36 Focusing on an idiotype/anti-idiotype pair embedded in an environment s

37 h that is analogous to the isolation of anti-idiotype antibodies and were able to isolate peptides th

38 (ELISA) assays for idiotype protein or anti-idiotype antibodies in serum.

39 Anti-idiotype antibodies, in addition to cytotoxic T cells, a

40 active disease in patients treated with anti-idiotype antibodies.

41 treated with 52 courses of custom-made anti-idiotype antibodies.

42 acterize the structural footprint of an anti-idiotype antibody (E1) specific for a potent, fully huma

43 itic cells (DCs) pulsed with the murine anti-idiotype antibody 3H1 as a tumor vaccine.

44 dies suggested that vaccination with an anti-idiotype antibody 3H1, which mimics a specific epitope o

45 confirmed (CR/CRu) to CVP and making an anti-idiotype antibody are 2 independent factors that each co

46 This material reacts with an anti-idiotype antibody by Western blotting, ELISA, and affini

47 The C3d-conjugated anti-idiotype antibody induces a strong idiotype and antigen-

48 We have reported that anti-idiotype antibody response and FcgammaRIIIa 158 valine/v

49 demonstrate the utility of employing an anti-idiotype antibody to monitor a patient's specific immune

50 to inhibit mAb HGAC 39.G3 binding to an anti-idiotype antibody with approximately 1000-fold greater a

51 embryonic antigen (CEA), and that of an anti-idiotype antibody, 3H1, which mimics CEA and can be used

52 We generated an anti-idiotype antibody, designated CeaVac, that is an interna

53 nds the same protein and is superior to anti-idiotype approaches.

54 cination strategies using the tumor-specific idiotype as a target antigen, this review focuses on the

55 ipheral B lymphocytes (that express the same idiotypes as the antibodies produce).

56 tion by shuffled gammadelta TCR chains of an idiotype associated with a specific anatomic site indica

57 eacted with Hib PS and expressed HibId-1, an idiotype associated with the kappaII-A2 V region.

58 anti-dsDNA autoantibodies expressed the same idiotypes associated with the in vivo IgG anti-dsDNA res

59 to expand and ablate variable heavy 3 (VH3) idiotype B cells.

60 ic, suggesting that SpA cross-linking of VH3 idiotype B-cell receptors and activation via attached pe

61 Idiotype-based immunotherapy has been explored in myelom

62 Idiotype-based vaccination has produced an apparent prol

63 ab appears to delay humoral responses to the idiotype but may still allow cellular responses.

64 in specificities not only expressed the same idiotype, but rearranged the same light (V(L)) and heavy

65 We have developed a method of targeting idiotype by using a semisynthetic personalized therapeut

66 dy elicits an anti-antibody response or anti-idiotype, consequently producing a disease-inciting auto

67 ections, schistosome-specific cross-reactive idiotypes (CRI) are present in the sera of mice with mod

68 the use of photopheresis to generate an anti-idiotype cytotoxic T-cell response.

69 This idiotype-derived mimotope of PC is a useful tool for und

70 The tumor idiotype differs, however, from patient to patient, maki

71 and cellular immune mechanisms recruited by idiotype-directed DNA vaccines in the 38C13 murine B cel

72 show that second-generation, chemokine-fused idiotype DNA vaccines, when combined with myotoxins that

73 king of this TCR with an antibody to the TCR idiotype elicited vigorous T cell hybridoma activation,

74 idoma method or by expression of recombinant idiotype-encoding sequences in mammalian or plant-based

75 dicated that there are at least two dominant idiotypes expressed in the human anti-alphaGal populatio

76 etermined, and the specificity, isotype, and idiotype expression of antibodies to C. neoformans capsu

77 nses of the mice to GXM and P13 and antibody idiotype expression were analyzed by an enzyme-linked im

78 ficant inter- and intrastrain differences in idiotype expression.

79 ase, and three Fab complexes with their anti-idiotype Fabs.

80 Use of DNA encoding an ld/GM-CSF (idiotype/granulocyte-macrophage colony-stimulating facto

81 osition, lymphocytes expressing the lymphoma idiotype have been detected in the splenic marginal zone

82 While Ab's specific for tumor idiotype have been well described in patients with B cel

83 erapeutic vaccines targeting B cell lymphoma idiotype have reached an advanced stage of clinical deve

84 based on tumor idiotype (Id) has shown anti-idiotype humoral immune responses in 40%-50% and cellula

85 in BALB/c mice frequently expresses the 2H1 idiotype (Id) and is restricted in variable gene usage.

86 We propose that the anti-idiotype (Id) binds to rituximab molecules bound univale

87 derived autologous tumor immunoglobulin (Ig) idiotype (Id) conjugated to keyhole limpet hemocyanin (K

88 The idiotype (Id) determinant on the multiple myeloma (MM) p

89 uble protein tumor Ag, the tumor-specific Ig idiotype (Id) expressed by a murine B cell lymphoma.

90 The unique immunoglobulin idiotype (Id) expressed by each B-cell lymphoma is a tar

91 zed immunotherapy of lymphoma based on tumor idiotype (Id) has shown anti-idiotype humoral immune res

92 nation with tumor-specific immunoglobulin or idiotype (Id) is a promising new form of immunotherapy f

93 is lower, and the dominant DEX-specific J558 idiotype (Id) is not detected in TdT(-/-) mice when comp

94 The idiotype (Id) of the Ig expressed on the surface of non-

95 tumor protection than a traditional lymphoma idiotype (Id) protein vaccine, and in combination with c

96 Idiotype (Id) protein, secreted by myeloma cells, is a t

97 istocompatibility complex (MHC) II, and anti-idiotype (Id) radiolabeled with 131-iodine.

98 Clinical studies of idiotype (Id) vaccination in patients with lymphoma have

99 munoglobulin, the variable regions of which [idiotype (Id)] can serve as a target for active immunoth

100 ice immunized with the BCL1 lymphoma-derived idiotype (Id+) IgM and subsequently challenged with BCL1

101 multiple donors resulting from idiotype/anti-idiotype (Id/anti-Id) interactions.

102 mmunoglobulin expressed by B-cell lymphomas (idiotype [Id]) can serve as a target for active immunoth

103 ells, carries unique antigenic determinants (idiotype [Id]) that can be regarded as a tumor-specific

104 lls contains a unique antigenic determinant (idiotype [Id]) that may serve as a tumor-specific antige

105 Idiotypes (Ids) are unique epitopes of Ab V regions and

106 Idiotypes (Ids), the unique portions of tumor immunoglob

107 VH3 plasmablast expansions and increased VH3 idiotype Ig; however, the mechanisms for staphylococcal

108 nt-specific immunization with immunoglobulin idiotype (Ig-Id present on the surface of most B-cell NH

109 survival of all 20 patients mounting an anti-idiotype immune response are significantly prolonged com

110 3H recipients reconstituted with marrow from idiotype immune, but not nonspecifically immune, donors

111 to prove a causal relationship between anti-idiotype immunity and improved clinical outcome.

112 d 38C13 scFv generate >10 micrograms/ml anti-idiotype immunoglobulins.

113 T15 antibodies, the dominant and protective idiotype induced in mice by PC immunization, self-associ

114 bound together via an apparent idiotype-anti-idiotype interaction.

115 ng the case previously studied using an anti-idiotype, involvement of the splenic marginal zone could

116 The F4 idiotype is a heavy chain determinant expressed almost e

117 Therapeutic vaccination against idiotype is a promising strategy for immunotherapy of B-

118 d, a small peptide with affinity for a tumor idiotype is identified by screening a library, chemicall

119 the experimental fact that the level of anti-idiotypes is low in autoimmune patients but high in heal

120 Ig receptor expressed by malignant B cells, idiotype, is a tumor-specific antigen and an attractive

121 mmunization with DNA constructs encoding the idiotype (ld) of a murine B-cell lymphoma induced specif

122 GH1002 was elicited with the syngeneic anti-idiotype mAb MK2-23 which mimics the determinant defined

123 adjuvant peptide is crosslinked to the anti-idiotype mimetic by chemical means without modifying oth

124 We isolated and characterized an anti-idiotype monoclonal antibody 3H1, which mimics a distinc

125 Anti-idiotype of (natural) autoantibodies participate in the

126 ty mAb (MB2A4) with fine specificity for the idiotype of rituximab.

127 The idiotype of the Ig expressed by a B-cell malignancy (Id)

128 resses and secretes clonally derived Ig, the idiotype of which can serve as a tumor-specific antigen,

129 erated specific immune responses against the idiotypes of their tumor Ig.

130 tudies, we generated an antibody against the idiotype on the A20 B-cell lymphoma line.

131 The unique immunoglobulin (Ig) idiotype on the surface of each B-cell lymphoma represen

132 anti-La/SS-B antibodies are antiidiotypes to idiotypes on anti-dsDNA and that they both mask and down

133 ccines, based on dendritic cells pulsed with idiotype or tumor lysate, have been met with limited suc

134 , B cells expressing IgG and IgA of the same idiotype or V(H) family and the same CDR3 length as thos

135 ll lymphoma patients with tumor-specific Ig (idiotype, or Id) chemically coupled to the immunogenic f

136 hown to retain a conformational determinant (idiotype) ordinarily expressed exclusively by such Vgamm

137 Focusing on an idiotype/anti-idiotype pair embedded in an environment such as the cen

138 rst detailed molecular comparison of an anti-idiotype paratope specific for a human antibody with its

139 strate that the resultant semisynthetic anti-idiotype peptibodies kill tumor cells in vitro with spec

140 samples were examined by flow cytometry for idiotype positive cells, and by polymerase chain reactio

141 inducing a mimotope response including VH3 (idiotype)-positive antibodies to GXM in G2 but not G4 mi

142 associated with the classical protective T15 idiotype-positive NAbs, whereas those without DFL16.1 co

143 es and that the presence or absence of these idiotypes predicts, and possibly determines, subsequent

144 b) reactive with a supratypic cross-reactive idiotype present on Ig encoded by a subgroup of Ig V(H)4

145 idoma-generated vaccines, we found that anti-idiotype production was even more highly associated with

146 st that treatment with vaccines comprised of idiotype protein may be associated with improved clinica

147 inked immunosorbent assay (ELISA) assays for idiotype protein or anti-idiotype antibodies in serum.

148 om lymphoma patients actively immunized with idiotype protein specifically recognized multiple, uniqu

149 tic cells pulsed ex vivo with tumor-specific idiotype protein to stimulate host antitumor immunity wh

150 We evaluated the ability of a new idiotype protein vaccine formulation to eradicate residu

151 Lymphoma idiotype protein vaccines have shown therapeutic potenti

152 The idiotype protein, secreted by myeloma plasma cells, is a

153 The manufacturing of autologous tumor idiotype proteins is being rapidly refined by the use of

154 Idiotype proteins were produced either by the hybridoma

155 These include the idiotype proteins, breakpoint cluster region (bcr)-abl a

156 Occasionally, CTLs responded to autologous idiotype-pulsed DCs and to allogeneic primary myeloma ce

157 n antibodies (the latter by an idiotype-anti-idiotype reaction).

158 ty through a network involving idiotype-anti-idiotype reactions termed 'autoantigen complementarity'.

159 ies, the precise antigenic epitopes in human idiotype recognized by autologous T cells remain largely

160 ltispecificity) that impact current views on idiotype regulation, autoimmunity, and B cell selection

161 Although anti-idiotype responses are theoretically possible against hu

162 ent with CAMPATH-1H can lead to patient anti-idiotype responses which may be exacerbated by the unusu

163 bcutaneous alemtuzumab made substantial anti-idiotype responses.

164 ibutes to the generation of Ab diversity and idiotype restriction.

165 The idiotype served as the tumor antigen.

166 Small molecules with idiotype-specific antibody targeting may be useful as re

167 m that antibody responses are the primary of idiotype-specific antitumor effects and support the opti

168 plenocytes with tumor cells failed to induce idiotype-specific cytotoxicity, and following vaccinatio

169 DNA vaccination can be largely attributed to idiotype-specific humoral immunity.

170 receptor (TCR) protein induces a protective, idiotype-specific immune response against a murine T-cel

171 safe to administer, and a viable option for idiotype-specific immune therapy in follicular lymphoma

172 , to test the principle of transfer of tumor idiotype-specific immunity with BM.

173 modified tobamoviral vector that encodes the idiotype-specific single-chain Fv fragment (scFv) of the

174 Association of idiotype-specific T cell responses with previously docum

175 in 5 FL patients and found an increase in FL idiotype-specific T cells after rituximab in 4 of 5 pati

176 In this study, we tested the efficacy of idiotype-specific Th2 cells for the treatment of mice wi

177 Analysis of the blocker mechanism indicated idiotype specificity, as (i) pyrano[2,3-c]pyrazoles did

178 tailed molecular comparison between the anti-idiotype surface and its analogous epitope located at th

179 The idea is to introduce an antigen or anti-idiotype that binds to the autoantibodies with high affi

180 GXM monoclonal antibody (MAb) 2E9 expresses idiotypes that are also found in naturally occurring ant

181 he bystander effect, molecular mimicry, anti-idiotype theory, antigenic complementarity, and dual-aff

182 inct B cell clones expressing characteristic idiotypes under genetic control and suggest that the 44.

183 reviously documented molecular remissions in idiotype-vaccinated patients suggests that the newly ide

184 f 136 follicular lymphoma patients receiving idiotype vaccination after induction chemotherapy.

185 n 1000 patients are now under way, which use idiotype vaccination after induction chemotherapy; one t

186 Idiotype vaccination in remission may prevent relapse in

187 orm of the Fc receptor in patients receiving idiotype vaccination regardless of their response to ind

188 Lymphoma idiotype vaccination represents a promising immunotherap

189 ted therapies, ie, monoclonal antibodies and idiotype vaccination.

190 de, vincristine, and prednisone) followed by idiotype vaccination.

191 ortant effectors of antitumor immunity after idiotype vaccination.

192 sed immune responses to a well-characterized idiotype vaccine in individuals with severe B-cell deple

193 To enhance the immunogenicity of an anti-idiotype vaccine we incorporated a molecular adjuvant pe

194 opened in 2004, using rituximab followed by idiotype vaccine with maintenance booster vaccines conti

195 personalized (patient-specific) recombinant idiotype vaccines against follicular B cell lymphoma and

196 s support the conclusion that plant-produced idiotype vaccines are feasible to produce, safe to admin

197 umor effects and support the optimization of idiotype vaccines designed to induce primarily T-cell im

198 While idiotype vaccines have shown promise for B-cell malignan

199 Immunotherapy with therapeutic idiotype vaccines offers promise for treatment of B-cell

200 We have developed several generations of idiotype vaccines that were tested in an animal model, t

201 phase III trials for three first-generation idiotype vaccines will become available in the next seve

202 sults in phase II trials of patient-specific idiotype vaccines, with very few side effects noted.

203 to overcome the barriers of patient-specific idiotype vaccines.

204 on each B-cell lymphoma has unique portions (idiotypes), which can be recognized by the immune system

205 The Vlambda2(+) antibodies express the 8.12 idiotype, which is expressed on anti-double-stranded-DNA

206 hypothesis that active immunization with the idiotype would evoke a polyclonal immune response that w

207 umatoid factors (mRF) that bear the WA cross-idiotype (Xid) are responsible for most cases of cryoglo