ライフサイエンスコーパス: iduronate

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1 ulfation of glucosamine residues rather than iduronate 2-O-sulfation being important for bioactivity.

2 lfate storage, consistent with inhibition of iduronate 2-sulfatase.

3 that heparan sulfate and heparin can inhibit iduronate 2-sulfatase.

4 ed a tandem mass spectrometry based assay of iduronate-2-sulfatase (IdS) activity for the neonatal de

5 om alpha-L-iduronidase (IDUA) deficiency and iduronate-2-sulfatase (IDS) deficiency, respectively.

6 caused by mutations in the IDS gene encoding iduronate-2-sulfatase, a crucial enzyme in the lysosomal

7 strates for the enzymes alpha-l-iduronidase, iduronate-2-sulfatase, and N-acetylgalactosamine-4-sulfa

8 Leukocyte L-O-(alpha-iduronate-2-sulfate)-(1->4)-D-O-2,5-anhydro[1-3H]mannito

9 etic substrate (IdS-S) consisting of alpha-L-iduronate-2-sulfate, which is glycosidically conjugated

10 -linked lysosomal storage disorder caused by iduronate-2-sulphatase (IDS) deficiency.

11 -ray structures of a novel distorted (4)C(1) iduronate 4,6-lactone.

12 (DS, formerly dermatan sulphate), contains L-iduronate, an elastic sugar unit.

13 es of phi (phi) and psi (psi) angles between iduronate and glucosamine rings.

14 teresting interplay between requirements for iduronate and sulfate density that may reflect in part a

15 ulfation of hexosamines and 2-O-sulfation of iduronates are not absolute requirements for glycosamino

16 iduronate diacetate C-4 acceptor, and also L-iduronate C-4 acceptor thioglycosides.

17 ts as a conformational switch to superdisarm iduronate components, reversible by lactone ring opening

18 e binding site in the protein to accommodate iduronate-containing sequences of variable sulfation pat

19 For biglycan and decorin, iduronate content was linearly correlated with age (incr

20 te enables short, scalable syntheses of an L-iduronate diacetate C-4 acceptor, and also L-iduronate C

21 adopt (1)C(4) conformations in solution, the iduronate ester adopts the (4)C(1) conformation in solid

22 fated trisaccharide comprised of an internal iduronate flanked by monosulfated hexosamine residues an

23 ulfation patterns, with only the presence of iduronate in common.

24 conformationally locked bicyclic 1,6-anhydro iduronate lactone along with an X-ray structures of a no

25 X-ray structures are reported for a [2.2.2] iduronate lactone and examples of both methyl L-idopyran

26 step routes to bicyclic [3.2.1] or [2.2.2] L-iduronate lactones.

27 nase I-like, cleaving at hexosamine-sulfated iduronate linkages, whereas the other is presumably hepa

28 X-ray and NMR data of the 1,2-diacetyl iduronate methyl ester and the analogous iduronamide sho

29 digests of heparin that contains a Delta-2S-iduronate on the non-reducing end does not initiate the

30 rbation of the conformational equilibrium of iduronate residue G through replacement of the nonessent

31 binding sequences separated by a nonsulfated iduronate residue.

32 cludes the carboxylate group at the adjacent iduronate residue.

33 The presence of 2-O-sulfation on the iduronate residues does not appear to be inhibitory.

34 A sequence comprising unsulfated iduronate residues in combination with 4-O-sulfated N-ac

35 L-iduronate residues in shape module decoran PGs are sugge

36 ppeared to contain at least two 2-O-sulfated iduronate residues, but no 6-O-sulfate groups.

37 oration of conformational variability of the iduronate residues.

38 lfate fine structure, where highly sulfated, iduronate-rich domains alternate with N-acetylated domai

39 rs endows these chains with highly sulfated, iduronate-rich regions, which are major determinants of

40 es either pure anomer of the novel [2.2.2] l-iduronate thioglycoside lactones.

41 from 1 to a new type of highly disarmed O-4 iduronate thioglycoside, which is an effective acceptor

42 arin, and (iii) that removal of the Delta-2S-iduronate to expose the fully sulfated trisaccharide (Gl

43 e of glucosamine, but not the 2-O-sulfate of iduronate within heparin is required for 3Q binding, ind

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