ライフサイエンスコーパス: immortality

1 tions, consistent with suppression of their 'immortality'.

2 ing how much telomerase is required for cell immortality.

3 ase pathway for telomere maintenance to gain immortality.

4 al role in chromosome stability and cellular immortality.

5 mere length, is sufficient to result in cell immortality.

6 e been overcome in a cancer cell's quest for immortality.

7 tion of the potential to achieve replicative immortality.

8 ibutes to the acquisition and maintenance of immortality.

9 east cells to overcome senescence and attain immortality.

10 m in addition to hTERT expression to achieve immortality.

11 ast known proliferative blockade to cellular immortality.

12 and essential feature of germ cells is their immortality.

13 el and may facilitate cell transformation to immortality.

14 echanism (TMM) is permissive for replicative immortality and a hallmark of human cancer.

15 key pathways required to support replicative immortality and anchorage independent growth, a predicto

16 The roles of telomerase in both cellular immortality and cancer are vibrant areas of current rese

17 Telomerase is associated with cell immortality and cancer, which may by related to the abil

18 me end-replicating enzyme, drives human cell immortality and cancer.

19 e tumor cells is sufficient to reverse their immortality and cause a phenotype that is, by all genera

20 on of telomeric repeats and may promote cell immortality and hence malignancy.

21 To acquire immortality and malignancy, the cultured finite lifespan

22 c DNA (TTAGGG)n, may be involved in cellular immortality and oncogenesis.

23 to investigate the contribution of cellular immortality and oncogenic transformation of primary huma

24 n of telomerase is crucial for cells to gain immortality and proliferation ability, we examined the r

25 elomere and genome stability to ensure their immortality and shed light on the regeneration medicine

26 rk is critical to understanding how cellular immortality and totipotency are retained, gained, and lo

27 suggest the existence of a suppressor of SCC immortality and tumour development at chromosome 6q14.3-

28 elomerase, which has been linked to cellular immortality and tumour progression.

29 The enzyme is required for cell immortality, and its activity has been detected in the v

30 ve (RSD)-2 and RSD-6 is to promote germ cell immortality at high temperature.

31 opose that RSD-2 and RSD-6 promote germ cell immortality at stressful temperatures by maintaining tra

32 Our previous work showed that acquisition of immortality at the dysplasia stage of oral cancer progre

33 te telomerase, contributing to proliferative immortality, but the molecular events driving TERT activ

34 e activity is closely linked to the cellular immortality characteristic of late stage carcinogenesis,

35 rowth potential before progression to clonal immortality could occur.

36 The development of cellular immortality has been implicated as an important factor i

37 on the dominance of cellular senescence over immortality, immortal human cell lines have been assigne

38 lls experience multiple barriers to cellular immortality in culture (mortality mechanisms 0, 1, and 2

39 broad dependence on telomerase for germline immortality in metazoans.

40 terized by serum independence in culture and immortality in vivo, when compared with wild type contro

41 bute to a molecular understanding of Hydra's immortality, indicate an evolutionarily conserved role o

42 phase transition between finite lifetime and immortality (infinite proliferation) of the cell populat

43 Our results show that the acquisition of immortality is a crucial and rate-limiting step towards

44 Replicative immortality is achieved in vitro by overcoming two morta

45 Squamous cell carcinoma (SCC) immortality is associated with p53 and INK4A dysfunction

46 mechanism of replicative senescence and cell immortality is still unclear.

47 nce telomerase plays a critical role in cell immortality, it is an attractive target for a selective

48 ibit telomerase reactivation and attain full immortality much more rapidly.

49 e is thought to be essential for replicative immortality, MYC, in conjunction with cofactors, confers

50 maintenance, and supports the proliferative immortality of cancer cells.

51 ans infection on the continuing survival and immortality of human peripheral blood mononuclear cells

52 etic ground state required for the continued immortality of the C. elegans germ line.

53 ltigenerational RNAi inheritance and promote immortality of the germ-cell lineage.

54 has thus been proposed to be a basis for the immortality of the germline and of malignant cells.

55 sfection with telomerase was shown to confer immortality on several types of human cells.

56 to try to confer some of the germ lineage's immortality on the somatic body.

57 f reactive oxygen species (ROS) during tumor immortality, proliferation and metastasis.

58 ther, these observations imply that cellular immortality promotes epigenetic adaptation to highly pro

59 In Caenorhabditis elegans, germline immortality requires the maternal contribution from four

60 r output from stem cells as well as inducing immortality, self-renewal, and tumorigenesis in myeloid

61 The majority of human tumor cells acquire immortality through expression of the catalytic subunit

62 e between cellular life and death, achieving immortality through pathologic enforcement of survival p

63 lls are distinct from somatic cells in their immortality, totipotency, and ability to undergo meiosis

64 ence of cells with stem-cell properties (ie, immortality, transplantability, and resistance to therap

65 ify the genes that are required for germline immortality, we isolated Caenorhabditis elegans mutants

66 A hallmark of tumor cells is replicative immortality, which can be achieved, in part, by the acti