ライフサイエンスコーパス: immediate-early gene

1 Plk3 first was identified and cloned as an immediate early gene.

2 on or expression of ICP27, a multifunctional immediate-early gene.

3 horylation and, in most cases, expression of immediate early genes.

4 The first wave includes conserved immediate early genes.

5 actor beta-inducible genes, and a third with immediate early genes.

6 at limit transcription of plasticity-related immediate early genes.

7 tency to reactivation requires expression of immediate early genes.

8 g variables examined and differed from other immediate early genes.

9 ssessed by quantifying mRNA levels for other immediate early genes.

10 sses in expression of VSV protein and MHV-68 immediate-early genes.

11 rogenic genes and the ubiquitously expressed immediate-early genes.

12 te the transcription of many proinflammatory immediate-early genes.

13 virus, and genetically dependent upon viral immediate-early genes.

14 d the induction of the expression of several immediate-early genes.

15 n by MAP kinase, activates the expression of immediate-early genes.

16 pression of their own genes, including their immediate-early genes.

17 CMV infection by targeting the expression of immediate-early genes.

18 , which regulates cellular proliferation and immediate early gene activation, CaMKII-mediated signali

19 VNX males and enhances medial amygdala (Me) immediate-early gene activation by chemosensory stimulat

20 The immediate early gene, activity-regulated cytoskeleton-as

21 We found dosage-dependent activation of immediate early genes after 1 h.

22 Immediate early gene analysis and single unit recordings

23 ty and neurons double-labeled with c-Fos, an immediate early gene and the tracer were increased signi

24 old higher levels of expression of mRNAs for immediate early genes and 2- to 5-fold higher levels of

25 nes that responded to fight outcome included immediate early genes and genes involved in neuroplastic

26 timulation, activated ERK1/2 is recruited to immediate early genes and phosphorylates INTS11, the cat

27 Insulin-stimulated expression of immediate early genes and proliferation were also potent

28 Although cell adhesion also can regulate immediate early genes and proliferation, the mechanism f

29 mulus-dependent recruitment of Integrator at immediate early genes and their enhancers.

30 revealed widespread changes in expression of immediate early genes and their targets, supporting the

31 or that is functionally deleted for all five immediate-early genes and the 15-kb internal repeat regi

32 of proper viral entry, normal expression of immediate early genes, and viral DNA replication.

33 ished prior to the stimuli, predominantly at immediate-early genes, and identified specific TF ensemb

34 The immediate early gene Arc (also Arg3.1) produces rapid ch

35 the plasticity related behaviourally-induced immediate early gene Arc is altered within the CA3 and t

36 Here, we report that the immediate early gene Arc is required for activity-depend

37 Visualization using the immediate early gene Arc revealed sparser and more robus

38 al neurons expressing the plasticity-related immediate early gene Arc.

39 to global synaptic plasticity, requires the immediate early gene Arc.

40 ellar Purkinje cells, as did deletion of the immediate early gene Arc.

41 The mRNA for the immediate early gene Arc/Arg3.1 is induced by strong syn

42 th the BLA and IC based on activation of the immediate early gene Arc; however, we found that infusio

43 tivity-dependent manner from the loci of the immediate early genes Arc and Fos.

44 These genes included altered levels of the immediate early genes arc, fosB, and nr4a3, as well as g

45 lar distribution of the behaviorally induced immediate-early gene Arc (activity-regulated cytoskeleto

46 sitive correlation between expression of the immediate-early gene Arc (activity-regulated, cytoskelet

47 Experience-induced expression of immediate-early gene Arc (also known as Arg3.1) is known

48 e cells (IGCs), many of which upregulate the immediate-early gene Arc after male-male social experien

49 We show that the plasticity-associated immediate-early gene Arc is selectively expressed in IGC

50 ed on the detection of the expression of the immediate-early gene Arc, used as a marker of neuronal a

51 show that fast dendritic translation of the immediate-early gene Arc/Arg3.1 is involved in hippocamp

52 significant increases in mRNA expression of immediate early genes (Arc, Egr1), Bdnf and its receptor

53 ade signal that induces transcription of the immediate early genes, Arc and c-Fos.

54 At the molecular level, immediate early genes are among the synaptic plasticity

55 viruses use microRNA-mediated suppression of immediate-early genes as part of their strategy to enter

56 R) and the 5-HT2c receptor (5-HT2cR), and an immediate early gene associated with neuronal plasticity

57 Using the immediate early gene-based brain-imaging method called c

58 ew mechanistic insights on the regulation of immediate early genes by anesthesia and hypothermia.

59 hat Ikaros did not bind to either of the EBV immediate early genes BZLF1 and BRLF1.

60 n compared with vehicle-pretreated rats, the immediate early gene c-Fos (a marker of neuronal activat

61 in the nTS was measured by expression of the immediate early gene c-Fos [c-Fos-like immunoreactivity

62 ssed LC activity by measuring changes in the immediate early gene c-fos and the enzyme tyrosine hydro

63 unctions, we have used the expression of the immediate early gene c-Fos as a marker for neurons activ

64 We also monitored immediate early gene c-fos expression following colorect

65 peated restraint stress on expression of the immediate early gene c-fos in neurons containing parvalb

66 APOS and NTS also showed expression of immediate early gene c-FOS in the hindbrain in AMN+LEP-t

67 anscriptional activation of mPeriod1 and the immediate early gene c-Fos in the SCN in response to a p

68 ons to light, and enhances expression of the immediate early gene c-fos in the SCN, which is involved

69 The immediate early gene c-Fos is necessary for CTA learning

70 rescent protein was under the control of the immediate early gene c-fos promoter as well as time-laps

71 Neuronal activity mapping using the immediate early gene c-fos reveals the engagement of dis

72 d for changes in FOS (protein product of the immediate early gene c-fos) and phosphate activated glut

73 Analysis of neuronal activity, using the immediate early gene c-fos, demonstrated a reduced neuro

74 es expression of the protein products of the immediate early genes c-fos and arc in new and mature gr

75 ssed long-term changes in activity-dependent immediate early genes c-Fos and Arc/Arg3.1 in auditory a

76 n levels of the learning- and memory-related immediate early genes c-Fos and Egr-1 were normalized or

77 partly facilitated by the expression of the immediate-early gene c-fos and the resulting transcripti

78 Experiment 1 assessed the expression of the immediate-early gene c-fos in rats that discriminated no

79 We first compared expression of the immediate-early gene c-Fos in the medial (VP-m) and late

80 experiments indicated that expression of the immediate-early gene c-fos was aberrantly elevated in th

81 ylation and expression of the product of the immediate-early gene c-Fos were assessed by immunohistoc

82 ing neurons was detected by staining for the immediate-early gene c-fos, thus supporting earlier find

83 , functional magnetic resonance imaging, and immediate early gene (c-fos) expression to assess the hy

84 sions also produced widespread reductions in immediate-early gene (c-fos) expression in a network of

85 n patterns with extracellular recordings and immediate-early gene (c-Fos) expression.

86 nserved non-coding sequences (CNSs) of three immediate early genes: c-fos, JunB and EGR-1.

87 at fear conditioning drove expression of the immediate early genes cFos and Nr4a2 in the hippocampus,

88 n-specific markers, retrograde tracings, and immediate early gene colocalizations.

89 Cholinergic signaling induces Arc/Arg3.1, an immediate early gene crucial for synaptic plasticity.

90 ne resulted in decreased expression of viral immediate early genes during infection.

91 actor and tumor suppressor, is induced as an immediate-early gene during hepatic stellate cell (HSC)

92 of artificial aptazymes into the adenoviral immediate early gene E1A enables small-molecule-triggere

93 The adenovirus immediate early gene E1A initiates the program of viral

94 The immediate-early gene early growth response 3 (Egr3) is a

95 d quantified sound-induced expression of the immediate early gene egr-1 in nine brain regions that co

96 t a common point involving activation of the immediate early gene Egr-1.

97 in (ERK/MAP) kinase signaling but not on the immediate early gene EGR-1.

98 n in anurans, the authors used expression of immediate-early gene egr-1 as a marker of neural activat

99 We report activation of the immediate-early gene Egr-1 in the lateral amygdala (LA),

100 ons highlighted the response element for the immediate early gene egr1 (EGR1-RE) as a candidate for a

101 down- or up-regulation, respectively, of the immediate early gene Egr1 in the bullwhip cells; indicat

102 was identified as a downstream target of the immediate early gene Egr1.

103 ockdown of Sap-1 decreased expression of the immediate early genes egr1 and fos and subsequent prolif

104 ction of angiogenic factors such as CCN1, an immediate-early gene-encoded matricellular molecule crit

105 ed GABABR activity reduced the expression of immediate-early gene-encoded protein Arc/Arg3.1, effecto

106 One of these immediate early genes encodes naked cuticle homolog 1 (N

107 Egr-1 (early growth response gene-1) is an immediate early gene encoding a zinc finger motif-contai

108 the mouse ~85% of these neurons express the immediate early genes Erg-1 and c-Fos, indicating that t

109 pression of Bpifa2 in mice lacking Nur77, an immediate early gene expressed in the kidneys during AKI

110 elivery does influence its ability to induce immediate early gene expression (IEG) in the striatum, a

111 neuronal marker profile and activity-induced immediate early gene expression 1-2 weeks earlier than t

112 deletion showed a lack of activity-triggered immediate early gene expression and altered sensory-rela

113 ands of fibronectin suppressed serum-induced immediate early gene expression and S phase entry.

114 Recent work using immediate early gene expression as a marker of neural ac

115 usion that HCMV pUL97 kinase regulates viral immediate early gene expression by phosphorylation-media

116 s of training-induced transient waves of Arc immediate early gene expression critical for synaptic pl

117 The capacity of SB-277011-A to trigger immediate early gene expression in these limbic regions

118 Immediate early gene expression patterns were informativ

119 Analysis of immediate early gene expression revealed parallel up-reg

120 kines such as TNF] can alter local astrocyte immediate early gene expression that, in turn, can provo

121 ity at cellular resolution through profiling immediate early gene expression using immunostaining and

122 tracellular signalling cascades that lead to immediate early gene expression, and in this way influen

123 lovian fear conditioning, activity-dependent immediate early gene expression, and in vivo electrophys

124 ar signal-regulated kinase (ERK) activation, immediate early gene expression, or expression of CCAAT/

125 pression in the ability of cocaine to induce immediate early gene expression.

126 co-chaperone, as a regulator of herpes virus immediate early gene expression.

127 A2 with no effect on neuronal firing rate or immediate early gene expression.

128 B phosphorylation that coordinately regulate immediate early gene expression.

129 s measured by intracellular calcium flux and immediate-early gene expression (FBJ murine osteosarcoma

130 ell measured using brain mapping analyses of immediate-early gene expression and produced a robust si

131 inhibitor, OSMI-1, affects initiation of HSV immediate-early gene expression and viral replication.

132 revealed an approximately 2-fold decrease in immediate-early gene expression at 4 to 10 h postinfecti

133 severely impaired behavioral stimulation of immediate-early gene expression in the mPFC, suggesting

134 These include ERK activity, immediate-early gene expression, and cdk inhibitor expre

135 s were dependent on progression beyond viral immediate-early gene expression, but not dependent on vi

136 ncy in vivo is associated with repression of immediate-early gene expression, deacetylation of histon

137 rus 1 (HSV-1) to limit viral replication and immediate-early gene expression.

138 of glutamate receptors and singing-dependent immediate-early gene expression.

139 and immunohistochemical methods to quantify immediate-early gene expression.

140 e UL29/28 locus contributes to activation of immediate-early gene expression.

141 ally unique signal that selectively triggers immediate-early gene expression.

142 p90RSK phosphorylation and the induction of immediate-early gene expression.

143 these results identify a novel role for HSV immediate-early-gene expression in regulating mucosal im

144 s impaired in expression of the ICP4 or ICP0 immediate-early gene failed to downregulate SLPI or acti

145 riatal DA was increased and the DA-regulated immediate early gene Fos was upregulated.

146 stochemical detection of the tracers and the immediate early gene Fos.

147 associated with increased expression of the immediate early genes Fos and FosB and the NMDA receptor

148 and Period2 (Per1 and Per2), as well as the immediate-early gene Fos in the SCN, dorsal hippocampus,

149 in disorders characterized by alterations in immediate early genes, further supporting the concept th

150 These changes are driven by the immediate early gene Homer1a and signaling from group I

151 receptor activation that is mediated by the immediate early gene Homer1a.

152 only a small percentage of cells expressing immediate-early genes (IE) and early genes.

153 influenced neural activity in females, using immediate early gene (IEG) expression as a proxy for bra

154 is an addictive psychostimulant that induces immediate early gene (IEG) expression by activating dopa

155 Operant learning induces immediate early gene (IEG) expression in key corticostri

156 ecursor protein (APP) and TIAM1, and between immediate early gene (IEG) proteins and the HSA21 protei

157 ering transcription factors and promoters of immediate early genes (IEG) accessible to PARP1-bound ph

158 us (SON) increases the expression of several immediate early genes (IEG) and the vasopressin gene.

159 The induction of expression of many cellular immediate early genes (IEG) involves the transcription f

160 Among these immediate early genes (IEG), members of the Early growth

161 thin this set of genes we identified several Immediate Early Genes (IEG), which were highly expressed

162 mory consolidation require expression of the immediate-early gene (IEG) Arc.

163 s work has shown that epigenetic changes and immediate-early gene (IEG) induction in stress-activated

164 ons (10% focal ablation) with singing-driven immediate-early gene (IEG) labeling to explore the netwo

165 Arc, an immediate-early gene (IEG) product involved in dendritic

166 Arc is a cellular immediate-early gene (IEG) that functions at excitatory

167 ed cytoskeletal-associated protein (Arc), an immediate-early gene (IEG) whose expression is tightly l

168 tex, Satb1 binds to genomic loci of multiple immediate early genes (IEGs) (Fos, Fosb, Egr1, Egr2, Arc

169 cues associated with those stimuli using the immediate early genes (IEGs) Arc and Homer1a.

170 g-related elevation in the expression of the immediate early genes (IEGs) Arc/Arg3.1 and Egr-1 in the

171 Immediate early genes (IEGs) are activated as a first li

172 PAR-1) increases the expression of multiple immediate early genes (IEGs) associated with growth and

173 Profound induction of immediate early genes (IEGs) by neural activation is a c

174 n 32 kDa (DARPP-32) and blunted induction of immediate early genes (IEGs) c-Fos, Egr-1, and Homer 1a

175 itiation and the release of paused RNAPII at immediate early genes (IEGs) following transcriptional a

176 Many immediate early genes (IEGs) have activity-dependent ind

177 Transcription of immediate early genes (IEGs) in neurons is highly sensit

178 tion factor (NELF) complex upon induction of immediate early genes (IEGs) in neurons.

179 Transcription of immediate early genes (IEGs) in response to extrinsic an

180 iption factor Elk-1 stimulates expression of immediate early genes (IEGs) in response to mitogens.

181 Alternatively, post hoc staining of immediate early genes (IEGs) indicates highly active cel

182 ence-driven induction of activity, including immediate early genes (IEGs) such as Fos, Arc and Egr1.

183 nges in the expression of several members of immediate early genes (IEGs) which are known to control

184 cators of functional activity, including the immediate early genes (IEGs) zif268 (egr1), c-fos, and a

185 investigated the acoustic modulation of two immediate early genes (IEGs), egr-1 and fos, in the audi

186 In addition and unlike mammalian immediate early genes (IEGs), fly ARGs do not have short

187 fic expression patterns of JUN, FOS and EGR1 immediate early genes (IEGs), reflected by the presence

188 ch to dissect how Erk activity is decoded by immediate early genes (IEGs).

189 that closely resemble the dynamics of known immediate-early genes (IEGs) and this enables a comprehe

190 Immediate-early genes (IEGs) are rapidly activated after

191 Immediate-early genes (IEGs) are tightly coupled to cell

192 Here, we used the expression of immediate-early genes (IEGs), protooncogene, c-Fos, and

193 hese conditions, we obtained profiles of the immediate-early genes (IEGs, at 30 minutes), early genes

194 tion elongation of the serum response genes (immediate early genes [IEGs]) FOS, EGR1, and cJUN.

195 Using immediate early gene imaging (c-Fos), fiber-sparing exci

196 trophysiological recordings, lesion studies, immediate-early gene imaging, transgenic mouse models, a

197 dentify Gadd45b as a neural activity-induced immediate early gene in mature hippocampal neurons.

198 how that activation of a learning-associated immediate early gene in rat olfactory cortices is uninte

199 was induced in endothelial cells (ECs) as an immediate early gene in response to PH.

200 The fruitless gene, immediate early genes in discrete serotonin neurons, or

201 associated with a striking up-regulation of immediate early genes in the prelimbic region of the med

202 ients tested had expression of the EBV major immediate-early gene in the blood indicative of active E

203 ed RNA polymerase II and drive expression of immediate-early genes in neurons.

204 that CIKS is essential for all IL-17-induced immediate-early genes in primary mouse embryo fibroblast

205 ng RNA (siRNA) reduced the expression of HSV immediate-early genes, in addition to reducing viral yie

206 Several of these p300 targets are immediate early genes, including FOS, implicating a prom

207 e have examined whether deletion of Narp, an immediate early gene induced by electroconvulsive seizur

208 e mice show deficient plasticity of striatal immediate early gene inducibility after repeated AMPH ad

209 these cortices in DH-compromised animals and immediate early gene induction profiles for amygdala-pro

210 stone H3 is a complex phenomenon involved in Immediate-early gene induction in metazoan eukaryotes.

211 t both receptor populations up-regulate many immediate early genes involved in growth and differentia

212 neural activity rapidly upregulates mRNAs of immediate early genes involved in synaptic plasticity, o

213 h as eukaryotic elongation factor 1A and the immediate early gene JunB.

214 1 was decreased along with the expression of immediate early genes like c-fos and Egr-1 by the diseas

215 ducible hnRNPK recruitment along a number of immediate early gene loci, including EGR1 and ZFP36, wit

216 of cohesins and loss of CTCF binding at the immediate early gene locus, suggesting that cohesins may

217 A whole brain immediate early gene mapping highlighted the dorsolatera

218 Immediate early gene mapping using zif268 in situ hybrid

219 95-mediated memory maintenance using ex vivo immediate-early gene mapping, in vivo neuronal recording

220 n the expression of c-Fos and C/EBPbeta, two immediate-early gene markers of neuronal activity.

221 Cooperation among the protein products of immediate early genes may be a common mechanism for driv

222 efects in the expression or activity of this immediate-early gene may also contribute to the pathophy

223 The immediate-early gene Narp (neuronal activity-regulated p

224 The immediate early gene neuronal activity-regulated pentrax

225 y presynaptic expression of the synaptogenic immediate early gene NPTX2 by pyramidal neurons.

226 ated transgenic mice expressing GFP from the immediate early gene Nr4a1 (Nur77) locus.

227 urthermore, abnormal expression of FosB, the immediate early gene of L-dopa induced dyskinesia (LID),

228 otein is essential for the expression of the immediate early genes of both herpes simplex virus (HSV)

229 n inducing Kruppel-like factor 2 and several immediate early genes of the AP1 and Egr family.

230 trongly turning on expression of both of the immediate early genes of the virus, probably by directly

231 that is required for transactivation of the immediate-early genes of herpes simplex virus (HSV).

232 or mediating the regulated expression of the immediate-early genes of the alphaherpesviruses herpes s

233 overexpression of the FosB, ARC, and Zif268 immediate-early genes only in rats experiencing abnormal

234 e, upstream of the predicted promoter of the immediate early gene open reading frame 63 (ORF63).

235 Expression of the homer 1a (H1a) immediate-early gene produces a short homer protein that

236 ofilin and is modulated by expression of the immediate early gene product Arc.

237 and breadth of functional importance as the immediate early gene product Arc.

238 At excitatory glutamatergic synapses, the immediate early gene product Arc/Arg3.1 couples synaptic

239 The pattern of expression of the immediate early gene product cFos was used to identify k

240 Immunostaining of the immediate early gene product Fos and CTB was performed t

241 at song production induced expression of the immediate early gene product Fos in trigeminal regions t

242 Colocalization of TH with the immediate early gene product Fos, an indirect marker of

243 d PSD-95, (3) the MAP kinase p38 and (4) the immediate early gene product MKP1.

244 Because Narp is an immediate early gene product that is secreted at synapti

245 We utilized the immediate early gene product, early growth response prot

246 mapped expression of the activity-dependent, immediate-early gene product Fos in the brains of wild-t

247 (ER(alpha)), androgen receptor (AR), and the immediate-early gene product Fos were identified immunoc

248 The immediate-early gene product K-Rta is the first viral pr

249 Consequently, induction of the immediate early gene products and transcription factors

250 A number of herpesvirus immediate early gene products play important roles in th

251 ion, SMin92 accumulated representative viral immediate-early gene products, early gene products, and

252 ffect on PML-NBs is similar to that of viral immediate-early gene products, such as infected cellular

253 TNFalpha and IL1 beta, as well as the immediate early gene protein Fos, were higher at the end

254 signals (male, female mouse urine) increased immediate early gene-protein (IEG) expression in both an

255 Here, we identify c-fos, an immediate early gene rapidly induced in striatum after a

256 Therefore, understanding of immediate early gene regulation might add insights into

257 previously that in white-throated sparrows, immediate early gene responses in the auditory pathway o

258 al amygdalar nucleus, and we used lesion and immediate-early gene studies to test our working hypothe

259 Here we show that after UV-C irradiation, immediate early genes such as activating transcription f

260 ced by tumor promoters (EGF, UV and TPA) and immediate early genes, such as c-myc, c-jun and c-fos.

261 d activation of multiple protein kinases and immediate early genes, such as cFos, enabling rapid and

262 Crest or Mef2, as well as activity-regulated immediate-early genes, such as fos and jun.

263 This network, based on the immediate early gene system, has two possible, mutually

264 Our work defines TSP-1 as a novel immediate early gene that could be a potential therapeut

265 eletal-associated protein (Arc/Arg3.1) is an immediate early gene that has been widely implicated in

266 Arc is an immediate early gene that is unique among neuronal mRNAs

267 cytoskeleton-associated protein (Arc) is an immediate early gene that modulates neuronal plasticity

268 nes, including Arc, also known as Arg3.1, an immediate early gene that plays a significant role in me

269 onal activity causes the rapid expression of immediate early genes that are crucial for experience-dr

270 ting universally at active genes, except for immediate early genes that are strongly induced before M

271 aintaining seizure activity and induction of immediate early genes that control hippocampal excitabil

272 Abnormalities in the expression profile of immediate early genes that play a critical role in memor

273 The FGFR immediate early genes that were identified include those

274 -1) is encoded by mkp-1, a stress-responsive immediate-early gene that dephosphorylates MAPKs in the

275 eletal-associated protein (Arc/Arg3.1) is an immediate-early gene that has been widely implicated in

276 the levels of Arc (also known as Arg3.1), an immediate-early gene that is required for long-term memo

277 CCN1 is a product of an immediate-early gene that is transcriptionally induced i

278 Transcribed as a 1.8-kb family of immediate-early genes, the mature bicistronic mRNAs have

279 s function in herpes simplex virus 1 (HSV-1) immediate early gene transcription, our findings suggest

280 AP kinase (MAPK) phosphorylation to regulate immediate early gene transcription.

281 CTCF are required for the repression of KSHV immediate early gene transcription.

282 gene expression early in development, and in immediate early gene transcription.

283 n of methionine import, leading to decreased immediate-early gene translation without significant tox

284 aired in iLC, the transcription of the viral immediate early genes UL122 and UL123 and of the delayed

285 After CO2 asphyxiation, several immediate early genes were expressed at lower levels in

286 Cs induced a robust expression of a panel of immediate early genes, which included the Nr4a subfamily

287 Nur77 is an immediate early gene whose expression is rapidly upregul

288 eleton-associated protein (Arc/Arg3.1) is an immediate early gene, whose expression in the central ne

289 factor-induced expression of c-Fos and Egr2, immediate-early genes with promoter-proximally paused po

290 s a member of a family of mRNAs expressed as immediate-early genes with two open reading frames (ORF)

291 ly, in AI, there was downregulation at 5T of immediate-early gene, Wnt (wingless integration site), i

292 activation (as the expression pattern of the immediate early gene ZENK) during sleep in juvenile zebr

293 0-15,000 genes, validating it by analysis of immediate-early gene (zenk) gene activation following so

294 Thus, altered expression of the immediate early gene Zif268 may contribute to lower leve

295 ewborn neurons that depends on the inducible immediate early gene zif268, processes that are critical

296 nce imaging and in situ hybridization of the immediate early gene zif268, respectively.

297 scription factor ATF4 to the promoter of the immediate early gene zif268, which competitively inhibit

298 ntegration of newborn neurons, the inducible immediate early gene zif268/egr1.

299 Induction of the immediate-early gene Zif268 was then measured, so reveal

300 ions in expression of the plasticity-related immediate early gene, zif268.