ライフサイエンスコーパス: idoxifene

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1 oxifene, 4-hydroxytamoxifen, nafoxidine, and idoxifene.

2 A series of homologs of idoxifene [1a, (E)-1-[4-(N-pyrrolidinoethoxy)phenyl]-1-(

3 week, which was maintained for 3 months with idoxifene (3.1 versus 0.48% compared to E2 controls) but

4 ioanalytical method for the determination of idoxifene, a selective estrogen receptor modulator, and

5 Idoxifene also inhibits calmodulin, a calcium-binding pr

6 The LOQ obtained was 10 ng/mL for idoxifene and 30 ng/mL for the metabolite.

7 t method was applied to the determination of idoxifene and its metabolite in clinical human plasma sa

8 mn temperatures to perform LC separations of idoxifene and its metabolite within 10 s/sample.

9 internal standard, the results obtained for idoxifene and tamoxifen satisfy current bioanalytical me

10 Both idoxifene and tamoxifen significantly inhibited E2-depen

11 In this study, the abilities of idoxifene and tamoxifen to antagonize E2-dependent MCF-7

12 lower relative binding affinity for ER than idoxifene but similar calmodulin-inhibitory activity.

13 ed to a greater extent following 3 months of idoxifene, compared to tamoxifen.

14 Using idoxifene-d5 as an internal standard, idoxifene showed a

15 Using idoxifene-d5 as an internal standard, the results obtain

16 bited E2-dependent tumor growth, whereas cis-idoxifene had little effect.

17 In contrast, cis-idoxifene had no effect on either cell proliferation or

18 Idoxifene (ID) is a tissue-selective estrogen receptor m

19 Both tamoxifen and idoxifene initially induced ER expression, whereas prolo

20 Idoxifene is a novel selective estrogen (E2) receptor (E

21 Compared to tamoxifen, idoxifene is metabolically more stable, with a higher re

22 f hormonal therapy with a SERM (tamoxifen or idoxifene) or an aromatase inhibitor (anastrozole or vor

23 cation was 5 and 50 ng/ mL for tamoxifen and idoxifene, respectively.

24 In conclusion, idoxifene resulted in similar inhibition of E2-dependent

25 The basis for idoxifene's antitumor activity was examined by comparing

26 Using idoxifene-d5 as an internal standard, idoxifene showed acceptable accuracy and precision value

27 Idoxifene showed acceptable results with accuracy rangin

28 ically used transisomer (referred to here as idoxifene) with its cis-isomer, which has a 50-fold lowe

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