ライフサイエンスコーパス: immature

1 the densification of a powder body is still immature.

2 In cells lacking LepA, immature 30S particles accumulate.

3 es status, these insulin-producing cells are immature, a common downfall off most current beta-cell d

4 Furthermore, contact with immature adipocytes increased the abundance of cancer ce

5 demonstrated that cancer cells cultured with immature adipocytes or cytokines activated Src, thus pro

6 s entered an insulin-expressing stage led to immature and dysfunctional islet beta cells carrying abn

7 l stages, glutamatergic synapses are sparse, immature and functionally 'silent', expressing mainly NM

8 Formation of new immature and leaky vessels along with inflammatory remod

9 G-MDSCs, made of immature and mature granulocytes expressing high levels

10 emical shifts and signal intensities between immature and mature lattice assemblies also support a ma

11 , we carried out transcriptional analysis on immature and mature stem cell-derived MKs exposed to phy

12 colocalized with a major membrane protein of immature and mature virions.

13 in T. cruzi, which uses EVs as vehicles for immature and misfolded proteins, forming circulating imm

14 ocess of Klhl6-deficient B cells between the immature and transitional stage.

15 d knockdown in the CA1 hippocampal region in immature animals causes rapid and lasting reductions in

16 4 eyes manifested with pupillary membranes, immature anterior chamber angles, loss of pigment and th

17 the graft bed is inflamed and vascularized, immature APCs in the donor corneal stroma quickly mature

18 se in MINT2 and FE65, both shown to increase immature APP in the early secretory pathway.

19 M344 also increases levels of immature APP, supporting an effect on APP trafficking, c

20 phenols have been detected and identified in immature Argan fruits.

21 ght contribute to inappropriate responses of immature arteries to stress or injury.

22 ehind astrocytic progenitor cells (APCs) and immature astrocytes.

23 The human gastrointestinal tract is immature at birth, yet must adapt to dramatic changes su

24 marked (180% increase) hyperrepopulation of immature B cells occurred with conversion to mature B ce

25 from large pre-B cells to small B cells and immature B cells.

26 iation process leading to an accumulation of immature blasts in the blood.

27 ated, in part, by both the formation of new, immature blood vessels and the formation of lymphatic ca

28 s synaptic overgrowth and an accumulation of immature boutons.

29 time windows of development during which the immature brain is vulnerable to injury.

30 f how epilepsy develops, particularly in the immature brain, likely contributes to the lack of effica

31 es and on excitotoxic neuronal injury in the immature brain.

32 pofol induces neuronal cell death in healthy immature brains by unbalancing neurotrophin homeostasis

33 (NCAM1)-positive and displayed an unexpected immature, but activated, phenotype with low or no cytoto

34 that adult dentate gyrus appears similar to immature CA1, demonstrating regional and developmental c

35 GUK loss in mature animals, behaving like an immature CA1.

36 ch their contact calls transform from noisy, immature calls to tonal adult-like "phee" calls [7, 8].

37 PR activity and strongly interacted with HIV immature capsid protein in pull-down experiments.

38 uces key aspects of post-natal maturation in immature cartilage and provides the basis to evaluate a

39 equently re-express phenotypic biomarkers of immature cartilage so tissue maturation is a potential p

40 expression in both mature CD11b(+)Gr1(-) and immature CD11b(+)Gr1(+) myeloid cells in vivo Strikingly

41 HEB is required in immature CD24(+)CD73(-) gammadelta T cells for the expre

42 nly in mature CD68(+) macrophages but not in immature CD33(+) immunosuppressive myeloid cells infiltr

43 The positive selection of immature CD4(+)CD8(+) double-positive thymocytes and the

44 cells in the lung consisted predominantly of immature CD56(bright)CD16(-) NK cells and less different

45 ally, patients with STAT1 GOF mutations have immature CD56(dim) NK cells with decreased expression of

46 ells and an increase in the frequency of the immature CD56bright NK cells, and this impairment in ter

47 By contrast, we found that immature CD66b(+)CD10(-) neutrophils, also present in GD

48 rentiated myocyte replication and progenitor/immature cell differentiation.

49 d to understand the process through which an immature cell undergoes differentiation.

50 ocytoid Sweet syndrome is composed mostly of immature cells of myeloid lineage.

51 torsinA in rodents, torsinA knockdown in the immature cerebellum failed to produce dystonia.

52 a cryo-EM, 6.8-A resolution structure of an "immature" Chikungunya virus in which the cleavage site h

53 SHH promoted expression of markers of immature chondrocytes but inhibited chondrocyte hypertro

54 udies revealed that Sox9 and Col2 expressing immature chondrocytes in the epiphysis transition into p

55 thereby control the transit of proliferating immature chondrocytes into mature hypertrophic chondrocy

56 In vitro treatment of immature chronic phase CML cells with TKI alone, or in c

57 erive discrete numbers accurately because of immature cognitive control.

58 ne for superoxide dismutase (Ccs1) activates immature copper-zinc superoxide dismutase (Sod1) by deli

59 animal models are known to occur in areas of immature cortex and drive their development, their origi

60 7-year-old children with normal hearing had immature cortical responses, adult patterns in cortical

61 as a discrete population from mature-DC and immature-DC, with 51 and 93 genes that were significantl

62 n Treg-DC, lower than mature-DC, higher than immature-DC.

63 Immature DCs derived from either source had a reduced ca

64 in terminally differentiated-macrophages and immature dendritic cells (iDC) in association with the i

65 ures of CD40L stimulation derived from human immature dendritic cells and naive B cells to assess the

66 ysis revealed that CD40L-responsive genes in immature dendritic cells and naive B cells were signific

67 CCR2 is expressed on monocytes, immature dendritic cells, and T-cell subpopulations, and

68 as percentages of total FA of triploids and immature diploid females significantly differed from tha

69 e (filets) compared to that of triploids and immature diploid females.

70 role in maintaining the genomic integrity of immature eggs cells.

71 abor and greenhouse space required to supply immature embryos for transformation.

72 mbryogenesis program resulting in seeds with immature embryos, and mycorrhiza-induced seed germinatio

73 i1+ cell population had the capacity to heal immature entheses after injury, but this capacity was lo

74 Our findings demonstrate that the immature epithelium is intrinsically capable of establis

75 on of hiPSC-CM, including lack of T-tubules, immature excitation-contraction coupling, and inefficien

76 GluN2B-containing NMDA receptors (NMDARs) at immature excitatory synapses, via a transcription-depend

77 d with non-newly generated neurons retaining immature features, suggesting that such plasticity might

78 parts, particularly if they are derived from immature females.

79 s used for cardiotoxicity testing display an immature, fetal-like cardiomyocyte structural and electr

80 The immature fiber tracts of the AVP, formed by secondary ne

81 , while small protrusions, rapid turnover of immature focal adhesions and lack of a Rac1 activity gra

82 retained in the endoplasmic reticulum, in an immature form.

83 metry, we also find increased frequencies of immature forms of neutrophils in the blood of women duri

84 ligomerization, which is a critical step for immature Gag lattice formation and virus particle buddin

85 nd PRMT5 is vital to support both mature and immature GBM tumour cell populations.

86 sulting in a marked increase in the ratio of immature Gr1(lo) cells in the bone marrow.

87 tate gyrus, it blocks dendritic outgrowth of immature granule cell neurons in the dentate molecular l

88 In addition, immature granulocyte (IG) count, plasma cell-free DNA (c

89 was done in parallel using sorted mature and immature granulocytes from WT and C/EBPepsilon KO bone m

90 l index (DNI) is the fraction of circulating immature granulocytes, which reflects severe bacterial i

91 neutrophilic leukocytosis and the release of immature granulocytic populations that accumulate in cir

92 radient of stiffness, this is not present in immature guard cells, yet young stomata show a normal op

93 total mortality, respectively) and also for immature gulls (ca. 90% of mortality).

94 ory GABA actions on spontaneous EPSCs in the immature hippocampus and neocortex in vivo SIGNIFICANCE

95 estinal organoids is globally similar to the immature human epithelium and we utilize HIOs to investi

96 w colonization influences development of the immature human intestine.

97 ctions is difficult due to limited access to immature human tissue.

98 cialization for relative disparity is highly immature in 4- to 6-month-old infants but is adult-like

99 wever, cells differentiated from PSCs remain immature in a dish, and thus there are serious caveats t

100 derived tissues often remain developmentally immature in vitro, and become more adult-like in their s

101 ral nutrition is central to the care of very immature infants.

102 Immature injured entheses retained high levels of Gli1 e

103 Within 2 hr of immature INP birth, downregulation of repressor activiti

104 anscriptional repressors to maintain the erm immature INP enhancer in an inactive but poised state in

105 Erm restricts the developmental potential in immature INPs by repressing genes encoding neuroblast tr

106 tructural abnormalities, including increased immature insulin granules, swollen mitochondria, and dis

107 By comparing the transcriptomes of immature interneurons to those of more mature neurons, w

108 ng species [6]-whether the transformation of immature into mature contact calls by infants is influen

109 PNN removal resets the neural network to an immature, juvenile state.

110 muscle and cutaneous afferent synapses onto immature lamina I projection neurons, which convey nocic

111 Metastability of the immature lattice has been proposed to depend on the exis

112 cellular metabolism were highly expressed in immature leaves, genes involved in lipid metabolism and

113 fringe (odds ratio [OR] = 5.3, P = .036) and immature lesion morphology (OR = 4.2, P = .015) were sig

114 tic lethality in quiescent and proliferating immature leukemia cells, and is thus a potential approac

115 spite the larger RFs and slower responses of immature LGN neurons compared with mature neurons, our r

116 AD, alters synaptic NMDAR composition to an immature-like GluN2B-rich profile.

117 We found immature-like neurons in the whole sheep cortex and in l

118 The expression levels of the immature-like neutrophil signature increased linearly wi

119 his study, we identified a gene signature of immature-like neutrophils, characterized by the overexpr

120 ponsible for the late secondary acylation of immature lipid A molecules.

121 An immature, low granular (LG) MK pool (defined by side sca

122 ing RUNX activity may not eradicate the most immature LSCs.

123 In the immature lung, inflammation and injury disrupt the epith

124 band form cells, and a striking expansion of immature (Ly6G(low)Ly6C(low)) hyposegmented neutrophils,

125 Our data indicate that immature lymphocytes exploit a common DDR signaling path

126 in the genomes of lymphocyte progenitors and immature lymphocytes regulates the expression of ubiquit

127 expression is a prevalent DSB response among immature lymphocytes.

128 optimal control signatures were enriched for immature lymphocytic patterns.

129 In response to a defined panel of stimuli, immature macrophages can be classified into two major ph

130 In this investigation, we identified immature MASP proteins containing the MASP SP in EVs sec

131 Both adult and immature material is present.

132 ore, we identified populations of mature and immature megakaryocytes along with haematopoietic progen

133 Although immature megakaryocytes express 2 nonmuscle myosin II is

134 ve waves of cargo delivery from endosomes to immature melanosomes, coupled with recycling of the traf

135 tic nerve ligation induces a re-emergence of immature metabotropic glutamate receptor 5 (mGluR5) sign

136 y thymic epithelial cell (mTEC) lineage from immature MHC class II (MHCII)(lo) to mature MHCII(hi) mT

137 pression are also induced by RV infection in immature mice and are required for maximum ILC2 expansio

138 ILC2s were isolated from RV-infected immature mice and treated with innate cytokines ex vivo.

139 inting of paternal Ube3a reflects an overall immature molecular phenotype.

140 CD40L promoted tumour-directed maturation of immature monocyte-derived dendritic cells (iDCs).

141 rface of mature multinuclear OCs, as well as immature mononuclear OCs, in primary cultures of RANKL-s

142 neutrophils, also present in GDs, display an immature morphology, promote T-cell survival, and enhanc

143 SD95) protein is synthesised by microglia in immature mouse and human, developmentally regulated, and

144 tioxidants in a culture medium could protect immature mouse oocytes from damages caused by oxidative

145 N-myc expression was restricted to the most immature, multipotent stem and progenitor populations.

146 NK cell and Th1 cytokine levels, and reduced immature myeloid cell infiltrate and blood chemokine lev

147 is expressed exclusively in granulocytes and immature myeloid cells and transforms the topoisomerase

148 ere we report that bone marrow (BM) Gr-1(lo) immature myeloid cells are responsible for the elevated,

149 the BM and the kidney, and they implicate BM immature myeloid cells as a key contributor to glomerula

150 AML is characterized by accumulation of immature myeloid cells in the bone marrow and phenotypic

151 eterogeneous population of immunosuppressive immature myeloid cells, expanded during chronic Staphylo

152 al cancer by accumulation of CD11b(+)Gr-1(+) immature myeloid cells, indicating a potential antitumor

153 characterized by the uncontrolled growth of immature myeloid cells.

154 relative numbers of splenic CD11b(+)Gr-1(+) immature myeloid cells.

155 d effector T-cell function, and expansion of immature myeloid-derived suppressor cells are all contri

156 mainly composed of myeloperoxidase-positive immature myelomonocytic cells with histiocytoid morpholo

157 )-expressed Ncam1, Pax2, and Sox9 markers of immature nephron structures and dedifferentiated proxima

158 active Rho-kinase diffuses to growing other immature neurites and inhibits their outgrowth.

159 s hypothesized to prevent outgrowth of other immature neurites and to differentiate them into dendrit

160 ngle axon and multiple dendrites from common immature neurites.

161 at vChATs directly innervate newly generated immature neurons (NGIs) in the dorsal hippocampus (dNGIs

162 ells, intermediate progenitors, neuroblasts, immature neurons and neurons.

163 In rodents, the immature neurons are restricted to the paleocortex, wher

164 Conditional knockout of TRF2 in post-mitotic immature neurons had virtually no detectable effect on c

165 However, all immature neurons in the CNS are required to migrate from

166 erexpression of NICD in the postnatally born immature neurons in the hippocampus increases mTOR signa

167 We found that a large percentage of immature neurons migrated past their normal stopping sit

168 ent of MGE progenitors was reconstructed and immature neurons were characterized as GABAergic, cells

169 fied as proliferating neural progenitors and immature neurons, both of which comprised sub-population

170 highest in intermediate progenitor cells and immature neurons.

171 tial and temporal cues determine the fate of immature neurons.

172 plasticity consists of non-newly generated, "immature" neurons of the adult cerebral cortex.

173 The cerebral cortex contains "immature" neurons, which are generated prenatally and th

174 arker discriminating mature neutrophils from immature neutrophil populations present in patients with

175 Resident immature neutrophils (Ly6G(intermediate)) in the spleen

176 uncover that in GDs, circulating mature and immature neutrophils, distinguished by their differentia

177 NK cells but also led to the emergence of an immature NK cell population that expressed high levels o

178 of interleukin-15 present in patients' sera, immature NK cells (CD62L(+)NKG2A(+)KIR(-)) became highly

179 maturation and egress out of the BM and that immature NK cells present in the periphery of NKp46-Cre-

180 from adipose mature natural killer (NK) and immature NK cells.

181 Early loss of AnkG creates immature nodes with abnormal morphology, which undergo a

182 ATM is critical for controlling apoptosis in immature noncycling neural cells after DNA damage.

183 The conversion of immature noninfectious HIV-1 particles to infectious vir

184 protein p24 and spacer protein-1, producing immature, noninfectious virions.

185 sites to facilitate viral RNA packaging into immature nucleocapsids (NCs) and the early stage of vira

186 s, clearly distinguishes the mature from the immature ones.

187 Pre-maturation aging of immature oocytes may adversely affect the fate of an ooc

188 proliferative globose basal cells as well as immature OSNs exhibiting the hallmarks of ongoing differ

189 persists for about 5 days, thereby labeling immature OSNs in both the main olfactory system and vome

190 rocessing patterns were found underlying the immature P1 ( approximately 100 ms) response peak with r

191 SV immature virions and further suggest that immature particle assembly and virion maturation are con

192 s: formation and release from the cell of an immature particle followed by an extracellular maturatio

193 he importance of the HTLV-1 CA NTD in HTLV-1 immature particle morphology.

194 apsid) impact Gag oligomerization as well as immature particle size and morphology.IMPORTANCE A key a

195 ulate HIV-1 maturation in vitro by digesting immature particles and assembled virus-like particles wi

196 fore likely representing mature viruses, and immature particles whose fusion cannot be detected.

197 d particles phenotypically similar to HTLV-1 immature particles, highlighting the importance of the H

198 deficiency virus type 1 (HIV-1) assembles as immature particles, which require the proteolytic cleava

199 Post-operative tooth-root development in immature permanent teeth represents a generalized challe

200 he dental clinic to obtain apical closure of immature permanent teeth with thin dentinal walls.

201 Immunologically, natural killer cells had an immature phenotype and impaired cytotoxicity and degranu

202 The immature phenotype of human pluripotent stem cell derive

203 induced by S100A9 activity and maintains AML immature phenotype.

204 sion is often associated with acquisition of immature phenotypes and resistance to therapy.

205 wall expansion, including immature xylem and immature phloem in the stem.

206 tes in cumulus-oocyte complexes derived from immature pig ovaries and provides a twofold increase in

207 grain size with the clay containing mostly (immature) plant derived OC and sand containing mostly th

208 tomated whole blood flow cytometry: absolute immature platelet count (IPC), immature platelet fractio

209 try: absolute immature platelet count (IPC), immature platelet fraction, and highly fluorescent immat

210 re platelet fraction, and highly fluorescent immature platelet fraction.

211 mon across various tumor types, resulting in immature populations termed myeloid-derived suppressor c

212 CD4(+) T cells, accompanied by reductions of immature PreB cells in BM.

213 f MPP, leading ultimately to accumulation of immature precursor proteins within mitochondria.

214 ion of Erf resulted in both reduced and more immature primitive erythroblasts at E9.5 to E10.5.

215 The ovary contains oocytes within immature (primordial) follicles that are fixed in number

216 ated from infected honey bees, including the immature procapsid, the genome-filled virion, the putati

217 atterns of neuron and glial production, with immature progenitors and neurons observed early and matu

218 under development involve transplantation of immature progenitors that subsequently undergo phenotypi

219 ginate from CD11b(+)CD15(hi)CD10(-)CD16(low) immature progenitors, are able to cross-present antigens

220 are highly expressed selectively on the most immature progenitors.

221 muscle and cutaneous afferent synapses onto immature rat lamina I spino-parabrachial neurons, which

222 utophagosome formation in the hippocampus of immature rats with SE.

223 notypic corticoamygdalar slice cultures from immature rats, treatment with letrozole significantly re

224 ferentially invades reticulocytes, which are immature red blood cells.

225 Our results show that the immature reticulocytes (CD71+) targeted by P. vivax inva

226 thod counts low abundance cell types such as immature reticulocytes as well as high abundance cell ty

227 ssociation of DBP with a small population of immature reticulocytes could explain the preference of P

228 is key to the preferential binding of DBP to immature reticulocytes, which is the potential mechanism

229 that some expression of VEGF remains in the immature retina after injection supports the idea that a

230 ascular drive for the vascularization of the immature retina.

231 The generation of mucous metaplasia in immature RV-infected mice involves a complex interplay a

232 nd Remak cells and 7- to 10-fold longer than immature Schwann cells.

233 gh mTORC1 activity promotes proliferation of immature SCs and antagonizes SC differentiation during n

234 Small RNA sequencing of dissected regions of immature seed coats demonstrated that CHS siRNA levels c

235 ain trigger for action potential activity in immature sensory inner hair cells (IHCs), which is cruci

236 nied by reduced numbers of both TCRbeta(low) immature single-positive CD8(+) cells and double-positiv

237 going positive selection and is sustained in immature single-positive thymocytes, despite the strong

238 Extensive proliferation of immature smooth muscle cells in the primitive embryonic

239 ouse model to map the fate of NG2(+)CD146(+) immature smooth muscle cells.

240 osed "entry site" for copper ion delivery on immature Sod1.

241 Hnt is not expressed in immature stage-13 follicle cells but is upregulated in m

242 squitoes were collected in central Panama at immature stages along linear transects in colonising, mi

243 natomical specializations in their adult and immature stages associated with particular aspects of th

244 n known that parasitizes both adults and the immature stages of different castes of ants, thus threat

245 d patients matched that of young children at immature stages, whereas that of binocularly deprived pa

246 res, which can be assigned to an off-pathway immature state (Fbeta*) and a mature stable state (Fbeta

247 that mature hepatocytes (MHs) convert to an immature state during chronic liver injury, and we inves

248 To further address the immature state of the cells, in vitro differentiated cel

249 feasible via reversion to a developmentally immature state.

250 tion including mature non-stem-like cell and immature stem-like cells within the tumour.

251 paired terminal differentiation manifests as immature stereocilia and kinocilia on the apical surface

252 parities, further evidence for qualitatively immature stereopsis based on relative disparity at 4-6 m

253 rogressed, we noted the selective loss of an immature subset of NK cells in leukemic mice and in AML

254 models have randomly oriented myotubes with immature synapses that contract asynchronously.

255 d to play a role in stabilizing receptors at immature synapses.

256 le, NRAS/FLT3 mutations were associated with immature T-ALL, JAK3/STAT5B mutations in HOXA1 deregulat

257 nstrated that ZEB2 is an oncogenic driver of immature T-cell acute lymphoblastic leukemia (T-ALL), a

258 ancy that results from the transformation of immature T-cell progenitors.

259 and excessive stress-induced steroids cause immature T-lymphocyte apoptosis in thymus.

260 election in the spleen, BCR signaling causes immature T1 B cells to become receptive to Notch ligands

261 ive to conventional root canal treatment for immature teeth.

262 About half of the fish showed immature testes around eleven weeks after fertilization.

263 esults in compensatory hyperproliferation of immature thymocytes and development of T cell lymphoma.

264 We also found that wild-type immature thymocytes can be separated into distinct popul

265 LL cells, and forced expression of ARID5B in immature thymocytes results in thymus retention, differe

266 The ordered migration of immature thymocytes through thymic microenvironments gen

267 ve selections, which are permissive only for immature thymocytes with intermediate avidity to the sel

268 ons and induces the programmed cell death of immature thymocytes.

269 (+)CD38(-)) and concomitantly decreasing the immature transitional (CD27(-)IgD(+)CD38(+)), unswitched

270 D27(+)CD24(high) B10 cells, CD24(hi)CD38(hi) immature transitional B cells, and CD73(-)CD25(+)CD71(+)

271 Immature transitional regulatory B (itBreg) cells are in

272 ent in the cortex and papilla and display an immature tubular phenotype.

273 Infection of immature urothelial cells can result in the formation of

274 of the heart, form through remodeling of an immature vascular plexus in a process triggered and shap

275 lungs are fragile, in part because of their immature vascular structure.

276 role in removing unwanted proteins from the immature vesicle.

277 proinsulin conversion or an accumulation of immature vesicles caused by an increase in insulin deman

278 tion is impaired, leading to accumulation of immature vesicles, or lysosomal vesicle degradation.

279 rrier (BRB) formation in mice, we found that immature vessel leakage occurs entirely through transcyt

280 o the virus and forms the shell of a budding immature viral capsid.

281 rphogenesis was interrupted at a stage after immature virion formation, resulting in the accumulation

282 pport of recent structural models of the RSV immature virions and further suggest that immature parti

283 (VMAPs), that are necessary for formation of immature virions were found.

284 rticles retained the D13 scaffold protein of immature virions, were severely deficient in the transme

285 nclosure of the viral core to form spherical immature virions.

286 t also in their subsequent enclosure to form immature virions.

287 1 polyproteins Gag and Gag-Pol, resulting in immature virions.

288 crescent formation and its enclosure to form immature virions.

289 mal A11 localization despite failing to form immature virions.

290 The beta-turn is critical for immature virus assembly and the 6-helix bundle regulates

291 The spikes in the immature virus have a larger radius and are less compact

292 In addition, the nucleocapsid of the immature virus is more compact than in the mature virus,

293 roteins have less freedom of movement in the immature virus, keeping the fusion loops protected under

294 It was found that immature wheats especially at early stages of kernel dev

295 because ES cell-derived cells are typically immature with impaired functional capacity.

296 two major challenges-(i) generated cells are immature, with limited functional properties; and (ii) c

297 ulated in quiescent (G0) mammalian cells and immature Xenopus laevis oocytes by an FXR1a-associated m

298 dergoing secondary wall expansion, including immature xylem and immature phloem in the stem.

299 facilitates morphogenesis of developmentally immature young.

300 Structures of the mature and immature ZIKV have demonstrated its similarity with othe