ライフサイエンスコーパス: if so,

1 If so, ACVP should be a cytotoxic agent if properly deli

2 If so, and in the absence of data to show that risk in v

3 If so, anti-microglial agents targeting the pro-inflamma

4 If so, antibiotics that block its invasiveness may ameli

5 If so, any long-lasting asexual lineage must have unusua

6 If so, are these "stoichiometries" preserved over time?

7 hether this objective has been achieved and, if so, at what cost.

8 If so, available evidence predicts that such stripes sho

9 If so, both neurodegeneration and cancer may be diseases

10 sea level rise is currently increasing and, if so, by how much.

11 channel mRNAs are actively maintained, and, if so, by what form of feedback.

12 er SSA directly impacts the spliceosome and, if so, by what mechanism, which limits interpretation of

13 ty acid oxidation influences ER function or, if so, by what mechanism.

14 oglin loss affects genistein's efficacy and, if so, by what mechanism.

15 modifying benefits in an AD mouse model and, if so, by what molecular mechanisms.

16 lt is particular to the in vitro model, and, if so, characterize the systems likely to behave differe

17 If so, colony function might fruitfully be studied using

18 If so, complexity could provide an advantage counteracti

19 r the BBB is disrupted in Ppt1-KO mice, (ii) if so, do T(H)17-lymphocytes underlie this complication,

20 (2) If so, do these definitively improve outcomes?

21 L chains exists in the human repertoire, and if so, do they edit H chains with anti-DNA signatures?

22 t inactivation produce similar deficits and, if so, do they recover?

23 n vitro is also important for virulence and, if so, during which phase of an infection it is required

24 her DUSP1 expression is regulated by SAM and if so, elucidate the molecular mechanisms.

25 ariants) were more likely to carry URFs and, if so, examined whether they progressed more rapidly tha

26 ns, and adults (nonsmokers and smokers) and, if so, factors influencing the decline(s).

27 If so, host organisms may use the local oxygen level to

28 as, are there defined DCV docking sites and, if so, how are DCVs delivered to these release sites?

29 If so, how did we get them in the first place, and when

30 And if so, how do its properties relate to the rapid adaptat

31 l-complex code directing movement exist, and if so, how does it effect changes in the control of limb

32 If so, how does this help us understand the mechanisms u

33 ionable assessment of hospital quality, and, if so, how hospitals might improve their performance.

34 And if so, how is this accomplished by the medial temporal l

35 to whether to correct for multiplicity and, if so, how it should be done.

36 physician noted any suspicious lesions, and, if so, how lesions were managed.

37 on with the DTC PGT experience; whether and, if so, how many results could be used to improve health;

38 anisms of target mRNA decay also exist, and, if so, how much they contribute to miRNA-induced mRNA de

39 ed whether they would be willing to pay, and if so, how much.

40 ntial to produce endogenous AHR ligands and, if so, how production of these ligands is controlled.

41 inate yeast strains based on odor alone, and if so, how such resolution is achieved by the olfactory

42 n primate OFC signal social information and, if so, how such signals compare with responses to primar

43 For understanding whether and, if so, how the multiple streams are organized via the ha

44 are also dependent on CSF1R signalling, and if so, how these cells contribute to disease pathogenesi

45 t role in the chaperoning of syntaxin-1 and, if so, how these dual functions of domain-3a are regulat

46 whether such Vbeta rearrangements occur and, if so, how they might be regulated, we analyzed mice wit

47 was predictive of future reading skill and, if so, how this brain-behavior correlation informs devel

48 including whether SRs compete for Cul1 and, if so, how this competition is managed.

49 atelet reactivity by sequestering RGS18 and, if so, how this is accomplished.

50 ptured FH becomes functionally enhanced and, if so, how this is achieved at a structural level.

51 of CSR as it is for V(D)J recombination and, if so, how this is achieved is unknown.

52 an isolated colony founded by isolates, and, if so, how this might happen and what type of social env

53 tually initiate colorectal cancer (CRC), and if so, how this might occur.

54 r actin binding reverses this transition and if so, how this reversal is coordinated with actin-activ

55 he lack of clear guidance about whether and, if so, how to return ES/WGS incidental results limits th

56 ntal images when understanding language, and if so, how truly visual are these representations?

57 Whether, and if so, how various isoforms play distinct roles in norma

58 ligand are actually promoting relapse, and, if so, how we can use this information to adjust our the

59 lymers interact with the mucus hydrogel, and if so, how, remains unclear.

60 ents could be used to produce analgesia, and if so, how.

61 omosome segregation fidelity in cancers and, if so, how.

62 mmunities respond to habitat conversion and, if so, how?

63 host, a process we term immunosensing, and, if so, how?

64 s or longer, but do they sleep in flight and if so, how?

65 ent impact the underlying gene circuits and, if so, how?

66 n occurs after sorafenib therapy in HCC, and if so, if it impacts the therapeutic efficacy.

67 online as behavioral preferences change and if so, if it is causally linked to specific components o

68 rect interaction between m152 and RAE-1 and, if so, if m152 interacts differentially with the five id

69 ticles (Ag NPs) elicit this same effect and, if so, if the NP itself and/or the dissociation of ionic

70 AM (neuron-glia cell adhesion molecule) and, if so, in what compartment it is required.

71 Do they improve movement, and, if so, in what way?

72 nctions of these excitatory projections, and if so, in which projection pathways.

73 If so, inhibition of CGRP receptors may be a clinically

74 If so, inhibition of tetherin activity by Vpu may balanc

75 If so, input from subduction zones into the overlying pl

76 If so, interventions such as stimulation might be used t

77 If so, is it in extrinsic (world-centered) or intrinsic

78 If so, is it possible that just as there are edifices th

79 If so, it constrains the WAIS contribution to global sea

80 crust production over the age of the Earth; if so, it is now either a primitive refugium at the core

81 If so, it would have important implications for our unde

82 If so, it would require considerable forethought.

83 rated in peripheral sympathetic ganglia and, if so, its effect on synaptic transmission.

84 determined whether IPC is present in WM and, if so, its mechanism.

85 If so, its signature might be present in how the motor s

86 dictate whether an organelle assembles, and, if so, its size, providing a mechanistic link between or

87 If so, lipid deltaD values could become an important bio

88 If so, LMAN neurons should maintain selectivity for the

89 If so, mitigating CH4 emissions must be balanced with th

90 If so, monitoring donor endothelium after DMEK or other

91 If so, motor control should be regained by reversing the

92 If so, neurons that are part of coherent ensembles may p

93 ther exploration of mechanistic linkage and, if so, novel therapeutic strategies such as demethylatin

94 e binding of biochemical signals occurs, and if so, on time scales relevant to microbial growth and c

95 If so, ORF23 expression could be a target for a novel an

96 If so, other aberrant positive-feedback networks might d

97 If so, parental smoking, commonly established before the

98 If so, participant behaviour on a high-level decision-ma

99 If so, personality may influence refractive error correc

100 If so, RanBP9 provides a great opportunity to develop no

101 treated in a hospital that conducts ECT and, if so, received the procedure.

102 If so, relatively simple therapies can be devised--of wh

103 If so, searches for similar events in nearby galaxies wi

104 If so, second-order statistics could themselves carry in

105 If so, should results of a platelet function test be use

106 If so, such covariance could be used to predict contacts

107 plex phenotypes in multi-cellular organisms; if so, such rewiring may leave traceable changes in the

108 If so, targeting extracellular tau species may slow the

109 If so, the American West, the Middle East, and southern

110 If so, the cell origin of leukemia-initiating stem cells

111 If so, the explanation could be that storing rapidly flu

112 If so, the genomic distribution of RNA editing site loss

113 If so, the high levels of membrane CL found in alkaliphi

114 inst new-onset depression and anxiety and 2) if so, the intensity and amount of exercise required to

115 uction of autophagy in intestinal cells and, if so, the mechanisms that underlie this action.

116 to coordinate their emerging functions and, if so, the mechanisms underlying this process.

117 dor that persists into late adolescence and, if so, the molecular mechanisms that may be associated w

118 prostate carcinogenesis and progression and, if so, the possible mechanism by which PSMA may exert it

119 sion involves a discrete tethering step and, if so, the potential role of GTP hydrolysis and cross-ov

120 If so, the presence of these T cells could alter the int

121 whether radiotherapy improves survival, and if so, the subgroup of men most likely to benefit.

122 If so, the sulfur isotope record of sedimentary rocks ma

123 t estrogen is combined with progesterone and if so, the type of progesterone used, as well as the rou

124 perature-sensitive phenotype can revert and, if so, the types of substitutions that will emerge (i.e.

125 y role in intestinal I/R-induced injury and, if so, the underlying mechanisms, remain unknown.

126 If so, the vasodilating effects of nitrite would be atte

127 whether females have a toxic humoral factor; if so, then its strength was compared with that of males

128 If so, then perhaps we can eliminate the unacceptable pr

129 If so, then phasic response of dopamine neurons to cues

130 If so, then priming offers no special insight into gramm

131 If so, then RSP lesions might also be expected to disrup

132 If so, then the risk of ALS would be influenced by devel

133 to analyzing temporal properties of sounds; if so, then there should be systematic depth-dependent c

134 (c) If so, then why do they let it happens?

135 If so, there may be equipoise to test if VT less than or

136 e asked if they were aware of their VF loss; if so, there were encouraged to describe it in their own

137 atiles were once thought to act identically; if so, they should be affected equally by genetic varian

138 If so, they should react in a similar manner to top-down

139 If so, this is preceded by a region of bistability.

140 smission in the cortico-striatal pathway and if so, this modulation will affect the behaviour of the

141 If so, this process could be distinct from human hematop

142 If so, this technique may have the potential to double t

143 If so, this type of collision will greatly affect molecu

144 If so, this widely used analgesic may potentiate the adv

145 If so, this would provide new insight into the functiona

146 If so, this would represent a fundamental feature of gen

147 n cocultures with pulmonary fibroblasts and, if so, through what possible mechanism.

148 ha stimulates insulin synthesis in vivo and, if so, through which mechanism(s) remain largely unknown

149 ding of the mouse and rat hair follicle and, if so, to assess its similarity to that of the rat muscl

150 sure by itself is an etiological factor and, if so, to determine the overall nature of cognitive defi

151 CG directly interact with ERCC1 and XPF and, if so, to determine the sites of interaction.

152 basal state in insulin-resistant muscle, and if so, to determine whether the effects were associated

153 ring goal-directed behaviors for sucrose and if so, to determine whether the two are causally linked.

154 are proapoptotic in colon cancer cells, and if so, to elucidate the molecular mechanisms.

155 on cytokines in their microenvironment and, if so, to establish the conditions under which these che

156 eine underlies the observed association and, if so, to evaluate its mechanisms of action.

157 h early forms of Alzheimer disease (AD), and if so, to examine the extent and pattern of leakage.

158 rly life can shape senescence schedules, and if so, to examine whether variation among individuals or

159 stomatitis virus (rVSV) vaccine vectors, and if so, to identify strategies by which IL-1beta mediated

160 during the exponential phase of growth and, if so, to identify the binding sites.

161 olytically released from cell membranes and, if so, to identify the responsible sheddase and determin

162 oteins directly interact with alphaIISp and, if so, to map the sites of interaction.

163 s with clinical response to bortezomib, and, if so, to optimize this oncolytic strategy.

164 k and urine produced by lactating women and, if so, to quantify typical consumption by breastfed infa

165 ingolipids, as it does in other tissues, and if so, to see whether the treatment ameliorates the affe

166 is expressed in insulin-producing cells and, if so, to what extent it affects beta cell function.

167 To determine whether and, if so, to what extent, blockade of complement cascade at

168 suicide attempt rates to assess whether, and if so, to what extent, the well-established relationship

169 nhibition may be genetically determined, and if so, transplant recipients should receive personalized

170 If so, two key properties determine its selectivity and

171 If so, under what conditions?

172 If so, unlike all other lignin pathway manipulations tha

173 If so, vaccines able to induce durable RSV-specific IgA

174 If so, volume loading of heat-stressed individuals would

175 ) from the reaction of .NO with O(2).(-) and if so, was ONOO(-) microbicidal toward B. anthracis.

176 If so, was that change for the better, worse, both or ne

177 If so, what (if any) characteristic properties might suc

178 If so, what are the effects on quality of mental and phy

179 And if so, what are the neural mechanisms that support such

180 tion occurs in physiological conditions and, if so, what are the possible cellular mechanisms.

181 th the results of the randomised trials and, if so, what could be concluded about the likely effects

182 And, if so, what determines evolutionary outcome of the confl

183 And, if so, what determines evolutionary outcome of the confl

184 istinctly different motifs on chromatin, and if so, what determines the usage of specific motifs.

185 er these networks functionally interact and, if so, what factors mediate such interactions.

186 icient synapses actually occurs in vivo, and if so, what factors regulate it and what role it might p

187 e sensory representations as perception, and if so, what functional consequences such an overlap migh

188 103+ DC even exist in the ocular mucosa, and if so, what functions they have in shaping immune respon

189 If so, what is arguably the greatest ever revolution in

190 ocular surface of normal living rabbits, and if so, what is its efficacy and tolerability versus cycl

191 ts have submicroscopic systemic disease and, if so, what is the clinical significance of this finding

192 technology over other novel approaches, and if so, what is the flip side to the use of this technolo

193 egrins outside FAs can transmit tension, and if so, what is the tension range.

194 unclear whether BBB is disrupted in INCL and if so, what might be the molecular mechanism(s) of this

195 we asked if they themselves aggregated and, if so, what parameters regulated their aggregation.

196 of its neurons is capable of exhibiting, and if so, what principles define this constraint.

197 r Tbx1 is expressed in multipotent CPCs and, if so, what role it may play in them.

198 it has a role within sympathetic neurons and if so, what target genes it regulates to facilitate targ

199 stinct and specialized neural machinery, and if so, what that machinery's organization might be.

200 lved in response to selective pressure--and, if so, what that pressure might have been--or whether th

201 hether hallucinations require treatment and, if so, what that treatment should be remains unclear.

202 ufficient to induce the damage response and, if so, what the genetic requirements and functional cons

203 n directly cause this phenotypic change and, if so, what the signaling mechanism is, were explored in

204 oderma sera could induce EPC apoptosis, and, if so, what the underlying apoptotic signaling pathway w

205 size as part of a regenerative program and, if so, what the underlying mechanism is have remained la

206 ther microRNAs regulated EPC senescence and, if so, what the underlying mechanisms are.

207 similar transients occurred in the past and, if so, what their forcing processes were.

208 are present in a diverse set of viruses and, if so, what they may imply about viral biology.

209 ar ataxia type 1, forms toxic oligomers and, if so, what underlies their toxicity.

210 rsibly retain a model nanoparticle, ZnO, and if so, what would be the difference between bound ZnO NP

211 e and TrkB activation occur during sLTP, and if so, when and where.

212 If so, when did consciousness evolve?

213 ed in the management of skin abscesses, and, if so, when, is controversial.

214 Is the metal positioning specific, and if so, where is which ion located?

215 were made whether to proceed with ICEEG, and if so, where to place electrodes such that the hypotheti

216 he subjacent white matter and neocortex and, if so, whether angiogenic inhibition could increase the

217 e contains anergic autoreactive B cells, and if so, whether antigen was encountered during or after t

218 referentially myelinated by glial cells, and if so, whether axo-glial synapses are involved, are long

219 ether pneumococci form biofilms in vivo, and if so, whether biofilms correlated with bacterial persis

220 ecific role during synaptic homeostasis and, if so, whether BMP signaling functions as an instructive

221 whether plant defenses show escalation, and if so, whether by enhancing one line of defense or by ad

222 HC contacts promote TCR-MHC specificity and, if so, whether differences exist in TCR V gene compatibi

223 s responses to bacteria in the airspace and, if so, whether differently from its effects in other tis

224 fers from that found in diseased tissue and, if so, whether glycosylation affects inhibitor binding.

225 lock to Vif-deficient virus replication and, if so, whether HIV-1 variants that resist restriction wo

226 nts information about aversive stimuli, and, if so, whether individual neurons process information ab

227 ignaling is functional in P2X-dblKO mice and if so, whether it activates the primary viscerosensory n

228 r insulin activates AMPK in these cells and, if so, whether it activates through a similar mechanism.

229 if an airway microbiome exists at birth and if so, whether it is associated with subsequent lung dis

230 nduces IFN-beta from myeloid phagocytes, and if so, whether it is helpful or harmful to the host to d

231 DTic human cardiac effect indeed exists, and if so, whether it is specific to JDTic or represents a K

232 SDB) is different from healthy children and, if so, whether it resolves with treatment, we used heart

233 ating exercise-induced cardioprotection, and if so, whether its activation independent of exercise ca

234 bone abnormalities associated with MDD and, if so, whether ketamine treatment corrected the abnormal

235 nterregulatory response to hypoglycemia, and if so, whether knockdown of in the VMH can improve count

236 r RB1 mutation drives tumor progression and, if so, whether loss of pRb/E2f interaction is responsibl

237 ediated by the ABCG5/G8 complex in vivo, and if so, whether LXRa is involved.

238 th sites can be simultaneously occupied, and if so, whether monobodies bind independently or cooperat

239 educing death and disability at 90 days, and if so, whether oxygen given at night only, when hypoxia

240 ET is able to detect additional disease and, if so, whether patient management is altered.

241 r these beneficial and harmful effects, and, if so, whether PDE3 can be targeted so as to increase co

242 y rings affect AML strains in patients, and, if so, whether ring-induced perturbations in leaflet str

243 ardium from ischemia/reperfusion injury, and if so, whether sex differences exist in TNFR2-mediated c

244 ed on the type and severity of symptoms, and if so, whether subgroups differ with respect to health c

245 and systemic proinflammatory mediators and, if so, whether such an increase is associated with enhan

246 onal (i.e., intracellular) consequences and, if so, whether such consequences are associated with inc

247 by PKA is required for Gli2 processing and, if so, whether such phosphorylation regulates additional

248 s by turning off their Foxp3 expression and, if so, whether Th17 is a default alternative fate choice

249 stimulated lipogenesis and lipotoxicity and, if so, whether the damage can be prevented by reducing l

250 ses proinflammatory cytokines in sepsis and, if so, whether the down-regulatory effect of ghrelin is

251 ytic function of the proteasome in mice and, if so, whether the enhancement can rescue a bona fide pr

252 (CT Topo I) on a native supercoiled DNA and, if so, whether the enzyme catalyzes its subsequent equil

253 with sigma(70) R4 at class II promoters and, if so, whether the interactions occlude the binding of s

254 ubset could be directly infected by HIV and, if so, whether the level of integration in naive cells w

255 ocess that is involved in cell survival, and if so, whether the regulation depends on Thr-201 phospho

256 re generic to the REFeAsO-type materials and if so, whether their exact topology is responsible for t

257 resented among myocardial sphingolipids and, if so, whether their function and metabolic routes were

258 ait for increased resistance to evolve, and, if so, whether there are correlated responses that might

259 vivo in overnight postabsorptive humans and, if so, whether there are regional differences in uptake

260 hether humans eating eggs generate TMAO and, if so, whether there is an associated increase in a mark

261 ligand to activate VMH EphA5 receptors, and if so, whether these changes could contribute to pathoge

262 Fs are assembled into similar complexes and, if so, whether these complexes are unique to SLFs.

263 network can have preferred frequencies and, if so, whether these frequencies are the same or correla

264 with multiple DNA replication proteins and, if so, whether these proteins bind UL44 at the site corr

265 ents express functional 5-HT3 receptors and, if so, whether these receptors play a role in transmissi

266 very different class of drug (ethanol), and if so, whether these systems might be involved in their

267 normal and diseased parathyroid glands, and if so, whether they had any functional effects on parath

268 alogous approach-avoidance dispositions and, if so, whether they share a homologous neurobiological s

269 cortex compare durations and distances and, if so, whether they use similar mechanisms.

270 ents, could be observed during encoding and, if so, whether they would predict different levels of ac

271 adverse metabolic profiles in offspring, and if so, whether this association is causal, via intrauter

272 agged adult cardiac tissue progenitors, and, if so, whether this cell-based signal could serve as a q

273 increase hepatic inflammatory signaling and if so, whether this effect 1) involves activation of Kup

274 rinking cessation phase (first 6 weeks), and if so, whether this effect persisted.

275 r readmission rates than white patients, and if so, whether this effect was mediated by the hospitals

276 ng GLP-1 and GIP concentrations in vivo and, if so, whether this is associated with an increase in pl

277 iac arrest has significantly increased, and, if so, whether this is attributable to AED use.

278 les during genomic surveillance in vivo and, if so, whether this is done via direct or indirect means

279 whether climate variability is changing, and if so, whether this is due to anthropogenic forcing, are

280 d with greater adiposity into adulthood, and if so, whether this is via intrauterine mechanisms or sh

281 dark toward haptically explored objects (and if so, whether this reactivation might be due to imagery

282 trophin modulated the expansion of OPCs and, if so, whether this was effected through the serial enga

283 ature of mice with diet-induced obesity, and if so, whether Toll-Like Receptor-4 (TLR4), a key mediat

284 ine whether the patient was followed up and, if so, whether treatment was initiated and/or symptoms w

285 e coagulation activation in heat stroke and, if so, whether upstream inhibition of coagulation activa

286 improves lipid metabolism in the liver and, if so, whether VASP's effects are mediated by AMPK.

287 essels associated with brain metastases, and if so, whether VCAM-1-targeted MRI enables early detecti

288 whether CTL inactivation is Ag specific and, if so, which APCs are involved.

289 tive bodies signal low FA to observers, and, if so, which aspects of attractive bodies are most predi

290 t of stress on brain gray matter volume and, if so, which brain regions mediate the effect of this ge

291 n support memory-guided decision making and, if so, which brain regions play a role in compensation.

292 oxidation and esterification in the MBH and, if so, which hypothalamic cell type(s) and intracellular

293 determine if an enhancement is indicated and if so, which method will be the safest and most efficaci

294 n individual mental process or disorder and, if so, which molecules confer such specificity.

295 ther OXTR is truly associated with ASD, and, if so, which OXTR single-nucleotide polymorphisms (SNPs)

296 se females from reproductive trade-offs and, if so, which senescence parameters are affected.

297 x vaccination is driving the phenomenon, and if so, why is re-emergence not universal throughout the

298 oughts occurred in the southwestern US, and, if so, with what regularity and intensity.

299 ny of the subunits in the septin collar and, if so, with which ones.

300 xplain the emergence of drug resistance, and if so, would have prognostic and predictive utility.