ライフサイエンスコーパス: iduronic

1 The resulting new iduronic [2.2.2] lactone disaccharides are readily rearm

2 Distinguishing the epimers iduronic acid (IdoA) and glucuronic acid (GlcA) has been

3 distinguishes DS from CS is the presence of iduronic acid (IdoA) in DS.

4 fers the sulfo group to the 2-OH position of iduronic acid (IdoA) or glucuronic acid (GlcA) within HS

5 The L-iduronic acid (IdoA) residue is a critically important s

6 The pyranose ring of L-iduronic acid (IdoA), a major constituent of the anticoa

7 of glucuronic acid (GlcA), converting it to iduronic acid (IdoA).

8 NAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl.

9 mnose linked to d-glucuronic acid (GlcUA), l-iduronic acid (IdoUA), or d-xylose (Xyl).

10 unique oligosaccharide sequences containing iduronic acid (IdUA), N-sulfated glucosamine residues, a

11 comprised predominantly of 2-O-sulfo-alpha-L-iduronic acid (the I ring) and 2-deoxy-2-sulfamido-6-O-s

12 d disaccharides accompanied by a decrease in iduronic acid 2-O-sulfated disaccharide structures.

13 e contained significantly reduced amounts of iduronic acid and disulfated disaccharides DeltaDi-2,4S

14 We have evaluated a series of iduronic acid and idose donors, including a couple of no

15 nts of 6-O-sulfated glucosamine residues and iduronic acid and somewhat higher levels of N-sulfated g

16 sferases, which in turn lead to the higher L-iduronic acid and sulfate content of heparin versus hepa

17 ges between GlcNAc, GlcNAc(6S), or GlcNS and iduronic acid as secondary sites.

18 e successfully applied to the synthesis of l-iduronic acid being an essential component of anticoagul

19 mutant (2OST Y94I) transfers sulfate to the iduronic acid but not to the glucuronic acid.

20 These elements, in addition to iduronic acid demonstrated previously, partially define

21 precede epimerization of glucuronic acid to iduronic acid during dermatan sulfate biosynthesis.

22 NETD is also able to distinguish the epimers iduronic acid from glucuronic acid in heparan sulfate te

23 ed hydrolysis of iduronamide into the parent iduronic acid functionality.

24 ggesting that the disaccharide; 2-O-sulfated iduronic acid linked to 6-O-sulfated N-glucosamine, whic

25 all four anomeric and ring size isomers of l-iduronic acid methyl glycosides, including the first syn

26 in 6-O-sulfation with a parallel increase in iduronic acid mono-2-O-sulfated disaccharides.

27 tact with either the 2-O-sulfo groups of the iduronic acid monosaccharides or the N- and 6-O-sulfo gr

28 ddition to the alpha-linkage anticipated for iduronic acid nucleophiles, resulting in an inseparable

29 lfate consists of glucosamine and glucuronic/iduronic acid repeating disaccharides with various sulfa

30 enriched in MPSIH, representing the terminal iduronic acid residue capping the non-reducing end of th

31 c mode by converting a glucuronic acid to an iduronic acid residue, and vice versa.

32 catalyst to convert a glucuronic acid to an iduronic acid residue, displaying an "irreversible" cata

33 emonstrated that glucuronic acid rather than iduronic acid residues are important for IRBC binding.

34 ning a glypican 5 core protein and 2-O-sulfo-iduronic acid residues at the nonreducing ends of the gl

35 e interconversion of d-glucuronic acid and l-iduronic acid residues encodes a truncated protein.

36 Although L-iduronic acid residues have been shown to exist in polys

37 These findings suggest that 2-O-sulfated iduronic acid residues in heparan sulfate are important

38 oss-peaks to the anomeric protons of the two iduronic acid residues, which overlap in normal two-dime

39 achea cells has a higher content of sulfated iduronic acid than from other tissues.

40 s containing a glypican 5 core and 2-O-sulfo-iduronic acid to promote neural precursor proliferation.

41 rmediate that may be further elaborated into iduronic acid trichloroacetimidate glycosyl donors for t

42 saccharide consisting of glucuronic acid (or iduronic acid) linked to glucosamine carrying various su

43 acid, GlcN is D-glucosamine, and IdoUA is L-iduronic acid).

44 onic residues (sulfated rhamnose, glucuronic/iduronic acid).

45 rase converts some of the glucuronic acid to iduronic acid, thus becoming a substrate for 2OST Y94I.

46 tion of D-glucuronic acid to its C5-epimer L-iduronic acid, which is essential for the function of he

47 tain noncognate GAGs (including sulfated and iduronic acid-containing forms) are elongated by PmHAS (

48 rmational equilibrium is pH-dependent in the iduronic acid.

49 S C(5)-epimerase converts glucuronic acid to iduronic acid.

50 group to the 2-OH-position of glucuronic or iduronic acid.

51 d, primarily 4-O-sulfated, disaccharides and iduronic acid.

52 ry cell mutant defective in 2-O-sulfation of iduronic acid.

53 Glucuronic (GlcA) and iduronic acids (IdoA) were subsequently defined by (1)H

54 lar, the preparation of fully differentiated iduronic acids has proven particularly challenging.

55 ld be successfully converted into terminal l-iduronic acids via the syn addition of 2-furylzinc bromi

56 y heterogeneously sulphated on alternating L-iduronic and D-glucosamino sugars, and are nearly ubiqui

57 C-5 of the hexuronic acid (glucuronic versus iduronic) is not crucial, and (c) additional negative su

58 cosamine residues but lacks any 2-O-sulfated iduronic or glucuronic acid residues.