ライフサイエンスコーパス: immediate-early

1 The immediate early 1 (IE1) protein of HCMV also rescues p10

2 ot rescued to the same extent as that of the immediate early 1 (IE1) protein, suggesting that TAg exp

3 HLA class I-restricted CMV epitopes from the immediate early 1 gene of CMV, coinfection with genetica

4 n thresholds (50 spots per 250 000 cells for immediate early 1 or 100 spots per 250 000 cells for pho

5 The HCMV immediate early 1 protein cooperated with UL97-L1m to in

6 h STAT3 phosphorylation did not require MCMV immediate early 1, pM27, and late gene expression, it wa

7 We show that the HCMV 72-kDa immediate-early 1 (IE1) protein associates with STAT3 an

8 sing Cas9 and guide RNAs targeting the BmNPV immediate early-1 (ie-1) and me53 genes effectively indu

9 Ag-expressing fibroblasts, expression of the immediate early 2 (IE2) protein was not rescued to the s

10 In this study, we show that the immediate-early 2 (IE2) protein may play a key role in H

11 The mouse cytomegalovirus (MCMV) immediate early 3 protein (611 amino acids; pIE611) is c

12 VZV protein immediate early 62 (IE62), which shares extensive homolo

13 The immediate early 62 protein (IE62) of varicella-zoster vi

14 The immediate early 62 protein (IE62) of varicella-zoster vi

15 y impairs VZV growth, transactivation of the immediate early 63 and glycoprotein E genes, and the pat

16 Tip60 binds to the immediate early adenovirus promoter and suppresses adeno

17 poor recognition of target cells compared to immediate early and early antigen-specific CD8(+) cells.

18 ZIC2 localized at immediate early and early gene cluster regions of the KS

19 a cytopathic effect and the accumulation of immediate early and late viral proteins.

20 lation, a heterochromatic histone mark, from immediate early and latent gene promoters in naturally i

21 uring SMin79 infection, representative viral immediate-early and early gene products as well as viral

22 locus (UL133-UL138(NULL) virus) complete the immediate-early and early phases of infection but are de

23 We have previously shown that ORF45, an immediate-early and tegument protein of Kaposi's sarcoma

24 luorescent protein (tagBFP), marking latent, immediate early, and late viral gene expression, respect

25 rus (CMV) primarily reflect anti-CMV pp65 or immediate early antigen 1 (IE-1) activity.

26 In contrast to US28, HCMV-encoded immediate early antigen was detected in less than 5% of

27 Here, we show that FOSL1 is the main immediate early AP-1 member induced by melanoma oncogene

28 g protein 1 (XBP-1), in trans-activating the immediate early BZLF-1 or BRLF1/gene 50 promoters of Eps

29 Differential modulation of immediate early cellular transcripts (e.g., c-Jun and mu

30 from the viral LTR but not from an internal immediate-early CMV promoter, suggesting a role of SSRP1

31 ngation) to promoters of NF-kappaB-dependent immediate-early cytokine genes, in ATM knockdown cells.

32 t regulates the expression of growth-related immediate-early, cytoskeletal, and muscle-specific genes

33 Immediate early E1A protein levels are unaffected by the

34 ripts, and proteins corresponding to the VZV immediate early, early, and late kinetic phases of repli

35 assified into three distinct kinetic groups: immediate-early, early, and late classes.

36 infection the association of representative immediate-early, early, and late mRNAs with polysomes wa

37 Here, we report that an immediate-early event of Arg-auxotrophic response involv

38 he cluster were generally negative for virus immediate-early expression.

39 d Per1 genes responded to cAMP stimuli in an immediate-early fashion.

40 , functional magnetic resonance imaging, and immediate early gene (c-fos) expression to assess the hy

41 ecursor protein (APP) and TIAM1, and between immediate early gene (IEG) proteins and the HSA21 protei

42 , which regulates cellular proliferation and immediate early gene activation, CaMKII-mediated signali

43 The immediate early gene Arc (also Arg3.1) produces rapid ch

44 Visualization using the immediate early gene Arc revealed sparser and more robus

45 al neurons expressing the plasticity-related immediate early gene Arc.

46 th the BLA and IC based on activation of the immediate early gene Arc; however, we found that infusio

47 R) and the 5-HT2c receptor (5-HT2cR), and an immediate early gene associated with neuronal plasticity

48 n compared with vehicle-pretreated rats, the immediate early gene c-Fos (a marker of neuronal activat

49 ons to light, and enhances expression of the immediate early gene c-fos in the SCN, which is involved

50 rescent protein was under the control of the immediate early gene c-fos promoter as well as time-laps

51 n-specific markers, retrograde tracings, and immediate early gene colocalizations.

52 of artificial aptazymes into the adenoviral immediate early gene E1A enables small-molecule-triggere

53 The adenovirus immediate early gene E1A initiates the program of viral

54 in (ERK/MAP) kinase signaling but not on the immediate early gene EGR-1.

55 was identified as a downstream target of the immediate early gene Egr1.

56 pression of Bpifa2 in mice lacking Nur77, an immediate early gene expressed in the kidneys during AKI

57 deletion showed a lack of activity-triggered immediate early gene expression and altered sensory-rela

58 usion that HCMV pUL97 kinase regulates viral immediate early gene expression by phosphorylation-media

59 s of training-induced transient waves of Arc immediate early gene expression critical for synaptic pl

60 Immediate early gene expression patterns were informativ

61 Analysis of immediate early gene expression revealed parallel up-reg

62 ity at cellular resolution through profiling immediate early gene expression using immunostaining and

63 A2 with no effect on neuronal firing rate or immediate early gene expression.

64 B phosphorylation that coordinately regulate immediate early gene expression.

65 riatal DA was increased and the DA-regulated immediate early gene Fos was upregulated.

66 stochemical detection of the tracers and the immediate early gene Fos.

67 These changes are driven by the immediate early gene Homer1a and signaling from group I

68 how that activation of a learning-associated immediate early gene in rat olfactory cortices is uninte

69 was induced in endothelial cells (ECs) as an immediate early gene in response to PH.

70 e have examined whether deletion of Narp, an immediate early gene induced by electroconvulsive seizur

71 these cortices in DH-compromised animals and immediate early gene induction profiles for amygdala-pro

72 ducible hnRNPK recruitment along a number of immediate early gene loci, including EGR1 and ZFP36, wit

73 A whole brain immediate early gene mapping highlighted the dorsolatera

74 The immediate early gene neuronal activity-regulated pentrax

75 y presynaptic expression of the synaptogenic immediate early gene NPTX2 by pyramidal neurons.

76 urthermore, abnormal expression of FosB, the immediate early gene of L-dopa induced dyskinesia (LID),

77 e, upstream of the predicted promoter of the immediate early gene open reading frame 63 (ORF63).

78 At excitatory glutamatergic synapses, the immediate early gene product Arc/Arg3.1 couples synaptic

79 The pattern of expression of the immediate early gene product cFos was used to identify k

80 at song production induced expression of the immediate early gene product Fos in trigeminal regions t

81 Colocalization of TH with the immediate early gene product Fos, an indirect marker of

82 Consequently, induction of the immediate early gene products and transcription factors

83 A number of herpesvirus immediate early gene products play important roles in th

84 Therefore, understanding of immediate early gene regulation might add insights into

85 Arc is an immediate early gene that is unique among neuronal mRNAs

86 cytoskeleton-associated protein (Arc) is an immediate early gene that modulates neuronal plasticity

87 nes, including Arc, also known as Arg3.1, an immediate early gene that plays a significant role in me

88 s function in herpes simplex virus 1 (HSV-1) immediate early gene transcription, our findings suggest

89 AP kinase (MAPK) phosphorylation to regulate immediate early gene transcription.

90 Nur77 is an immediate early gene whose expression is rapidly upregul

91 activation (as the expression pattern of the immediate early gene ZENK) during sleep in juvenile zebr

92 Thus, altered expression of the immediate early gene Zif268 may contribute to lower leve

93 ewborn neurons that depends on the inducible immediate early gene zif268, processes that are critical

94 nce imaging and in situ hybridization of the immediate early gene zif268, respectively.

95 ntegration of newborn neurons, the inducible immediate early gene zif268/egr1.

96 sions also produced widespread reductions in immediate-early gene (c-fos) expression in a network of

97 s work has shown that epigenetic changes and immediate-early gene (IEG) induction in stress-activated

98 Arc, an immediate-early gene (IEG) product involved in dendritic

99 Arc is a cellular immediate-early gene (IEG) that functions at excitatory

100 e cells (IGCs), many of which upregulate the immediate-early gene Arc after male-male social experien

101 We show that the plasticity-associated immediate-early gene Arc is selectively expressed in IGC

102 ed on the detection of the expression of the immediate-early gene Arc, used as a marker of neuronal a

103 We first compared expression of the immediate-early gene c-Fos in the medial (VP-m) and late

104 experiments indicated that expression of the immediate-early gene c-fos was aberrantly elevated in th

105 actor and tumor suppressor, is induced as an immediate-early gene during hepatic stellate cell (HSC)

106 We report activation of the immediate-early gene Egr-1 in the lateral amygdala (LA),

107 ell measured using brain mapping analyses of immediate-early gene expression and produced a robust si

108 inhibitor, OSMI-1, affects initiation of HSV immediate-early gene expression and viral replication.

109 severely impaired behavioral stimulation of immediate-early gene expression in the mPFC, suggesting

110 p90RSK phosphorylation and the induction of immediate-early gene expression.

111 rus 1 (HSV-1) to limit viral replication and immediate-early gene expression.

112 of glutamate receptors and singing-dependent immediate-early gene expression.

113 and Period2 (Per1 and Per2), as well as the immediate-early gene Fos in the SCN, dorsal hippocampus,

114 ients tested had expression of the EBV major immediate-early gene in the blood indicative of active E

115 95-mediated memory maintenance using ex vivo immediate-early gene mapping, in vivo neuronal recording

116 n the expression of c-Fos and C/EBPbeta, two immediate-early gene markers of neuronal activity.

117 efects in the expression or activity of this immediate-early gene may also contribute to the pathophy

118 ion, SMin92 accumulated representative viral immediate-early gene products, early gene products, and

119 al amygdalar nucleus, and we used lesion and immediate-early gene studies to test our working hypothe

120 the levels of Arc (also known as Arg3.1), an immediate-early gene that is required for long-term memo

121 CCN1 is a product of an immediate-early gene that is transcriptionally induced i

122 n of methionine import, leading to decreased immediate-early gene translation without significant tox

123 ed GABABR activity reduced the expression of immediate-early gene-encoded protein Arc/Arg3.1, effecto

124 on or expression of ICP27, a multifunctional immediate-early gene.

125 significant increases in mRNA expression of immediate early genes (Arc, Egr1), Bdnf and its receptor

126 ering transcription factors and promoters of immediate early genes (IEG) accessible to PARP1-bound ph

127 Among these immediate early genes (IEG), members of the Early growth

128 thin this set of genes we identified several Immediate Early Genes (IEG), which were highly expressed

129 tex, Satb1 binds to genomic loci of multiple immediate early genes (IEGs) (Fos, Fosb, Egr1, Egr2, Arc

130 g-related elevation in the expression of the immediate early genes (IEGs) Arc/Arg3.1 and Egr-1 in the

131 Immediate early genes (IEGs) are activated as a first li

132 PAR-1) increases the expression of multiple immediate early genes (IEGs) associated with growth and

133 Profound induction of immediate early genes (IEGs) by neural activation is a c

134 itiation and the release of paused RNAPII at immediate early genes (IEGs) following transcriptional a

135 tion factor (NELF) complex upon induction of immediate early genes (IEGs) in neurons.

136 Transcription of immediate early genes (IEGs) in response to extrinsic an

137 iption factor Elk-1 stimulates expression of immediate early genes (IEGs) in response to mitogens.

138 Alternatively, post hoc staining of immediate early genes (IEGs) indicates highly active cel

139 ence-driven induction of activity, including immediate early genes (IEGs) such as Fos, Arc and Egr1.

140 In addition and unlike mammalian immediate early genes (IEGs), fly ARGs do not have short

141 fic expression patterns of JUN, FOS and EGR1 immediate early genes (IEGs), reflected by the presence

142 ch to dissect how Erk activity is decoded by immediate early genes (IEGs).

143 tion elongation of the serum response genes (immediate early genes [IEGs]) FOS, EGR1, and cJUN.

144 We found dosage-dependent activation of immediate early genes after 1 h.

145 nes that responded to fight outcome included immediate early genes and genes involved in neuroplastic

146 timulation, activated ERK1/2 is recruited to immediate early genes and phosphorylates INTS11, the cat

147 Insulin-stimulated expression of immediate early genes and proliferation were also potent

148 mulus-dependent recruitment of Integrator at immediate early genes and their enhancers.

149 revealed widespread changes in expression of immediate early genes and their targets, supporting the

150 tivity-dependent manner from the loci of the immediate early genes Arc and Fos.

151 At the molecular level, immediate early genes are among the synaptic plasticity

152 ew mechanistic insights on the regulation of immediate early genes by anesthesia and hypothermia.

153 hat Ikaros did not bind to either of the EBV immediate early genes BZLF1 and BRLF1.

154 es expression of the protein products of the immediate early genes c-fos and arc in new and mature gr

155 ssed long-term changes in activity-dependent immediate early genes c-Fos and Arc/Arg3.1 in auditory a

156 at fear conditioning drove expression of the immediate early genes cFos and Nr4a2 in the hippocampus,

157 ne resulted in decreased expression of viral immediate early genes during infection.

158 ockdown of Sap-1 decreased expression of the immediate early genes egr1 and fos and subsequent prolif

159 One of these immediate early genes encodes naked cuticle homolog 1 (N

160 the mouse ~85% of these neurons express the immediate early genes Erg-1 and c-Fos, indicating that t

161 associated with increased expression of the immediate early genes Fos and FosB and the NMDA receptor

162 1 was decreased along with the expression of immediate early genes like c-fos and Egr-1 by the diseas

163 n inducing Kruppel-like factor 2 and several immediate early genes of the AP1 and Egr family.

164 trongly turning on expression of both of the immediate early genes of the virus, probably by directly

165 Here we show that after UV-C irradiation, immediate early genes such as activating transcription f

166 onal activity causes the rapid expression of immediate early genes that are crucial for experience-dr

167 ting universally at active genes, except for immediate early genes that are strongly induced before M

168 aintaining seizure activity and induction of immediate early genes that control hippocampal excitabil

169 The FGFR immediate early genes that were identified include those

170 aired in iLC, the transcription of the viral immediate early genes UL122 and UL123 and of the delayed

171 After CO2 asphyxiation, several immediate early genes were expressed at lower levels in

172 of proper viral entry, normal expression of immediate early genes, and viral DNA replication.

173 Cs induced a robust expression of a panel of immediate early genes, which included the Nr4a subfamily

174 horylation and, in most cases, expression of immediate early genes.

175 tency to reactivation requires expression of immediate early genes.

176 g variables examined and differed from other immediate early genes.

177 ssessed by quantifying mRNA levels for other immediate early genes.

178 at limit transcription of plasticity-related immediate early genes.

179 only a small percentage of cells expressing immediate-early genes (IE) and early genes.

180 that closely resemble the dynamics of known immediate-early genes (IEGs) and this enables a comprehe

181 Immediate-early genes (IEGs) are rapidly activated after

182 Here, we used the expression of immediate-early genes (IEGs), protooncogene, c-Fos, and

183 or that is functionally deleted for all five immediate-early genes and the 15-kb internal repeat regi

184 ed RNA polymerase II and drive expression of immediate-early genes in neurons.

185 that is required for transactivation of the immediate-early genes of herpes simplex virus (HSV).

186 overexpression of the FosB, ARC, and Zif268 immediate-early genes only in rats experiencing abnormal

187 factor-induced expression of c-Fos and Egr2, immediate-early genes with promoter-proximally paused po

188 ished prior to the stimuli, predominantly at immediate-early genes, and identified specific TF ensemb

189 ng RNA (siRNA) reduced the expression of HSV immediate-early genes, in addition to reducing viral yie

190 Crest or Mef2, as well as activity-regulated immediate-early genes, such as fos and jun.

191 CMV infection by targeting the expression of immediate-early genes.

192 We demonstrate that the viral immediate early ICP0 protein plays a dominant role in th

193 lated by a deletion of the gene encoding the immediate-early ICP0 protein.

194 The levels of immediate early (IE) (IE2), early (E) (pp65), and early/

195 ucleosis (IM) patients, appear skewed toward immediate early (IE) and some early (E) lytic cycle prot

196 HCF-1 stabilizes the viral Immediate Early (IE) gene enhancer complex and mediates

197 ate that pUL97 also functions by influencing immediate early (IE) gene expression during the initial

198 lin-dependent kinase (CDK)-mediated block of immediate early (IE) gene expression in S/G2 phase that

199 Although viral immediate early (IE) gene expression is essential for HC

200 scriptional repressor that can silence viral immediate early (IE) gene expression.

201 HSV mutants defective in multiple immediate early (IE) gene functions are highly defective

202 38-L and pUL138-S are able to suppress major immediate early (IE) gene transcription and the generati

203 HSV mutants defective in multiple immediate early (IE) genes establish a quiescent infecti

204 For example, herpes simplex virus 1 (HSV-1) immediate early (IE) protein ICP0 overcomes the restrict

205 MP1 expression is activated by the BRLF1 (R) immediate early (IE) protein.

206 Indeed, the major immediate early (IE) proteins IE1 and IE2 stimulated the

207 sustained activation of ERK-RSK induce viral immediate early (IE) transcription and late transcriptio

208 al coactivator of herpes simplex virus (HSV) immediate early (IE) transcription, suggesting that OriP

209 nificantly, are typically positive for viral immediate-early (IE) gene expression, in contrast to cir

210 Tegument protein pp71 was cytoplasmic, and immediate-early (IE) genes were silenced as in primary C

211 tone H3 at serine 10 or 28 and expression of immediate-early (IE) genes.

212 Polymerase II (Pol II), hallmarks of poised immediate-early (IE) genes.

213 al gene expression encoded at the hCMV major immediate-early (IE) locus.

214 sequently reduced, but not eliminated, by an immediate-early (IE) or early (E) virus-encoded function

215 sed on the regulatory functions of ICP27, an immediate-early (IE) protein of herpes simplex virus 1 (

216 Human cytomegalovirus (HCMV) immediate-early (IE) proteins that are endogenously expr

217 hly regulated, with sequential expression of immediate-early (IE), early (E), and late (L) gene trans

218 ranscription of mouse cytomegalovirus (MCMV) immediate early ie1 and ie3 is controlled by the major i

219 on factor, an event triggering expression of immediate early, IFN-stimulated genes (ISGs).

220 Imaging of brain slices revealed immediate early induction of beta-actin transcription af

221 In comparison, immediate early IRF3 activation was not observed in infl

222 eolar macrophages from HCMV carriers express immediate early lytic genes and produce infectious virus

223 , without much effect on lytic switch ORF50, immediate early lytic K8, and viral interferon-regulator

224 ot increase T cell responses to rhBZLF-1, an immediate early lytic phase antigen of rhLCV, thus indic

225 RNAs (EBERs) and the increased expression of immediate-early lytic and latency mRNAs and proteins.

226 epitope if KCSRNRQYL is expressed within the immediate-early MCMV gene ie2 The same epitope expressed

227 The human cytomegalovirus (HCMV) major immediate early (MIE) gene is essential for viral replic

228 vely link human cytomegalovirus (HCMV) major immediate early (MIE) latent-lytic switch activation wit

229 acetylation associating with the viral major immediate early (MIE) promoter.

230 Two of the alternative major immediate early (MIE) transcripts initiate in the first

231 expression impacts the accumulation of major immediate early (MIE) transcripts.

232 intron A of the cytomegalovirus (CMV) major immediate-early (MIE) gene and functions to repress MIE

233 tly reduced the accumulation of late but not immediate early or early viral antigens and had no appre

234 ine type) was found in the resected stomach; immediate early (ORF63p) and late (gE) VZV proteins were

235 ing molecules, that MyD88 is required for an immediate early phase, whereas Toll/IL-1R domain-contain

236 (HSV-1) infected cell protein 0 (ICP0) is an immediate-early phosphoprotein that transactivates viral

237 matintranscription (FACT) binds to the major immediate early promoter (MIEP) and that inhibition of t

238 ion of the core promoter region of the major immediate early promoter (MIEP) from a plasmid containin

239 t 19S RP subunits are recruited to the major immediate early promoter (MIEP) that directs IE transcri

240 tte under the control of the cytomegalovirus immediate early promoter into the VC2 vector in place of

241 GPCR results in transcription from the major immediate early promoter, the production of extracellula

242 early ie1 and ie3 is controlled by the major immediate early promoter/enhancer (MIEP) and requires di

243 ty of promoters, such as the cytomegalovirus immediate-early promoter, the IFN-beta promoter, and a p

244 ls by synergistically activating the two EBV immediate early promoters (Zp and Rp).

245 KAP1 also binds to EBV OriLyt and immediate early promoters in a CTAR3-dependent manner, a

246 sion protein under the control of endogenous immediate early promoters.

247 R-200 miRNA family members target the UL122 (immediate early protein 2) 3' untranslated region, resul

248 Epstein-Barr virus (EBV) is mediated by the immediate early protein BZLF1 (Z).

249 The immediate early protein ICP0 of herpes simplex virus 1 (

250 The herpes simplex virus 1 (HSV-1) immediate early protein ICP0 performs many functions dur

251 DNA-PKcs and in cells cotransfected with the immediate early protein ICP0, which degrades DNA-PKcs.

252 larities with herpes simplex virus 1 (HSV-1) immediate early protein ICP0, which stimulates lytic HSV

253 ro cells and that certain mutations in viral immediate early protein ICP27 can confer LMB resistance.

254 In addition, synthesis of the immediate early protein ICP27 causes partial inhibition

255 Human cytomegalovirus (HCMV) immediate early protein IE1 and the tegument protein pp7

256 was dependent on the expression of ICP0, an immediate early protein of HSV-1.

257 The immediate early protein of the virus ICP0 plays major ro

258 ORF59 binds to oriLyt through an immediate early protein, replication and transcription a

259 T inhibitors prevent expression of the viral immediate-early protein BZLF1.

260 the interaction between the C-USP7 and HSV-1 immediate-early protein ICP0 (infected cell protein 0),

261 Herpes simplex virus type 1 immediate-early protein ICP0 is an E3 ubiquitin ligase o

262 Herpes simplex virus 1 (HSV-1) immediate-early protein ICP0 is required for efficient l

263 The immediate-early protein ICP0, which requires VP22 for pa

264 Human cytomegalovirus immediate-early protein pUL37 x 1 induces Bax mitochondr

265 The human cytomegalovirus immediate-early protein pUL37x1 induces the release of C

266 The herpes simplex virus 1 (HSV-1) immediate-early protein, infected cell protein 22 (ICP22

267 s all required prior expression of the viral immediate early proteins for activation in fibroblasts.

268 reased and prolonged expression of the viral immediate early proteins.

269 The Epstein-Barr virus (EBV) immediate-early proteins BZLF1 and BRLF1 can both induce

270 erentially affect the ability of the two EBV immediate-early proteins, BZLF1 (Z) and BRLF1 (R), to in

271 s normally overcome by viral tegument and/or immediate-early proteins.

272 IK-1 also complexed with the EBV immediate early R protein in coimmunoprecipitation assay

273 Because ICER is an immediate-early repressor, the circadian nature of adren

274 formation, associates with the expression of immediate early response 3 (Ier3) as part of a prooncoge

275 Here, we report an unexpected role for immediate early response gene X-1 (IEX-1), a downstream

276 We also show that a number of immediate early response genes (IEGs) are responsible fo

277 of non-coding RNAs in the attenuation of the immediate early response in a small RNA sequencing datas

278 hways, the key molecular determinants during immediate early response remain elusive.

279 ormal conditions, it initiates the so-called immediate early response, which encompasses the transien

280 and the multifunctional stress response gene immediate early response-3 (IER3) has a crucial role und

281 n data we have examined the induction of the immediate-early response in unparalleled detail, across

282 The immediate-early response mediates cell fate in response

283 tial therapeutic intervention point at a pre-immediate early stage for the inhibition of HCMV infecti

284 svirus (KSHV) is a gammaherpesvirus-specific immediate-early tegument protein.

285 ts Bax to the MAM as well as to the OMM from immediate early through late times of infection.

286 MIE mRNA was the most abundant transcript at immediate early times, the novel MIE transcripts accumul

287 on, indicating important roles for the BZLF1 immediate early transactivator, the BHRF1 vBcl-2 homolog

288 irus engineered with a mutation in the major immediate-early transactivator protein RTA.

289 The immediate early transcription unit 1 (IEtu1) promoter, w

290 The essential immediate early transcriptional activator RTA, encoded b

291 omoter driving expression of RTA, a critical immediate early transcriptional activator.

292 ever, the extent of their involvement in the immediate-early transcriptional response, and their wide

293 The accumulation of immediate early transcripts differed between MRC5 cells

294 idization (RNA-FISH) of the intron region of immediate early transcripts, we visualized active transc

295 usceptibility to the inhibition of early and immediate early viral gene expression.

296 posi's sarcoma-associated herpesvirus (KSHV) immediate early viral gene K4.2 encodes an endoplasmic r

297 ells successfully based on the expression of immediate early viral protein.

298 of cells with CRISPR targeting ICP0 plus the immediate early viral proteins, ICP4 or ICP27, completel

299 , function to initiate entry, participate in immediate early viral replication steps, and are major t

300 se degrades stable cellular mRNAs and alpha (immediate early) viral mRNAs; (b) it stabilizes host str