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1 r only part of the secretory response to the imidazoline.
2 ecretion evoked by glucose, tolbutamide, and imidazolines.
3 o nonsymmetric cis-stilbene diamines and cis-imidazolines.
4 he NO-scavenger 2-phenyl-4,4,5,5-tetramethyl-imidazoline-1-oxyl 3-oxide (PTIO).By blocking the activi
5 ited by carboxy-2-phenyl-4,4,5,5-tetramethyl-imidazoline-1-oxyl-3-oxide (-85.0 +/- 10.0%; p = 0.008)
6 nger 2-(4-carboxyphenyl)-4,4,5,5-tetramethyl-imidazoline-1-oxyl-3-oxide (PTIO) had opposite effects,
7 oxide scavenger 2-phenyl-4,4,5,5-ketramethyl-imidazoline-1-oxyl-3-oxide or by the nitric oxide syntha
8 , or 2-(4-carboxyphenyl)-4,4,5,5-tetramethyl-imidazoline-1-oxyl-3-oxide potassium (cPTIO), a NO scave
9 helator carboxy-2-phenyl-4,4,5,5-tetramethyl-imidazoline-1-oxyl-3-oxide, mitochondrial hyperpolarizat
10 be blocked by 2-phenyl-4,4,5, 5-tetramethyl-imidazoline-1-oxyl-oxide and could not be mimicked by de
12 atment of cancer cells with the noncytotoxic imidazoline 1d (10 nM) resulted in a significant increas
15 ynthesized 2-[(5-methylbenz-1-ox-4-azin-6-yl)imidazoline, 3, a potent, peripherally acting alpha 2 ad
16 7,10-tetraazacyclododecane, 1) utilizing bis-imidazoline, 6 (1,1'-ethylenedi-2-imidazoline), with 1,2
17 is replaced by an appropriately substituted imidazoline, a 1,2,4- or 1,3,4-oxadiazole, or an alkylat
18 ll as for other phenethylamines, but not for imidazolines, a class of structurally distinct alpha ago
19 ,5,6-tetrahydropyrimidine, H(2)bim = 2,2'-bi-imidazoline, acac = 2,4-pentandionato, py-imH = 2-(2'-py
22 pletely blocked by pretreatment with the non-imidazoline alpha(2)AR-antagonist, SKF86466 (0.5 or 1.0
23 evious report that the 2-(substituted-benzyl)imidazoline alpha-adrenergic agonist oxymetazoline (8) b
24 as prevented by idazoxan (5 mg/kg, i.p.), an imidazoline/alpha(2)-adrenoeceptor receptor antagonist.
25 in addition to effects on the KATP channel, imidazolines also interact with a more distal component
29 ated NO production and could be inhibited by imidazoline and alpha-2 AR antagonists, thus indicating
30 operties of the series of 2,2,5,5-tetraalkyl imidazoline and imidazolidine nitroxides were investigat
35 hesis and biological activity of a series of imidazoline-based scaffolds as potent inhibitors of NF-k
39 immunoprecipitation of labeled peptides, the imidazoline binding domain was localized to residues K14
40 entified B-CK to be the approximately 45 kDa imidazoline binding protein and we have demonstrated the
41 port the isolation of a approximately 45 kDa imidazoline binding protein from rabbit and rat brain us
42 uencing of the isolated approximately 45 kDa imidazoline binding protein, we identified it to be brai
45 opment of a PET radioligand selective for I2-imidazoline binding sites (I2BS) would enable, for the f
48 nomolar) affinity for both type 1 and type 2 imidazoline binding sites, and the synthetic standards w
49 he structure of the endogenous ligand(s) for imidazoline binding sites, clonidine-displacing substanc
50 as developed to preferentially interact with imidazoline binding sites, it requires the alpha(2A)-AR
54 we observed effects that indicated that the imidazoline class of p38 MAPK inhibitors prevented nucle
59 by scientists at Hoffmann-La Roche that cis-imidazolines could disrupt the protein-protein interacti
62 te) and FeII(H2bim) (iron(II) tris[2,2'-bi-2-imidazoline]diperchlorate) both transfer H* to TEMPO (2,
63 AA-RP acts at I-Rs, and because few (if any) imidazolines exist in vivo, we have adopted the term "im
66 Additionally, a base-catalyzed formation of imidazolines from a nitrile and ethylenediamine was also
68 s in a more "classical" model that uses both imidazoline groups for H-bonding while the carbazole NH
69 ither the 3,6 or 2,7 positions with cationic imidazoline groups gave conclusive, but very surprising,
70 the potential pharmacological development of imidazoline/guanidinium compounds and also presents addi
73 ds for the enantioselective synthesis of cis-imidazolines, however, has limited their more general us
77 ey all share low micromolar affinity for the imidazoline I(2) receptor, while being devoid of any sig
84 sed to prepare a wide variety of enantiopure imidazolines, in a modular fashion, from readily availab
85 aroxan or phentolamine selectively inhibited imidazoline-induced insulin secretion but not the secret
87 equent proton migrations in zwitterionic His imidazoline intermediates that reform the COOH group and
91 enry strategy for preparing nonsymmetric cis-imidazolines is illustrated by a comparison of the roles
93 ed methamphetamine, ketamine, the endogenous imidazoline ligand agmatine, the monoamine oxidase (MAO)
97 om 1a undergoes spontaneous isomerization by imidazoline N-H migration, re-forming the COOH group and
99 r 4- and 5-azido analogues; imidazolidine, 4-imidazoline or 4-thiazoline; and N-unsubstituted imine,
100 ocked by the NO scavenger phenyl-tetramethyl-imidazoline-oxyl-oxide as well as by the PKC inhibitor s
101 ain on MAO-B, we labeled the domain with the imidazoline photoaffinity adduct [125I]2-(3-azido-4-iodo
103 on of access to cis-stilbene diamine-derived imidazolines provided by this platform should streamline
105 onors wherein the active doping species, the imidazoline radical, is generated in a postdeposition th
107 ), the H2 histamine receptor antagonist with imidazoline receptor activating properties, prevented th
109 ha2-AR) agonist guanabenz, but not by the Ih-imidazoline receptor agonists moxonidine or rilmenidine.
111 contrast, pretreatment with the specific I1 imidazoline receptor blocker, efaroxan (100-500 microg;
112 ion, i.c.v. or i.v. pretreatment with the I1-imidazoline receptor blocker, efaroxan, failed to inhibi
115 te signal transduction pathways for the I(1)-imidazoline receptor in PC12 cells and their interaction
118 vous system with a polyclonal antibody to an imidazoline receptor protein (IRP) with binding characte
120 line compound with preferential affinity for imidazoline receptors (IR) over alpha(2)-adrenoceptors (
121 e cross-reactivity of alpha2AR agonists with imidazoline receptors has precluded an understanding of
126 ity and selectivity of some compounds for I1 imidazoline receptors over alpha2-adreergic receptors.
128 nd tested for their binding properties on I1 imidazoline receptors vs alpha2-adrenergic receptors and
129 ine is known to bind to alpha-adrenergic and imidazoline receptors, it has been suggested that some o
137 ha(2)-adrenoceptor agonists does not involve imidazoline sites but rather the activation of alpha(2)-
138 gnificantly from planarity and projected the imidazoline substituents R(1) and R(2) on opposite faces
139 ation of P53 in tumor cells by Nutlin, a cis-imidazoline that inhibits the Hdm2-P53 interaction.
140 to prepare highly substituted cis-4,5-diaryl imidazolines that project unique aromatic rings, and the
141 nd, BL-1743 (2-[3-azaspiro (5,5)undecanol]-2-imidazoline), that inhibits influenza virus growth was i
142 CF(3)) in combination with an imidazolidine, imidazoline, thiazolidine, or thiazoline heterocycle.
144 residues are involved in the binding of all imidazoline-type agonists such as oxymetazoline, cirazol
145 alkyl group derives from the substrate; this imidazoline undergoes further reaction in situ to afford
148 A series of 2'-alkylthio-2-(anilinomethyl)imidazolines were prepared to examine the effect of the
151 iamagnetic 4-R-amino-1,2,2,5,5-pentamethyl-3-imidazolines with bromoacetic acid ethyl ester; the prod
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