ライフサイエンスコーパス: imaginal disc

1 he Ubx gene is repressed (first thoracic leg imaginal disc).

2 ferentially expressed in the Drosophila wing imaginal disc.

3 nit (RnrL) reduce compensatory growth in the imaginal disc.

4 elopment of the Drosophila melanogaster wing imaginal disc.

5 C1 double null clones in the Drosophila wing imaginal disc.

6 ly enhance robustness in the Drosophila wing imaginal disc.

7 lium is essential for patterning of the wing imaginal disc.

8 Branchless FGF-expressing cells in the wing imaginal disc.

9 itted progenitor cells of the Drosophila eye imaginal disc.

10 ence that the DVM FCs may arise from the leg imaginal disc.

11 s enriched in the dorsal portion of the wing imaginal disc.

12 crete subpopulation of cells within the wing imaginal disc.

13 ling the formation of SOPs in the adult wing imaginal disc.

14 e embryonic head and developing eye-antennal imaginal disc.

15 expression of brm(K804R) in the eye-antennal imaginal disc.

16 proliferative program and growth of the eye imaginal disc.

17 dorsoventral boundary in the Drosophila wing imaginal disc.

18 al timer coordinating development within the imaginal disc.

19 oximodistal (PD) axis of the Drosophila wing imaginal disc.

20 tic pathway elucidated in the Drosophila eye imaginal disc.

21 tations that impair regeneration in the wing imaginal disc.

22 rogenitor cells develop together in the wing imaginal disc.

23 ol of epithelial integrity in the Drosophila imaginal disc.

24 regulates folds within the third instar wing imaginal disc.

25 r/posterior compartment boundary of the wing imaginal disc.

26 the progression of S phase in Drosophila eye imaginal discs.

27 texts; for example, in the wing, leg and eye imaginal discs.

28 cell proliferation and promotes apoptosis in imaginal discs.

29 ession domain of homothorax (hth) in the leg imaginal discs.

30 leg regeneration in fragments of Drosophila imaginal discs.

31 -induced p53-independent apoptosis in larval imaginal discs.

32 nt Crumbs (Crb) affects growth in Drosophila imaginal discs.

33 ss of Crb similarly results in overgrowth of imaginal discs.

34 phila Schneider line 2 (S2) cells and larval imaginal discs.

35 dispensable in primary epithelia such as the imaginal discs.

36 direct targets of PcG-mediated repression in imaginal discs.

37 rior compartment boundary of Drosophila wing imaginal discs.

38 it was rescued by expression of nito in wing imaginal discs.

39 the Ultrabithorax (Ubx) gene in larval wing imaginal discs.

40 e mutants and disproportionate growth of the imaginal discs.

41 d/or Phol for binding to the bxd PRE in wing imaginal discs.

42 is deregulated in rbf mutant cells in larval imaginal discs.

43 eded to limit IR-induced apoptosis in larval imaginal discs.

44 arge cohort of miRNAs expressed primarily in imaginal discs.

45 the pathway by which Ras regulates growth in imaginal discs.

46 entially expressed genes in wing and haltere imaginal discs.

47 en signaling in Drosophila melanogaster wing imaginal discs.

48 on and hyperplastic overgrowth of Drosophila imaginal discs.

49 ila, and fat mutants have severely overgrown imaginal discs.

50 NA-mediated translational repression in wing imaginal discs.

51 gene expression, cell affinity and growth in imaginal discs.

52 uses abnormal epithelial cysts in Drosophila imaginal discs.

53 led2 leads to Wingless stabilization in wing imaginal discs.

54 se early larval lethality and the absence of imaginal discs.

55 capacity to regulate cell differentiation in imaginal discs.

56 daries and the compartment boundaries in the imaginal discs.

57 l septate junctions and causes overgrowth of imaginal discs.

58 h for mRNAs misregulated in pacman null wing imaginal discs.

59 n the epithelia of the foregut, hindgut, and imaginal discs.

60 ved in the cytoplasmic retention of Ci155 in imaginal discs.

61 r regions of the Drosophila Ubx gene in wing imaginal discs.

62 in G1/G0-arrested, uncommitted cells in eye imaginal discs.

63 n long-range Hh signaling in Drosophila wing imaginal discs.

64 postembryonic morphogenesis of leg and wing imaginal discs.

65 Wingless signaling in the eye, wing and leg imaginal discs.

66 for PHO in repressing transcription in wing imaginal discs.

67 he transcription activation by Trl in larval imaginal discs.

68 apoptosis in surface epithelia of Drosophila imaginal discs.

69 in, in contrast to epithelial tissues of the imaginal discs.

70 al size or the state of development of their imaginal discs.

71 hough more restricted, results in the larval imaginal discs.

72 (SAC) genes and preventing apoptosis in wing imaginal discs.

73 silencing, some PcG mutants also have small imaginal discs.

74 ibble (scrib) are eliminated from Drosophila imaginal discs.

75 in every segment boundary within the larval imaginal discs.

76 een reported to be a survival factor in wing imaginal discs.

77 t translational repression in developing eye imaginal discs; (2) in dendritic elaboration of larval s

78 ssues [5, 6] or transplantation of a damaged imaginal disc [7, 8] delays the onset of metamorphosis.

79 logous Drosophila genes that specify the eye imaginal disc, a finding that is consistent with the ide

80 la, null mutations in pacman result in small imaginal discs, a delay in onset of pupariation and leth

81 n ligase, cause dramatic loss of polarity in imaginal discs accompanied by tumorous proliferation def

82 both cases, the epidermal tissue of the wing imaginal disc acts as a niche expressing the ligands Ser

83 rder cells or proneural clusters of the wing imaginal discs affects DRONC-dependent patterning.

84 ligands, Gbb and Dpp, to patterning the wing imaginal disc along its A/P axis, change as a function o

85 Genetic evidence in the developing eye imaginal discs also demonstrates the critical functions

86 To study this question the Drosophila wing imaginal disc, an epithelial primordial organ that later

87 onditionally ablate patches of tissue in the imaginal disc and assess the ability of the surviving si

88 other developing epithelia, such as the wing imaginal disc and the embryonic germband in Drosophila,

89 hogenetic furrow, that sweeps across the eye imaginal disc and transforms thousands of undifferentiat

90 h factor (FGF) proteins produced by the wing imaginal disc and transported by cytonemes to the air sa

91 ulates Wingless internalization both in wing imaginal discs and cultured cells.

92 1 and okra, show progressive degeneration of imaginal discs and die as pupae, while other genotypes s

93 lly activate PI(3)K signalling in Dp110(RBD) imaginal discs and Dp110(RBD) flies are small.

94 ling pathway functions to suppress growth in imaginal discs and has been suggested to control organ s

95 rs, including the histone demethylase little imaginal discs and histone-interacting protein p55, that

96 derably reduces toxic mHtt aggregates in eye imaginal discs and partially restores rhabdomere morphol

97 he cell cycle and consequently for growth of imaginal discs and the derived adult organs.

98 le that is expressed in all cells of the eye imaginal discs and, unlike many other Egfr inhibitors, d

99 itates with Egfr from cultured cells and eye imaginal discs, and Egfr activity promotes tyrosine phos

100 teristic of Hh signaling loss in embryos and imaginal discs, and epistasis analysis places ihog actio

101 modulator of Hippo pathway activity in wing imaginal discs, and implicate Yorkie activation in compe

102 in has a graded distribution in eye and wing imaginal discs, and is largely localised to the Golgi in

103 ua (Cic) restricts cell growth in Drosophila imaginal discs, and its levels are, in turn, downregulat

104 posterior compartments in the embryo and in imaginal discs, and posterior to the morphogenetic furro

105 osophila tumor suppressor lethal(2) tumorous imaginal discs, and showed that hTid-1L promoted while h

106 When all cells in imaginal discs are mutant for scrib, they hyperactivate

107 Hippo pathway components in Drosophila wing imaginal discs are organized into distinct junctional co

108 ate that the developing adult organs, called imaginal discs, are a regulator of critical size in larv

109 cle and cell growth control using Drosophila imaginal discs as a genetically accessible system.

110 Using Drosophila imaginal discs as an in vivo model, we show that Wts, bu

111 However, the development of appendages from imaginal discs as in Drosophila is a derived state, whil

112 replication and proliferation in brains and imaginal discs, as well as for gene amplification in ova

113 t specifically reduced misfolded Rh-1 in the imaginal disc assay also delayed age-related retinal deg

114 regulates Dpp and Notch signaling in larval imaginal discs, at least partially via regulation of thi

115 d-type Rh-1 were overexpressed in developing imaginal discs beyond the ER protein folding capacity of

116 in damaged and regenerating Drosophila wing imaginal discs but that is dispensable for these fates i

117 sues where Ubx is active (third thoracic leg imaginal disc) but is not bound in tissues where the Ubx

118 d activate transcription in embryos and wing imaginal discs, but it is no longer processed into the r

119 The Thor gene is normally repressed in imaginal discs, but Thor mRNA and 4E-BP protein levels a

120 ed a glycolytic tumor in the Drosophila wing imaginal disc by activating the oncogene PDGF/VEGF-recep

121 antiproliferative action of DNOS1 in the eye imaginal disc by impacting the retinoblastoma-dependent

122 We propose that p53 maintains plasticity of imaginal discs by co-regulating the maintenance of genom

123 patterns the embryonic epidermis and larval imaginal discs by regulating the transcription factor, C

124 Drosophila melanogaster larval imaginal discs can recover from extensive damage, produc

125 , many cells in the posterior regions of eye imaginal discs carrying a double knockdown of Mcm10 and

126 In homozygous E(z) mutants, imaginal disc cells are smaller than cells in normally p

127 larity gene scribble in clones of Drosophila imaginal disc cells can cooperate with Ras signaling to

128 In Drosophila, damaged imaginal disc cells can induce the proliferation of neig

129 Drosophila imaginal disc cells can switch fates by transdetermining

130 y (CLPs) able to induce the proliferation of imaginal disc cells in vitro.

131 Imaginal disc cells mutant for the tumor-suppressor gene

132 In imaginal disc cells mutant for Vps4, EGFR and other rece

133 Previous studies have shown that imaginal disc cells that are mutant for TSC have increas

134 enes that are required for the transition of imaginal disc cells through S phase.

135 We find that after IR, p53 is required for imaginal disc cells to repair DNA, and in its absence th

136 dBre1 affects the levels of Su(H) in imaginal disc cells, and it stimulates the Su(H)-mediate

137 14 kb upstream of the bantam hairpin in eye imaginal disc cells, arguing that this regulation is dir

138 preferentially localizes to the membrane of imaginal disc cells.

139 ay modulate Hippo transcriptional effects in imaginal disc cells.

140 tion is dramatically increased in lgl larval imaginal discs compared to both wild type and brat mutan

141 ental checkpoint extends larval growth after imaginal disc damage by inhibiting the transcription of

142 Imaginal disc damage inflicted early in larval developme

143 sine-specific demethylase 1) and Lid (little imaginal discs), demethylate histone H3 at Lys 4 (H3K4),

144 Most remarkable is that imaginal disc-derived lines can generally be assigned, o

145 While most previous analyses of imaginal disc development have not distinguished between

146 Imaginal disc development in Drosophila requires coordin

147 Fas2 is expressed in dynamic patterns during imaginal disc development, and in the eye we have shown

148 l genes and genetic pathways involved in leg imaginal disc development, we employed a Genome Wide Ass

149 dMyc in this process during Drosophila wing imaginal disc development.

150 for both viability and the initial stages of imaginal disc development.

151 ase (JNK)-specific MKP, during embryonic and imaginal disc development.

152 e Drosophila YAP homolog Yorkie (Yki) during imaginal disc development.

153 ene expression patterns observed during wing imaginal disc development.

154 etic furrow sweeps anteriorly across the eye imaginal disc, driven by Hedgehog secretion from photore

155 f adult structures through expression in all imaginal discs, driven by enhancers from the 3' cis-regu

156 of founder cells that give rise to the wing-imaginal disc during normal development and following co

157 essive cell death restricted to the antennal imaginal disc during the middle third instar larval stag

158 In the Drosophila wing imaginal disc, dying cells trigger compensatory prolifer

159 Damage to Drosophila imaginal discs elicits a robust regenerative response fr

160 (5) mutants of the Broad-Complex (BR-C), and imaginal disc elongation and eversion is abolished in br

161 ng element is required for the action of the imaginal disc enhancer(s).

162 Mutant imaginal disc epithelia have defects in apical/basal cel

163 The imaginal disc epithelia that give rise to the adult ecto

164 -suppressor genes (nTSGs) in Drosophila wing imaginal disc epithelia that tumor initiation depends on

165 suppressor genes that regulate the growth of imaginal disc epithelia.

166 Finally, loss of Wts in Drosophila imaginal disc epithelial cells results in diminished cor

167 In Drosophila oocytes and imaginal discs, epithelial organization, fundamental to

168 In the growing Drosophila wing imaginal disc epithelium, most of the cell divisions in

169 sequestering Hedgehog protein signal within imaginal disc epithelium.

170 In mosaic Drosophila imaginal discs, for example, wild-type cells induce the

171 Without juvenile hormone, imaginal discs form and grow despite severe starvation.

172 inal discs in mid-third instar larvae, since imaginal discs from larvae with reduced or no ecdysone s

173 tep in the development of these late-forming imaginal discs from the imaginal primordia appears to be

174 lesser extent, Ds suppress overgrowth of the imaginal discs from which appendages develop and regulat

175 The Drosophila wing imaginal disc gives rise to three main regions along the

176 t Drosophila melanogaster body develops from imaginal discs, groups of cells set-aside during embryog

177 chanism of growth control is not specific to imaginal disc growth and could be of general relevance.

178 d downstream of fat, both for its effects on imaginal disc growth and for the expression of Wingless

179 Drosophila imaginal disc growth factor 2 (IDGF2) is a member of chi

180 ess of EpiTools by analyzing Drosophila wing imaginal disc growth, revealing previously overlooked pr

181 xpected requirement for the miRNA pathway in imaginal disc growth.

182 pment is delayed by apoptosis during earlier imaginal disc growth.

183 In larval imaginal discs, growth and cell fate specification occur

184 Specification and development of Drosophila imaginal discs have been studied for many years as model

185 In the Drosophila wing imaginal disc, Hh signaling differentially regulates the

186 ila larvae by inducing apoptosis in the wing imaginal disc in a spatially and temporally regulated ma

187 KA-RII is uniformly overproduced in the wing imaginal disc in Cos1(A1) mutants, but only certain cell

188 ining olfactory sensory cells) from a common imaginal disc in Drosophila, we investigated whether the

189 onset of metamorphosis are regulated by the imaginal discs in Drosophila, and suggest that the termi

190 es, Hippo and Warts, restricts the growth of imaginal discs in Drosophila.

191 s of GFP-expressing salivary glands and wing imaginal discs in living Drosophila melanogaster pupae i

192 Instead, creation of the late-forming imaginal discs in Manduca appears to be controlled by un

193 we show that ecdysone promotes the growth of imaginal discs in mid-third instar larvae, since imagina

194 uction is essential for proliferation of the imaginal discs, in part, by regulating JAK/STAT signalin

195 tion needed to transform a relatively simple imaginal disc into a more complex and three-dimensional

196 The division of the wing imaginal disc into anterior, posterior, dorsal, and vent

197 Following segregation of the Drosophila wing imaginal disc into dorsal (D) and ventral (V) compartmen

198 The genital imaginal disc is composed of three primordia (female gen

199 Neurogenesis in Drosophila eye imaginal disc is controlled by interactions of positive

200 The Drosophila wing imaginal disc is subdivided along the proximodistal axis

201 The evagination of Drosophila imaginal discs is a classic system for studying tissue l

202 upation phenotype seen when a single pair of imaginal discs is homozygous for a neoplastic TSG mutati

203 t the initial ato transcription in different imaginal discs is regulated by distinct 3' cis-regulator

204 The initial expression of ato in imaginal discs is regulated by sequences that lie 3' to

205 Car for late endosome-to-lysosome fusion in imaginal discs is specific as early endosomes are unaffe

206 show that damage to, or slow growth of, the imaginal discs is sufficient to retard metamorphosis bot

207 t the normal role of this exoribonuclease in imaginal discs is to suppress the expression of transcri

208 t expressed until differentiation in the eye imaginal disc it was more easily trans-inactivated than

209 sophila tumor suppressor lethal (2) tumorous imaginal discs (l(2)tid) gene, hTID1, encodes two protei

210 Expression of BID in eye imaginal discs leads to a rough-eye phenotype, and this

211 Genetic analysis of dally-like in wing imaginal discs leads us to a model whereby, at the surfa

212 dentified the Trithorax group protein Little imaginal discs (Lid) as a regulator of dMyc-induced cell

213 Imaginal discs, like appendages in lower vertebrates, in

214 In Drosophila imaginal discs, loss of the neoplastic tumor suppressor

215 topic expression of DIP1 in wing and haltere imaginal discs malforms the adult structures and enhance

216 Using the wing imaginal disc model in Drosophila, we identified new SMO

217 velopment, suggesting a role for paxillin in imaginal disc morphogenesis.

218 input derived from the transplanted antennal imaginal disc, most antennal lobe projection neurons (29

219 The Drosophila larval eye-antennal imaginal disc must be subdivided into regions that diffe

220 Regeneration of fragmented Drosophila imaginal discs occurs in an epimorphic manner involving

221 ne expression analyses of the larval genital imaginal disc of D. mauritiana, D. sechellia, and two D.

222 Misexpression in wing imaginal discs of a dominant negative DMRTF mutant also

223 hat IR-induced apoptosis still occurs in the imaginal discs of chk2 and p53 mutant larvae, albeit wit

224 The imaginal discs of Drosophila are subdivided into distinc

225 The imaginal discs of Drosophila are the larval primordia fo

226 Imaginal discs of Drosophila have the remarkable ability

227 The imaginal discs of Drosophila melanogaster provide a part

228 Imaginal discs of Drosophila provide an excellent system

229 compartment borders that subdivide the wing imaginal discs of Drosophila third instar larvae are eac

230 ion under physiological conditions using the imaginal discs of Drosophila.

231 anscriptional profiling of dissected genital imaginal discs of each sex at three time points during e

232 la melanogaster, IR induces apoptosis in the imaginal discs of larvae, typically assayed at 4-6 hr af

233 he exception of the wing imaginal discs, the imaginal discs of Manduca sexta are not formed until ear

234 RNA and 4E-BP protein levels are elevated in imaginal discs of PRC2 subunit mutant larvae.

235 that Rig protein is present in the brain and imaginal discs of second and third instar larvae, where

236 The larval imaginal discs of the genetically tractable model organi

237 ytoneme modulation was recapitulated in wing imaginal discs of transgenic Drosophila, providing evide

238 Ptip (Paxip1) gene in early development and imaginal disc patterning.

239 Here we show that the small imaginal disc phenotype arises, at least in part, from a

240 Drosophila, including controlling growth of imaginal discs, planar cell polarity (PCP) and the proxi

241 The Drosophila leg imaginal disc provides a paradigm with which to understa

242 The Drosophila wing imaginal disc provides a powerful system with which to u

243 The study of regeneration in Drosophila imaginal discs provides an opportunity to use powerful g

244 gaster Live imaging of single DSBs in larval imaginal discs recapitulates the spatio-temporal dynamic

245 Damaged Drosophila imaginal discs regenerate efficiently early in the third

246 When Drosophila imaginal discs regenerate, specific groups of cells can

247 In Drosophila, imaginal disc regeneration can be induced either by frag

248 Here we test the role of Sp1 during imaginal disc regeneration.

249 of aveugle mutant cells in the eye and wing imaginal discs resemble those caused by reduction of EGF

250 cumulation of cyclin B in the developing eye imaginal disc, resulting in additional mitotic cycles an

251 -epsilon or sgg/gsk3beta in Drosophila wing imaginal discs results in the accumulation of dMyc prote

252 (c) Diffuse damage to imaginal discs, results in compensatory proliferation of

253 Intriguingly, pixie mutant wing imaginal discs show complex regional and temporal defect

254 etic circuits tumors depend on because their imaginal discs, simple epithelia present in the larva, c

255 Thor gene in E(z) mutants partially restores imaginal disc size toward wild-type and results in an in

256 that kill about half of the cells in larval imaginal discs still develop into viable adults.

257 nduction of apoptosis in the Drosophila wing imaginal disc stimulates activation of the Hippo pathway

258 nonoverlapping patterns in both embryos and imaginal discs, suggesting that transcription of these n

259 re types of filopodia in the Drosophila wing imaginal disc that are proposed to serve as conduits in

260 ecified during embryogenesis and, unlike the imaginal discs that make up the thoracic and head segmen

261 We show that in imaginal discs the single Drosophila STAT protein (STAT9

262 We suggest that in imaginal discs the unliganded EcR/USP complex acts as a

263 on of h in a narrow stripe in the dorsal leg imaginal disc (the D-h stripe).

264 In epithelial cells of Drosophila imaginal discs, the Caspase-9 ortholog Dronc drives AiP

265 With the exception of the wing imaginal discs, the imaginal discs of Manduca sexta are

266 2 mutants show impaired development of their imaginal discs, the primordial tissues that form the adu

267 In wing imaginal discs, these PcG proteins also are present at d

268 distribution of Hedgehog protein in the wing imaginal disc through a Wnt-independent mechanism.

269 ous, induced strong overgrowth in Drosophila imaginal discs through modulating the activity of the Hi

270 brid screens to identify a protein, tumorous imaginal discs (Tid1), that binds to the cytoplasmic dom

271 mammalian homolog of the Drosophila tumorous imaginal discs (Tid1).

272 Thus, in Drosophila eye imaginal discs, Trr, likely functioning together with Ut

273 at a subset of peripodial cells in different imaginal discs undergo a cuboidal-to-squamous cell shape

274 Similar to most organs, Drosophila imaginal discs undergo a fast, near-exponential growth p

275 ell fate specification in the Drosophila eye imaginal disc using fibrillarin antibody labeling.

276 val is accompanied by compensatory growth of imaginal discs via increased nutritional uptake and cell

277 Ft also inhibits the overgrowth of imaginal discs via the Hippo pathway, repressing the act

278 , ecdysone appears to regulate the growth of imaginal discs via Thor/4E-BP, a negative growth regulat

279 The antennal imaginal disc was transplanted between male larvae of tw

280 The antennal imaginal disc was transplanted between premetamorphic ma

281 nder cells specified in the mesothoracic leg imaginal disc, we also demonstrate that the TGFbeta path

282 /N-deacetylase-sulphotransferase in the wing imaginal disc, we find that lack of Heparan Sulfate (HS)

283 m, the embryonic nervous system and the wing imaginal disc, we show that Flybow in conjunction with s

284 mitotic cell junction dynamics in Drosophila imaginal discs, we mathematically predict the convergenc

285 eceptor development begins in the larval eye imaginal disc, where eight distinct photoreceptor cells

286 esses gene expression in the Drosophila wing imaginal disc, where it is expressed in symmetrical late

287 stat92E is active ubiquitously in early wing imaginal discs, where it acts to inhibit the induction o

288 required for development of the wing and leg imaginal discs, whereas cleavage at the S1 site is suffi

289 eveloping and intact epithelium ( Drosophila imaginal discs), wherein cell-cell adhesion properties a

290 ferentially expressed in the Drosophila wing imaginal disc, which gives rise to two distinct adult st

291 Imaginal discs, which are larval precursors of fly limbs

292 Drosophila adult structures derive from imaginal discs, which are sacs with apposed epithelial s

293 sophila melanogaster are derived from larval imaginal discs, which originate as clusters of cells wit

294 or the observed uniformity of growth in wing imaginal discs, which persists in the presence of gradie

295 including upregulation of the same genes in imaginal discs, which suggests that Sbb cooperates with

296 sophila, the adult wing is derived from wing imaginal discs, which undergo a period of growth and pro

297 ation along the basal surface of larval wing imaginal discs, which was restored with wild type pgant3

298 In the mosaic eye imaginal discs, while ph(del), a null allele, causes onl

299 In the Drosophila eye imaginal disc, Wingless (Wg) signaling defines the regio

300 Treating imaginal discs with microtubule-destabilizing reagent no