ライフサイエンスコーパス: imidazole

1 limidazole was found to be the most abundant imidazole.

2 thiol oxidation and weak binding affinity of imidazole.

3 -dimethylaminopropyl) carbodiimide (EDC) and imidazole.

4 rum or in a million fold excess of competing imidazole.

5 tizing properties of small alkyl-substituted imidazoles.

6 one cations, but the D-DOPP does not use the imidazoles.

7 t is also applicable to preparation of fused-imidazoles.

8 ee VANOL ligands and two protonated N-methyl imidazoles.

9 asitic potencies of a new set of beta-phenyl imidazoles.

10 bles a modular approach for the synthesis of imidazoles.

11 Within the present study, five imidazoles (1-butylimidazole, 1-ethylimidazole, 2-ethyli

12 The most appealing series contain imidazole, 1,2,4-triazole, or benzimidazole rings fused

13 ,2-bipyridine and 1,10-phenanthroline and L= imidazole, 1-methylimidazole, and histamine have been sy

14 Imidazole-1-sulfonyl azide and salts thereof are valuabl

15 Using the recently reported bench-stable imidazole-1-sulfonyl azide as diazotransfer reagent, thi

16 Imidazole-1-sulfonyl azide hydrogen sulfate is presented

17 Imidazole-1-sulfonyl azide hydrogen sulfate provides a c

18 ons for diazotransfer reaction indicate that imidazole-1-sulphonyl azide and K2CO3 give the best resu

19 ules via a key guanylation step employing di(imidazole-1-yl)methanimine (6) followed by a two-fold cy

20 Subsequent thermolysis of imidazoles 14 in diphenyl ether affords 2-phenyl-3H-imid

21 Quantification of the imidazole (15)N intensities yielded two resolved proton

22 of indoles to alpha,beta-unsaturated 2-acyl imidazoles (19 examples) with high yields (75%-99%) and

23 h K2CO3 and benzoxazole (1a) with 1H-benzo[d]imidazole (1b) or quinazoline (1c).

24 It was recently shown that imidazole-2-carboxaldehyde (IC) can act as a photosensit

25 Photosensitized reactions involving imidazole-2-carboxaldehyde (IC) have been experimentally

26 Piperazine-1,4-diylbis(6-benzo[d]imidazole-2-yl)pyridine-2-yl)methanone, 7, was identifie

27 azol-2-yl, ortho pyridyl, 1-alkyl-1H-benzo[d]imidazole-2-yl, 4-bromo-1-methyl-1H-pyrazol-3-yl, thiazo

28 l ligands, and spectra are obtained from the imidazole-2-ylidene (13)C atoms that are not bound to Fe

29 s a byproduct ([(i)Pr2Im] = 1,3-di(isopropyl)imidazole-2-ylidene).

30 is(N-heterocyclic carbene) ligand bis(N-Dipp-imidazole-2-ylidene)methylene (bisNHC, 1) affords [(bisN

31 Mes)], [IMes=1,3-bis(2,4,6-trimethylphenyl), imidazole-2-ylidene; COD=cyclooctadiene] catalyst onto s

32 -d-ribofuranose and 1'-beta-[1-naphtho[2,3-d]imidazole]-2'-deoxy-d-ribofuranose and their use for qua

33 ing covalent inhibitor, the tetrasubstituted imidazole 3-acrylamido-N-(4-((4-(4-(4-fluorophenyl)-1-me

34 A 4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazole-3-oxide-1-oxyl (1) lithium derivative was foun

35 ere solved in complex with 4-(4-chlorophenyl)imidazole (4-CPI).

36 from acid-catalyzed cyclocondensation of an imidazole-4,5-dicarbaldehyde (20) and a alpha-hydrazino

37 MPK activator 5-amino-1-beta-D-ribofuranosyl-imidazole-4-carboxamide (AICAR) or adenovirus expressing

38 in and AICAR (5-amino-1-beta-D-ribofuranosyl-imidazole-4-carboxamide).

39 methyl)pyrrolidin-3-yl)-5-fluoro-1H-benzo [d]imidazole (42) with IC50 values of 44 and 50 nM, respect

40 yl-3H-diaziren-3-yl)ethyl 1-(phenylethyl)-1H-imidazole-5-carboxylate (azietomidate) and R-[(3)H]5-all

41 active analogs of 2-ethyl 1-(phenylethyl)-1H-imidazole-5-carboxylate (etomidate) and mephobarbital, r

42 its flexible inner loop of the 4-methylidene-imidazole-5-one (MIO) domain compared with that of dicot

43 ene-stabilized Si2Cl2 (2) and substituted 1H-imidazole (9), combination of the corresponding Fe(CO)4-

44 Imidazole, a well-known (1)O2 scavenger, was incorporate

45 arum (Pf) led to the identification of amino imidazoles, a robust starting point for initiating a hit

46 on our previously reported 2-aryl-4-benzoyl-imidazole (ABI) derivatives.

47 zation of TRPV1 by histamine, its metabolite imidazole acetaldehyde, and supernatants from biopsy spe

48 effect could be reproduced by histamine and imidazole acetaldehyde.

49 However, they require unstable ascorbate or imidazole activation.

50 NTAmers are highly stable but upon imidazole addition, they decay rapidly to pMHC monomers,

51 ates by uncharged and nonprotonated tertiary imidazole aldoximes allows the design of a new OP counte

52 and initial in vitro characterization of 14 imidazole aldoximes and their structural refinement into

53 eactivation efficacy determined for tertiary imidazole aldoximes compared to that of their quaternary

54 trate that (-)-agelastatin A (1a), a pyrrole-imidazole alkaloid obtained from a marine sponge, exhibi

55 ton of massadine and related dimeric pyrrole-imidazole alkaloids is a synthetic challenge.

56 The dimeric pyrrole-imidazole alkaloids represent a unique marine natural pr

57 ly understood mechanism in producing pyrrole-imidazole alkaloids sceptrin, massadine, and ageliferin.

58 d B are broad-spectrum antibacterial pyrrole-imidazole alkaloids that have a complex polycyclic skele

59 y chlorospirocyclization en route to pyrrole imidazole alkaloids.

60 n previously, oligomers derived from achiral imidazole amino acids fold into canonical helices.

61 cally 23-53%) from the corresponding N-alkyl imidazole, an alkylating agent (usually MeI), and sodium

62 ymerization rate relative to activation with imidazole, an observation that parallels earlier finding

63 1-yl)methyl)-5-(trifluoromethyl)-1H-benzo [d]imidazole], an inhibitor of S6K1, alone blocked the reco

64 This has allowed us to introduce several imidazole anchoring groups along the polymer chain for t

65 vatives and also for the differences between imidazole and 1,2,4-triazole analogues.

66 as promoted by UV254 exposure of chlorinated imidazole and guanidine compounds, which suggested that

67 A small library of imidazole and imidazolium reactivators was successfully

68 tilt angle between high and low pH, push the imidazole and indole rings closer together at low pH.

69 can be readily condensed to give a range of imidazole and pyrazine derivatives.

70 mpared to furan, and small but noticeable in imidazole and pyrrole and in thiazole and thiophene.

71 e examined the redox activities of pyridine, imidazole and their alkyl derivatives using a cell-free

72 ecifically encapsulates guests incorporating imidazole and thiazole moieties, including drugs and pep

73 The imidazole and triazole series with the short -CH2- linke

74 Three series of biarylpyrazole imidazole and triazoles are described, which vary in the

75 N-Acyl imidazoles and catalytic isothiourea hydrochloride salts

76 the previously reported Ru(2,2'-bipyridine)2(imidazole) and an unreported phototrigger, Ru(bpy)2(phen

77 reening of ALP inhibitors, including Na3VO4, imidazole, and arginine.

78 3-dicarbonyl compounds with indole, pyrrole, imidazole, and pyrazole nucleophiles via an allylic link

79 in the regions of space surrounding oxazole, imidazole, and thiazole are used to investigate aromatic

80 Strong Lewis bases like amines and imidazoles, and labile functionalities like epoxides, ar

81 This was shown for imidazole- and thiazole-amides by comparing low energy c

82 We introduce a set of multicoordinating imidazole- and zwitterion-based ligands suited for surfa

83 llulose (CNC) modified with 1-(3-aminopropyl)imidazole (APIm) is proposed as a reversible coagulant f

84 Chiral substituted furans and imidazoles are key intermediates to access biologically

85 rates the laboratory studies by showing that imidazoles are present in ambient aerosol samples in mea

86 Imidazoles are widely discussed in recent literature.

87 imerization inhibitors, including pyrimidine imidazoles, are being evaluated for therapeutic inhibiti

88 tic ion-imprinted polymer was synthesized by imidazole as a new ligand and grafted onto the surface o

89 binding buffer at pH 7 and the use of 300 mM imidazole as elution buffer, which gave the overall yiel

90 chloroauric acid as precursor and N-dodecyl imidazole as functional monomer, gold nanoroots (AuNRs)

91 ne group at the homopropargylic position and imidazole as the catalyst to deliver 2,4-cyclohexadienon

92 s or ring cleavage was only observed for the imidazoles as expected from the general mechanism of oxi

93 evaluation of a novel series of 1-methyl-1H-imidazole, as potent Jak2 inhibitors to modulate the Jak

94 porphyrin moiety with a covalently tethered imidazole axial "base" donor ligand) has been identified

95 amesitylporphyrin dianion), with and without imidazole axial ligands.

96 proton is transferred to the hydrogen-bonded imidazole base.

97 antioselective alkynylation using the chiral imidazole-based biaryl P,N ligand StackPhos to establish

98 ion reaction using novel N,P-ligated iridium imidazole-based catalysts (Crabtree type).

99 eaction employs StackPhos, a newly developed imidazole-based chiral biaryl P,N ligand, and copper bro

100 orks (ZIFs) can be tuned by mixing different imidazole-based linkers within the same structure.

101 Pyrrole/imidazole-based polyamides can be rationally designed to

102 onverted into a range of 1-methyl-2-nitro-1H-imidazole-based precursors of bioreductive prodrugs.

103 The selectivity observed in imidazole-based systems was exploited to complete a form

104 We discovered that phenanthro[9,10-d]imidazoles bearing a 2-halogenoaryl substituent at posit

105 f heterocycles, including pyrroles, indoles, imidazoles, benzoxazoles, and furans.

106 y predicted sorption behavior of aniline and imidazole between pH 3 and 10.

107 A bridging ligand with carboxylate and imidazole binding sites forms spokes between the two rin

108 e the syntheses and reactivity of three Ntau-imidazole bonded Cu(II) 2 O2 species at solution tempera

109 Synthetic monodentate imidazole-bonded Cu(II) 2 O2 species self-assemble in a

110 The greater amount of H2O2 production by the imidazole bound complex under fast electron transfer is

111 f that observed for comparable 6-coordinate, imidazole-bound heme-O2 complexes, a difference that fur

112 n this study, 3-amine-N-[3-(N-pyrrole)propyl]imidazole bromide (APPIBr) ionic liquid was successfully

113 eavage and isomerization of UpU catalyzed by imidazole buffers as well as other relevant studies.

114 tentials for the resulting phenanthro[9,10-d]imidazoles but also to improved stability of the corresp

115 pharmacological activator of AMPK, 5-amino-4-imidazole carboxamide riboside (AICAR), inhibited oxidat

116 C with 150 mM NaCl, 100 mM N-(hydroxylethyl)imidazole catalyst, and 5 mM activated nucleotide.

117 nd alpha-alkylation, respectively, of 2-acyl imidazoles catalyzed by a chiral-at-metal rhodium-based

118 synthetic steps) and its microwave-assisted imidazole-catalyzed domino rearrangement to generate the

119 omising antimycobacterial activity, with the imidazole-CH2- series (7) showing low MIC values (6.25-2

120 ansion-induced PDT enhancement by controlled imidazole chemistry.

121 as designed based on our lead acyclic phenyl imidazole chemotype.

122 In the second method, imidazole, chloromethyl (1R,2S,5R)-(-)-menthyl ether, an

123 containing fluorene functionalized with two imidazole chromophores as donors and cyanoacrylic acid a

124 n log scale) of the unprotonated form of the imidazole compounds (B) and the pKa of their conjugated

125 e of binding buffer pH, crude extract pH and imidazole concentration in elution buffer upon the purif

126 on was found between aerosol particle pH and imidazole concentration.

127 Hydrogen-bond accepting heterocycles (e.g., imidazole) conferred the highest affinity and agonist po

128 PI-Ph shares the same imidazole conjugation structure with DPI-BP and is expec

129 nd polybases (e.g., polyamines, pyridine and imidazole containing polymers, cationic polysaccharides,

130 of optically active (poly)hydroxy furans and imidazoles containing multiple stereocenters with good y

131 ne-pot synthesis of highly substituted fused imidazole-containing 5,5- and 5,6-fused bicyclic heteroc

132 se ligands combine the benefits of thiol and imidazole coordination to reduce issues of thiol oxidati

133 n unsymmetric benzimidazole-difluorofluorene-imidazole core and distal [2.2.1]azabicyclic ring system

134 mechanism of iNOS inhibition by a pyrimidine imidazole core compound and its derivative (PID), having

135 1H-imidazol-5-yl)buta-1,3-diynyl]phe nyl}-1H-imidazole cores was designed based on the SAR studies av

136 r the pH range 5.5-6.5 and they suggest that imidazole deprotonation is not a barrier to the folding

137 Treatment with the oxindole/imidazole derivative C16 rescued oHSV-1 replication in m

138 ady access to a wide array of functionalized imidazole derivatives in good to excellent yields.

139 ould contain anti-archaeal compounds such as imidazole derivatives in most cases.

140 ect functionalization of rationally designed imidazole derivatives through electrophilic fluorination

141 Thiophene, oxazole, and imidazole derivatives were used as aryl moieties.

142 re verified with eight new phenanthro[9,10-d]imidazole derivatives, using cyclic voltammetry and DFT

143 organic molecules such as benzocarbazole and imidazole derivatives.

144 iety of 3,6-di(hetero)arylated imidazo[1,2-a]imidazole derivatives.

145 producing light-absorbing compounds such as imidazole derivatives.

146 ctrode surface followed by its reaction with imidazole derivatives.

147 The contact of imidazolium and imidazole-derived PDA with various bacterial strains inc

148 with the [M8L12] (M=In/Cr, L=dinegative 4,5-imidazole-dicarboxylate) cubane-like structure.

149 re of the biosynthesis of the cyclic pyrrole-imidazole dimers is the production of antipodal congener

150 truct both highly substituted and polycyclic imidazoles directly from available substrates, without m

151 Upon adding an imidazole donor group and a pyridine acceptor group to t

152 re of L as well as the rotational freedom of imidazole donor moieties around C-N bond make it a speci

153 mplar 2-ethyl-1-(3-phenoxypropyl)-1H-benzo[d]imidazole for its antitubercular activity.

154 inct metal-chelating groups, lipoic acid and imidazole, for the surface functionalization of QDs.

155 ISPR/Cas9 encapsulated by nanoscale zeolitic imidazole frameworks (ZIFs) with a loading efficiency of

156 robable mechanism for the formation of these imidazoles from hydroxyiminoimine intermediates has also

157 A new, one-pot synthesis of imidazoles from imines, acid chlorides, and N-nosyl imin

158 carbaldehyde required for the preparation of imidazole-functionalized fluorenes.

159 y regioselective N-methylation of (NH)-(benz)imidazoles furnishing the sterically more hindered, less

160 Imidazole glycerol phosphate synthase (IGPS) is a V-type

161 haracterized a cyclase subunit (HisF) of the imidazole glycerol phosphate synthase (ImGP-S), which wa

162 This strong acid interacts with the imidazole group of DPI-BP to convert it into a DPI-BP/HC

163 hydrogen bond between a phenol group and an imidazole group.

164 In addition, the imidazole groups attached to the cationic polymer segmen

165 stent with evidence that the L-DOPP uses its imidazole groups for catalysis, in addition to the backb

166 The surface of paper was modified with imidazole groups to assemble a transduction interface th

167 ar bridging of Cu(I) by Cys thiolate and His imidazole groups, whereas the coordination of Cu(II) inv

168 les becomes thiophene > thiazole > pyrrole > imidazole > furan > oxazole.

169 romaticity decreases in the order thiazole > imidazole > oxazole; in combination with previous result

170 es and imidazolidinones for the synthesis of imidazoles has been developed.

171 Three crystal structures complexed with imidazole, HOL, and His with NAD(+) provided in-depth in

172 Among the imidazole homologues, a linear relationship was observed

173 The imidazole (Im) deoxyribonucleoside was chosen as a highl

174 Many imidazole (IMZ) derivatives of pharmaceutical interest,

175 S would be 1.5-4.4 times more effective than imidazole in facilitating HULIS-mediated ROS generation.

176 oxalyl boronates to afford substituted boryl imidazoles in a regiocontrolled fashion.

177 y studies, no quantitative information about imidazoles in ambient aerosol particles is available.

178 o-fold cross-coupling to give trisubstituted imidazoles in good yields.

179 g to a series of fluorinated polysubstituted imidazoles in gram scale.

180 g alpha-hydroxyiminoimines to trisubstituted imidazoles in high yields under mild conditions.

181 fords 1-N-methy-2,5-bishet(aryl)-4-het(aroyl)imidazoles in highly regioselective fashion in most of t

182 fied substrates, owing to the specific metal-imidazole interaction between ZnAl-CO3 LDHs and ZIF-8.

183 vasive network of dynamic metal-ligand (zinc-imidazole) interactions are programmed in the soft matri

184 d rotating ring disk electrochemistry), when imidazole is bound to the heme (Fe(Im)Cu), this same sel

185 4 heteroaryl substituents reveal that the 1H-imidazole is essential for high anticancer activity.

186 lil ([1-(beta-allyloxy-2,4-dichlorophenethyl)imidazole]) is a systemic chiral fungicide used in posth

187 fluconazole, propiconazole, tebuconazole and imidazoles: ketoconazole, prochloraz) was investigated i

188 ctionalization strategy was employed for bis(imidazole), leading to high density compound 14 (2.007 g

189 In the presence of 2-phosphino-substituted imidazole ligands and Ru3(CO)12 or Ru(methylallyl)2(COD)

190 ET initiates displacement of the inert axial imidazole ligands, promoting coordination to active site

191 onded Cu(II) 2 O2 species, hinting that Ntau-imidazole ligation, conserved in all characterized Ty, h

192 eral mechanism of oxidative ring openings of imidazoles, likely affecting the bioactivity of these BT

193 cyano-3-,12-dioxooleana-1,9 (11)-dien-28-oyl]imidazole limited aspiration-induced ALI in wild-type mi

194 onding weakening of the trans-axial histidyl imidazole linkage at lower pH.

195 t molecules and the chemical function of the imidazole linker is essential for directing the swing ef

196 effect of chemical functionalization of the imidazole linker on the framework dynamics.

197 ZIFs containing only one type of imidazole linker show separation capability for limited

198 metal oxide (ZnO or CoO), the corresponding imidazole linker, and N,N dimethylformamide (DMF) in the

199 asing polarity (-CH3, -CHO, and -NO2) on the imidazole linkers provide control over the degree of rot

200 e conditions and at 80 degrees C, a DMAP- or imidazole-mediated clean and rapid conversion of cyclic

201 Comparison between the bis-imidazole model complex and cyt c in ferrous and ferric

202 endosomal escape promoted by the protonated imidazole moieties.

203 The imidazole moiety of caffeine was critical for the specia

204 Moreover, the imidazole moiety was found to abstract the sulfur atom f

205 ycles investigated, compound 23, carrying an imidazole moiety, exhibited the highest potency in this

206 99 with H261 acts to increase the pKa of the imidazole moiety, which in turn serves as the catalytic

207 oly(organophosphazenes) hydrogel lacking the imidazole moiety, which physically interacts with macrop

208 tructure possesses a large cavity binding an imidazole molecule, while the closed structure forms a u

209 the hydrophobic region I and methylation of imidazole-N1 position increased the activity and reduced

210 The complex structure revealed the imidazole nitrogen atom of 24 to coordinate with the hem

211 Both imidazole nitrogens can be phosphorylated, forming 1-pho

212 narrow (15)N chemical exchange peaks for the imidazole nitrogens, indicating fast proton shuttling th

213 hate groups, which were activated by EDC and imidazole, of the hybridized PNA/DNA heteroduplexes, and

214 -2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole]) of p38 MAPK.

215 l-known that the coordination of copper with imidazoles on Histidine-13 and 14 (H13, H14) of Abeta pe

216 nal group such as an amide, carboxylic acid, imidazole, or phenol appeared to negatively affect amino

217 Quantum chemical analysis on the imidazole, oxazole, and thiazole derivatives of thiazole

218 I) 2 O2 cores bonded by three histidine Ntau-imidazoles per Cu center.

219 hotosystem II (PSII)-inspired [Ru(bpy)2(phen-imidazole-Ph(OH)((t)Bu)2)](2+), in which Ru(III) generat

220 mutation R132H identified compound 1, a bis-imidazole phenol that inhibits d-2-hydroxyglutaric acid

221 gue of DPI-BP, 2-phenyl-1H-phenanthro[9,10-d]imidazole (PI-Ph), was synthesized and investigated in c

222 f TRPV1 antagonists constructed on a benzo[d]imidazole platform that evolved from a biaryl amide lead

223 d 5-phenyl headgroup attached to the benzo[d]imidazole platform, which is tethered at the two positio

224 Here the authors show an injection of imidazole poly(organophosphazenes), a hydrogel with ther

225 Here we report that injection of imidazole-poly(organophosphazenes) (I-5), a hydrogel wit

226 using a synthetic alkylating agent (pyrrole-imidazole polyamide indole-seco-CBI conjugate; KR12) tha

227 Pyrrole-imidazole polyamides targeted to the androgen response e

228 screened a small library of hairpin pyrrole-imidazole polyamides targeting the sequence 5'-CGCG-3' a

229 s been working on the development of pyrrole-imidazole polyamides that bind to the minor groove of DN

230 Cyclooctyne-derivatized pyrrole-imidazole polyamides were immobilized on azide-modified

231 with oligodeoxynucleotide decoys or pyrrole-imidazole polyamides) has demonstrated antitumor respons

232 It has been applied here to a bis-imidazole porphyrin model complex and cyt c.

233 The additional imidazole present on the fluorene has been found to reta

234 ds, sugars, organic acids, amides, triazine, imidazole, protein, and biological tissue.

235 ling, notably for 4-[3-(benzyloxy)propyl]-1H-imidazole (proxyfan) [e.g., strong bias toward phosphory

236 study, the C-14 labeled radioactive pyrrole-imidazole (Py-Im) polyamide 1, targeted to the 5'-WGWWCW

237 We reported previously that a pyrrole-imidazole (Py-Im) polyamide designed to bind the consens

238 t a DNA minor groove binding hairpin pyrrole-imidazole (Py-Im) polyamide interferes with RNA polymera

239 Pyrrole-imidazole (Py-Im) polyamides bind to the minor groove of

240 Several reactions are applied to alkenyl imidazoles, pyrazoles, and triazoles to provide products

241 novel one-pot regioselective preparations of imidazole-pyrazolo and pyrazolo-1,2,4-triazole ring syst

242 We report artificial imidazole-quartet water channels with 2.6 A pores, simil

243 tential precursors for heterocycles, such as imidazoles, quinoxalines, and benzo[1,4]thiazines.

244 Subsequent treatment with imidazole removes attached proteins, enabling repeated b

245 ineered into structural homologs lacking the imidazole residue, alpha-l-rhamnosidase activity was est

246 ced different products: namely, pyrazine and imidazoles, respectively.

247 s inhibited strongly by azoles containing an imidazole ring but not by those tested containing a tria

248 uld raise the pK(a) of His-54 and freeze the imidazole ring in the place optimal for forming an ion p

249 te with its benzo ring pointing to F150, its imidazole ring inserted between residue D112 and residue

250 unit of 2 into the olefinic C-H bond of the imidazole ring of 1 and four-membered cyclic silylene (4

251 ms: the coordinating epsilon-nitrogen of the imidazole ring of each histidine ligand (A = [3.45, 3.71

252 he phenol ring of tyrosine to stack with the imidazole ring of His263, thus competing for the substra

253 ution on the phenyl at the 2-position of the imidazole ring on biological activity.

254 N7-methylation of deoxyguanosine followed by imidazole ring opening.

255 that singlet oxygen reacts with the histidyl imidazole ring to form an endoperoxide and then converte

256 rocyclic core of these inhibitors by a fused imidazole ring with the triazine to provide imidazo[1,2-

257 N1 (1-pHis) or N3 (3-pHis) positions of the imidazole ring, we detect for the first time phosphoisof

258 cationic NM-N7-dG adduct that can yield the imidazole ring-fragmented lesion, N(5)-NM-substituted fo

259 recognizes and excises the highly mutagenic imidazole ring-opened AFB1-deoxyguanosine adduct (AFB1-F

260 mposed of two pyrimidine rings fused with an imidazole ring.

261 on process involving the amine moiety of the imidazole ring.

262 undergoes either spontaneous depurination or imidazole-ring opening yielding formamidopyrimidine AFB1

263 to the vicinity of H13 and H14 of Abeta, and imidazole rings were incorporated to compete with H13/H1

264 the 1-(3',4',5'-trimethoxyphenyl)-2-aryl-1H-imidazole scaffold and designed as cis-restricted combre

265 inhibitors based on the 1,4,5-trisubstituted imidazole scaffold which are appended with aliphatic lin

266 functionalizable 6-substituted imidazo[1,2-a]imidazole scaffolds is described.

267 oarenes furnished the desired trisubstituted imidazole scaffolds.

268 The occurrence of imidazoles seems to be favored at sites with strong biom

269 ygen entry with only a small rotation of the imidazole side chain and movement of the E helix.

270 releases at a pH similar to the pK(a) of the imidazole side chain of histidine residues.

271 like previous extended peptide networks, the imidazole side chain of the histidine residue is deproto

272 The histidine imidazole side chain plays a critical role in protein fu

273 ough modulating the degree of freedom of the imidazole site as well as tuning the relative surface co

274 nitrogen heterocycles such as pyrazines and imidazoles starting from alpha-diketones using phosphine

275 The synthesis of imidazole styrylbenzamide, tert-butyl styrylimidazole, a

276 The imidazole styrylbenzamides are optimally positioned to a

277 tory activity against CYP24A1 identified the imidazole styrylbenzamides as potent inhibitors of CYP24

278 thod has been developed for the synthesis of imidazole-substituted allenes by the reaction of 1,1,3-t

279 t of the N substituent size and shape on the imidazole substrate shows that compared to N-Me, N-iPr a

280 ally required for coordination to the 2-acyl imidazole substrate, the metal-centered chirality is mai

281 method for preparation of the nonaromatic 4H-imidazole tautomer in the core.

282 ell as N-heterocycles including pyrimidines, imidazoles, tetrazoles, and oxadiazoles.

283 after derivatization with 1-(trifluoroacetyl)imidazole (TFAI) was described.

284 by itraconazole but not by ketoconazole, an imidazole that does not block cholesterol export.

285 thiophene, benzo[b]thiophene, furan, indole, imidazole, thiazole, oxazole, pyrazole) have been involv

286 icle size expansion due to the conversion of imidazole to hydrophilic urea, resulting in instantaneou

287 e of NBS 3-methylindole reacted with various imidazoles to give the (indol-2-yl)imidazolium salts 21a

288 n the linker between the biaryl pyrazole and imidazole/triazole group.

289 eridines, quinolines, indoles, N-substituted imidazoles, triazoles and heterocyclic amides.

290 osylation, or with 1-(2-trifluromethylphenyl)imidazole (TRIM), an inhibitor of neuronal NO synthase,

291 e cation, bearing on the structure a neutral imidazole unit as basic functionality.

292 act of acid-catalyzed formation rates of the imidazole units on the porosity levels of BILPs and subs

293 fied 2,3,6-tri(hetero)arylated imidazo[1,2-a]imidazoles was generated in good yields.

294 A series of 4-aryl-2-benzoyl-imidazoles were designed and synthesized based on our pr

295 Tetra-substituted imidazoles were designed as dual inhibitors of c-Jun N-t

296 as C-beta-d-glucosaminyl 1,2,4-triazoles and imidazoles were synthesized and tested as inhibitors aga

297 ew 4(5)-(2-hydroxyphenyl)-2,5(4)-substituted imidazoles, which are known to be good coordinating liga

298 he 2-(beta-d-glucosaminyl)-4(5)-(2-naphthyl)-imidazole with a Ki value of 143 nM against human liver

299 mally positioned to allow interaction of the imidazole with the heme, and, in the case of the methoxy

300 We have prepared a set of trisubstituted imidazoles with a rigidized 7-azaindole hinge binding mo