ライフサイエンスコーパス: immediate-early protein

1 ly protein activates expression of the other immediate-early protein.

2 domain found in a bovine herpesvirus 4 major immediate-early protein.

3 l cells) or BRLF1 (in epithelial cells only) immediate-early protein.

4 miR-UL112-1 inhibits expression of the major immediate-early protein.

5 oma-associated herpesvirus (KSHV) encodes an immediate-early protein.

6 ecognition of virion input proteins or viral immediate early proteins.

7 reased and prolonged expression of the viral immediate early proteins.

8 accumulates at ND10 before the production of immediate-early proteins.

9 ranscriptional activation by cytomegalovirus immediate-early proteins.

10 s normally overcome by viral tegument and/or immediate-early proteins.

11 mutants deleted for various combinations of immediate-early proteins.

12 n 65 (pp65), phosphoprotein 150 (pp150), and immediate early protein 1 (IE1) immunodominant antigens

13 8(+) T cell responses to the pp65 (UL83) and immediate early protein 1 (IE1; UL123) gene products in

14 lls recognized the CMV phosphoprotein 65 and immediate early protein 1, which have been considered ma

15 The cytomegalovirus (CMV) immediate-early protein 1 (IE1) was previously shown to

16 miR-112-1, was predicted to target the viral immediate-early protein 1 mRNA.

17 human cytomegalovirus tegument proteins and immediate-early protein 1.

18 ve characterized the mechanisms by which the immediate early protein 2 (IE2 or IE86), a master transc

19 te for the human cytomegalovirus (CMV) UL122 immediate early protein 2 (IE86).

20 R-200 miRNA family members target the UL122 (immediate early protein 2) 3' untranslated region, resul

21 Immediate-early protein 2 expression is modestly reduced

22 VZV immediate early protein 62 (IE62) is recognized by cytot

23 n did not require VZV replication; the viral immediate-early protein 62 (IE62) alone was sufficient t

24 and 2 confer amino acid substitutions in the immediate-early protein 62.

25 racterized by the abundant expression of the immediate early protein 63 (IE63), whereas other viral p

26 hibition of CaMKK has a negligible impact on immediate-early-protein accumulation yet severely attenu

27 ins are transcriptional activators, and each immediate-early protein activates expression of the othe

28 utant virus accumulated representative viral immediate-early proteins and early proteins normally.

29 We find that the HCMV immediate early proteins are mutagenic, and we propose t

30 st CD8+ cytotoxic T lymphocytes specific for immediate-early protein are present in seropositive indi

31 e previously demonstrated that ORF45, a KSHV immediate-early protein as well as a tegument protein of

32 ription factor Oct-1 cooperates with the EBV immediate-early protein BRLF1 (R, Rta) to induce lytic v

33 The Epstein-Barr virus (EBV) immediate-early protein BRLF1 is a transcriptional activ

34 The Epstein-Barr Virus (EBV) immediate-early protein BRLF1 is one of two transactivat

35 t, unexpectedly, expression of another viral immediate-early protein, BRLF1, can disrupt viral latenc

36 ired virus resulted in similar levels of VZV immediate-early proteins but reduced levels of glycoprot

37 Epstein-Barr virus (EBV) is mediated by the immediate early protein BZLF1 (Z).

38 The Epstein-Barr virus (EBV) immediate-early protein BZLF1 (Z) is a key regulator of

39 The Epstein-Barr virus (EBV) immediate-early protein BZLF1 (Z) mediates the switch be

40 xpression of either Epstein-Barr virus (EBV) immediate-early protein BZLF1 (Z) or BRLF1 (R) is suffic

41 The EBV immediate-early protein BZLF1 functions as a transcripti

42 The Epstein-Barr virus (EBV) immediate-early protein BZLF1 is a transcriptional activ

43 The Epstein-Barr virus immediate-early protein BZLF1 is a transcriptional activ

44 The Epstein-Barr virus (EBV) immediate-early protein BZLF1 mediates the switch betwee

45 re we show that the Epstein-Barr virus (EBV) immediate-early protein BZLF1 prevents TNF-alpha activat

46 T inhibitors prevent expression of the viral immediate-early protein BZLF1.

47 ntegral role during lytic replication is the immediate-early protein BZLF1.

48 c EBV infection is mediated by the two viral immediate-early proteins BZLF1 (Z) and BRLF1 (R), which

49 The Epstein-Barr virus (EBV) immediate-early proteins BZLF1 and BRLF1 can both induce

50 the ability of rAd vectors encoding the EBV immediate-early proteins BZLF1 and BRLF1 to induce the l

51 of EBV infection, expression of either viral immediate-early protein (BZLF1 or BRLF1) is sufficient t

52 s gene silencing, yet the Epstein-Barr virus immediate-early protein, BZLF1 (Z), converts the virus f

53 The Epstein-Barr virus immediate-early protein, BZLF1 (Z), initiates the switch

54 We demonstrate that the EBV immediate-early protein, BZLF1, activates the DHRS9 prom

55 emonstrate that the Epstein-Barr virus (EBV) immediate-early protein, BZLF1, inhibits the IFN-gamma s

56 t is known that expression of a single viral immediate-early protein, BZLF1, is sufficient to initiat

57 erentially affect the ability of the two EBV immediate-early proteins, BZLF1 (Z) and BRLF1 (R), to in

58 However, expression of either of the EBV immediate-early proteins, BZLF1 and BRLF1, is sufficient

59 ment, an immunohistochemical analysis of the immediate early protein c-Fos was performed as a marker

60 follow-up experiment, expression of a second immediate early protein, egr-1, was blocked as well, sug

61 ycin-D, which results in accumulation of the immediate-early protein, failed to down-regulate class I

62 C-5 cells with a virus that does not express immediate-early proteins, followed by superinfection wit

63 s all required prior expression of the viral immediate early proteins for activation in fibroblasts.

64 The data suggest that the TTP and TIS11 immediate early proteins have similar but distinct effec

65 26-95 except K3 and K5 (bovine herpesvirus-4 immediate-early protein homologues), K7 (nut-1), and K12

66 Herpes simplex virus type 1 immediate early protein ICP0 influences virus infection

67 The immediate early protein ICP0 of herpes simplex virus 1 (

68 The herpes simplex virus 1 (HSV-1) immediate early protein ICP0 performs many functions dur

69 DNA-PKcs and in cells cotransfected with the immediate early protein ICP0, which degrades DNA-PKcs.

70 larities with herpes simplex virus 1 (HSV-1) immediate early protein ICP0, which stimulates lytic HSV

71 The alpha (immediate early) protein ICP0 of herpes simplex virus 1

72 the interaction between the C-USP7 and HSV-1 immediate-early protein ICP0 (infected cell protein 0),

73 The immediate-early protein ICP0 (infected-cell polypeptide

74 of the late viral proteins gE and gD and the immediate-early protein ICP0 but did not have discernibl

75 When expressed in the infected cell, the HSV immediate-early protein ICP0 has E3 ubiquitin ligase act

76 SV-1) mutants that fail to express the viral immediate-early protein ICP0 have a pronounced defect in

77 The herpes simplex virus type 1 (HSV-1) immediate-early protein ICP0 interacts with several cell

78 Herpes simplex virus type 1 (HSV-1) immediate-early protein ICP0 is a general activator of v

79 Herpes simplex virus type 1 immediate-early protein ICP0 is an E3 ubiquitin ligase o

80 Herpes simplex virus 1 (HSV-1) immediate-early protein ICP0 is required for efficient l

81 Herpes simplex virus 1 (HSV-1) immediate-early protein ICP0 localizes to cellular struc

82 The immediate-early protein ICP0 of herpes simplex virus typ

83 Immediate-early protein ICP0 of herpes simplex virus typ

84 In herpes simplex virus type 1 (HSV-1), the immediate-early protein ICP0 serves as a counterdefense

85 Using mutant viruses, we determined that the immediate-early protein ICP0 was necessary for the inhib

86 The immediate-early protein ICP0, which requires VP22 for pa

87 ns, which in turn are destroyed by the HSV-1 immediate-early protein ICP0.

88 Another clone recognized an immediate early protein, ICP0.

89 , in the absence of the "nonessential" viral immediate-early protein, ICP0, HSV-1 is severely impaire

90 s, US11 and gC, and increased amounts of two immediate-early proteins, ICP0 and ICP4, as well as prot

91 that the herpes simplex virus type 1 (HSV-1) immediate-early protein ICP22 alters the phosphorylation

92 n in Vero and other cells requires the HSV-1 immediate-early protein ICP22.

93 ro cells and that certain mutations in viral immediate early protein ICP27 can confer LMB resistance.

94 In addition, synthesis of the immediate early protein ICP27 causes partial inhibition

95 The herpes simplex virus type 1 (HSV-1) immediate-early protein ICP27 is an RNA-binding protein

96 The herpes simplex virus type 1 (HSV-1) immediate-early protein ICP27 is required posttranscript

97 of the HSV genome, we provide evidence that immediate-early protein ICP4 is involved in the process

98 infected with DeltaU(L)31, expression of the immediate-early protein ICP4, early protein ICP8, and la

99 ific viral DNA sequence, OriS, and the viral immediate-early proteins ICP4 and ICP27 are sufficient f

100 e discernible effects on accumulation of the immediate-early proteins ICP4 or ICP27.

101 le component, granzyme B, degrades the HSV-1 immediate early protein, ICP4, which is essential for fu

102 The herpes simplex virus (HSV) immediate early protein ICP47 inhibits the transporter a

103 The immediate early protein ICP47 of herpes simplex virus (H

104 implex virus serotype 1 (HSV-1) expresses an immediate-early protein, ICP47, that effectively blocks

105 s types 1 and 2 (HSV-1 and HSV-2) express an immediate-early protein, ICP47, that effectively inhibit

106 Human cytomegalovirus (HCMV) immediate early protein IE1 and the tegument protein pp7

107 Immediate-early protein IE1 is a principal regulator of

108 Human cytomegalovirus (HCMV) major immediate-early protein IE1 is an abundant 72-kDa nuclea

109 The immediate-early protein IE1 is the principal transcripti

110 us-induced alteration of the pre-RC, and the immediate-early protein IE1 was not required.

111 We also demonstrate that the HCMV immediate-early protein IE1-72 complexes in vivo with th

112 d through individual expression of the viral immediate-early protein IE1-72, mimicking full virus inf

113 Human cytomegalovirus (HCMV) immediate-early protein IE1/IE72 is involved in undermin

114 observed to express high levels of the major immediate-early proteins IE1 and IE2.

115 However, the viral immediate-early proteins IE1-72 and IE2-86, either alone

116 ting a transactivator plasmid expressing the immediate early protein (IE1) from the Bombyx mori nucle

117 rnica multicapsid nuclear polyhedrosis virus immediate-early protein, IE1, is a 582-amino-acid phosph

118 Immediate-early protein IE180, major capsid protein VP5,

119 ndent DNA replication and interacts with the immediate-early protein IE2 in lytically infected cells.

120 The human cytomegalovirus (HCMV) major immediate-early protein IE2 is a nuclear phosphoprotein

121 ally identified as a binding element for the immediate-early protein IE2, was essential for oriLyt(PM

122 The 86-kDa major immediate-early protein (IE2/IEP86) of human cytomegalov

123 Peptides corresponding to residues of the immediate early protein, IE62, of varicella-zoster virus

124 oclonal antibody (rec-MAb 63P4) that detects immediate-early protein IE63 encoded by varicella-zoster

125 viral major immediate promoter (MIEP) by its immediate-early protein IE72 (determined by cotransfecti

126 fic for either HCMV tegument protein pp65 or immediate-early protein IE72 are found in both CD45RO(hi

127 ated by a mechanism involving the HCMV major immediate-early protein IE72.

128 and this attenuation is mediated by the HCMV immediate-early protein IE86.

129 Stimulation of this promoter by the 86-kDa immediate-early protein (IE86) is controlled by sequence

130 R2 protein (IR2P) is a truncated form of the immediate-early protein (IEP) lacking the essential acid

131 e-specific DNA-binding activity of the EHV-1 immediate-early protein (IEP).

132 The 86-kDa major immediate-early protein, IEP86 (IE2, IE2(579aa), or ppUL

133 We demonstrate that an immediate-early protein, infected cell protein 0 (ICP0),

134 The herpes simplex virus 1 (HSV-1) immediate-early protein, infected cell protein 22 (ICP22

135 resistant translation, the presence of viral immediate-early proteins is sufficient to establish a st

136 iral transcription factor, the 72K principal immediate-early protein, is abundantly expressed before

137 ICP0, a herpes simplex virus (HSV) immediate-early protein, is necessary and sufficient to

138 iRNAs targeted to sequences encoding Rta, an immediate-early protein known as an initiator of the lyt

139 These data suggest that the R immediate-early protein may activate a key early EBV pro

140 that the human cytomegalovirus (HCMV) major immediate-early proteins (MIEPs) can rescue the transcri

141 We found that a viral immediate-early protein, namely ORF45, interacts with ce

142 was dependent on the expression of ICP0, an immediate early protein of HSV-1.

143 The immediate early protein of the virus ICP0 plays major ro

144 ICP22, an immediate-early protein of herpes simplex virus type 1 (

145 Although the immediate-early proteins of both herpes simplex virus (H

146 this regulation has come from studies using immediate-early proteins of DNA tumor viruses.

147 3 and UL122 transcripts encoding IE1 and IE2 immediate-early proteins of HCMV.

148 ein interactions between ICP4 and ICP27, two immediate-early proteins of HSV-1 that are essential for

149 ICP0, an alpha (immediate-early) protein of herpes simplex virus 1, perf

150 copy studies indicated that Rosco caused the immediate-early proteins ORF4 and IE62 to abnormally loc

151 ansactivation was also mediated by the viral immediate-early protein Orf50/Rta, suggesting that the K

152 cient to reactivate latent VZV or target the immediate-early protein ORF62p to the nucleus in culture

153 The herpes simplex virus (HSV) ICP27 immediate-early protein plays an essential role in the e

154 Human cytomegalovirus immediate-early protein pUL37 x 1 induces Bax mitochondr

155 The human cytomegalovirus immediate-early protein pUL37x1 induces the release of C

156 ORF59 binds to oriLyt through an immediate early protein, replication and transcription a

157 HV genome, including repression of the viral immediate-early protein Rta and a cellular factor, Rbl2,

158 One of the genes, ORF4, encodes an immediate-early protein that is present in the virion te

159 ssential herpes simplex virus type 1 (HSV-1) immediate-early protein that stimulates viral mRNA expre

160 1 (R) is one of two Epstein-Barr virus (EBV) immediate-early proteins that mediate the switch from th

161 Expression of the immediate early protein tristetraprolin (TTP) is induced

162 The immediate early protein tristetraprolin (TTP) is require

163 rus type 1 infection revealed that the viral immediate-early protein Vmw110 (also known as ICP0) form

164 Herpes simplex virus type 1 immediate-early protein Vmw110 is a non-specific activat

165 Herpes simplex virus type 1 (HSV-1) immediate-early protein Vmw110 stimulates the onset of v

166 Herpes simplex virus type 1 immediate-early protein Vmw110 stimulates the onset of v

167 ss is reliant on the expression of the HSV-1 immediate-early protein Vmw110.

168 ability to interact with the mammalian TIS21 immediate-early protein, was then shown to have protein

169 While the 86- and 72-kDa immediate-early proteins were not detected in HPCs infec

170 rus IRS1 and TRS1 open reading frames encode immediate-early proteins with identical N-terminal domai

171 and replication function of the EBV-encoded immediate-early protein Zta (also referred to as ZEBRA,

172 Epstein-Barr virus (EBV) immediate-early protein Zta is a member of the basic-leu

173 The immediate-early protein Zta is a member of the basic-leu

174 scriptional activation function of the viral immediate-early protein Zta.

175 (EBV) lytic replication is initiated by the immediate-early protein Zta.

176 The Epstein-Barr virus immediate-early protein (Zta) plays an essential role in

177 lly activated by overexpression of the viral immediate-early protein, Zta.